VANER: Leveraging Large Language Model for Versatile and Adaptive Biomedical Named Entity Recognition

Prevalent solution for BioNER involves using representation learning techniques coupled with sequence labeling. However, such methods are inherently task-specific, demonstrate poor generalizability, and often require dedicated model for each dataset. To leverage the versatile capabilities of recently remarkable large language models (LLMs), several endeavors have explored generative approaches to entity extraction. Yet, these approaches often fall short of the effectiveness of previouly sequence labeling approaches. In this paper, we utilize the open-sourced LLM LLaMA2 as the backbone model, and design specific instructions to distinguish between different types of entities and datasets. By combining the LLM's understanding of instructions with sequence labeling techniques, we use mix of datasets to train a model capable of extracting various types of entities. Given that the backbone LLMs lacks specialized medical knowledge, we also integrate external entity knowledge bases and employ instruction tuning to compel the model to densely recognize carefully curated entities. Our model VANER, trained with a small partition of parameters, significantly outperforms previous LLMs-based models and, for the first time, as a model based on LLM, surpasses the majority of conventional state-of-the-art BioNER systems, achieving the highest F1 scores across three datasets.

DMNER: Biomedical Entity Recognition by Detection and Matching

Biomedical named entity recognition (BNER) serves as the foundation for numerous biomedical text mining tasks. Unlike general NER, BNER require a comprehensive grasp of the domain, and incorporating external knowledge beyond training data poses a significant challenge. In this study, we propose a novel BNER framework called DMNER. By leveraging existing entity representation models SAPBERT, we tackle BNER as a two-step process: entity boundary detection and biomedical entity matching. DMNER exhibits applicability across multiple NER scenarios: 1) In supervised NER, we observe that DMNER effectively rectifies the output of baseline NER models, thereby further enhancing performance. 2) In distantly supervised NER, combining MRC and AutoNER as span boundary detectors enables DMNER to achieve satisfactory results. 3) For training NER by merging multiple datasets, we adopt a framework similar to DS-NER but additionally leverage ChatGPT to obtain high-quality phrases in the training. Through extensive experiments conducted on 10 benchmark datasets, we demonstrate the versatility and effectiveness of DMNER.