Look in Different Views: Multi-Scheme Regression Guided Cell Instance Segmentation

Cell instance segmentation is a new and challenging task aiming at joint detection and segmentation of every cell in an image. Recently, many instance segmentation methods have applied in this task. Despite their great success, there still exists two main weaknesses caused by uncertainty of localizing cell center points. First, densely packed cells can easily be recognized into one cell. Second, elongated cell can easily be recognized into two cells. To overcome these two weaknesses, we propose a novel cell instance segmentation network based on multi-scheme regression guidance. With multi-scheme regression guidance, the network has the ability to look each cell in different views. Specifically, we first propose a gaussian guidance attention mechanism to use gaussian labels for guiding the network's attention. We then propose a point-regression module for assisting the regression of cell center. Finally, we utilize the output of the above two modules to further guide the instance segmentation. With multi-scheme regression guidance, we can take full advantage of the characteristics of different regions, especially the central region of the cell. We conduct extensive experiments on benchmark datasets, DSB2018, CA2.5 and SCIS. The encouraging results show that our network achieves SOTA (state-of-the-art) performance. On the DSB2018 and CA2.5, our network surpasses previous methods by 1.2% (AP50). Particularly on SCIS dataset, our network performs stronger by large margin (3.0% higher AP50). Visualization and analysis further prove that our proposed method is interpretable.

A Multi-Modality Ovarian Tumor Ultrasound Image Dataset for Unsupervised Cross-Domain Semantic Segmentation

Ovarian cancer is one of the most harmful gynecological diseases. Detecting ovarian tumors in early stage with computer-aided techniques can efficiently decrease the mortality rate. With the improvement of medical treatment standard, ultrasound images are widely applied in clinical treatment. However, recent notable methods mainly focus on single-modality ultrasound ovarian tumor segmentation or recognition, which means there still lacks of researches on exploring the representation capability of multi-modality ultrasound ovarian tumor images. To solve this problem, we propose a Multi-Modality Ovarian Tumor Ultrasound (MMOTU) image dataset containing 1469 2d ultrasound images and 170 contrast enhanced ultrasonography (CEUS) images with pixel-wise and global-wise annotations. Based on MMOTU, we mainly focus on unsupervised cross-domain semantic segmentation task. To solve the domain shift problem, we propose a feature alignment based architecture named Dual-Scheme Domain-Selected Network (DS$^2$Net). Specifically, we first design source-encoder and target-encoder to extract two-style features of source and target images. Then, we propose Domain-Distinct Selected Module (DDSM) and Domain-Universal Selected Module (DUSM) to extract the distinct and universal features in two styles (source-style or target-style). Finally, we fuse these two kinds of features and feed them into the source-decoder and target-decoder to generate final predictions. Extensive comparison experiments and analysis on MMOTU image dataset show that DS$^2$Net can boost the segmentation performance for bidirectional cross-domain adaptation of 2d ultrasound images and CEUS images.

Attention in Reasoning: Dataset, Analysis, and Modeling

While attention has been an increasingly popular component in deep neural networks to both interpret and boost the performance of models, little work has examined how attention progresses to accomplish a task and whether it is reasonable. In this work, we propose an Attention with Reasoning capability (AiR) framework that uses attention to understand and improve the process leading to task outcomes. We first define an evaluation metric based on a sequence of atomic reasoning operations, enabling a quantitative measurement of attention that considers the reasoning process. We then collect human eye-tracking and answer correctness data, and analyze various machine and human attention mechanisms on their reasoning capability and how they impact task performance. To improve the attention and reasoning ability of visual question answering models, we propose to supervise the learning of attention progressively along the reasoning process and to differentiate the correct and incorrect attention patterns. We demonstrate the effectiveness of the proposed framework in analyzing and modeling attention with better reasoning capability and task performance. The code and data are available at https://github.com/szzexpoi/AiR

Efficient and practical quantum compiler towards multi-qubit systems with deep reinforcement learning

Efficient quantum compiling tactics greatly enhance the capability of quantum computers to execute complicated quantum algorithms. Due to its fundamental importance, a plethora of quantum compilers has been designed in past years. However, there are several caveats to current protocols, which are low optimality, high inference time, limited scalability, and lack of universality. To compensate for these defects, here we devise an efficient and practical quantum compiler assisted by advanced deep reinforcement learning (RL) techniques, i.e., data generation, deep Q-learning, and AQ* search. In this way, our protocol is compatible with various quantum machines and can be used to compile multi-qubit operators. We systematically evaluate the performance of our proposal in compiling quantum operators with both inverse-closed and inverse-free universal basis sets. In the task of single-qubit operator compiling, our proposal outperforms other RL-based quantum compilers in the measure of compiling sequence length and inference time. Meanwhile, the output solution is near-optimal, guaranteed by the Solovay-Kitaev theorem. Notably, for the inverse-free universal basis set, the achieved sequence length complexity is comparable with the inverse-based setting and dramatically advances previous methods. These empirical results contribute to improving the inverse-free Solovay-Kitaev theorem. In addition, for the first time, we demonstrate how to leverage RL-based quantum compilers to accomplish two-qubit operator compiling. The achieved results open an avenue for integrating RL with quantum compiling to unify efficiency and practicality and thus facilitate the exploration of quantum advantages.

AutoOpt: A Methodological Framework of Automatically Designing Metaheuristics for Optimization Problems

Metaheuristics are gradient-free and problem-independent search algorithms. They have gained huge success in solving various optimization problems in academia and industry. Automated metaheuristic design is a promising alternative to human-made design. This paper proposes a general and comprehensive methodological framework, AutoOpt, for automatically designing metaheuristics for various optimization problems. AutoOpt consists of: (1) a bi-level criterion to evaluate the designed algorithms' performance; (2) a general schema of the decision space from where the algorithms will be designed; (3) a mixed graph- and real number-based representation to represent the designed algorithms; and (4) a model-free method to conduct the design process. AutoOpt benefits academic researchers and practical users struggling to design metaheuristics for optimization problems. A real-world case study demonstrates AutoOpt's effectiveness and efficiency.

Artificial Intelligence Enables Real-Time and Intuitive Control of Prostheses via Nerve Interface

Objective: The next generation prosthetic hand that moves and feels like a real hand requires a robust neural interconnection between the human minds and machines. Methods: Here we present a neuroprosthetic system to demonstrate that principle by employing an artificial intelligence (AI) agent to translate the amputee's movement intent through a peripheral nerve interface. The AI agent is designed based on the recurrent neural network (RNN) and could simultaneously decode six degree-of-freedom (DOF) from multichannel nerve data in real-time. The decoder's performance is characterized in motor decoding experiments with three human amputees. Results: First, we show the AI agent enables amputees to intuitively control a prosthetic hand with individual finger and wrist movements up to 97-98% accuracy. Second, we demonstrate the AI agent's real-time performance by measuring the reaction time and information throughput in a hand gesture matching task. Third, we investigate the AI agent's long-term uses and show the decoder's robust predictive performance over a 16-month implant duration. Conclusion & significance: Our study demonstrates the potential of AI-enabled nerve technology, underling the next generation of dexterous and intuitive prosthetic hands.

REX: Reasoning-aware and Grounded Explanation

Effectiveness and interpretability are two essential properties for trustworthy AI systems. Most recent studies in visual reasoning are dedicated to improving the accuracy of predicted answers, and less attention is paid to explaining the rationales behind the decisions. As a result, they commonly take advantage of spurious biases instead of actually reasoning on the visual-textual data, and have yet developed the capability to explain their decision making by considering key information from both modalities. This paper aims to close the gap from three distinct perspectives: first, we define a new type of multi-modal explanations that explain the decisions by progressively traversing the reasoning process and grounding keywords in the images. We develop a functional program to sequentially execute different reasoning steps and construct a new dataset with 1,040,830 multi-modal explanations. Second, we identify the critical need to tightly couple important components across the visual and textual modalities for explaining the decisions, and propose a novel explanation generation method that explicitly models the pairwise correspondence between words and regions of interest. It improves the visual grounding capability by a considerable margin, resulting in enhanced interpretability and reasoning performance. Finally, with our new data and method, we perform extensive analyses to study the effectiveness of our explanation under different settings, including multi-task learning and transfer learning. Our code and data are available at https://github.com/szzexpoi/rex.

Speckle-based optical cryptosystem and its application for human face recognition via deep learning

Face recognition has recently become ubiquitous in many scenes for authentication or security purposes. Meanwhile, there are increasing concerns about the privacy of face images, which are sensitive biometric data that should be carefully protected. Software-based cryptosystems are widely adopted nowadays to encrypt face images, but the security level is limited by insufficient digital secret key length or computing power. Hardware-based optical cryptosystems can generate enormously longer secret keys and enable encryption at light speed, but most reported optical methods, such as double random phase encryption, are less compatible with other systems due to system complexity. In this study, a plain yet high-efficient speckle-based optical cryptosystem is proposed and implemented. A scattering ground glass is exploited to generate physical secret keys of gigabit length and encrypt face images via seemingly random optical speckles at light speed. Face images can then be decrypted from the random speckles by a well-trained decryption neural network, such that face recognition can be realized with up to 98% accuracy. The proposed cryptosystem has wide applicability, and it may open a new avenue for high-security complex information encryption and decryption by utilizing optical speckles.

Learning to Predict Gradients for Semi-Supervised Continual Learning

A key challenge for machine intelligence is to learn new visual concepts without forgetting the previously acquired knowledge. Continual learning is aimed towards addressing this challenge. However, there is a gap between existing supervised continual learning and human-like intelligence, where human is able to learn from both labeled and unlabeled data. How unlabeled data affects learning and catastrophic forgetting in the continual learning process remains unknown. To explore these issues, we formulate a new semi-supervised continual learning method, which can be generically applied to existing continual learning models. Specifically, a novel gradient learner learns from labeled data to predict gradients on unlabeled data. Hence, the unlabeled data could fit into the supervised continual learning method. Different from conventional semi-supervised settings, we do not hypothesize that the underlying classes, which are associated to the unlabeled data, are known to the learning process. In other words, the unlabeled data could be very distinct from the labeled data. We evaluate the proposed method on mainstream continual learning, adversarial continual learning, and semi-supervised learning tasks. The proposed method achieves state-of-the-art performance on classification accuracy and backward transfer in the continual learning setting while achieving desired performance on classification accuracy in the semi-supervised learning setting. This implies that the unlabeled images can enhance the generalizability of continual learning models on the predictive ability on unseen data and significantly alleviate catastrophic forgetting. The code is available at \url{https://github.com/luoyan407/grad_prediction.git}.

Learning to Minimize the Remainder in Supervised Learning

The learning process of deep learning methods usually updates the model's parameters in multiple iterations. Each iteration can be viewed as the first-order approximation of Taylor's series expansion. The remainder, which consists of higher-order terms, is usually ignored in the learning process for simplicity. This learning scheme empowers various multimedia based applications, such as image retrieval, recommendation system, and video search. Generally, multimedia data (e.g., images) are semantics-rich and high-dimensional, hence the remainders of approximations are possibly non-zero. In this work, we consider the remainder to be informative and study how it affects the learning process. To this end, we propose a new learning approach, namely gradient adjustment learning (GAL), to leverage the knowledge learned from the past training iterations to adjust vanilla gradients, such that the remainders are minimized and the approximations are improved. The proposed GAL is model- and optimizer-agnostic, and is easy to adapt to the standard learning framework. It is evaluated on three tasks, i.e., image classification, object detection, and regression, with state-of-the-art models and optimizers. The experiments show that the proposed GAL consistently enhances the evaluated models, whereas the ablation studies validate various aspects of the proposed GAL. The code is available at \url{https://github.com/luoyan407/gradient_adjustment.git}.