WBCBench 2026: A Challenge for Robust White Blood Cell Classification Under Class Imbalance

We present WBCBench 2026, an ISBI challenge and benchmark for automated WBC classification designed to stress-test algorithms under three key difficulties: (i) severe class imbalance across 13 morphologically fine-grained WBC classes, (ii) strict patient-level separation between training, validation and test sets, and (iii) synthetic scanner- and setting-induced domain shift via controlled noise, blur and illumination perturbations. All images are single-site microscopic blood smear acquisitions with standardised staining and expert hematopathologist annotations. This paper reviews the challenge and summarises the proposed solutions and final outcomes. The benchmark is organised into two phases. Phase 1 provides a pristine training set. Phase 2 introduces degraded images with split-specific severity distributions for train, validation and test, emulating a realistic shift between development and deployment conditions. We specify a standardised submission schema, open-source evaluator, and macro-averaged F1 score as the primary ranking metric.

Region-Graph Optimal Transport Routing for Mixture-of-Experts Whole-Slide Image Classification

Multiple Instance Learning (MIL) is the dominant framework for gigapixel whole-slide image (WSI) classification in computational pathology. However, current MIL aggregators route all instances through a shared pathway, constraining their capacity to specialise across the pathological heterogeneity inherent in each slide. Mixture-of-Experts (MoE) methods offer a natural remedy by partitioning instances across specialised expert subnetworks; yet unconstrained softmax routing may yield highly imbalanced utilisation, where one or a few experts absorb most routing mass, collapsing the mixture back to a near-single-pathway solution. To address these limitations, we propose ROAM (Region-graph OptimAl-transport Mixture-of-experts), a spatially aware MoE-MIL aggregator that routes region tokens to expert poolers via capacity-constrained entropic optimal transport, promoting balanced expert utilisation by construction. ROAM operates on spatial region tokens, obtained by compressing dense patch bags into spatially binned units that align routing with local tissue neighbourhoods and introduces two key mechanisms: (i) region-to-expert assignment formulated as entropic optimal transport (Sinkhorn) with explicit per slide capacity marginals, enforcing balanced expert utilisation without auxiliary load-balancing losses; and (ii) graph-regularised Sinkhorn iterations that diffuse routing assignments over the spatial region graph, encouraging neighbouring regions to coherently route to the same experts. Evaluated on four WSI benchmarks with frozen foundation-model patch embeddings, ROAM achieves performance competitive against strong MIL and MoE baselines, and on NSCLC generalisation (TCGA-CPTAC) reaches external AUC 0.845 +- 0.019.

MiniCPM-SALA: Hybridizing Sparse and Linear Attention for Efficient Long-Context Modeling

The evolution of large language models (LLMs) towards applications with ultra-long contexts faces challenges posed by the high computational and memory costs of the Transformer architecture. While existing sparse and linear attention mechanisms attempt to mitigate these issues, they typically involve a trade-off between memory efficiency and model performance. This paper introduces MiniCPM-SALA, a 9B-parameter hybrid architecture that integrates the high-fidelity long-context modeling of sparse attention (InfLLM-V2) with the global efficiency of linear attention (Lightning Attention). By employing a layer selection algorithm to integrate these mechanisms in a 1:3 ratio and utilizing a hybrid positional encoding (HyPE), the model maintains efficiency and performance for long-context tasks. Furthermore, we introduce a cost-effective continual training framework that transforms pre-trained Transformer-based models into hybrid models, which reduces training costs by approximately 75% compared to training from scratch. Extensive experiments show that MiniCPM-SALA maintains general capabilities comparable to full-attention models while offering improved efficiency. On a single NVIDIA A6000D GPU, the model achieves up to 3.5x the inference speed of the full-attention model at the sequence length of 256K tokens and supports context lengths of up to 1M tokens, a scale where traditional full-attention 8B models fail because of memory constraints.

SFormer: SNR-guided Transformer for Underwater Image Enhancement from the Frequency Domain

Recent learning-based underwater image enhancement (UIE) methods have advanced by incorporating physical priors into deep neural networks, particularly using the signal-to-noise ratio (SNR) prior to reduce wavelength-dependent attenuation. However, spatial domain SNR priors have two limitations: (i) they cannot effectively separate cross-channel interference, and (ii) they provide limited help in amplifying informative structures while suppressing noise. To overcome these, we propose using the SNR prior in the frequency domain, decomposing features into amplitude and phase spectra for better channel modulation. We introduce the Fourier Attention SNR-prior Transformer (FAST), combining spectral interactions with SNR cues to highlight key spectral components. Additionally, the Frequency Adaptive Transformer (FAT) bottleneck merges low- and high-frequency branches using a gated attention mechanism to enhance perceptual quality. Embedded in a unified U-shaped architecture, these modules integrate a conventional RGB stream with an SNR-guided branch, forming SFormer. Trained on 4,800 paired images from UIEB, EUVP, and LSUI, SFormer surpasses recent methods with a 3.1 dB gain in PSNR and 0.08 in SSIM, successfully restoring colors, textures, and contrast in underwater scenes.

Gaussian Primitive Optimized Deformable Retinal Image Registration

Deformable retinal image registration is notoriously difficult due to large homogeneous regions and sparse but critical vascular features, which cause limited gradient signals in standard learning-based frameworks. In this paper, we introduce Gaussian Primitive Optimization (GPO), a novel iterative framework that performs structured message passing to overcome these challenges. After an initial coarse alignment, we extract keypoints at salient anatomical structures (e.g., major vessels) to serve as a minimal set of descriptor-based control nodes (DCN). Each node is modelled as a Gaussian primitive with trainable position, displacement, and radius, thus adapting its spatial influence to local deformation scales. A K-Nearest Neighbors (KNN) Gaussian interpolation then blends and propagates displacement signals from these information-rich nodes to construct a globally coherent displacement field; focusing interpolation on the top (K) neighbors reduces computational overhead while preserving local detail. By strategically anchoring nodes in high-gradient regions, GPO ensures robust gradient flow, mitigating vanishing gradient signal in textureless areas. The framework is optimized end-to-end via a multi-term loss that enforces both keypoint consistency and intensity alignment. Experiments on the FIRE dataset show that GPO reduces the target registration error from 6.2\,px to ~2.4\,px and increases the AUC at 25\,px from 0.770 to 0.938, substantially outperforming existing methods. The source code can be accessed via https://github.com/xintian-99/GPOreg.

From Rankings to Insights: Evaluation Should Shift Focus from Leaderboard to Feedback

Automatic evaluation benchmarks such as MT-Bench, Arena-Hard, and Auto-Arena are seeing growing adoption for the evaluation of Large Language Models (LLMs). Existing research has primarily focused on approximating human-based model rankings using limited data and LLM-as-a-Judge. However, the fundamental premise of these studies, which attempts to replicate human rankings, is flawed. Specifically, these benchmarks typically offer only overall scores, limiting their utility to leaderboard rankings, rather than providing feedback that can guide model optimization and support model profiling. Therefore, we advocate for an evaluation paradigm shift from approximating human-based model rankings to providing feedback with analytical value. To this end, we introduce Feedbacker, an evaluation framework that provides comprehensive and fine-grained results, thereby enabling thorough identification of a model's specific strengths and weaknesses. Such feedback not only supports the targeted optimization of the model but also enhances the understanding of its behavior. Feedbacker comprises three key components: an extensible tree-based query taxonomy builder, an automated query synthesis scheme, and a suite of visualization and analysis tools. Furthermore, we propose a novel LLM-as-a-Judge method: PC2 (Pre-Comparison-derived Criteria) pointwise evaluation. This method derives evaluation criteria by pre-comparing the differences between several auxiliary responses, achieving the accuracy of pairwise evaluation while maintaining the time complexity of pointwise evaluation. Finally, leveraging the evaluation results of 17 mainstream LLMs, we demonstrate the usage of Feedbacker and highlight its effectiveness and potential. Our homepage project is available at https://liudan193.github.io/Feedbacker.

Mamba-Based Ensemble learning for White Blood Cell Classification

White blood cell (WBC) classification assists in assessing immune health and diagnosing various diseases, yet manual classification is labor-intensive and prone to inconsistencies. Recent advancements in deep learning have shown promise over traditional methods; however, challenges such as data imbalance and the computational demands of modern technologies, such as Transformer-based models which do not scale well with input size, limit their practical application. This paper introduces a novel framework that leverages Mamba models integrated with ensemble learning to improve WBC classification. Mamba models, known for their linear complexity, provide a scalable alternative to Transformer-based approaches, making them suitable for deployment in resource-constrained environments. Additionally, we introduce a new WBC dataset, Chula-WBC-8, for benchmarking. Our approach not only validates the effectiveness of Mamba models in this domain but also demonstrates their potential to significantly enhance classification efficiency without compromising accuracy. The source code can be found at https://github.com/LewisClifton/Mamba-WBC-Classification.

Multimodal Image Matching based on Frequency-domain Information of Local Energy Response

Complicated nonlinear intensity differences, nonlinear local geometric distortions, noises and rotation transformation are main challenges in multimodal image matching. In order to solve these problems, we propose a method based on Frequency-domain Information of Local Energy Response called FILER. The core of FILER is the local energy response model based on frequency-domain information, which can overcome the effect of nonlinear intensity differences. To improve the robustness to local nonlinear geometric distortions and noises, we design a new edge structure enhanced feature detector and convolutional feature weighted descriptor, respectively. In addition, FILER overcomes the sensitivity of the frequency-domain information to the rotation angle and achieves rotation invariance. Extensive experiments multimodal image pairs show that FILER outperforms other state-of-the-art algorithms and has good robustness and universality.

SpatialMe: Stereo Video Conversion Using Depth-Warping and Blend-Inpainting

Stereo video conversion aims to transform monocular videos into immersive stereo format. Despite the advancements in novel view synthesis, it still remains two major challenges: i) difficulty of achieving high-fidelity and stable results, and ii) insufficiency of high-quality stereo video data. In this paper, we introduce SpatialMe, a novel stereo video conversion framework based on depth-warping and blend-inpainting. Specifically, we propose a mask-based hierarchy feature update (MHFU) refiner, which integrate and refine the outputs from designed multi-branch inpainting module, using feature update unit (FUU) and mask mechanism. We also propose a disparity expansion strategy to address the problem of foreground bleeding. Furthermore, we conduct a high-quality real-world stereo video dataset -- StereoV1K, to alleviate the data shortage. It contains 1000 stereo videos captured in real-world at a resolution of 1180 x 1180, covering various indoor and outdoor scenes. Extensive experiments demonstrate the superiority of our approach in generating stereo videos over state-of-the-art methods.

Enhancing Text-to-SQL Capabilities of Large Language Models via Domain Database Knowledge Injection

Text-to-SQL is a subtask in semantic parsing that has seen rapid progress with the evolution of Large Language Models (LLMs). However, LLMs face challenges due to hallucination issues and a lack of domain-specific database knowledge(such as table schema and cell values). As a result, they can make errors in generating table names, columns, and matching values to the correct columns in SQL statements. This paper introduces a method of knowledge injection to enhance LLMs' ability to understand schema contents by incorporating prior knowledge. This approach improves their performance in Text-to-SQL tasks. Experimental results show that pre-training LLMs on domain-specific database knowledge and fine-tuning them on downstream Text-to-SQL tasks significantly improves the Execution Match (EX) and Exact Match (EM) metrics across various models. This effectively reduces errors in generating column names and matching values to the columns. Furthermore, the knowledge-injected models can be applied to many downstream Text-to-SQL tasks, demonstrating the generalizability of the approach presented in this paper.