Bridging Sequence and Graph Structure for Epigenetic Age Prediction

Epigenetic clocks based on DNA methylation have emerged as powerful tools for estimating biological age, with broad applications in aging research, age-related disease studies, and longevity science. Despite advances across machine learning approaches to epigenetic age prediction, spanning penalised linear regression, deep feedforward networks, residual architectures, and graph neural networks, no existing method jointly models co-methylation graph structure and site-specific DNA sequence context within a unified framework. We propose a unified sequence--graph integration framework for epigenetic age prediction that addresses this gap, integrating eight-dimensional DNA sequence statistical features through a lightweight gated modulation mechanism that adaptively scales each site's methylation signal according to its sequence-determined biological relevance prior to graph convolution. Evaluated on 3,707 blood methylation samples against a comprehensive set of baselines, our method achieves a test MAE of 3.149 years, a 12.8\% improvement over the strongest graph-based baseline. Biologically informed statistical features outperform CNN-based sequence encoding, demonstrating that handcrafted sequence features are more effective than end-to-end learned representations in this data regime. Post-hoc interpretability analysis identifies CpG density and local adenine frequency as features with age-dependent importance shifts, consistent with known mechanisms of age-related hypermethylation at CpG-dense promoter regions. Our code is at https://github.com/yaoli2022/graphage-seq.

Stable Multimodal Graph Unlearning via Feature-Dimension Aware Quantile Selection

Graph unlearning remains a critical technique for supporting privacy-preserving and sustainable multimodal graph learning. However, we observe that existing unlearning strategies tend to apply uniform parameter selection and editing across all graph neural network (GNN) layers, which is especially harmful for multimodal graphs where high-dimensional input projections encode dominant cross-modal knowledge. As a result, over-editing these sensitive layers often leads to catastrophic utility degradation after forgetting, undermining both stable learning and effective privacy protection. To address this gap, we propose FDQ, a Feature-Dimension Aware Quantile framework for multimodal graph unlearning. FDQ adaptively identifies high-dimensional input projection layers and applies more conservative, FDQ-guided quantile thresholds when constructing suppression sets, while keeping the underlying importance estimation mechanism unchanged. FDQ is seamlessly integrated with diagonal sensitivity-based parameter importance analysis to enable efficient node and edge unlearning under general forget requests. Through extensive experiments on Ele-Fashion and Goodreads-NC, we demonstrate that FDQ consistently achieves strong utility preservation while maintaining effective forgetting against membership inference attacks. Overall, FDQ offers a principled and robust solution for privacy-aware unlearning in high-dimensional multimodal graph systems.

Interplay: Training Independent Simulators for Reference-Free Conversational Recommendation

Training conversational recommender systems (CRS) requires extensive dialogue data, which is challenging to collect at scale. To address this, researchers have used simulated user-recommender conversations. Traditional simulation approaches often utilize a single large language model (LLM) that generates entire conversations with prior knowledge of the target items, leading to scripted and artificial dialogues. We propose a reference-free simulation framework that trains two independent LLMs, one as the user and one as the conversational recommender. These models interact in real-time without access to predetermined target items, but preference summaries and target attributes, enabling the recommender to genuinely infer user preferences through dialogue. This approach produces more realistic and diverse conversations that closely mirror authentic human-AI interactions. Our reference-free simulators match or exceed existing methods in quality, while offering a scalable solution for generating high-quality conversational recommendation data without constraining conversations to pre-defined target items. We conduct both quantitative and human evaluations to confirm the effectiveness of our reference-free approach.

Sim2Act: Robust Simulation-to-Decision Learning via Adversarial Calibration and Group-Relative Perturbation

Simulation-to-decision learning enables safe policy training in digital environments without risking real-world deployment, and has become essential in mission-critical domains such as supply chains and industrial systems. However, simulators learned from noisy or biased real-world data often exhibit prediction errors in decision-critical regions, leading to unstable action ranking and unreliable policies. Existing approaches either focus on improving average simulation fidelity or adopt conservative regularization, which may cause policy collapse by discarding high-risk high-reward actions. We propose Sim2Act, a robust simulation-to-decision framework that addresses both simulator and policy robustness. First, we introduce an adversarial calibration mechanism that re-weights simulation errors in decision-critical state-action pairs to align surrogate fidelity with downstream decision impact. Second, we develop a group-relative perturbation strategy that stabilizes policy learning under simulator uncertainty without enforcing overly pessimistic constraints. Extensive experiments on multiple supply chain benchmarks demonstrate improved simulation robustness and more stable decision performance under structured and unstructured perturbations.

Spiking Graph Predictive Coding for Reliable OOD Generalization

Graphs provide a powerful basis for modeling Web-based relational data, with expressive GNNs to support the effective learning in dynamic web environments. However, real-world deployment is hindered by pervasive out-of-distribution (OOD) shifts, where evolving user activity and changing content semantics alter feature distributions and labeling criteria. These shifts often lead to unstable or overconfident predictions, undermining the trustworthiness required for Web4Good applications. Achieving reliable OOD generalization demands principled and interpretable uncertainty estimation; however, existing methods are largely post-hoc, insensitive to distribution shifts, and unable to explain where uncertainty arises especially in high-stakes settings. To address these limitations, we introduce SpIking GrapH predicTive coding (SIGHT), an uncertainty-aware plug-in graph learning module for reliable OOD Generalization. SIGHT performs iterative, error-driven correction over spiking graph states, enabling models to expose internal mismatch signals that reveal where predictions become unreliable. Across multiple graph benchmarks and diverse OOD scenarios, SIGHT consistently enhances predictive accuracy, uncertainty estimation, and interpretability when integrated with GNNs.

Decoding Ambiguous Emotions with Test-Time Scaling in Audio-Language Models

Emotion recognition from human speech is a critical enabler for socially aware conversational AI. However, while most prior work frames emotion recognition as a categorical classification problem, real-world affective states are often ambiguous, overlapping, and context-dependent, posing significant challenges for both annotation and automatic modeling. Recent large-scale audio language models (ALMs) offer new opportunities for nuanced affective reasoning without explicit emotion supervision, but their capacity to handle ambiguous emotions remains underexplored. At the same time, advances in inference-time techniques such as test-time scaling (TTS) have shown promise for improving generalization and adaptability in hard NLP tasks, but their relevance to affective computing is still largely unknown. In this work, we introduce the first benchmark for ambiguous emotion recognition in speech with ALMs under test-time scaling. Our evaluation systematically compares eight state-of-the-art ALMs and five TTS strategies across three prominent speech emotion datasets. We further provide an in-depth analysis of the interaction between model capacity, TTS, and affective ambiguity, offering new insights into the computational and representational challenges of ambiguous emotion understanding. Our benchmark establishes a foundation for developing more robust, context-aware, and emotionally intelligent speech-based AI systems, and highlights key future directions for bridging the gap between model assumptions and the complexity of real-world human emotion.

Explaining Synergistic Effects in Social Recommendations

In social recommenders, the inherent nonlinearity and opacity of synergistic effects across multiple social networks hinders users from understanding how diverse information is leveraged for recommendations, consequently diminishing explainability. However, existing explainers can only identify the topological information in social networks that significantly influences recommendations, failing to further explain the synergistic effects among this information. Inspired by existing findings that synergistic effects enhance mutual information between inputs and predictions to generate information gain, we extend this discovery to graph data. We quantify graph information gain to identify subgraphs embodying synergistic effects. Based on the theoretical insights, we propose SemExplainer, which explains synergistic effects by identifying subgraphs that embody them. SemExplainer first extracts explanatory subgraphs from multi-view social networks to generate preliminary importance explanations for recommendations. A conditional entropy optimization strategy to maximize information gain is developed, thereby further identifying subgraphs that embody synergistic effects from explanatory subgraphs. Finally, SemExplainer searches for paths from users to recommended items within the synergistic subgraphs to generate explanations for the recommendations. Extensive experiments on three datasets demonstrate the superiority of SemExplainer over baseline methods, providing superior explanations of synergistic effects.

When to Invoke: Refining LLM Fairness with Toxicity Assessment

Large Language Models (LLMs) are increasingly used for toxicity assessment in online moderation systems, where fairness across demographic groups is essential for equitable treatment. However, LLMs often produce inconsistent toxicity judgements for subtle expressions, particularly those involving implicit hate speech, revealing underlying biases that are difficult to correct through standard training. This raises a key question that existing approaches often overlook: when should corrective mechanisms be invoked to ensure fair and reliable assessments? To address this, we propose FairToT, an inference-time framework that enhances LLM fairness through prompt-guided toxicity assessment. FairToT identifies cases where demographic-related variation is likely to occur and determines when additional assessment should be applied. In addition, we introduce two interpretable fairness indicators that detect such cases and improve inference consistency without modifying model parameters. Experiments on benchmark datasets show that FairToT reduces group-level disparities while maintaining stable and reliable toxicity predictions, demonstrating that inference-time refinement offers an effective and practical approach for fairness improvement in LLM-based toxicity assessment systems. The source code can be found at https://aisuko.github.io/fair-tot/.

FairGU: Fairness-aware Graph Unlearning in Social Network

Graph unlearning has emerged as a critical mechanism for supporting sustainable and privacy-preserving social networks, enabling models to remove the influence of deleted nodes and thereby better safeguard user information. However, we observe that existing graph unlearning techniques insufficiently protect sensitive attributes, often leading to degraded algorithmic fairness compared with traditional graph learning methods. To address this gap, we introduce FairGU, a fairness-aware graph unlearning framework designed to preserve both utility and fairness during the unlearning process. FairGU integrates a dedicated fairness-aware module with effective data protection strategies, ensuring that sensitive attributes are neither inadvertently amplified nor structurally exposed when nodes are removed. Through extensive experiments on multiple real-world datasets, we demonstrate that FairGU consistently outperforms state-of-the-art graph unlearning methods and fairness-enhanced graph learning baselines in terms of both accuracy and fairness metrics. Our findings highlight a previously overlooked risk in current unlearning practices and establish FairGU as a robust and equitable solution for the next generation of socially sustainable networked systems. The codes are available at https://github.com/LuoRenqiang/FairGU.

FairGE: Fairness-Aware Graph Encoding in Incomplete Social Networks

Graph Transformers (GTs) are increasingly applied to social network analysis, yet their deployment is often constrained by fairness concerns. This issue is particularly critical in incomplete social networks, where sensitive attributes are frequently missing due to privacy and ethical restrictions. Existing solutions commonly generate these incomplete attributes, which may introduce additional biases and further compromise user privacy. To address this challenge, FairGE (Fair Graph Encoding) is introduced as a fairness-aware framework for GTs in incomplete social networks. Instead of generating sensitive attributes, FairGE encodes fairness directly through spectral graph theory. By leveraging the principal eigenvector to represent structural information and padding incomplete sensitive attributes with zeros to maintain independence, FairGE ensures fairness without data reconstruction. Theoretical analysis demonstrates that the method suppresses the influence of non-principal spectral components, thereby enhancing fairness. Extensive experiments on seven real-world social network datasets confirm that FairGE achieves at least a 16% improvement in both statistical parity and equality of opportunity compared with state-of-the-art baselines. The source code is shown in https://github.com/LuoRenqiang/FairGE.