Clinical-Inspired Cytological Whole Slide Image Screening with Just Slide-Level Labels

Cytology test is effective, non-invasive, convenient, and inexpensive for clinical cancer screening. ThinPrep, a commonly used liquid-based specimen, can be scanned to generate digital whole slide images (WSIs) for cytology testing. However, WSIs classification with gigapixel resolutions is highly resource-intensive, posing significant challenges for automated medical image analysis. In order to circumvent this computational impasse, existing methods emphasize learning features at the cell or patch level, typically requiring labor-intensive and detailed manual annotations, such as labels at the cell or patch level. Here we propose a novel automated Label-Efficient WSI Screening method, dubbed LESS, for cytology-based diagnosis with only slide-level labels. Firstly, in order to achieve label efficiency, we suggest employing variational positive-unlabeled (VPU) learning, enhancing patch-level feature learning using WSI-level labels. Subsequently, guided by the clinical approach of scrutinizing WSIs at varying fields of view and scales, we employ a cross-attention vision transformer (CrossViT) to fuse multi-scale patch-level data and execute WSI-level classification. We validate the proposed label-efficient method on a urine cytology WSI dataset encompassing 130 samples (13,000 patches) and FNAC 2019 dataset with 212 samples (21,200 patches). The experiment shows that the proposed LESS reaches 84.79%, 85.43%, 91.79% and 78.30% on a urine cytology WSI dataset, and 96.53%, 96.37%, 99.31%, 94.95% on FNAC 2019 dataset in terms of accuracy, AUC, sensitivity and specificity. It outperforms state-of-the-art methods and realizes automatic cytology-based bladder cancer screening.

A Cross-direction Task Decoupling Network for Small Logo Detection

Logo detection plays an integral role in many applications. However, handling small logos is still difficult since they occupy too few pixels in the image, which burdens the extraction of discriminative features. The aggregation of small logos also brings a great challenge to the classification and localization of logos. To solve these problems, we creatively propose Cross-direction Task Decoupling Network (CTDNet) for small logo detection. We first introduce Cross-direction Feature Pyramid (CFP) to realize cross-direction feature fusion by adopting horizontal transmission and vertical transmission. In addition, Multi-frequency Task Decoupling Head (MTDH) decouples the classification and localization tasks into two branches. A multi frequency attention convolution branch is designed to achieve more accurate regression by combining discrete cosine transform and convolution creatively. Comprehensive experiments on four logo datasets demonstrate the effectiveness and efficiency of the proposed method.

Implementing Active Learning in Cybersecurity: Detecting Anomalies in Redacted Emails

Research on email anomaly detection has typically relied on specially prepared datasets that may not adequately reflect the type of data that occurs in industry settings. In our research, at a major financial services company, privacy concerns prevented inspection of the bodies of emails and attachment details (although subject headings and attachment filenames were available). This made labeling possible anomalies in the resulting redacted emails more difficult. Another source of difficulty is the high volume of emails combined with the scarcity of resources making machine learning (ML) a necessity, but also creating a need for more efficient human training of ML models. Active learning (AL) has been proposed as a way to make human training of ML models more efficient. However, the implementation of Active Learning methods is a human-centered AI challenge due to potential human analyst uncertainty, and the labeling task can be further complicated in domains such as the cybersecurity domain (or healthcare, aviation, etc.) where mistakes in labeling can have highly adverse consequences. In this paper we present research results concerning the application of Active Learning to anomaly detection in redacted emails, comparing the utility of different methods for implementing active learning in this context. We evaluate different AL strategies and their impact on resulting model performance. We also examine how ratings of confidence that experts have in their labels can inform AL. The results obtained are discussed in terms of their implications for AL methodology and for the role of experts in model-assisted email anomaly screening.

Low-Dose CT Denoising via Sinogram Inner-Structure Transformer

Low-Dose Computed Tomography (LDCT) technique, which reduces the radiation harm to human bodies, is now attracting increasing interest in the medical imaging field. As the image quality is degraded by low dose radiation, LDCT exams require specialized reconstruction methods or denoising algorithms. However, most of the recent effective methods overlook the inner-structure of the original projection data (sinogram) which limits their denoising ability. The inner-structure of the sinogram represents special characteristics of the data in the sinogram domain. By maintaining this structure while denoising, the noise can be obviously restrained. Therefore, we propose an LDCT denoising network namely Sinogram Inner-Structure Transformer (SIST) to reduce the noise by utilizing the inner-structure in the sinogram domain. Specifically, we study the CT imaging mechanism and statistical characteristics of sinogram to design the sinogram inner-structure loss including the global and local inner-structure for restoring high-quality CT images. Besides, we propose a sinogram transformer module to better extract sinogram features. The transformer architecture using a self-attention mechanism can exploit interrelations between projections of different view angles, which achieves an outstanding performance in sinogram denoising. Furthermore, in order to improve the performance in the image domain, we propose the image reconstruction module to complementarily denoise both in the sinogram and image domain.

Unsupervised Belief Representation Learning in Polarized Networks with Information-Theoretic Variational Graph Auto-Encoders

This paper develops a novel unsupervised algorithm for belief representation learning in polarized networks that (i) uncovers the latent dimensions of the underlying belief space and (ii) jointly embeds users and content items (that they interact with) into that space in a manner that facilitates a number of downstream tasks, such as stance detection, stance prediction, and ideology mapping. Inspired by total correlation in information theory, we propose a novel Information-Theoretic Variational Graph Auto-Encoder (InfoVGAE) that learns to project both users and content items (e.g., posts that represent user views) into an appropriate disentangled latent space. In order to better disentangle orthogonal latent variables in that space, we develop total correlation regularization, PI control module, and adopt rectified Gaussian Distribution for the latent space. The latent representation of users and content can then be used to quantify their ideological leaning and detect/predict their stances on issues. We evaluate the performance of the proposed InfoVGAE on three real-world datasets, of which two are collected from Twitter and one from U.S. Congress voting records. The evaluation results show that our model outperforms state-of-the-art unsupervised models and produce comparable result with supervised models. We also discuss stance prediction and user ranking within ideological groups.

Boosting Offline Reinforcement Learning with Residual Generative Modeling

Offline reinforcement learning (RL) tries to learn the near-optimal policy with recorded offline experience without online exploration. Current offline RL research includes: 1) generative modeling, i.e., approximating a policy using fixed data; and 2) learning the state-action value function. While most research focuses on the state-action function part through reducing the bootstrapping error in value function approximation induced by the distribution shift of training data, the effects of error propagation in generative modeling have been neglected. In this paper, we analyze the error in generative modeling. We propose AQL (action-conditioned Q-learning), a residual generative model to reduce policy approximation error for offline RL. We show that our method can learn more accurate policy approximations in different benchmark datasets. In addition, we show that the proposed offline RL method can learn more competitive AI agents in complex control tasks under the multiplayer online battle arena (MOBA) game Honor of Kings.

Neuromorphic Algorithm-hardware Codesign for Temporal Pattern Learning

Neuromorphic computing and spiking neural networks (SNN) mimic the behavior of biological systems and have drawn interest for their potential to perform cognitive tasks with high energy efficiency. However, some factors such as temporal dynamics and spike timings prove critical for information processing but are often ignored by existing works, limiting the performance and applications of neuromorphic computing. On one hand, due to the lack of effective SNN training algorithms, it is difficult to utilize the temporal neural dynamics. Many existing algorithms still treat neuron activation statistically. On the other hand, utilizing temporal neural dynamics also poses challenges to hardware design. Synapses exhibit temporal dynamics, serving as memory units that hold historical information, but are often simplified as a connection with weight. Most current models integrate synaptic activations in some storage medium to represent membrane potential and institute a hard reset of membrane potential after the neuron emits a spike. This is done for its simplicity in hardware, requiring only a "clear" signal to wipe the storage medium, but destroys temporal information stored in the neuron. In this work, we derive an efficient training algorithm for Leaky Integrate and Fire neurons, which is capable of training a SNN to learn complex spatial temporal patterns. We achieved competitive accuracy on two complex datasets. We also demonstrate the advantage of our model by a novel temporal pattern association task. Codesigned with this algorithm, we have developed a CMOS circuit implementation for a memristor-based network of neuron and synapses which retains critical neural dynamics with reduced complexity. This circuit implementation of the neuron model is simulated to demonstrate its ability to react to temporal spiking patterns with an adaptive threshold.

Learned Indexes for a Google-scale Disk-based Database

There is great excitement about learned index structures, but understandable skepticism about the practicality of a new method uprooting decades of research on B-Trees. In this paper, we work to remove some of that uncertainty by demonstrating how a learned index can be integrated in a distributed, disk-based database system: Google's Bigtable. We detail several design decisions we made to integrate learned indexes in Bigtable. Our results show that integrating learned index significantly improves the end-to-end read latency and throughput for Bigtable.

Hybrid Imitation Learning for Real-Time Service Restoration in Resilient Distribution Systems

Self-healing capability is one of the most critical factors for a resilient distribution system, which requires intelligent agents to automatically perform restorative actions online, including network reconfiguration and reactive power dispatch. These agents should be equipped with a predesigned decision policy to meet real-time requirements and handle highly complex $N-k$ scenarios. The disturbance randomness hampers the application of exploration-dominant algorithms like traditional reinforcement learning (RL), and the agent training problem under $N-k$ scenarios has not been thoroughly solved. In this paper, we propose the imitation learning (IL) framework to train such policies, where the agent will interact with an expert to learn its optimal policy, and therefore significantly improve the training efficiency compared with the RL methods. To handle tie-line operations and reactive power dispatch simultaneously, we design a hybrid policy network for such a discrete-continuous hybrid action space. We employ the 33-node system under $N-k$ disturbances to verify the proposed framework.

Data Troubles in Sentence Level Confidence Estimation for Machine Translation

The paper investigates the feasibility of confidence estimation for neural machine translation models operating at the high end of the performance spectrum. As a side product of the data annotation process necessary for building such models we propose sentence level accuracy $SACC$ as a simple, self-explanatory evaluation metric for quality of translation. Experiments on two different annotator pools, one comprised of non-expert (crowd-sourced) and one of expert (professional) translators show that $SACC$ can vary greatly depending on the translation proficiency of the annotators, despite the fact that both pools are about equally reliable according to Krippendorff's alpha metric; the relatively low values of inter-annotator agreement confirm the expectation that sentence-level binary labeling $good$ / $needs\ work$ for translation out of context is very hard. For an English-Spanish translation model operating at $SACC = 0.89$ according to a non-expert annotator pool we can derive a confidence estimate that labels 0.5-0.6 of the $good$ translations in an "in-domain" test set with 0.95 Precision. Switching to an expert annotator pool decreases $SACC$ dramatically: $0.61$ for English-Spanish, measured on the exact same data as above. This forces us to lower the CE model operating point to 0.9 Precision while labeling correctly about 0.20-0.25 of the $good$ translations in the data. We find surprising the extent to which CE depends on the level of proficiency of the annotator pool used for labeling the data. This leads to an important recommendation we wish to make when tackling CE modeling in practice: it is critical to match the end-user expectation for translation quality in the desired domain with the demands of annotators assigning binary quality labels to CE training data.