SPL: A Socratic Playground for Learning Powered by Large Language Mode

Dialogue-based Intelligent Tutoring Systems (ITSs) have significantly advanced adaptive and personalized learning by automating sophisticated human tutoring strategies within interactive dialogues. However, replicating the nuanced patterns of expert human communication remains a challenge in Natural Language Processing (NLP). Recent advancements in NLP, particularly Large Language Models (LLMs) such as OpenAI's GPT-4, offer promising solutions by providing human-like and context-aware responses based on extensive pre-trained knowledge. Motivated by the effectiveness of LLMs in various educational tasks (e.g., content creation and summarization, problem-solving, and automated feedback provision), our study introduces the Socratic Playground for Learning (SPL), a dialogue-based ITS powered by the GPT-4 model, which employs the Socratic teaching method to foster critical thinking among learners. Through extensive prompt engineering, SPL can generate specific learning scenarios and facilitates efficient multi-turn tutoring dialogues. The SPL system aims to enhance personalized and adaptive learning experiences tailored to individual needs, specifically focusing on improving critical thinking skills. Our pilot experimental results from essay writing tasks demonstrate SPL has the potential to improve tutoring interactions and further enhance dialogue-based ITS functionalities. Our study, exemplified by SPL, demonstrates how LLMs enhance dialogue-based ITSs and expand the accessibility and efficacy of educational technologies.

BEACON: Benchmark for Comprehensive RNA Tasks and Language Models

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms. Despite the emergence of numerous deep learning approaches for RNA, particularly universal RNA language models, there remains a significant lack of standardized benchmarks to assess the effectiveness of these methods. In this study, we introduce the first comprehensive RNA benchmark BEACON (\textbf{BE}nchm\textbf{A}rk for \textbf{CO}mprehensive R\textbf{N}A Task and Language Models). First, BEACON comprises 13 distinct tasks derived from extensive previous work covering structural analysis, functional studies, and engineering applications, enabling a comprehensive assessment of the performance of methods on various RNA understanding tasks. Second, we examine a range of models, including traditional approaches like CNNs, as well as advanced RNA foundation models based on language models, offering valuable insights into the task-specific performances of these models. Third, we investigate the vital RNA language model components from the tokenizer and positional encoding aspects. Notably, our findings emphasize the superiority of single nucleotide tokenization and the effectiveness of Attention with Linear Biases (ALiBi) over traditional positional encoding methods. Based on these insights, a simple yet strong baseline called BEACON-B is proposed, which can achieve outstanding performance with limited data and computational resources. The datasets and source code of our benchmark are available at https://github.com/terry-r123/RNABenchmark.

pFedLVM: A Large Vision Model -Driven and Latent Feature-Based Personalized Federated Learning Framework in Autonomous Driving

Deep learning-based Autonomous Driving (AD) models often exhibit poor generalization due to data heterogeneity in an ever domain-shifting environment. While Federated Learning (FL) could improve the generalization of an AD model (known as FedAD system), conventional models often struggle with under-fitting as the amount of accumulated training data progressively increases. To address this issue, instead of conventional small models, employing Large Vision Models (LVMs) in FedAD is a viable option for better learning of representations from a vast volume of data. However, implementing LVMs in FedAD introduces three challenges: (I) the extremely high communication overheads associated with transmitting LVMs between participating vehicles and a central server; (II) lack of computing resource to deploy LVMs on each vehicle; (III) the performance drop due to LVM focusing on shared features but overlooking local vehicle characteristics. To overcome these challenges, we propose pFedLVM, a LVM-Driven, Latent Feature-Based Personalized Federated Learning framework. In this approach, the LVM is deployed only on central server, which effectively alleviates the computational burden on individual vehicles. Furthermore, the exchange between central server and vehicles are the learned features rather than the LVM parameters, which significantly reduces communication overhead. In addition, we utilize both shared features from all participating vehicles and individual characteristics from each vehicle to establish a personalized learning mechanism. This enables each vehicle's model to learn features from others while preserving its personalized characteristics, thereby outperforming globally shared models trained in general FL. Extensive experiments demonstrate that pFedLVM outperforms the existing state-of-the-art approaches.

RSBuilding: Towards General Remote Sensing Image Building Extraction and Change Detection with Foundation Model

The intelligent interpretation of buildings plays a significant role in urban planning and management, macroeconomic analysis, population dynamics, etc. Remote sensing image building interpretation primarily encompasses building extraction and change detection. However, current methodologies often treat these two tasks as separate entities, thereby failing to leverage shared knowledge. Moreover, the complexity and diversity of remote sensing image scenes pose additional challenges, as most algorithms are designed to model individual small datasets, thus lacking cross-scene generalization. In this paper, we propose a comprehensive remote sensing image building understanding model, termed RSBuilding, developed from the perspective of the foundation model. RSBuilding is designed to enhance cross-scene generalization and task universality. Specifically, we extract image features based on the prior knowledge of the foundation model and devise a multi-level feature sampler to augment scale information. To unify task representation and integrate image spatiotemporal clues, we introduce a cross-attention decoder with task prompts. Addressing the current shortage of datasets that incorporate annotations for both tasks, we have developed a federated training strategy to facilitate smooth model convergence even when supervision for some tasks is missing, thereby bolstering the complementarity of different tasks. Our model was trained on a dataset comprising up to 245,000 images and validated on multiple building extraction and change detection datasets. The experimental results substantiate that RSBuilding can concurrently handle two structurally distinct tasks and exhibits robust zero-shot generalization capabilities.

ContraNovo: A Contrastive Learning Approach to Enhance De Novo Peptide Sequencing

De novo peptide sequencing from mass spectrometry (MS) data is a critical task in proteomics research. Traditional de novo algorithms have encountered a bottleneck in accuracy due to the inherent complexity of proteomics data. While deep learning-based methods have shown progress, they reduce the problem to a translation task, potentially overlooking critical nuances between spectra and peptides. In our research, we present ContraNovo, a pioneering algorithm that leverages contrastive learning to extract the relationship between spectra and peptides and incorporates the mass information into peptide decoding, aiming to address these intricacies more efficiently. Through rigorous evaluations on two benchmark datasets, ContraNovo consistently outshines contemporary state-of-the-art solutions, underscoring its promising potential in enhancing de novo peptide sequencing. The source code is available at https://github.com/BEAM-Labs/ContraNovo.

CorefPrompt: Prompt-based Event Coreference Resolution by Measuring Event Type and Argument Compatibilities

Event coreference resolution (ECR) aims to group event mentions referring to the same real-world event into clusters. Most previous studies adopt the "encoding first, then scoring" framework, making the coreference judgment rely on event encoding. Furthermore, current methods struggle to leverage human-summarized ECR rules, e.g., coreferential events should have the same event type, to guide the model. To address these two issues, we propose a prompt-based approach, CorefPrompt, to transform ECR into a cloze-style MLM (masked language model) task. This allows for simultaneous event modeling and coreference discrimination within a single template, with a fully shared context. In addition, we introduce two auxiliary prompt tasks, event-type compatibility and argument compatibility, to explicitly demonstrate the reasoning process of ECR, which helps the model make final predictions. Experimental results show that our method CorefPrompt performs well in a state-of-the-art (SOTA) benchmark.

Representation Disparity-aware Distillation for 3D Object Detection

In this paper, we focus on developing knowledge distillation (KD) for compact 3D detectors. We observe that off-the-shelf KD methods manifest their efficacy only when the teacher model and student counterpart share similar intermediate feature representations. This might explain why they are less effective in building extreme-compact 3D detectors where significant representation disparity arises due primarily to the intrinsic sparsity and irregularity in 3D point clouds. This paper presents a novel representation disparity-aware distillation (RDD) method to address the representation disparity issue and reduce performance gap between compact students and over-parameterized teachers. This is accomplished by building our RDD from an innovative perspective of information bottleneck (IB), which can effectively minimize the disparity of proposal region pairs from student and teacher in features and logits. Extensive experiments are performed to demonstrate the superiority of our RDD over existing KD methods. For example, our RDD increases mAP of CP-Voxel-S to 57.1% on nuScenes dataset, which even surpasses teacher performance while taking up only 42% FLOPs.

DCP-NAS: Discrepant Child-Parent Neural Architecture Search for 1-bit CNNs

Neural architecture search (NAS) proves to be among the effective approaches for many tasks by generating an application-adaptive neural architecture, which is still challenged by high computational cost and memory consumption. At the same time, 1-bit convolutional neural networks (CNNs) with binary weights and activations show their potential for resource-limited embedded devices. One natural approach is to use 1-bit CNNs to reduce the computation and memory cost of NAS by taking advantage of the strengths of each in a unified framework, while searching the 1-bit CNNs is more challenging due to the more complicated processes involved. In this paper, we introduce Discrepant Child-Parent Neural Architecture Search (DCP-NAS) to efficiently search 1-bit CNNs, based on a new framework of searching the 1-bit model (Child) under the supervision of a real-valued model (Parent). Particularly, we first utilize a Parent model to calculate a tangent direction, based on which the tangent propagation method is introduced to search the optimized 1-bit Child. We further observe a coupling relationship between the weights and architecture parameters existing in such differentiable frameworks. To address the issue, we propose a decoupled optimization method to search an optimized architecture. Extensive experiments demonstrate that our DCP-NAS achieves much better results than prior arts on both CIFAR-10 and ImageNet datasets. In particular, the backbones achieved by our DCP-NAS achieve strong generalization performance on person re-identification and object detection.

Bi-ViT: Pushing the Limit of Vision Transformer Quantization

Vision transformers (ViTs) quantization offers a promising prospect to facilitate deploying large pre-trained networks on resource-limited devices. Fully-binarized ViTs (Bi-ViT) that pushes the quantization of ViTs to its limit remain largely unexplored and a very challenging task yet, due to their unacceptable performance. Through extensive empirical analyses, we identify the severe drop in ViT binarization is caused by attention distortion in self-attention, which technically stems from the gradient vanishing and ranking disorder. To address these issues, we first introduce a learnable scaling factor to reactivate the vanished gradients and illustrate its effectiveness through theoretical and experimental analyses. We then propose a ranking-aware distillation method to rectify the disordered ranking in a teacher-student framework. Bi-ViT achieves significant improvements over popular DeiT and Swin backbones in terms of Top-1 accuracy and FLOPs. For example, with DeiT-Tiny and Swin-Tiny, our method significantly outperforms baselines by 22.1% and 21.4% respectively, while 61.5x and 56.1x theoretical acceleration in terms of FLOPs compared with real-valued counterparts on ImageNet.

AF2-Mutation: Adversarial Sequence Mutations against AlphaFold2 on Protein Tertiary Structure Prediction

Deep learning-based approaches, such as AlphaFold2 (AF2), have significantly advanced protein tertiary structure prediction, achieving results comparable to real biological experimental methods. While AF2 has shown limitations in predicting the effects of mutations, its robustness against sequence mutations remains to be determined. Starting with the wild-type (WT) sequence, we investigate adversarial sequences generated via an evolutionary approach, which AF2 predicts to be substantially different from WT. Our experiments on CASP14 reveal that by modifying merely three residues in the protein sequence using a combination of replacement, deletion, and insertion strategies, the alteration in AF2's predictions, as measured by the Local Distance Difference Test (lDDT), reaches 46.61. Moreover, when applied to a specific protein, SPNS2, our proposed algorithm successfully identifies biologically meaningful residues critical to protein structure determination and potentially indicates alternative conformations, thus significantly expediting the experimental process.