CenTime: Event-Conditional Modelling of Censoring in Survival Analysis

Survival analysis is a valuable tool for estimating the time until specific events, such as death or cancer recurrence, based on baseline observations. This is particularly useful in healthcare to prognostically predict clinically important events based on patient data. However, existing approaches often have limitations; some focus only on ranking patients by survivability, neglecting to estimate the actual event time, while others treat the problem as a classification task, ignoring the inherent time-ordered structure of the events. Furthermore, the effective utilization of censored samples - training data points where the exact event time is unknown - is essential for improving the predictive accuracy of the model. In this paper, we introduce CenTime, a novel approach to survival analysis that directly estimates the time to event. Our method features an innovative event-conditional censoring mechanism that performs robustly even when uncensored data is scarce. We demonstrate that our approach forms a consistent estimator for the event model parameters, even in the absence of uncensored data. Furthermore, CenTime is easily integrated with deep learning models with no restrictions on batch size or the number of uncensored samples. We compare our approach with standard survival analysis methods, including the Cox proportional-hazard model and DeepHit. Our results indicate that CenTime offers state-of-the-art performance in predicting time-to-death while maintaining comparable ranking performance. Our implementation is publicly available at https://github.com/ahmedhshahin/CenTime.

A data-centric deep learning approach to airway segmentation

The morphology and distribution of airway tree abnormalities enables diagnosis and disease characterisation across a variety of chronic respiratory conditions. In this regard, airway segmentation plays a critical role in the production of the outline of the entire airway tree to enable estimation of disease extent and severity. In this study, we propose a data-centric deep learning technique to segment the airway tree. The proposed technique utilises interpolation and image split to improve data usefulness and quality. Then, an ensemble learning strategy is implemented to aggregate the segmented airway trees at different scales. In terms of segmentation performance (dice similarity coefficient), our method outperforms the baseline model by 2.5% on average when a combined loss is used. Further, our proposed technique has a low GPU usage and high flexibility enabling it to be deployed on any 2D deep learning model.

A hybrid CNN-RNN approach for survival analysis in a Lung Cancer Screening study

In this study, we present a hybrid CNN-RNN approach to investigate long-term survival of subjects in a lung cancer screening study. Subjects who died of cardiovascular and respiratory causes were identified whereby the CNN model was used to capture imaging features in the CT scans and the RNN model was used to investigate time series and thus global information. The models were trained on subjects who underwent cardiovascular and respiratory deaths and a control cohort matched to participant age, gender, and smoking history. The combined model can achieve an AUC of 0.76 which outperforms humans at cardiovascular mortality prediction. The corresponding F1 and Matthews Correlation Coefficient are 0.63 and 0.42 respectively. The generalisability of the model is further validated on an 'external' cohort. The same models were applied to survival analysis with the Cox Proportional Hazard model. It was demonstrated that incorporating the follow-up history can lead to improvement in survival prediction. The Cox neural network can achieve an IPCW C-index of 0.75 on the internal dataset and 0.69 on an external dataset. Delineating imaging features associated with long-term survival can help focus preventative interventions appropriately, particularly for under-recognised pathologies thereby potentially reducing patient morbidity.

VAFO-Loss: VAscular Feature Optimised Loss Function for Retinal Artery/Vein Segmentation

Estimating clinically-relevant vascular features following vessel segmentation is a standard pipeline for retinal vessel analysis, which provides potential ocular biomarkers for both ophthalmic disease and systemic disease. In this work, we integrate these clinical features into a novel vascular feature optimised loss function (VAFO-Loss), in order to regularise networks to produce segmentation maps, with which more accurate vascular features can be derived. Two common vascular features, vessel density and fractal dimension, are identified to be sensitive to intra-segment misclassification, which is a well-recognised problem in multi-class artery/vein segmentation particularly hindering the estimation of these vascular features. Thus we encode these two features into VAFO-Loss. We first show that incorporating our end-to-end VAFO-Loss in standard segmentation networks indeed improves vascular feature estimation, yielding quantitative improvement in stroke incidence prediction, a clinical downstream task. We also report a technically interesting finding that the trained segmentation network, albeit biased by the feature optimised loss VAFO-Loss, shows statistically significant improvement in segmentation metrics, compared to those trained with other state-of-the-art segmentation losses.

Optimizing Short-Time Fourier Transform Parameters via Gradient Descent

The Short-Time Fourier Transform (STFT) has been a staple of signal processing, often being the first step for many audio tasks. A very familiar process when using the STFT is the search for the best STFT parameters, as they often have significant side effects if chosen poorly. These parameters are often defined in terms of an integer number of samples, which makes their optimization non-trivial. In this paper we show an approach that allows us to obtain a gradient for STFT parameters with respect to arbitrary cost functions, and thus enable the ability to employ gradient descent optimization of quantities like the STFT window length, or the STFT hop size. We do so for parameter values that stay constant throughout an input, but also for cases where these parameters have to dynamically change over time to accommodate varying signal characteristics.

Domain-Adaptive Few-Shot Learning

Existing few-shot learning (FSL) methods make the implicit assumption that the few target class samples are from the same domain as the source class samples. However, in practice this assumption is often invalid -- the target classes could come from a different domain. This poses an additional challenge of domain adaptation (DA) with few training samples. In this paper, the problem of domain-adaptive few-shot learning (DA-FSL) is tackled, which requires solving FSL and DA in a unified framework. To this end, we propose a novel domain-adversarial prototypical network (DAPN) model. It is designed to address a specific challenge in DA-FSL: the DA objective means that the source and target data distributions need to be aligned, typically through a shared domain-adaptive feature embedding space; but the FSL objective dictates that the target domain per class distribution must be different from that of any source domain class, meaning aligning the distributions across domains may harm the FSL performance. How to achieve global domain distribution alignment whilst maintaining source/target per-class discriminativeness thus becomes the key. Our solution is to explicitly enhance the source/target per-class separation before domain-adaptive feature embedding learning in the DAPN, in order to alleviate the negative effect of domain alignment on FSL. Extensive experiments show that our DAPN outperforms the state-of-the-art FSL and DA models, as well as their na\"ive combinations. The code is available at https://github.com/dingmyu/DAPN.

Face-Focused Cross-Stream Network for Deception Detection in Videos

Automated deception detection (ADD) from real-life videos is a challenging task. It specifically needs to address two problems: (1) Both face and body contain useful cues regarding whether a subject is deceptive. How to effectively fuse the two is thus key to the effectiveness of an ADD model. (2) Real-life deceptive samples are hard to collect; learning with limited training data thus challenges most deep learning based ADD models. In this work, both problems are addressed. Specifically, for face-body multimodal learning, a novel face-focused cross-stream network (FFCSN) is proposed. It differs significantly from the popular two-stream networks in that: (a) face detection is added into the spatial stream to capture the facial expressions explicitly, and (b) correlation learning is performed across the spatial and temporal streams for joint deep feature learning across both face and body. To address the training data scarcity problem, our FFCSN model is trained with both meta learning and adversarial learning. Extensive experiments show that our FFCSN model achieves state-of-the-art results. Further, the proposed FFCSN model as well as its robust training strategy are shown to be generally applicable to other human-centric video analysis tasks such as emotion recognition from user-generated videos.

Zero and Few Shot Learning with Semantic Feature Synthesis and Competitive Learning

Zero-shot learning (ZSL) is made possible by learning a projection function between a feature space and a semantic space (e.g.,~an attribute space). Key to ZSL is thus to learn a projection that is robust against the often large domain gap between the seen and unseen class domains. In this work, this is achieved by unseen class data synthesis and robust projection function learning. Specifically, a novel semantic data synthesis strategy is proposed, by which semantic class prototypes (e.g., attribute vectors) are used to simply perturb seen class data for generating unseen class ones. As in any data synthesis/hallucination approach, there are ambiguities and uncertainties on how well the synthesised data can capture the targeted unseen class data distribution. To cope with this, the second contribution of this work is a novel projection learning model termed competitive bidirectional projection learning (BPL) designed to best utilise the ambiguous synthesised data. Specifically, we assume that each synthesised data point can belong to any unseen class; and the most likely two class candidates are exploited to learn a robust projection function in a competitive fashion. As a third contribution, we show that the proposed ZSL model can be easily extended to few-shot learning (FSL) by again exploiting semantic (class prototype guided) feature synthesis and competitive BPL. Extensive experiments show that our model achieves the state-of-the-art results on both problems.

Domain-Invariant Projection Learning for Zero-Shot Recognition

Zero-shot learning (ZSL) aims to recognize unseen object classes without any training samples, which can be regarded as a form of transfer learning from seen classes to unseen ones. This is made possible by learning a projection between a feature space and a semantic space (e.g. attribute space). Key to ZSL is thus to learn a projection function that is robust against the often large domain gap between the seen and unseen classes. In this paper, we propose a novel ZSL model termed domain-invariant projection learning (DIPL). Our model has two novel components: (1) A domain-invariant feature self-reconstruction task is introduced to the seen/unseen class data, resulting in a simple linear formulation that casts ZSL into a min-min optimization problem. Solving the problem is non-trivial, and a novel iterative algorithm is formulated as the solver, with rigorous theoretic algorithm analysis provided. (2) To further align the two domains via the learned projection, shared semantic structure among seen and unseen classes is explored via forming superclasses in the semantic space. Extensive experiments show that our model outperforms the state-of-the-art alternatives by significant margins.