Breast cancer has become one of the most prevalent cancers by which people all over the world are affected and is posed serious threats to human beings, in a particular woman. In order to provide effective treatment or prevention of this cancer, disease diagnosis in the early stages would be of high importance. There have been various methods to detect this disorder in which using images have to play a dominant role. Deep learning has been recently adopted widely in different areas of science, especially medicine. In breast cancer detection problems, some diverse deep learning techniques have been developed on different datasets and resulted in good accuracy. In this article, we aimed to present a deep neural network model to classify histopathological images from the Databiox image dataset as the first application on this image database. Our proposed model named BCNet has taken advantage of the transfer learning approach in which VGG16 is selected from available pertained models as a feature extractor. Furthermore, to address the problem of insufficient data, we employed the data augmentation technique to expand the input dataset. All implementations in this research, ranging from pre-processing actions to depicting the diagram of the model architecture, have been carried out using tf.keras API. As a consequence of the proposed model execution, the significant validation accuracy of 88% and evaluation accuracy of 72% obtained.
Convolutional Neural Networks (CNNs) have been used for automated detection of prostate cancer where Area Under Receiver Operating Characteristic (ROC) curve (AUC) is usually used as the performance metric. Given that AUC is not differentiable, common practice is to train the CNN using a loss functions based on other performance metrics such as cross entropy and monitoring AUC to select the best model. In this work, we propose to fine-tune a trained CNN for prostate cancer detection using a Genetic Algorithm to achieve a higher AUC. Our dataset contained 6-channel Diffusion-Weighted MRI slices of prostate. On a cohort of 2,955 training, 1,417 validation, and 1,334 test slices, we reached test AUC of 0.773; a 9.3% improvement compared to the base CNN model.
In this paper, we studied extensively on different deep learning based methods to detect melanoma and skin lesion cancers. Melanoma, a form of malignant skin cancer is very threatening to health. Proper diagnosis of melanoma at an earlier stage is crucial for the success rate of complete cure. Dermoscopic images with Benign and malignant forms of skin cancer can be analyzed by computer vision system to streamline the process of skin cancer detection. In this study, we experimented with various neural networks which employ recent deep learning based models like PNASNet-5-Large, InceptionResNetV2, SENet154, InceptionV4. Dermoscopic images are properly processed and augmented before feeding them into the network. We tested our methods on International Skin Imaging Collaboration (ISIC) 2018 challenge dataset. Our system has achieved best validation score of 0.76 for PNASNet-5-Large model. Further improvement and optimization of the proposed methods with a bigger training dataset and carefully chosen hyper-parameter could improve the performances. The code available for download at https://github.com/miltonbd/ISIC_2018_classification
Digital image plays a vital role in the early detection of cancers, such as prostate cancer, breast cancer, lungs cancer, cervical cancer. Ultrasound imaging method is also suitable for early detection of the abnormality of fetus. The accurate detection of region of interest in ultrasound image is crucial. Since the result of reflection, refraction and deflection of ultrasound waves from different types of tissues with different acoustic impedance. Usually, the contrast in ultrasound image is very low and weak edges make the image difficult to identify the fetus region in the ultrasound image. So the analysis of ultrasound image is more challenging one. We try to develop a new algorithmic approach to solve the problem of non clarity and find disorder of it. Generally there is no common enhancement approach for noise reduction. This paper proposes different filtering techniques based on statistical methods for the removal of various noise. The quality of the enhanced images is measured by the statistical quantity measures: Signal-to-Noise Ratio (SNR), Peak Signal-to-Noise Ratio (PSNR), and Root Mean Square Error (RMSE).
Hepatocellular carcinoma (HCC) is the second most frequent cause of malignancy-related death and is one of the diseases with the highest incidence in the world. Because the liver is the only organ in the human body that is supplied by two major vessels: the hepatic artery and the portal vein, various types of malignant tumors can spread from other organs to the liver. And due to the liver masses' heterogeneous and diffusive shape, the tumor lesions are very difficult to be recognized, thus automatic lesion detection is necessary for the doctors with huge workloads. To assist doctors, this work uses the existing large-scale annotation medical image data to delve deep into liver lesion detection from multiple directions. To solve technical difficulties, such as the image-recognition task, traditional deep learning with convolution neural networks (CNNs) has been widely applied in recent years. However, this kind of neural network, such as Faster Regions with CNN features (R-CNN), cannot leverage the spatial information because it is applied in natural images (2D) rather than medical images (3D), such as computed tomography (CT) images. To address this issue, we propose a novel algorithm that is appropriate for liver CT imaging. Furthermore, according to radiologists' experience in clinical diagnosis and the characteristics of CT images of liver cancer, a liver cancer-detection framework with CNN, including image processing, feature extraction, region proposal, image registration, and classification recognition, was proposed to facilitate the effective detection of liver lesions.
Pathological diagnosis is the gold standard for cancer diagnosis, but it is labor-intensive, in which tasks such as cell detection, classification, and counting are particularly prominent. A common solution for automating these tasks is using nucleus segmentation technology. However, it is hard to train a robust nucleus segmentation model, due to several challenging problems, the nucleus adhesion, stacking, and excessive fusion with the background. Recently, some researchers proposed a series of automatic nucleus segmentation methods based on point annotation, which can significant improve the model performance. Nevertheless, the point annotation needs to be marked by experienced pathologists. In order to take advantage of segmentation methods based on point annotation, further alleviate the manual workload, and make cancer diagnosis more efficient and accurate, it is necessary to develop an automatic nucleus detection algorithm, which can automatically and efficiently locate the position of the nucleus in the pathological image and extract valuable information for pathologists. In this paper, we propose a W-shaped network for automatic nucleus detection. Different from the traditional U-Net based method, mapping the original pathology image to the target mask directly, our proposed method split the detection task into two sub-tasks. The first sub-task maps the original pathology image to the binary mask, then the binary mask is mapped to the density mask in the second sub-task. After the task is split, the task's difficulty is significantly reduced, and the network's overall performance is improved.
In this paper, we introduced a novel feature extraction approach, named exclusive autoencoder (XAE), which is a supervised version of autoencoder (AE), able to largely improve the performance of nucleus detection and classification on hematoxylin and eosin (H&E) histopathological images. The proposed XAE can be used in any AE-based algorithm, as long as the data labels are also provided in the feature extraction phase. In the experiments, we evaluated the performance of an approach which is the combination of an XAE and a fully connected neural network (FCN) and compared with some AE-based methods. For a nucleus detection problem (considered as a nucleus/non-nucleus classification problem) on breast cancer H&E images, the F-score of the proposed XAE+FCN approach achieved 96.64% while the state-of-the-art was at 84.49%. For nucleus classification on colorectal cancer H&E images, with the annotations of four categories of epithelial, inflammatory, fibroblast and miscellaneous nuclei. The F-score of the proposed method reached 70.4%. We also proposed a lymphocyte segmentation method. In the step of lymphocyte detection, we have compared with cutting-edge technology and gained improved performance from 90% to 98.67%. We also proposed an algorithm for lymphocyte segmentation based on nucleus detection and classification. The obtained Dice coefficient achieved 88.31% while the cutting-edge approach was at 74%.
This study focuses on automatic skin cancer detection using a Meta-learning approach for dermoscopic images. The aim of this study is to explore the benefits of the generalization of the knowledge extracted from non-medical data in the classification performance of medical data and the impact of the distribution shift problem within limited data by using a simple class and distribution balancer algorithm. In this study, a small sample of a combined dataset from 3 different sources was used to fine-tune a ResNet model pre-trained on non-medical data. The results show an increase in performance on detecting melanoma, malignant (skin cancer), and benign moles with the prior knowledge obtained from images of everyday objects from the ImageNet dataset by 20 points. These findings suggest that features from non-medical images can be used towards the classification of skin moles and that the distribution of the data affects the performance of the model.
The appearance of microcalcifications in mammograms is one of the early signs of breast cancer. So, early detection of microcalcification clusters (MCCs) in mammograms can be helpful for cancer diagnosis and better treatment of breast cancer. In this paper a computer method has been proposed to support radiologists in detection MCCs in digital mammography. First, in order to facilitate and improve the detection step, mammogram images have been enhanced with wavelet transformation and morphology operation. Then for segmentation of suspicious MCCs, two methods have been investigated. The considered methods are: adaptive threshold and watershed segmentation. Finally, the detected MCCs areas in different algorithms will be compared to find out which segmentation method is more appropriate for extracting MCCs in mammograms.
Breast cancer has become a symbol of tremendous concern in the modern world, as it is one of the major causes of cancer mortality worldwide. In this concern, many people are frequently screening for breast cancer in order to be identified early and avert mortality from the disease by receiving treatment. Breast Ultrasonography Images are frequently utilized by doctors to diagnose breast cancer at an early stage. However, the complex artifacts and heavily noised Breast Ultrasonography Images make detecting Breast Cancer a tough challenge. Furthermore, the ever-increasing number of patients being screened for Breast Cancer necessitates the use of automated Computer Aided Technology for high accuracy diagnosis at a cheap cost and in a short period of time. The current progress of Artificial Intelligence (AI) in the fields of Medical Image Analysis and Health Care is a boon to humanity. In this study, we have proposed a compact integrated automated pipelining framework which integrates ultrasonography image preprocessing with Simple Linear Iterative Clustering (SLIC) to tackle the complex artifact of Breast Ultrasonography Images complementing semantic segmentation with Modified U-Net leading to Breast Tumor classification with robust feature extraction using a transfer learning approach with pretrained VGG 16 model and densely connected neural network architecture. The proposed automated pipeline can be effectively implemented to assist medical practitioners in making more accurate and timely diagnoses of breast cancer.
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