Multi-Scale Multi-Target Domain Adaptation for Angle Closure Classification

Deep learning (DL) has made significant progress in angle closure classification with anterior segment optical coherence tomography (AS-OCT) images. These AS-OCT images are often acquired by different imaging devices/conditions, which results in a vast change of underlying data distributions (called "data domains"). Moreover, due to practical labeling difficulties, some domains (e.g., devices) may not have any data labels. As a result, deep models trained on one specific domain (e.g., a specific device) are difficult to adapt to and thus may perform poorly on other domains (e.g., other devices). To address this issue, we present a multi-target domain adaptation paradigm to transfer a model trained on one labeled source domain to multiple unlabeled target domains. Specifically, we propose a novel Multi-scale Multi-target Domain Adversarial Network (M2DAN) for angle closure classification. M2DAN conducts multi-domain adversarial learning for extracting domain-invariant features and develops a multi-scale module for capturing local and global information of AS-OCT images. Based on these domain-invariant features at different scales, the deep model trained on the source domain is able to classify angle closure on multiple target domains even without any annotations in these domains. Extensive experiments on a real-world AS-OCT dataset demonstrate the effectiveness of the proposed method.

Dataset and Evaluation algorithm design for GOALS Challenge

Glaucoma causes irreversible vision loss due to damage to the optic nerve, and there is no cure for glaucoma.OCT imaging modality is an essential technique for assessing glaucomatous damage since it aids in quantifying fundus structures. To promote the research of AI technology in the field of OCT-assisted diagnosis of glaucoma, we held a Glaucoma OCT Analysis and Layer Segmentation (GOALS) Challenge in conjunction with the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) 2022 to provide data and corresponding annotations for researchers studying layer segmentation from OCT images and the classification of glaucoma. This paper describes the released 300 circumpapillary OCT images, the baselines of the two sub-tasks, and the evaluation methodology. The GOALS Challenge is accessible at https://aistudio.baidu.com/aistudio/competition/detail/230.

Effective Token Graph Modeling using a Novel Labeling Strategy for Structured Sentiment Analysis

The state-of-the-art model for structured sentiment analysis casts the task as a dependency parsing problem, which has some limitations: (1) The label proportions for span prediction and span relation prediction are imbalanced. (2) The span lengths of sentiment tuple components may be very large in this task, which will further exacerbate the imbalance problem. (3) Two nodes in a dependency graph cannot have multiple arcs, therefore some overlapped sentiment tuples cannot be recognized. In this work, we propose nichetargeting solutions for these issues. First, we introduce a novel labeling strategy, which contains two sets of token pair labels, namely essential label set and whole label set. The essential label set consists of the basic labels for this task, which are relatively balanced and applied in the prediction layer. The whole label set includes rich labels to help our model capture various token relations, which are applied in the hidden layer to softly influence our model. Moreover, we also propose an effective model to well collaborate with our labeling strategy, which is equipped with the graph attention networks to iteratively refine token representations, and the adaptive multi-label classifier to dynamically predict multiple relations between token pairs. We perform extensive experiments on 5 benchmark datasets in four languages. Experimental results show that our model outperforms previous SOTA models by a large margin.

REFUGE2 Challenge: Treasure for Multi-Domain Learning in Glaucoma Assessment

Glaucoma is the second leading cause of blindness and is the leading cause of irreversible blindness disease in the world. Early screening for glaucoma in the population is significant. Color fundus photography is the most cost effective imaging modality to screen for ocular diseases. Deep learning network is often used in color fundus image analysis due to its powful feature extraction capability. However, the model training of deep learning method needs a large amount of data, and the distribution of data should be abundant for the robustness of model performance. To promote the research of deep learning in color fundus photography and help researchers further explore the clinical application signification of AI technology, we held a REFUGE2 challenge. This challenge released 2,000 color fundus images of four models, including Zeiss, Canon, Kowa and Topcon, which can validate the stabilization and generalization of algorithms on multi-domain. Moreover, three sub-tasks were designed in the challenge, including glaucoma classification, cup/optic disc segmentation, and macular fovea localization. These sub-tasks technically cover the three main problems of computer vision and clinicly cover the main researchs of glaucoma diagnosis. Over 1,300 international competitors joined the REFUGE2 challenge, 134 teams submitted more than 3,000 valid preliminary results, and 22 teams reached the final. This article summarizes the methods of some of the finalists and analyzes their results. In particular, we observed that the teams using domain adaptation strategies had high and robust performance on the dataset with multi-domain. This indicates that UDA and other multi-domain related researches will be the trend of deep learning field in the future, and our REFUGE2 datasets will play an important role in these researches.

ADAM Challenge: Detecting Age-related Macular Degeneration from Fundus Images

Age-related macular degeneration (AMD) is the leading cause of visual impairment among elderly in the world. Early detection of AMD is of great importance as the vision loss caused by AMD is irreversible and permanent. Color fundus photography is the most cost-effective imaging modality to screen for retinal disorders. \textcolor{red}{Recently, some algorithms based on deep learning had been developed for fundus image analysis and automatic AMD detection. However, a comprehensive annotated dataset and a standard evaluation benchmark are still missing.} To deal with this issue, we set up the Automatic Detection challenge on Age-related Macular degeneration (ADAM) for the first time, held as a satellite event of the ISBI 2020 conference. The ADAM challenge consisted of four tasks which cover the main topics in detecting AMD from fundus images, including classification of AMD, detection and segmentation of optic disc, localization of fovea, and detection and segmentation of lesions. The ADAM challenge has released a comprehensive dataset of 1200 fundus images with the category labels of AMD, the pixel-wise segmentation masks of the full optic disc and lesions (drusen, exudate, hemorrhage, scar, and other), as well as the location coordinates of the macular fovea. A uniform evaluation framework has been built to make a fair comparison of different models. During the ADAM challenge, 610 results were submitted for online evaluation, and finally, 11 teams participated in the onsite challenge. This paper introduces the challenge, dataset, and evaluation methods, as well as summarizes the methods and analyzes the results of the participating teams of each task. In particular, we observed that ensembling strategy and clinical prior knowledge can better improve the performances of the deep learning models.

GAMMA Challenge:Glaucoma grAding from Multi-Modality imAges

Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both two modalities of images have prominent biomarkers to indicate glaucoma suspected. Clinically, it is often recommended to take both of the screenings for a more accurate and reliable diagnosis. However, although numerous algorithms are proposed based on fundus images or OCT volumes in computer-aided diagnosis, there are still few methods leveraging both of the modalities for the glaucoma assessment. Inspired by the success of Retinal Fundus Glaucoma Challenge (REFUGE) we held previously, we set up the Glaucoma grAding from Multi-Modality imAges (GAMMA) Challenge to encourage the development of fundus \& OCT-based glaucoma grading. The primary task of the challenge is to grade glaucoma from both the 2D fundus images and 3D OCT scanning volumes. As part of GAMMA, we have publicly released a glaucoma annotated dataset with both 2D fundus color photography and 3D OCT volumes, which is the first multi-modality dataset for glaucoma grading. In addition, an evaluation framework is also established to evaluate the performance of the submitted methods. During the challenge, 1272 results were submitted, and finally, top-10 teams were selected to the final stage. We analysis their results and summarize their methods in the paper. Since all these teams submitted their source code in the challenge, a detailed ablation study is also conducted to verify the effectiveness of the particular modules proposed. We find many of the proposed techniques are practical for the clinical diagnosis of glaucoma. As the first in-depth study of fundus \& OCT multi-modality glaucoma grading, we believe the GAMMA Challenge will be an essential starting point for future research.

Relative velocity-based reward functions for crowd navigation of robots

The four-wheeled Mecanum robot is widely used in various industries due to its maneuverability and strong load capacity, which is suitable for performing precise transportation tasks in a narrow environment, but while the Mecanum wheel robot has mobility, it also consumes more energy than ordinary robots. The power consumed by the Mecanum wheel mobile robot varies enormously depending on their operating regimes and environments. Therefore, only knowing the working environment of the robot and the accurate power consumption model can we accurately predict the power consumption of the robot. In order to increase the appli-cable scenarios of energy consumption modeling for Mecanum wheel robots and improve the accuracy of energy consumption modeling, this paper focuses on various factors that affect the energy consumption of the Mecanum wheel robot, such as motor temperature, terrain, the center of gravity position, etc. The model is derived from the kinematic and kinetic model combined with electrical engineering and energy flow principles. The model has been simulated in MATLAB and experimentally validated with the four-wheeled Mecanum robot platform in our lab. Experimental results show that the model is 90% accurate. The results of energy consumption modeling can help robots to save energy by helping them to perform rational path planning and task planning.

Multi-task Joint Strategies of Self-supervised Representation Learning on Biomedical Networks for Drug Discovery

Self-supervised representation learning (SSL) on biomedical networks provides new opportunities for drug discovery which is lack of available biological or clinic phenotype. However, how to effectively combine multiple SSL models is challenging and rarely explored. Therefore, we propose multi-task joint strategies of self-supervised representation learning on biomedical networks for drug discovery, named MSSL2drug. We design six basic SSL tasks that are inspired by various modality features including structures, semantics, and attributes in biomedical heterogeneous networks. In addition, fifteen combinations of multiple tasks are evaluated by a graph attention-based adversarial multi-task learning framework in two drug discovery scenarios. The results suggest two important findings. (1) The combinations of multimodal tasks achieve the best performance compared to other multi-task joint strategies. (2) The joint training of local and global SSL tasks yields higher performance than random task combinations. Therefore, we conjecture that the multimodal and local-global combination strategies can be regarded as a guideline for multi-task SSL to drug discovery.