Learning Varying Physical Therapist-Patient Interactions for Robot-mediated Upper Limb Task-Specific Training

Upper extremity motor function recovery is positively linked to Task-Specific Training (TST) and sufficient therapy dosage. Rehabilitation robots can increase TST dosage via controlled, repetitive treatment and free therapists to simultaneously manage other patients, but it has yet to demonstrate significant benefits over conventional treatment. This is potentially linked to inaccurate robotic representation of personalised physical therapist-patient interaction and lack of practice variability during TST. Hence, we advocate for robotic interventions that preserve the personalised physical therapist-patient interactions when delivering TST for patients across varying practise conditions. We propose a Learning-from-Demonstration framework using Task-Parameterised Gaussian Mixture Models (TPGMM) to learn personalised physical therapist-patient interaction in Task-Specific exercises, mapping patient joint kinematics to therapist-applied torques using few demonstrations. The model is generalised to reconstruct therapist torques in new task variations. The framework was evaluated on physical interactions from 14 mock "therapist-patient" pairs over three tasks of increasing complexity, each with six variations. A benchmark comparison against a Look-Up Table was conducted. The results show both methods reproducing interactions in unseen task variations that deviate slightly from the actual interaction, with TPGMM slightly outperforming LUT. Both methods reproduced interactions that gets increasingly closer to the actual interaction as task complexity increases.

FUSEP: A Multi-Center Benchmark for Diverse Tasks in Early Pregnancy Fetal Ultrasound Screening

A large number of infants with congenital anomalies are born each year globally, especially in areas with underdeveloped medical resources. Currently, fetal ultrasound screening is the most common modality for early pregnancy anatomy detection. This modality can detect anomalies earlier and provide opportune treatment advice. However, the lack of an ultrasound dataset on early fetal gestation has slowed down the development of automated assisted diagnosis. In this work, we present a benchmark dataset for Fetal Ultrasound Screening in Early Pregnancy to facilitate intelligent ultrasound examination and assisted diagnosis called FUSEP. Our dataset consists of two ultrasound views recommended by the international guideline, i.e., Crown-rump Length (CRL) and Nuchal Translucency (NT) views in three hospitals, totaling 4,017 ultrasound images, with 45,820 box-level expert-level annotations. Our dataset and baseline present the following three contributions: 1) Our medical experts annotated a total of 14 key anatomical structures in two views using a box-level format; 2) Our data is collected extensively from different sonographers, devices, scanning angles, hospitals, etc; 3) We report the performance of the semi-supervised learning, fully supervised learning, unsupervised domain adaptation (UDA), and source-free UDA in ultrasound images multi-object detection. To the best of our knowledge, this is the first publicly available dataset and benchmark for fetal early pregnancy ultrasound screening. We believe that FUSEP and benchmark can contribute to the medical community in the development of multiple tasks such as standard plane recognition, quality control on ultrasound images, automated assisted diagnostics in early fetal pregnancy, medical multi-object detection, domain adaptation for object detection, etc.

Tri-Space Operational Control of Redundant Multilink and Hybrid Cable-Driven Parallel Robots Using an Iterative-Learning based Reactive Approach

Cable-Driven Parallel Robots (CDPRs) are a type of parallel mechanism in which cables are used as actuators. Due to the two levels of redundancy and numerous constraints within the CDPR actuation, joint and operational spaces (together known as the tri-space), tracking a given trajectory in the operational space while satisfying constraints in tri-space simultaneously is challenging. To the best of the authors' knowledge, there does not exist any tri-space control framework, which is robust, effective, and directly applicable to several architectures of redundantly actuated CDPRs. This paper proposes a tri-space control framework that combines Reactive Control (RC) and Iterative-Learning Control (ILC) to perform repetitive tasks in the operational space. The framework allows the tracking of operational space trajectories online with feasible cable forces, while avoiding undesirable situations such as cable-link interference, joint interference, and loss of manipulability. On the other hand, by finding an optimal parameter in the null space using a novel parameterization of a null space vector, the performance can be improved through ILC when the task is repeatedly executed. Simulation and hardware results on various Multilink Cable-Driven Robot (MCDRs) and Hybrid Cable-Driven Robots (HCDRs) show that the proposed tri-space control framework can be conveniently and effectively applied to the real-time control of different CDPRs.

Efficient Image Registration for Ultrasound Localization Microscopy by Obtaining Gradients via Integration Across Iterations

Tissue motion correction through image registration is essential for ultrasound localization microscopy (ULM). Parametric image registration is commonly formulated as an optimization problem where motion parameters are iteratively updated to maximize image similarity, and used optimization algorithms typically rely on gradient information, the explicit evaluation of which can become computationally demanding. This work investigates Extremum Seeking Control (ESC) as an alternative to explicit derivative evaluation in image registration. By obtaining descent information via integrating perturbed and demodulated image similarity metric across iterations, ESC avoids differentiation of the image similarity metric with respect to motion parameters in each iteration. The classical ESC, whose optimization behavior approximates that of classical gradient descent (GD), is first compared with GD for affine image registration using simulated ground-truth motions derived from a beating ex vivo porcine heart dataset. The results show that ESC achieves registration accuracy and convergence behavior comparable to GD while reducing per-iteration computational cost by approximately 3.5-fold. ESC is subsequently employed in a two-stage motion correction pipeline, where affine registration compensates for global tissue motion and B-spline registration corrects residual local deformation. The proposed method is applied to ULM imaging of a beating ex vivo porcine heart and achieves a spatial resolution of 219 um, substantially below the half-wavelength diffraction limit of 321 um associated with 2.4 MHz diverging-wave imaging. These results demonstrate that ESC provides an effective alternative to explicit derivative evaluation in ULM image registration, enabling accurate motion correction and high-quality super-resolution imaging.

Prior-Informed Zeroth-Order Optimization with Adaptive Direction Alignment for Memory-Efficient LLM Fine-Tuning

Fine-tuning large language models (LLMs) has achieved remarkable success across various NLP tasks, but the substantial memory overhead during backpropagation remains a critical bottleneck, especially as model scales grow. Zeroth-order (ZO) optimization alleviates this issue by estimating gradients through forward passes and Gaussian sampling, avoiding the need for backpropagation. However, conventional ZO methods suffer from high variance in gradient estimation due to their reliance on random perturbations, leading to slow convergence and suboptimal performance. We propose a simple plug-and-play method that incorporates prior-informed perturbations to refine gradient estimation. Our method dynamically computes a guiding vector from Gaussian samples, which directs perturbations toward more informative directions, significantly accelerating convergence compared to standard ZO approaches. We further investigate a greedy perturbation strategy to explore the impact of prior knowledge on gradient estimation. Theoretically, we prove that our gradient estimator achieves stronger alignment with the true gradient direction, enhancing optimization efficiency. Extensive experiments across LLMs of varying scales and architectures demonstrate that our proposed method could seamlessly integrate into existing optimization methods, delivering faster convergence and superior performance. Notably, on the OPT-13B model, our method outperforms traditional ZO optimization across all 11 benchmark tasks and surpasses gradient-based baselines on 9 out of 11 tasks, establishing a robust balance between efficiency and accuracy.

Beyond Algorithm Evolution: An LLM-Driven Framework for the Co-Evolution of Swarm Intelligence Optimization Algorithms and Prompts

The field of automated algorithm design has been advanced by frameworks such as EoH, FunSearch, and Reevo. Yet, their focus on algorithm evolution alone, neglecting the prompts that guide them, limits their effectiveness with LLMs, especially in complex, uncertain environments where they nonetheless implicitly rely on strategies from swarm intelligence optimization algorithms. Recognizing this, we argue that swarm intelligence optimization provides a more generalized and principled foundation for automated design. Consequently, this paper proposes a novel framework for the collaborative evolution of both swarm intelligence algorithms and guiding prompts using a single LLM. To enhance interpretability, we also propose a simple yet efficient evaluation method for prompt templates. The framework was rigorously evaluated on a range of NP problems, where it demonstrated superior performance compared to several state-of-the-art automated design approaches. Experiments with various LLMs (e.g., GPT-4o-mini, Qwen3-32B, GPT-5) reveal significantly divergent evolutionary trajectories in the generated prompts, further underscoring the necessity of a structured co-evolution framework. Importantly, our approach maintains leading performance across different models, demonstrating reduced reliance on the most powerful LLMs and enabling more cost-effective deployments. Ablation studies and in-depth analysis of the evolved prompts confirm that collaborative evolution is essential for achieving optimal performance. Our work establishes a new paradigm for swarm intelligence optimization algorithms, underscoring the indispensable role of prompt evolution.

Prospect Theory in Physical Human-Robot Interaction: A Pilot Study of Probability Perception

Understanding how humans respond to uncertainty is critical for designing safe and effective physical human-robot interaction (pHRI), as physically working with robots introduces multiple sources of uncertainty, including trust, comfort, and perceived safety. Conventional pHRI control frameworks typically build on optimal control theory, which assumes that human actions minimize a cost function; however, human behavior under uncertainty often departs from such optimal patterns. To address this gap, additional understanding of human behavior under uncertainty is needed. This pilot study implemented a physically coupled target-reaching task in which the robot delivered assistance or disturbances with systematically varied probabilities (10\% to 90\%). Analysis of participants' force inputs and decision-making strategies revealed two distinct behavioral clusters: a "trade-off" group that modulated their physical responses according to disturbance likelihood, and an "always-compensate" group characterized by strong risk aversion irrespective of probability. These findings provide empirical evidence that human decision-making in pHRI is highly individualized and that the perception of probability can differ to its true value. Accordingly, the study highlights the need for more interpretable behavioral models, such as cumulative prospect theory (CPT), to more accurately capture these behaviors and inform the design of future adaptive robot controllers.

MS-UMamba: An Improved Vision Mamba Unet for Fetal Abdominal Medical Image Segmentation

Recently, Mamba-based methods have become popular in medical image segmentation due to their lightweight design and long-range dependency modeling capabilities. However, current segmentation methods frequently encounter challenges in fetal ultrasound images, such as enclosed anatomical structures, blurred boundaries, and small anatomical structures. To address the need for balancing local feature extraction and global context modeling, we propose MS-UMamba, a novel hybrid convolutional-mamba model for fetal ultrasound image segmentation. Specifically, we design a visual state space block integrated with a CNN branch (SS-MCAT-SSM), which leverages Mamba's global modeling strengths and convolutional layers' local representation advantages to enhance feature learning. In addition, we also propose an efficient multi-scale feature fusion module that integrates spatial attention mechanisms, which Integrating feature information from different layers enhances the feature representation ability of the model. Finally, we conduct extensive experiments on a non-public dataset, experimental results demonstrate that MS-UMamba model has excellent performance in segmentation performance.

DCD: A Semantic Segmentation Model for Fetal Ultrasound Four-Chamber View

Accurate segmentation of anatomical structures in the apical four-chamber (A4C) view of fetal echocardiography is essential for early diagnosis and prenatal evaluation of congenital heart disease (CHD). However, precise segmentation remains challenging due to ultrasound artifacts, speckle noise, anatomical variability, and boundary ambiguity across different gestational stages. To reduce the workload of sonographers and enhance segmentation accuracy, we propose DCD, an advanced deep learning-based model for automatic segmentation of key anatomical structures in the fetal A4C view. Our model incorporates a Dense Atrous Spatial Pyramid Pooling (Dense ASPP) module, enabling superior multi-scale feature extraction, and a Convolutional Block Attention Module (CBAM) to enhance adaptive feature representation. By effectively capturing both local and global contextual information, DCD achieves precise and robust segmentation, contributing to improved prenatal cardiac assessment.

FAMSeg: Fetal Femur and Cranial Ultrasound Segmentation Using Feature-Aware Attention and Mamba Enhancement

Accurate ultrasound image segmentation is a prerequisite for precise biometrics and accurate assessment. Relying on manual delineation introduces significant errors and is time-consuming. However, existing segmentation models are designed based on objects in natural scenes, making them difficult to adapt to ultrasound objects with high noise and high similarity. This is particularly evident in small object segmentation, where a pronounced jagged effect occurs. Therefore, this paper proposes a fetal femur and cranial ultrasound image segmentation model based on feature perception and Mamba enhancement to address these challenges. Specifically, a longitudinal and transverse independent viewpoint scanning convolution block and a feature perception module were designed to enhance the ability to capture local detail information and improve the fusion of contextual information. Combined with the Mamba-optimized residual structure, this design suppresses the interference of raw noise and enhances local multi-dimensional scanning. The system builds global information and local feature dependencies, and is trained with a combination of different optimizers to achieve the optimal solution. After extensive experimental validation, the FAMSeg network achieved the fastest loss reduction and the best segmentation performance across images of varying sizes and orientations.