ADAgent: LLM Agent for Alzheimer's Disease Analysis with Collaborative Coordinator

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Early and precise diagnosis of AD is crucial for timely intervention and treatment planning to alleviate the progressive neurodegeneration. However, most existing methods rely on single-modality data, which contrasts with the multifaceted approach used by medical experts. While some deep learning approaches process multi-modal data, they are limited to specific tasks with a small set of input modalities and cannot handle arbitrary combinations. This highlights the need for a system that can address diverse AD-related tasks, process multi-modal or missing input, and integrate multiple advanced methods for improved performance. In this paper, we propose ADAgent, the first specialized AI agent for AD analysis, built on a large language model (LLM) to address user queries and support decision-making. ADAgent integrates a reasoning engine, specialized medical tools, and a collaborative outcome coordinator to facilitate multi-modal diagnosis and prognosis tasks in AD. Extensive experiments demonstrate that ADAgent outperforms SOTA methods, achieving significant improvements in accuracy, including a 2.7% increase in multi-modal diagnosis, a 0.7% improvement in multi-modal prognosis, and enhancements in MRI and PET diagnosis tasks.

Modification Takes Courage: Seamless Image Stitching via Reference-Driven Inpainting

Current image stitching methods often produce noticeable seams in challenging scenarios such as uneven hue and large parallax. To tackle this problem, we propose the Reference-Driven Inpainting Stitcher (RDIStitcher), which reformulates the image fusion and rectangling as a reference-based inpainting model, incorporating a larger modification fusion area and stronger modification intensity than previous methods. Furthermore, we introduce a self-supervised model training method, which enables the implementation of RDIStitcher without requiring labeled data by fine-tuning a Text-to-Image (T2I) diffusion model. Recognizing difficulties in assessing the quality of stitched images, we present the Multimodal Large Language Models (MLLMs)-based metrics, offering a new perspective on evaluating stitched image quality. Compared to the state-of-the-art (SOTA) method, extensive experiments demonstrate that our method significantly enhances content coherence and seamless transitions in the stitched images. Especially in the zero-shot experiments, our method exhibits strong generalization capabilities. Code: https://github.com/yayoyo66/RDIStitcher