Temporal Dynamic Synchronous Functional Brain Network for Schizophrenia Diagnosis and Lateralization Analysis

Available evidence suggests that dynamic functional connectivity (dFC) can capture time-varying abnormalities in brain activity in rs-fMRI data and has a natural advantage in uncovering mechanisms of abnormal brain activity in schizophrenia(SZ) patients. Hence, an advanced dynamic brain network analysis model called the temporal brain category graph convolutional network (temporal-BCGCN) was employed. Firstly, a unique dynamic brain network analysis module, DSF-BrainNet, was designed to construct dynamic synchronization features. Subsequently, a revolutionary graph convolution method, TemporalConv, was proposed, based on the synchronous temporal properties of feature. Finally, the first modular abnormal hemispherical lateralization test tool in deep learning based on rs-fMRI data, named CategoryPool, was proposed. This study was validated on COBRE and UCLA datasets and achieved 83.62% and 89.71% average accuracy, respectively, outperforming the baseline model and other State-of-the-Art methods. The ablation results also demonstrate the advantages of TemporalConv over the traditional edge feature convolution approach of graph convolutional neural network (GCN) and the improvement of CategoryPool over the classical graph pooling approach. Interestingly, this study showed that the lower order perceptual system and higher order network regions in the left hemisphere are more severely dysfunctional than in the right hemisphere of SZ, and reaffirms the importance of the left medial superior frontal gyrus in SZ. Our core code is available at: https://github.com/swfen/Temporal-BCGCN.

Forecasting with Deep Learning

This paper presents a method for time series forecasting with deep learning and its assessment on two datasets. The method starts with data preparation, followed by model training and evaluation. The final step is a visual inspection. Experimental work demonstrates that a single time series can be used to train deep learning networks if time series in a dataset contain patterns that repeat even with a certain variation. However, for less structured time series such as stock market closing prices, the networks perform just like a baseline that repeats the last observed value. The implementation of the method as well as the experiments are open-source.

Variational Inference for Neyman-Scott Processes

Neyman-Scott processes (NSPs) have been applied across a range of fields to model points or temporal events with a hierarchy of clusters. Markov chain Monte Carlo (MCMC) is typically used for posterior sampling in the model. However, MCMC's mixing time can cause the resulting inference to be slow, and thereby slow down model learning and prediction. We develop the first variational inference (VI) algorithm for NSPs, and give two examples of suitable variational posterior point process distributions. Our method minimizes the inclusive Kullback-Leibler (KL) divergence for VI to obtain the variational parameters. We generate samples from the approximate posterior point processes much faster than MCMC, as we can directly estimate the approximate posterior point processes without any MCMC steps or gradient descent. We include synthetic and real-world data experiments that demonstrate our VI algorithm achieves better prediction performance than MCMC when computational time is limited.

T-Phenotype: Discovering Phenotypes of Predictive Temporal Patterns in Disease Progression

Clustering time-series data in healthcare is crucial for clinical phenotyping to understand patients' disease progression patterns and to design treatment guidelines tailored to homogeneous patient subgroups. While rich temporal dynamics enable the discovery of potential clusters beyond static correlations, two major challenges remain outstanding: i) discovery of predictive patterns from many potential temporal correlations in the multi-variate time-series data and ii) association of individual temporal patterns to the target label distribution that best characterizes the underlying clinical progression. To address such challenges, we develop a novel temporal clustering method, T-Phenotype, to discover phenotypes of predictive temporal patterns from labeled time-series data. We introduce an efficient representation learning approach in frequency domain that can encode variable-length, irregularly-sampled time-series into a unified representation space, which is then applied to identify various temporal patterns that potentially contribute to the target label using a new notion of path-based similarity. Throughout the experiments on synthetic and real-world datasets, we show that T-Phenotype achieves the best phenotype discovery performance over all the evaluated baselines. We further demonstrate the utility of T-Phenotype by uncovering clinically meaningful patient subgroups characterized by unique temporal patterns.

Primal and Dual Analysis of Entropic Fictitious Play for Finite-sum Problems

The entropic fictitious play (EFP) is a recently proposed algorithm that minimizes the sum of a convex functional and entropy in the space of measures -- such an objective naturally arises in the optimization of a two-layer neural network in the mean-field regime. In this work, we provide a concise primal-dual analysis of EFP in the setting where the learning problem exhibits a finite-sum structure. We establish quantitative global convergence guarantees for both the continuous-time and discrete-time dynamics based on properties of a proximal Gibbs measure introduced in Nitanda et al. (2022). Furthermore, our primal-dual framework entails a memory-efficient particle-based implementation of the EFP update, and also suggests a connection to gradient boosting methods. We illustrate the efficiency of our novel implementation in experiments including neural network optimization and image synthesis.

Reservoir computing based on solitary-like waves dynamics of film flows: a proof of concept

Several theoretical works have shown that solitons -- waves that self-maintain constant shape and velocity as they propagate -- can be used as a physical computational reservoir, a concept where machine learning algorithms designed for digital computers are replaced by analog physical systems that exhibit nonlinear dynamical behaviour. Here we propose and experimentally validate a novel reservoir computing (RC) system that for the first time employs solitary-like (SL) waves propagating on the surface of a liquid film flowing over an inclined surface. We demonstrate the ability of the SL wave RC system (SLRC) to forecast chaotic time series and to successfully pass essential benchmark tests, including a memory capacity test and a Mackey-Glass model test.

Few-Shot 3D Point Cloud Semantic Segmentation via Stratified Class-Specific Attention Based Transformer Network

3D point cloud semantic segmentation aims to group all points into different semantic categories, which benefits important applications such as point cloud scene reconstruction and understanding. Existing supervised point cloud semantic segmentation methods usually require large-scale annotated point clouds for training and cannot handle new categories. While a few-shot learning method was proposed recently to address these two problems, it suffers from high computational complexity caused by graph construction and inability to learn fine-grained relationships among points due to the use of pooling operations. In this paper, we further address these problems by developing a new multi-layer transformer network for few-shot point cloud semantic segmentation. In the proposed network, the query point cloud features are aggregated based on the class-specific support features in different scales. Without using pooling operations, our method makes full use of all pixel-level features from the support samples. By better leveraging the support features for few-shot learning, the proposed method achieves the new state-of-the-art performance, with 15\% less inference time, over existing few-shot 3D point cloud segmentation models on the S3DIS dataset and the ScanNet dataset.

CryoFormer: Continuous Reconstruction of 3D Structures from Cryo-EM Data using Transformer-based Neural Representations

High-resolution heterogeneous reconstruction of 3D structures of proteins and other biomolecules using cryo-electron microscopy (cryo-EM) is essential for understanding fundamental processes of life. However, it is still challenging to reconstruct the continuous motions of 3D structures from hundreds of thousands of noisy and randomly oriented 2D cryo-EM images. Existing methods based on coordinate-based neural networks show compelling results to model continuous conformations of 3D structures in the Fourier domain, but they suffer from a limited ability to model local flexible regions and lack interpretability. We propose a novel approach, cryoFormer, that utilizes a transformer-based network architecture for continuous heterogeneous cryo-EM reconstruction. We for the first time directly reconstruct continuous conformations of 3D structures using an implicit feature volume in the 3D spatial domain. A novel deformation transformer decoder further improves reconstruction quality and, more importantly, locates and robustly tackles flexible 3D regions caused by conformations. In experiments, our method outperforms current approaches on three public datasets (1 synthetic and 2 experimental) and a new synthetic dataset of PEDV spike protein. The code and new synthetic dataset will be released for better reproducibility of our results. Project page: https://cryoformer.github.io.

On the Local Cache Update Rules in Streaming Federated Learning

In this study, we address the emerging field of Streaming Federated Learning (SFL) and propose local cache update rules to manage dynamic data distributions and limited cache capacity. Traditional federated learning relies on fixed data sets, whereas in SFL, data is streamed, and its distribution changes over time, leading to discrepancies between the local training dataset and long-term distribution. To mitigate this problem, we propose three local cache update rules - First-In-First-Out (FIFO), Static Ratio Selective Replacement (SRSR), and Dynamic Ratio Selective Replacement (DRSR) - that update the local cache of each client while considering the limited cache capacity. Furthermore, we derive a convergence bound for our proposed SFL algorithm as a function of the distribution discrepancy between the long-term data distribution and the client's local training dataset. We then evaluate our proposed algorithm on two datasets: a network traffic classification dataset and an image classification dataset. Our experimental results demonstrate that our proposed local cache update rules significantly reduce the distribution discrepancy and outperform the baseline methods. Our study advances the field of SFL and provides practical cache management solutions in federated learning.

A Hierarchical Game-Theoretic Decision-Making for Cooperative Multi-Agent Systems Under the Presence of Adversarial Agents

Underlying relationships among Multi-Agent Systems (MAS) in hazardous scenarios can be represented as Game-theoretic models. This paper proposes a new hierarchical network-based model called Game-theoretic Utility Tree (GUT), which decomposes high-level strategies into executable low-level actions for cooperative MAS decisions. It combines with a new payoff measure based on agent needs for real-time strategy games. We present an Explore game domain, where we measure the performance of MAS achieving tasks from the perspective of balancing the success probability and system costs. We evaluate the GUT approach against state-of-the-art methods that greedily rely on rewards of the composite actions. Conclusive results on extensive numerical simulations indicate that GUT can organize more complex relationships among MAS cooperation, helping the group achieve challenging tasks with lower costs and higher winning rates. Furthermore, we demonstrated the applicability of the GUT using the simulator-hardware testbed - Robotarium. The performances verified the effectiveness of the GUT in the real robot application and validated that the GUT could effectively organize MAS cooperation strategies, helping the group with fewer advantages achieve higher performance.