Harvard Eye Fairness: A Large-Scale 3D Imaging Dataset for Equitable Eye Diseases Screening and Fair Identity Scaling

Fairness or equity in machine learning is profoundly important for societal well-being, but limited public datasets hinder its progress, especially in the area of medicine. It is undeniable that fairness in medicine is one of the most important areas for fairness learning's applications. Currently, no large-scale public medical datasets with 3D imaging data for fairness learning are available, while 3D imaging data in modern clinics are standard tests for disease diagnosis. In addition, existing medical fairness datasets are actually repurposed datasets, and therefore they typically have limited demographic identity attributes with at most three identity attributes of age, gender, and race for fairness modeling. To address this gap, we introduce our Eye Fairness dataset with 30,000 subjects (Harvard-EF) covering three major eye diseases including age-related macular degeneration, diabetic retinopathy, and glaucoma affecting 380 million patients globally. Our Harvard-EF dataset includes both 2D fundus photos and 3D optical coherence tomography scans with six demographic identity attributes including age, gender, race, ethnicity, preferred language, and marital status. We also propose a fair identity scaling (FIS) approach combining group and individual scaling together to improve model fairness. Our FIS approach is compared with various state-of-the-art fairness learning methods with superior performance in the racial, gender, and ethnicity fairness tasks with 2D and 3D imaging data, which demonstrate the utilities of our Harvard-EF dataset for fairness learning. To facilitate fairness comparisons between different models, we propose performance-scaled disparity measures, which can be used to compare model fairness accounting for overall performance levels. The dataset and code are publicly accessible via https://ophai.hms.harvard.edu/datasets/harvard-ef30k.

Harvard Glaucoma Detection and Progression: A Multimodal Multitask Dataset and Generalization-Reinforced Semi-Supervised Learning

Glaucoma is the number one cause of irreversible blindness globally. A major challenge for accurate glaucoma detection and progression forecasting is the bottleneck of limited labeled patients with the state-of-the-art (SOTA) 3D retinal imaging data of optical coherence tomography (OCT). To address the data scarcity issue, this paper proposes two solutions. First, we develop a novel generalization-reinforced semi-supervised learning (SSL) model called pseudo supervisor to optimally utilize unlabeled data. Compared with SOTA models, the proposed pseudo supervisor optimizes the policy of predicting pseudo labels with unlabeled samples to improve empirical generalization. Our pseudo supervisor model is evaluated with two clinical tasks consisting of glaucoma detection and progression forecasting. The progression forecasting task is evaluated both unimodally and multimodally. Our pseudo supervisor model demonstrates superior performance than SOTA SSL comparison models. Moreover, our model also achieves the best results on the publicly available LAG fundus dataset. Second, we introduce the Harvard Glaucoma Detection and Progression (Harvard-GDP) Dataset, a multimodal multitask dataset that includes data from 1,000 patients with OCT imaging data, as well as labels for glaucoma detection and progression. This is the largest glaucoma detection dataset with 3D OCT imaging data and the first glaucoma progression forecasting dataset that is publicly available. Detailed sex and racial analysis are provided, which can be used by interested researchers for fairness learning studies. Our released dataset is benchmarked with several SOTA supervised CNN and transformer deep learning models. The dataset and code are made publicly available via \url{https://ophai.hms.harvard.edu/datasets/harvard-gdp1000}.

Focus the Discrepancy: Intra- and Inter-Correlation Learning for Image Anomaly Detection

Humans recognize anomalies through two aspects: larger patch-wise representation discrepancies and weaker patch-to-normal-patch correlations. However, the previous AD methods didn't sufficiently combine the two complementary aspects to design AD models. To this end, we find that Transformer can ideally satisfy the two aspects as its great power in the unified modeling of patch-wise representations and patch-to-patch correlations. In this paper, we propose a novel AD framework: FOcus-the-Discrepancy (FOD), which can simultaneously spot the patch-wise, intra- and inter-discrepancies of anomalies. The major characteristic of our method is that we renovate the self-attention maps in transformers to Intra-Inter-Correlation (I2Correlation). The I2Correlation contains a two-branch structure to first explicitly establish intra- and inter-image correlations, and then fuses the features of two-branch to spotlight the abnormal patterns. To learn the intra- and inter-correlations adaptively, we propose the RBF-kernel-based target-correlations as learning targets for self-supervised learning. Besides, we introduce an entropy constraint strategy to solve the mode collapse issue in optimization and further amplify the normal-abnormal distinguishability. Extensive experiments on three unsupervised real-world AD benchmarks show the superior performance of our approach. Code will be available at https://github.com/xcyao00/FOD.

Harvard Glaucoma Fairness: A Retinal Nerve Disease Dataset for Fairness Learning and Fair Identity Normalization

Fairness in machine learning is important for societal well-being, but limited public datasets hinder its progress. Currently, no dedicated public medical datasets with imaging data for fairness learning are available, though minority groups suffer from more health issues. To address this gap, we introduce Harvard Glaucoma Fairness (Harvard-GF), a retinal nerve disease dataset with both 2D and 3D imaging data and balanced racial groups for glaucoma detection. Glaucoma is the leading cause of irreversible blindness globally with Blacks having doubled glaucoma prevalence than other races. We also propose a fair identity normalization (FIN) approach to equalize the feature importance between different identity groups. Our FIN approach is compared with various the-state-of-the-arts fairness learning methods with superior performance in both racial and gender fairness tasks with 2D and 3D imaging data, which demonstrate the utilities of our dataset Harvard-GF for fairness learning. To facilitate fairness comparisons between different models, we propose an equity-scaled performance measure, which can be flexibly used to compare all kinds of performance metrics in the context of fairness. The dataset and code are publicly accessible via https://doi.org/10.7910/DVN/A4XMO1 and https://github.com/luoyan407/Harvard-GF, respectively.

Timestamps as Prompts for Geography-Aware Location Recommendation

Location recommendation plays a vital role in improving users' travel experience. The timestamp of the POI to be predicted is of great significance, since a user will go to different places at different times. However, most existing methods either do not use this kind of temporal information, or just implicitly fuse it with other contextual information. In this paper, we revisit the problem of location recommendation and point out that explicitly modeling temporal information is a great help when the model needs to predict not only the next location but also further locations. In addition, state-of-the-art methods do not make effective use of geographic information and suffer from the hard boundary problem when encoding geographic information by gridding. To this end, a Temporal Prompt-based and Geography-aware (TPG) framework is proposed. The temporal prompt is firstly designed to incorporate temporal information of any further check-in. A shifted window mechanism is then devised to augment geographic data for addressing the hard boundary problem. Via extensive comparisons with existing methods and ablation studies on five real-world datasets, we demonstrate the effectiveness and superiority of the proposed method under various settings. Most importantly, our proposed model has the superior ability of interval prediction. In particular, the model can predict the location that a user wants to go to at a certain time while the most recent check-in behavioral data is masked, or it can predict specific future check-in (not just the next one) at a given timestamp.

End-to-End Personalized Next Location Recommendation via Contrastive User Preference Modeling

Predicting the next location is a highly valuable and common need in many location-based services such as destination prediction and route planning. The goal of next location recommendation is to predict the next point-of-interest a user might go to based on the user's historical trajectory. Most existing models learn mobility patterns merely from users' historical check-in sequences while overlooking the significance of user preference modeling. In this work, a novel Point-of-Interest Transformer (POIFormer) with contrastive user preference modeling is developed for end-to-end next location recommendation. This model consists of three major modules: history encoder, query generator, and preference decoder. History encoder is designed to model mobility patterns from historical check-in sequences, while query generator explicitly learns user preferences to generate user-specific intention queries. Finally, preference decoder combines the intention queries and historical information to predict the user's next location. Extensive comparisons with representative schemes and ablation studies on four real-world datasets demonstrate the effectiveness and superiority of the proposed scheme under various settings.

mmAlert: mmWave Link Blockage Prediction via Passive Sensing

In this letter, the mmAlert system, predicting millimeter wave (mmWave) link blockage during data communication, is elaborated and demonstrated. The passive sensing method is adopted for mobile blocker detection, where two receive beams with separated radio frequency (RF) chains are equipped at the data communication receiver. One receive beam is aligned to the direction of line-of-sight (LoS) path, and the other one periodically sweeps the region close to the LoS path. By comparing the signals received by the above two beams, the Doppler frequencies of the signal scattered from the mobile blocker can be detected. Furthermore, by tracking the Doppler frequencies and the angle-of-arrivals (AoAs) of the scattered signals, the trajectory of the mobile blocker can be estimated, such that the potential link blockage can be predicted by assuming consistent mobile velocity. It is demonstrated via experiments that the mmAlert system can always detect the motions of the walking person close to the LoS path, and predict 90\% of the LoS blockage with sensing time of 1.4 seconds.

Long-Range Zero-Shot Generative Deep Network Quantization

Quantization approximates a deep network model with floating-point numbers by the one with low bit width numbers, in order to accelerate inference and reduce computation. Quantizing a model without access to the original data, zero-shot quantization can be accomplished by fitting the real data distribution by data synthesis. However, zero-shot quantization achieves inferior performance compared to the post-training quantization with real data. We find it is because: 1) a normal generator is hard to obtain high diversity of synthetic data, since it lacks long-range information to allocate attention to global features; 2) the synthetic images aim to simulate the statistics of real data, which leads to weak intra-class heterogeneity and limited feature richness. To overcome these problems, we propose a novel deep network quantizer, dubbed Long-Range Zero-Shot Generative Deep Network Quantization (LRQ). Technically, we propose a long-range generator to learn long-range information instead of simple local features. In order for the synthetic data to contain more global features, long-range attention using large kernel convolution is incorporated into the generator. In addition, we also present an Adversarial Margin Add (AMA) module to force intra-class angular enlargement between feature vector and class center. As AMA increases the convergence difficulty of the loss function, which is opposite to the training objective of the original loss function, it forms an adversarial process. Furthermore, in order to transfer knowledge from the full-precision network, we also utilize a decoupled knowledge distillation. Extensive experiments demonstrate that LRQ obtains better performance than other competitors.

GM-TCNet: Gated Multi-scale Temporal Convolutional Network using Emotion Causality for Speech Emotion Recognition

In human-computer interaction, Speech Emotion Recognition (SER) plays an essential role in understanding the user's intent and improving the interactive experience. While similar sentimental speeches own diverse speaker characteristics but share common antecedents and consequences, an essential challenge for SER is how to produce robust and discriminative representations through causality between speech emotions. In this paper, we propose a Gated Multi-scale Temporal Convolutional Network (GM-TCNet) to construct a novel emotional causality representation learning component with a multi-scale receptive field. GM-TCNet deploys a novel emotional causality representation learning component to capture the dynamics of emotion across the time domain, constructed with dilated causal convolution layer and gating mechanism. Besides, it utilizes skip connection fusing high-level features from different gated convolution blocks to capture abundant and subtle emotion changes in human speech. GM-TCNet first uses a single type of feature, mel-frequency cepstral coefficients, as inputs and then passes them through the gated temporal convolutional module to generate the high-level features. Finally, the features are fed to the emotion classifier to accomplish the SER task. The experimental results show that our model maintains the highest performance in most cases compared to state-of-the-art techniques.

A New Task: Deriving Semantic Class Targets for the Physical Sciences

We define deriving semantic class targets as a novel multi-modal task. By doing so, we aim to improve classification schemes in the physical sciences which can be severely abstracted and obfuscating. We address this task for upcoming radio astronomy surveys and present the derived semantic radio galaxy morphology class targets.