Communicating Smartly in the Molecular Domain: Neural Networks in the Internet of Bio-Nano Things

Recent developments in the Internet of Bio-Nano Things (IoBNT) are laying the groundwork for innovative applications across the healthcare sector. Nanodevices designed to operate within the body, managed remotely via the internet, are envisioned to promptly detect and actuate on potential diseases. In this vision, an inherent challenge arises due to the limited capabilities of individual nanosensors; specifically, nanosensors must communicate with one another to collaborate as a cluster. Aiming to research the boundaries of the clustering capabilities, this survey emphasizes data-driven communication strategies in molecular communication (MC) channels as a means of linking nanosensors. Relying on the flexibility and robustness of machine learning (ML) methods to tackle the dynamic nature of MC channels, the MC research community frequently refers to neural network (NN) architectures. This interdisciplinary research field encompasses various aspects, including the use of NNs to facilitate communication in MC environments, their implementation at the nanoscale, explainable approaches for NNs, and dataset generation for training. Within this survey, we provide a comprehensive analysis of fundamental perspectives on recent trends in NN architectures for MC, the feasibility of their implementation at the nanoscale, applied explainable artificial intelligence (XAI) techniques, and the accessibility of datasets along with best practices for their generation. Additionally, we offer open-source code repositories that illustrate NN-based methods to support reproducible research for key MC scenarios. Finally, we identify emerging research challenges, such as robust NN architectures, biologically integrated NN modules, and scalable training strategies.

Zero-Trust Foundation Models: A New Paradigm for Secure and Collaborative Artificial Intelligence for Internet of Things

This paper focuses on Zero-Trust Foundation Models (ZTFMs), a novel paradigm that embeds zero-trust security principles into the lifecycle of foundation models (FMs) for Internet of Things (IoT) systems. By integrating core tenets, such as continuous verification, least privilege access (LPA), data confidentiality, and behavioral analytics into the design, training, and deployment of FMs, ZTFMs can enable secure, privacy-preserving AI across distributed, heterogeneous, and potentially adversarial IoT environments. We present the first structured synthesis of ZTFMs, identifying their potential to transform conventional trust-based IoT architectures into resilient, self-defending ecosystems. Moreover, we propose a comprehensive technical framework, incorporating federated learning (FL), blockchain-based identity management, micro-segmentation, and trusted execution environments (TEEs) to support decentralized, verifiable intelligence at the network edge. In addition, we investigate emerging security threats unique to ZTFM-enabled systems and evaluate countermeasures, such as anomaly detection, adversarial training, and secure aggregation. Through this analysis, we highlight key open research challenges in terms of scalability, secure orchestration, interpretable threat attribution, and dynamic trust calibration. This survey lays a foundational roadmap for secure, intelligent, and trustworthy IoT infrastructures powered by FMs.

Second-Order Convergence in Private Stochastic Non-Convex Optimization

We investigate the problem of finding second-order stationary points (SOSP) in differentially private (DP) stochastic non-convex optimization. Existing methods suffer from two key limitations: (i) inaccurate convergence error rate due to overlooking gradient variance in the saddle point escape analysis, and (ii) dependence on auxiliary private model selection procedures for identifying DP-SOSP, which can significantly impair utility, particularly in distributed settings. To address these issues, we propose a generic perturbed stochastic gradient descent (PSGD) framework built upon Gaussian noise injection and general gradient oracles. A core innovation of our framework is using model drift distance to determine whether PSGD escapes saddle points, ensuring convergence to approximate local minima without relying on second-order information or additional DP-SOSP identification. By leveraging the adaptive DP-SPIDER estimator as a specific gradient oracle, we develop a new DP algorithm that rectifies the convergence error rates reported in prior work. We further extend this algorithm to distributed learning with arbitrarily heterogeneous data, providing the first formal guarantees for finding DP-SOSP in such settings. Our analysis also highlights the detrimental impacts of private selection procedures in distributed learning under high-dimensional models, underscoring the practical benefits of our design. Numerical experiments on real-world datasets validate the efficacy of our approach.

Undermining Federated Learning Accuracy in EdgeIoT via Variational Graph Auto-Encoders

EdgeIoT represents an approach that brings together mobile edge computing with Internet of Things (IoT) devices, allowing for data processing close to the data source. Sending source data to a server is bandwidth-intensive and may compromise privacy. Instead, federated learning allows each device to upload a shared machine-learning model update with locally processed data. However, this technique, which depends on aggregating model updates from various IoT devices, is vulnerable to attacks from malicious entities that may inject harmful data into the learning process. This paper introduces a new attack method targeting federated learning in EdgeIoT, known as data-independent model manipulation attack. This attack does not rely on training data from the IoT devices but instead uses an adversarial variational graph auto-encoder (AV-GAE) to create malicious model updates by analyzing benign model updates intercepted during communication. AV-GAE identifies and exploits structural relationships between benign models and their training data features. By manipulating these structural correlations, the attack maximizes the training loss of the federated learning system, compromising its overall effectiveness.

O-RIS-ing: Evaluating RIS-Assisted NextG Open RAN

Reconfigurable Intelligent Surfaces (RISs) pose as a transformative technology to revolutionize the cellular architecture of Next Generation (NextG) Radio Access Networks (RANs). Previous studies have demonstrated the capabilities of RISs in optimizing wireless propagation, achieving high spectral efficiency, and improving resource utilization. At the same time, the transition to softwarized, disaggregated, and virtualized architectures, such as those being standardized by the O-RAN ALLIANCE, enables the vision of a reconfigurable Open RAN. In this work, we aim to integrate these technologies by studying how different resource allocation policies enhance the performance of RIS-assisted Open RANs. We perform a comparative analysis among various network configurations and show how proper network optimization can enhance the performance across the Enhanced Mobile Broadband (eMBB) and Ultra Reliable and Low Latency Communications (URLLC) network slices, achieving up to ~34% throughput improvement. Furthermore, leveraging the capabilities of OpenRAN Gym, we deploy an xApp on Colosseum, the world's largest wireless system emulator with hardware-in-the-loop, to control the Base Station (BS)'s scheduling policy. Experimental results demonstrate that RIS-assisted topologies achieve high resource efficiency and low latency, regardless of the BS's scheduling policy.

Personalized and Context-aware Route Planning for Edge-assisted Vehicles

Conventional route planning services typically offer the same routes to all drivers, focusing primarily on a few standardized factors such as travel distance or time, overlooking individual driver preferences. With the inception of autonomous vehicles expected in the coming years, where vehicles will rely on routes decided by such planners, there arises a need to incorporate the specific preferences of each driver, ensuring personalized navigation experiences. In this work, we propose a novel approach based on graph neural networks (GNNs) and deep reinforcement learning (DRL), aimed at customizing routes to suit individual preferences. By analyzing the historical trajectories of individual drivers, we classify their driving behavior and associate it with relevant road attributes as indicators of driver preferences. The GNN is capable of representing the road network as graph-structured data effectively, while DRL is capable of making decisions utilizing reward mechanisms to optimize route selection with factors such as travel costs, congestion level, and driver satisfaction. We evaluate our proposed GNN-based DRL framework using a real-world road network and demonstrate its ability to accommodate driver preferences, offering a range of route options tailored to individual drivers. The results indicate that our framework can select routes that accommodate driver's preferences with up to a 17% improvement compared to a generic route planner, and reduce the travel time by 33% (afternoon) and 46% (evening) relatively to the shortest distance-based approach.

Leverage Variational Graph Representation For Model Poisoning on Federated Learning

This paper puts forth a new training data-untethered model poisoning (MP) attack on federated learning (FL). The new MP attack extends an adversarial variational graph autoencoder (VGAE) to create malicious local models based solely on the benign local models overheard without any access to the training data of FL. Such an advancement leads to the VGAE-MP attack that is not only efficacious but also remains elusive to detection. VGAE-MP attack extracts graph structural correlations among the benign local models and the training data features, adversarially regenerates the graph structure, and generates malicious local models using the adversarial graph structure and benign models' features. Moreover, a new attacking algorithm is presented to train the malicious local models using VGAE and sub-gradient descent, while enabling an optimal selection of the benign local models for training the VGAE. Experiments demonstrate a gradual drop in FL accuracy under the proposed VGAE-MP attack and the ineffectiveness of existing defense mechanisms in detecting the attack, posing a severe threat to FL.

Empowering the 6G Cellular Architecture with Open RAN

Innovation and standardization in 5G have brought advancements to every facet of the cellular architecture. This ranges from the introduction of new frequency bands and signaling technologies for the radio access network (RAN), to a core network underpinned by micro-services and network function virtualization (NFV). However, like any emerging technology, the pace of real-world deployments does not instantly match the pace of innovation. To address this discrepancy, one of the key aspects under continuous development is the RAN with the aim of making it more open, adaptive, functional, and easy to manage. In this paper, we highlight the transformative potential of embracing novel cellular architectures by transitioning from conventional systems to the progressive principles of Open RAN. This promises to make 6G networks more agile, cost-effective, energy-efficient, and resilient. It opens up a plethora of novel use cases, ranging from ubiquitous support for autonomous devices to cost-effective expansions in regions previously underserved. The principles of Open RAN encompass: (i) a disaggregated architecture with modular and standardized interfaces; (ii) cloudification, programmability and orchestration; and (iii) AI-enabled data-centric closed-loop control and automation. We first discuss the transformative role Open RAN principles have played in the 5G era. Then, we adopt a system-level approach and describe how these Open RAN principles will support 6G RAN and architecture innovation. We qualitatively discuss potential performance gains that Open RAN principles yield for specific 6G use cases. For each principle, we outline the steps that research, development and standardization communities ought to take to make Open RAN principles central to next-generation cellular network designs.

Resource Allocation for UAV-Assisted Industrial IoT User with Finite Blocklength

We consider a relay system empowered by an unmanned aerial vehicle (UAV) that facilitates downlink information delivery while adhering to finite blocklength requirements. The setup involves a remote controller transmitting information to both a UAV and an industrial Internet of Things (IIoT) or remote device, employing the non-orthogonal multiple access (NOMA) technique in the first phase. Subsequently, the UAV decodes and forwards this information to the remote device in the second phase. Our primary objective is to minimize the decoding error probability (DEP) at the remote device, which is influenced by the DEP at the UAV. To achieve this goal, we optimize the blocklength, transmission power, and location of the UAV. However, the underlying problem is highly non-convex and generally intractable to be solved directly. To overcome this challenge, we adopt an alternative optimization (AO) approach and decompose the original problem into three sub-problems. This approach leads to a sub-optimal solution, which effectively mitigates the non-convexity issue. In our simulations, we compare the performance of our proposed algorithm with baseline schemes. The results reveal that the proposed framework outperforms the baseline schemes, demonstrating its superiority in achieving lower DEP at the remote device. Furthermore, the simulation results illustrate the rapid convergence of our proposed algorithm, indicating its efficiency and effectiveness in solving the optimization problem.

Insights from the Design Space Exploration of Flow-Guided Nanoscale Localization

Nanodevices with Terahertz (THz)-based wireless communication capabilities are providing a primer for flow-guided localization within the human bloodstreams. Such localization is allowing for assigning the locations of sensed events with the events themselves, providing benefits in precision medicine along the lines of early and precise diagnostics, and reduced costs and invasiveness. Flow-guided localization is still in a rudimentary phase, with only a handful of works targeting the problem. Nonetheless, the performance assessments of the proposed solutions are already carried out in a non-standardized way, usually along a single performance metric, and ignoring various aspects that are relevant at such a scale (e.g., nanodevices' limited energy) and for such a challenging environment (e.g., extreme attenuation of in-body THz propagation). As such, these assessments feature low levels of realism and cannot be compared in an objective way. Toward addressing this issue, we account for the environmental and scale-related peculiarities of the scenario and assess the performance of two state-of-the-art flow-guided localization approaches along a set of heterogeneous performance metrics such as the accuracy and reliability of localization.