IntentTune: Using user demand and personalization to resolve "unknown" query intents for e-commerce search

Understanding user intent is fundamental to delivering relevant search results in e-commerce. However, substantial fraction of real-world queries are under-specified (e.g., "watch" or "shirt"), lacking explicit attributes such as gender or age group. This ambiguity poses a significant challenge for query intent detection models in e-commerce search systems, which must accurately infer latent user intent (e.g., age, gender) to support effective downstream retrieval. We introduce IntentTune, a framework for resolving ambiguous or under-specified query intents by leveraging either (1) user-specific behavioral signals including search history, browsing activity, and profile attributes or (2) population-level demand patterns aggregated across all users. Through experiments on real-world e-commerce data, we first demonstrate that population-level demand patterns alone are insufficient to reliably infer intent in under-specified queries. We then demonstrate that user-specific behavioral signals -- particularly prior search queries -- outperform both population-level statistics and static profile information for inferring gender, age group, product category, and size intent from underspecified queries.

DynamicMem: A Long-Horizon Memory Benchmark in Real-World Settings

LLM agents increasingly act as personal assistants that must remember a user's profile over months: who they are (attributes), what they routinely do (habits), and what they prefer (preferences), and keep it updated as jobs, routines, and tastes drift. Existing benchmarks evaluate this "memory" ability through short, simplified interactions, missing three core properties of real behavior: the profile is heterogeneous, with attributes, habits, and preferences evolving on different timelines; changes are driven by external context such as seasons and life events; and evidence is rarely stated explicitly, instead scattered across many small actions in different apps that a memory system must infer from. We introduce DynamicMem, a synthetic benchmark that constructs 15 months of activity per user, providing long-term multi-app data that real users' privacy keeps out of reach. It provides user-consistent trajectories averaging 2.2M tokens and 1,772 grounded events per user across 16 applications such as e-commerce, fitness, and social platforms. The profile evolves over this period and is never given explicitly: each attribute, habit, or preference must be inferred from small signals scattered across apps. We evaluate at five quarterly checkpoints to track how systems scale as history grows. Benchmarking five representative systems exposes problems a single accuracy score hides: (i) profile reconstruction degrades with history length while service-task accuracy stays flat, despite both drawing on the same memory; (ii) no system both keeps facts that stay true and replaces facts that change, with errors clustering on preferences and on naming the exact referent; and (iii) over 93% of failures trace to what the memory retrieves, not to the model writing the answer, so the largest room for improvement lies in memory itself. Code: https://wenyaxie023.github.io/DynamicMem/

Let LLMs Judge Each Other: Multi-Agent Peer-Reviewed Reasoning for Medical Question Answering

Objective: To enhance the accuracy, interpretability, and robustness of large language models (LLMs) in medical question answering (MedQA). Method: We designed a multi-agent peer-reviewed reasoning method in which multiple LLM agents independently generate chain-of-thought reasoning with candidate answers, then act as peer reviewers to evaluate each other's reasoning for factual correctness and logical soundness. The highest-rated reasoning chain is selected to produce the final answer. Experiments were conducted with five state-of-the-art LLMs (Llama-3.1-8B, Qwen2.5-7B, Phi-4, DeepSeek-LLM-7B, GPT-oss-20B) on three benchmark datasets: HeadQA, MedQA-USMLE, and PubMedQA. Performance was compared against single-model chain-of-thought reasoning and chain-of-thought-based majority voting. Results: Peer-reviewed reasoning consistently outperformed both baselines. The best model combination achieved an average accuracy of 0.820 across datasets, exceeding the strongest single model (0.777) and majority voting ensembles (up to 0.789). The method also scaled effectively with more participating models, while peer assessments reliably distinguished high- from low-quality reasoning chains. Conclusion: The proposed multi-agent peer-reviewed reasoning method enables LLMs to act as both solvers and evaluators, yielding superior performance in MedQA. By emphasizing reasoning quality rather than answer agreement alone, this approach improves accuracy, interpretability, and robustness, offering a promising direction for trustworthy biomedical AI systems.

Iterating Toward Better Search: A Two-Agent Simulation Framework for Evaluating Agentic Search Architectures in E-Commerce

We present a modular two-agent simulation framework for evaluating conversational shopping assistant architectures. An independent buyer agent, configured with personas, missions, and patience levels, is paired with an interchangeable responder that integrates with a real e-commerce search API. Holding the buyer constant across experiments enables controlled comparison of responder designs on identical scenarios. Using 2011 conversations across 14 persona buckets, we establish four empirical findings. First, rolling-window memory outperforms intent-extraction memory on all quality metrics while being 35% faster per query. Second, illustrating rapid evidence-driven iteration, a systematic failure analysis of a responder version enables targeted fixes that reduce failure and near-failure rates by 62% across the full dataset. Third, swapping the responder LLM backbone from Gemini~2.5 to Llama~3.3~70B costs 0.16--0.45 points despite identical architecture. Finally, we document systematic philosophical disagreement between frontier LLM judges: Gemini rewards process correctness while Claude demands concrete outcomes, despite using the same evaluation prompt.

Asuka-Bench: Benchmarking Code Agents on Underspecified User Intent and Multi-Round Refinement

Existing code-generation benchmarks score a single mapping from a complete prompt to a one-shot output. However, real web development is different. Users seldom write a full spec at the start; many requirements only become clear once they look at an intermediate result and react to it. We present Asuka-Bench, a benchmark that pairs underspecified user intent with multi-round refinement, grounded in browser-rendered behavior. Each task is resolved through a closed loop: a Code Agent generates a web project, a UI Agent executes test cases on the deployed site, and a User LLM turns evaluation outcomes into natural-language feedback for the next round. The benchmark comprises 50 web tasks with 784 evaluation criteria and 2402 expected outcomes. We benchmark 8 LLMs across 2 agent frameworks. The results separate models clearly: weighted Task Pass Rate varies by 38 percentage points and models also differ substantially in their ability to repair from feedback. Asuka-Bench is also far from saturated: even the strongest model completes only 52% of projects after three rounds.

General365: Benchmarking General Reasoning in Large Language Models Across Diverse and Challenging Tasks

Contemporary large language models (LLMs) have demonstrated remarkable reasoning capabilities, particularly in specialized domains like mathematics and physics. However, their ability to generalize these reasoning skills to more general and broader contexts--often termed general reasoning--remains under-explored. Unlike domain-specific reasoning, general reasoning relies less on expert knowledge but still presents formidable reasoning challenges, such as complex constraints, nested logical branches, and semantic interference. To address this gap, we introduce General365, a benchmark specifically designed to assess general reasoning in LLMs. By restricting background knowledge to a K-12 level, General365 explicitly decouples reasoning from specialized expertise. The benchmark comprises 365 seed problems and 1,095 variant problems across eight categories, ensuring both high difficulty and diversity. Evaluations across 26 leading LLMs reveal that even the top-performing model achieves only 62.8% accuracy, in stark contrast to the near-perfect performances of LLMs in math and physics benchmarks. These results suggest that the reasoning abilities of current LLMs are heavily domain-dependent, leaving significant room for improvement in broader applications. We envision General365 as a catalyst for advancing LLM reasoning beyond domain-specific tasks toward robust, general-purpose real-world scenarios. Code, Dataset, and Leaderboard: https://general365.github.io

PRIME: Prototype-Driven Multimodal Pretraining for Cancer Prognosis with Missing Modalities

Multimodal self-supervised pretraining offers a promising route to cancer prognosis by integrating histopathology whole-slide images, gene expression, and pathology reports, yet most existing approaches require fully paired and complete inputs. In practice, clinical cohorts are fragmented and often miss one or more modalities, limiting both supervised fusion and scalable multimodal pretraining. We propose PRIME, a missing-aware multimodal self-supervised pretraining framework that learns robust and transferable representations from partially observed cohorts. PRIME maps heterogeneous modality embeddings into a unified token space and introduces a shared prototype memory bank for latent-space semantic imputation via patient-level consensus retrieval, producing structurally aligned tokens without reconstructing raw signals. Two complementary pretraining objectives: inter-modality alignment and post-fusion consistency under structured missingness augmentation, jointly learn representations that remain predictive under arbitrary modality subsets. We evaluate PRIME on The Cancer Genome Atlas with label-free pretraining on 32 cancer types and downstream 5-fold evaluation on five cohorts across overall survival prediction, 3-year mortality classification, and 3-year recurrence classification. PRIME achieves the best macro-average performance among all compared methods, reaching 0.653 C-index, 0.689 AUROC, and 0.637 AUROC on the three tasks, respectively, while improving robustness under test-time missingness and supporting parameter-efficient and label-efficient adaptation. These results support missing-aware multimodal pretraining as a practical strategy for prognosis modeling in fragmented clinical data settings.

EpiScreen: Early Epilepsy Detection from Electronic Health Records with Large Language Models

Epilepsy and psychogenic non-epileptic seizures often present with similar seizure-like manifestations but require fundamentally different management strategies. Misdiagnosis is common and can lead to prolonged diagnostic delays, unnecessary treatments, and substantial patient morbidity. Although prolonged video-electroencephalography is the diagnostic gold standard, its high cost and limited accessibility hinder timely diagnosis. Here, we developed a low-cost, effective approach, EpiScreen, for early epilepsy detection by utilizing routinely collected clinical notes from electronic health records. Through fine-tuning large language models on labeled notes, EpiScreen achieved an AUC of up to 0.875 on the MIMIC-IV dataset and 0.980 on a private cohort of the University of Minnesota. In a clinician-AI collaboration setting, EpiScreen-assisted neurologists outperformed unaided experts by up to 10.9%. Overall, this study demonstrates that EpiScreen supports early epilepsy detection, facilitating timely and cost-effective screening that may reduce diagnostic delays and avoid unnecessary interventions, particularly in resource-limited regions.

MedCL-Bench: Benchmarking stability-efficiency trade-offs and scaling in biomedical continual learning

Medical language models must be updated as evidence and terminology evolve, yet sequential updating can trigger catastrophic forgetting. Although biomedical NLP has many static benchmarks, no unified, task-diverse benchmark exists for evaluating continual learning under standardized protocols, robustness to task order and compute-aware reporting. We introduce MedCL-Bench, which streams ten biomedical NLP datasets spanning five task families and evaluates eleven continual learning strategies across eight task orders, reporting retention, transfer, and GPU-hour cost. Across backbones and task orders, direct sequential fine-tuning on incoming tasks induces catastrophic forgetting, causing update-induced performance regressions on prior tasks. Continual learning methods occupy distinct retention-compute frontiers: parameter-isolation provides the best retention per GPU-hour, replay offers strong protection at higher cost, and regularization yields limited benefit. Forgetting is task-dependent, with multi-label topic classification most vulnerable and constrained-output tasks more robust. MedCL-Bench provides a reproducible framework for auditing model updates before deployment.

HeartAgent: An Autonomous Agent System for Explainable Differential Diagnosis in Cardiology

Heart diseases remain a leading cause of morbidity and mortality worldwide, necessitating accurate and trustworthy differential diagnosis. However, existing artificial intelligence-based diagnostic methods are often limited by insufficient cardiology knowledge, inadequate support for complex reasoning, and poor interpretability. Here we present HeartAgent, a cardiology-specific agent system designed to support a reliable and explainable differential diagnosis. HeartAgent integrates customized tools and curated data resources and orchestrates multiple specialized sub-agents to perform complex reasoning while generating transparent reasoning trajectories and verifiable supporting references. Evaluated on the MIMIC dataset and a private electronic health records cohort, HeartAgent achieved over 36% and 20% improvements over established comparative methods, in top-3 diagnostic accuracy, respectively. Additionally, clinicians assisted by HeartAgent demonstrated gains of 26.9% in diagnostic accuracy and 22.7% in explanatory quality compared with unaided experts. These results demonstrate that HeartAgent provides reliable, explainable, and clinically actionable decision support for cardiovascular care.