Deep Few-view High-resolution Photon-counting Extremity CT at Halved Dose for a Clinical Trial

The latest X-ray photon-counting computed tomography (PCCT) for extremity allows multi-energy high-resolution (HR) imaging for tissue characterization and material decomposition. However, both radiation dose and imaging speed need improvement for contrast-enhanced and other studies. Despite the success of deep learning methods for 2D few-view reconstruction, applying them to HR volumetric reconstruction of extremity scans for clinical diagnosis has been limited due to GPU memory constraints, training data scarcity, and domain gap issues. In this paper, we propose a deep learning-based approach for PCCT image reconstruction at halved dose and doubled speed in a New Zealand clinical trial. Particularly, we present a patch-based volumetric refinement network to alleviate the GPU memory limitation, train network with synthetic data, and use model-based iterative refinement to bridge the gap between synthetic and real-world data. The simulation and phantom experiments demonstrate consistently improved results under different acquisition conditions on both in- and off-domain structures using a fixed network. The image quality of 8 patients from the clinical trial are evaluated by three radiologists in comparison with the standard image reconstruction with a full-view dataset. It is shown that our proposed approach is essentially identical to or better than the clinical benchmark in terms of diagnostic image quality scores. Our approach has a great potential to improve the safety and efficiency of PCCT without compromising image quality.

Short-lived High-volume Multi-A(rmed)/B(andits) Testing

Modern platforms leverage randomized experiments to make informed decisions from a given set of items (``treatments''). As a particularly challenging scenario, these items may (i) arrive in high volume, with thousands of new items being released per hour, and (ii) have short lifetime, say, due to the item's transient nature or underlying non-stationarity that impels the platform to perceive the same item as distinct copies over time. Thus motivated, we study a Bayesian multiple-play bandit problem that encapsulates the key features of the multivariate testing (or ``multi-A/B testing'') problem with a high volume of short-lived arms. In each round, a set of $k$ arms arrive, each available for $w$ rounds. Without knowing the mean reward for each arm, the learner selects a multiset of $n$ arms and immediately observes their realized rewards. We aim to minimize the loss due to not knowing the mean rewards, averaged over instances generated from a given prior distribution. We show that when $k = O(n^\rho)$ for some constant $\rho>0$, our proposed policy has $\tilde O(n^{-\min \{\rho, \frac 12 (1+\frac 1w)^{-1}\}})$ loss on a sufficiently large class of prior distributions. We complement this result by showing that every policy suffers $\Omega (n^{-\min \{\rho, \frac 12\}})$ loss on the same class of distributions. We further validate the effectiveness of our policy through a large-scale field experiment on {\em Glance}, a content-card-serving platform that faces exactly the above challenge. A simple variant of our policy outperforms the platform's current recommender by 4.32\% in total duration and 7.48\% in total number of click-throughs.

Markdown Pricing Under an Unknown Parametric Demand Model

Consider a single-product revenue-maximization problem where the seller monotonically decreases the price in $n$ rounds with an unknown demand model coming from a given family. Without monotonicity, the minimax regret is $\tilde O(n^{2/3})$ for the Lipschitz demand family and $\tilde O(n^{1/2})$ for a general class of parametric demand models. With monotonicity, the minimax regret is $\tilde O(n^{3/4})$ if the revenue function is Lipschitz and unimodal. However, the minimax regret for parametric families remained open. In this work, we provide a complete settlement for this fundamental problem. We introduce the crossing number to measure the complexity of a family of demand functions. In particular, the family of degree-$k$ polynomials has a crossing number $k$. Based on conservatism under uncertainty, we present (i) a policy with an optimal $\Theta(\log^2 n)$ regret for families with crossing number $k=0$, and (ii) another policy with an optimal $\tilde \Theta(n^{k/(k+1)})$ regret when $k\ge 1$. These bounds are asymptotically higher than the $\tilde O(\log n)$ and $\tilde \Theta(\sqrt n)$ minimax regret for the same families without the monotonicity constraint.

FLIQS: One-Shot Mixed-Precision Floating-Point and Integer Quantization Search

Quantization has become a mainstream compression technique for reducing model size, computational requirements, and energy consumption for modern deep neural networks (DNNs). With the improved numerical support in recent hardware, including multiple variants of integer and floating point, mixed-precision quantization has become necessary to achieve high-quality results with low model cost. Prior mixed-precision quantization methods have performed a post-training quantization search, which compromises on accuracy, or a differentiable quantization search, which leads to high memory usage from branching. Therefore, we propose the first one-shot mixed-precision quantization search that eliminates the need for retraining in both integer and low-precision floating point models. We evaluate our floating-point and integer quantization search (FLIQS) on multiple convolutional networks and vision transformer models to discover Pareto-optimal models. Our approach discovers models that improve upon uniform precision, manual mixed-precision, and recent integer quantization search methods. With the proposed integer quantization search, we increase the accuracy of ResNet-18 on ImageNet by 1.31% points and ResNet-50 by 0.90% points with equivalent model cost over previous methods. Additionally, for the first time, we explore a novel mixed-precision floating-point search and improve MobileNetV2 by up to 0.98% points compared to prior state-of-the-art FP8 models. Finally, we extend FLIQS to simultaneously search a joint quantization and neural architecture space and improve the ImageNet accuracy by 2.69% points with similar model cost on a MobileNetV2 search space.

Multimodal Image-Text Matching Improves Retrieval-based Chest X-Ray Report Generation

Automated generation of clinically accurate radiology reports can improve patient care. Previous report generation methods that rely on image captioning models often generate incoherent and incorrect text due to their lack of relevant domain knowledge, while retrieval-based attempts frequently retrieve reports that are irrelevant to the input image. In this work, we propose Contrastive X-Ray REport Match (X-REM), a novel retrieval-based radiology report generation module that uses an image-text matching score to measure the similarity of a chest X-ray image and radiology report for report retrieval. We observe that computing the image-text matching score with a language-image model can effectively capture the fine-grained interaction between image and text that is often lost when using cosine similarity. X-REM outperforms multiple prior radiology report generation modules in terms of both natural language and clinical metrics. Human evaluation of the generated reports suggests that X-REM increased the number of zero-error reports and decreased the average error severity compared to the baseline retrieval approach. Our code is available at: https://github.com/rajpurkarlab/X-REM

Approximation Algorithms for Active Sequential Hypothesis Testing

In the problem of active sequential hypotheses testing (ASHT), a learner seeks to identify the true hypothesis $h^*$ from among a set of hypotheses $H$. The learner is given a set of actions and knows the outcome distribution of any action under any true hypothesis. While repeatedly playing the entire set of actions suffices to identify $h^*$, a cost is incurred with each action. Thus, given a target error $\delta>0$, the goal is to find the minimal cost policy for sequentially selecting actions that identify $h^*$ with probability at least $1 - \delta$. This paper provides the first approximation algorithms for ASHT, under two types of adaptivity. First, a policy is partially adaptive if it fixes a sequence of actions in advance and adaptively decides when to terminate and what hypothesis to return. Under partial adaptivity, we provide an $O\big(s^{-1}(1+\log_{1/\delta}|H|)\log (s^{-1}|H| \log |H|)\big)$-approximation algorithm, where $s$ is a natural separation parameter between the hypotheses. Second, a policy is fully adaptive if action selection is allowed to depend on previous outcomes. Under full adaptivity, we provide an $O(s^{-1}\log (|H|/\delta)\log |H|)$-approximation algorithm. We numerically investigate the performance of our algorithms using both synthetic and real-world data, showing that our algorithms outperform a previously proposed heuristic policy.

LTL2Action: Generalizing LTL Instructions for Multi-Task RL

We address the problem of teaching a deep reinforcement learning (RL) agent to follow instructions in multi-task environments. The combinatorial task sets we target consist of up to $~10^{39}$ unique tasks. We employ a well-known formal language -- linear temporal logic (LTL) -- to specify instructions, using a domain-specific vocabulary. We propose a novel approach to learning that exploits the compositional syntax and the semantics of LTL, enabling our RL agent to learn task-conditioned policies that generalize to new instructions, not observed during training. The expressive power of LTL supports the specification of a diversity of complex temporally extended behaviours that include conditionals and alternative realizations. To reduce the overhead of learning LTL semantics, we introduce an environment-agnostic LTL pretraining scheme which improves sample-efficiency in downstream environments. Experiments on discrete and continuous domains demonstrate the strength of our approach in learning to solve (unseen) tasks, given LTL instructions.

Searching for Fast Model Families on Datacenter Accelerators

Neural Architecture Search (NAS), together with model scaling, has shown remarkable progress in designing high accuracy and fast convolutional architecture families. However, as neither NAS nor model scaling considers sufficient hardware architecture details, they do not take full advantage of the emerging datacenter (DC) accelerators. In this paper, we search for fast and accurate CNN model families for efficient inference on DC accelerators. We first analyze DC accelerators and find that existing CNNs suffer from insufficient operational intensity, parallelism, and execution efficiency. These insights let us create a DC-accelerator-optimized search space, with space-to-depth, space-to-batch, hybrid fused convolution structures with vanilla and depthwise convolutions, and block-wise activation functions. On top of our DC accelerator optimized neural architecture search space, we further propose a latency-aware compound scaling (LACS), the first multi-objective compound scaling method optimizing both accuracy and latency. Our LACS discovers that network depth should grow much faster than image size and network width, which is quite different from previous compound scaling results. With the new search space and LACS, our search and scaling on datacenter accelerators results in a new model series named EfficientNet-X. EfficientNet-X is up to more than 2X faster than EfficientNet (a model series with state-of-the-art trade-off on FLOPs and accuracy) on TPUv3 and GPUv100, with comparable accuracy. EfficientNet-X is also up to 7X faster than recent RegNet and ResNeSt on TPUv3 and GPUv100.

Segmenting Unknown 3D Objects from Real Depth Images using Mask R-CNN Trained on Synthetic Data

The ability to segment unknown objects in depth images has potential to enhance robot skills in grasping and object tracking. Recent computer vision research has demonstrated that Mask R-CNN can be trained to segment specific categories of objects in RGB images when massive hand-labeled datasets are available. As generating these datasets is time consuming, we instead train with synthetic depth images. Many robots now use depth sensors, and recent results suggest training on synthetic depth data can transfer successfully to the real world. We present a method for automated dataset generation and rapidly generate a synthetic training dataset of 50,000 depth images and 320,000 object masks using simulated heaps of 3D CAD models. We train a variant of Mask R-CNN with domain randomization on the generated dataset to perform category-agnostic instance segmentation without any hand-labeled data and we evaluate the trained network, which we refer to as Synthetic Depth (SD) Mask R-CNN, on a set of real, high-resolution depth images of challenging, densely-cluttered bins containing objects with highly-varied geometry. SD Mask R-CNN outperforms point cloud clustering baselines by an absolute 15% in Average Precision and 20% in Average Recall on COCO benchmarks, and achieves performance levels similar to a Mask R-CNN trained on a massive, hand-labeled RGB dataset and fine-tuned on real images from the experimental setup. We deploy the model in an instance-specific grasping pipeline to demonstrate its usefulness in a robotics application. Code, the synthetic training dataset, and supplementary material are available at https://bit.ly/2letCuE.