EvTrajGS: Accurate and Efficient 3D Gaussian Splatting from Unposed Event Streams

Event cameras, with high temporal resolution, high dynamic range, and asynchronous sensing characteristics, have shown great potential for dense 3D reconstruction. Traditional reconstruction methods based on off-the-shelf pose estimates achieve high efficiency but produce low-fidelity results, as inaccurate pose initialization introduces cumulative reconstruction errors. In contrast, recent SLAM-style methods stabilize joint pose-scene optimization through incremental tracking and mapping, yielding higher reconstruction fidelity at the expense of considerable computational overhead. To address this trade-off, this paper presents EvTrajGS, an accurate and efficient 3D Gaussian Splatting framework for unposed event streams. Our method enables reliable joint pose-scene optimization initialized from coarse pose priors, eliminating the need for computationally expensive SLAM-style pipelines. EvTrajGS parameterizes camera motion as a continuous-time trajectory initialized from discrete camera poses, providing a unified representation for pose refinement. We then aggregate adjacent trajectory states into a temporally coupled pose, promoting temporally consistent pose updates during joint optimization. Additionally, we introduce a loss-reweighted event sampling strategy to adaptively emphasize temporally under-reconstructed intervals. Extensive experiments on both synthetic and real-world datasets demonstrate that EvTrajGS outperforms state-of-the-art methods in terms of both geometric reconstruction quality and pose estimation accuracy, achieving 3.8 dB higher PSNR, 0.1 higher SSIM, and over 40\% lower ATE RMSE while retaining high computational efficiency.

FUSE: FK-Steered Multi-Modal Flow Matching for Efficient Simulation-Based Posterior Estimation

Simulation-Based Inference (SBI) is critical for scientific discovery, with generative models offering a promising path toward efficient inference. However, existing methods struggle with effective multimodal modeling. They often rely on brute-force fusion strategies that ignore the structural disparities between parameters and observations, thus limiting estimation fidelity. In this work, we introduce FUSE (Feynman-Kac steered mUlti-modal flow matching for efficient Simulation-based posterior Estimation). Unlike prior work, FUSE employs a dual-track architecture that preserves the distinct features of multimodal inputs while facilitating dynamic interaction. Additionally, we propose an FK-steered sampling strategy that leverages intermediate observation likelihoods to guide the generative trajectories, effectively improving the sample quality during inference. Our approach outperforms state-of-the-art baselines on standard SBI benchmarks, producing posteriors that closely match ground-truth MCMC. Furthermore, in a real-world exoplanet orbital estimation task, FUSE successfully resolves complex parameter degeneracies that challenge existing methods, highlighting its potential to accelerate complex scientific discoveries in astrophysics and beyond.

CryoACE: An Atom-centric Framework for Accurate and Automated Model Building in Cryo-EM

Protein automodeling from cryo-EM density maps faces unique challenges in enforcing physicochemical validity and managing conformational heterogeneity. Current solvers are often limited to static predictions or require computationally intensive heuristic searches. We present CryoACE, an end-to-end framework that reconstructs precise atomic graphs for both homogeneous and heterogeneous structures. Our method features two key innovations: an atom-centric reconstruction paradigm, where density features are sampled directly at atomic coordinates and iteratively recycled to refine structures, replacing expensive voxel convolutions for efficient multimodal fusion; and a training-free guidance mechanism that leverages predicted local resolution priors to resolve dynamic ambiguity. Validated on a newly constructed high-quality dataset, CryoACE significantly outperforms existing baselines on static benchmarks and, for the first time, unveils atomic-level dynamic conformations on complex real-world datasets like EMPIAR-10345 without relying on pre-built static structures.

CryoFastAR: Fast Cryo-EM Ab Initio Reconstruction Made Easy

Pose estimation from unordered images is fundamental for 3D reconstruction, robotics, and scientific imaging. Recent geometric foundation models, such as DUSt3R, enable end-to-end dense 3D reconstruction but remain underexplored in scientific imaging fields like cryo-electron microscopy (cryo-EM) for near-atomic protein reconstruction. In cryo-EM, pose estimation and 3D reconstruction from unordered particle images still depend on time-consuming iterative optimization, primarily due to challenges such as low signal-to-noise ratios (SNR) and distortions from the contrast transfer function (CTF). We introduce CryoFastAR, the first geometric foundation model that can directly predict poses from Cryo-EM noisy images for Fast ab initio Reconstruction. By integrating multi-view features and training on large-scale simulated cryo-EM data with realistic noise and CTF modulations, CryoFastAR enhances pose estimation accuracy and generalization. To enhance training stability, we propose a progressive training strategy that first allows the model to extract essential features under simpler conditions before gradually increasing difficulty to improve robustness. Experiments show that CryoFastAR achieves comparable quality while significantly accelerating inference over traditional iterative approaches on both synthetic and real datasets.

DRACO: A Denoising-Reconstruction Autoencoder for Cryo-EM

Foundation models in computer vision have demonstrated exceptional performance in zero-shot and few-shot tasks by extracting multi-purpose features from large-scale datasets through self-supervised pre-training methods. However, these models often overlook the severe corruption in cryogenic electron microscopy (cryo-EM) images by high-level noises. We introduce DRACO, a Denoising-Reconstruction Autoencoder for CryO-EM, inspired by the Noise2Noise (N2N) approach. By processing cryo-EM movies into odd and even images and treating them as independent noisy observations, we apply a denoising-reconstruction hybrid training scheme. We mask both images to create denoising and reconstruction tasks. For DRACO's pre-training, the quality of the dataset is essential, we hence build a high-quality, diverse dataset from an uncurated public database, including over 270,000 movies or micrographs. After pre-training, DRACO naturally serves as a generalizable cryo-EM image denoiser and a foundation model for various cryo-EM downstream tasks. DRACO demonstrates the best performance in denoising, micrograph curation, and particle picking tasks compared to state-of-the-art baselines. We will release the code, pre-trained models, and the curated dataset to stimulate further research.

LightCAM: A Fast and Light Implementation of Context-Aware Masking based D-TDNN for Speaker Verification

Traditional Time Delay Neural Networks (TDNN) have achieved state-of-the-art performance at the cost of high computational complexity and slower inference speed, making them difficult to implement in an industrial environment. The Densely Connected Time Delay Neural Network (D-TDNN) with Context Aware Masking (CAM) module has proven to be an efficient structure to reduce complexity while maintaining system performance. In this paper, we propose a fast and lightweight model, LightCAM, which further adopts a depthwise separable convolution module (DSM) and uses multi-scale feature aggregation (MFA) for feature fusion at different levels. Extensive experiments are conducted on VoxCeleb dataset, the comparative results show that it has achieved an EER of 0.83 and MinDCF of 0.0891 in VoxCeleb1-O, which outperforms the other mainstream speaker verification methods. In addition, complexity analysis further demonstrates that the proposed architecture has lower computational cost and faster inference speed.

GenEM: Physics-Informed Generative Cryo-Electron Microscopy

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is crucial in resolving near-atomic resolution 3D structures of proteins, such as the SARS-COV-2 spike protein. To achieve high-resolution reconstruction, AI models for particle picking and pose estimation have been adopted. However, their performance is still limited as they lack high-quality annotated datasets. To address this, we introduce physics-informed generative cryo-electron microscopy (GenEM), which for the first time integrates physical-based cryo-EM simulation with a generative unpaired noise translation to generate physically correct synthetic cryo-EM datasets with realistic noises. Initially, GenEM simulates the cryo-EM imaging process based on a virtual specimen. To generate realistic noises, we leverage an unpaired noise translation via contrastive learning with a novel mask-guided sampling scheme. Extensive experiments show that GenEM is capable of generating realistic cryo-EM images. The generated dataset can further enhance particle picking and pose estimation models, eventually improving the reconstruction resolution. We will release our code and annotated synthetic datasets.

CryoFormer: Continuous Reconstruction of 3D Structures from Cryo-EM Data using Transformer-based Neural Representations

High-resolution heterogeneous reconstruction of 3D structures of proteins and other biomolecules using cryo-electron microscopy (cryo-EM) is essential for understanding fundamental processes of life. However, it is still challenging to reconstruct the continuous motions of 3D structures from hundreds of thousands of noisy and randomly oriented 2D cryo-EM images. Existing methods based on coordinate-based neural networks show compelling results to model continuous conformations of 3D structures in the Fourier domain, but they suffer from a limited ability to model local flexible regions and lack interpretability. We propose a novel approach, cryoFormer, that utilizes a transformer-based network architecture for continuous heterogeneous cryo-EM reconstruction. We for the first time directly reconstruct continuous conformations of 3D structures using an implicit feature volume in the 3D spatial domain. A novel deformation transformer decoder further improves reconstruction quality and, more importantly, locates and robustly tackles flexible 3D regions caused by conformations. In experiments, our method outperforms current approaches on three public datasets (1 synthetic and 2 experimental) and a new synthetic dataset of PEDV spike protein. The code and new synthetic dataset will be released for better reproducibility of our results. Project page: https://cryoformer.github.io.

Human Performance Modeling and Rendering via Neural Animated Mesh

We have recently seen tremendous progress in the neural advances for photo-real human modeling and rendering. However, it's still challenging to integrate them into an existing mesh-based pipeline for downstream applications. In this paper, we present a comprehensive neural approach for high-quality reconstruction, compression, and rendering of human performances from dense multi-view videos. Our core intuition is to bridge the traditional animated mesh workflow with a new class of highly efficient neural techniques. We first introduce a neural surface reconstructor for high-quality surface generation in minutes. It marries the implicit volumetric rendering of the truncated signed distance field (TSDF) with multi-resolution hash encoding. We further propose a hybrid neural tracker to generate animated meshes, which combines explicit non-rigid tracking with implicit dynamic deformation in a self-supervised framework. The former provides the coarse warping back into the canonical space, while the latter implicit one further predicts the displacements using the 4D hash encoding as in our reconstructor. Then, we discuss the rendering schemes using the obtained animated meshes, ranging from dynamic texturing to lumigraph rendering under various bandwidth settings. To strike an intricate balance between quality and bandwidth, we propose a hierarchical solution by first rendering 6 virtual views covering the performer and then conducting occlusion-aware neural texture blending. We demonstrate the efficacy of our approach in a variety of mesh-based applications and photo-realistic free-view experiences on various platforms, i.e., inserting virtual human performances into real environments through mobile AR or immersively watching talent shows with VR headsets.

Fourier PlenOctrees for Dynamic Radiance Field Rendering in Real-time

Implicit neural representations such as Neural Radiance Field (NeRF) have focused mainly on modeling static objects captured under multi-view settings where real-time rendering can be achieved with smart data structures, e.g., PlenOctree. In this paper, we present a novel Fourier PlenOctree (FPO) technique to tackle efficient neural modeling and real-time rendering of dynamic scenes captured under the free-view video (FVV) setting. The key idea in our FPO is a novel combination of generalized NeRF, PlenOctree representation, volumetric fusion and Fourier transform. To accelerate FPO construction, we present a novel coarse-to-fine fusion scheme that leverages the generalizable NeRF technique to generate the tree via spatial blending. To tackle dynamic scenes, we tailor the implicit network to model the Fourier coefficients of timevarying density and color attributes. Finally, we construct the FPO and train the Fourier coefficients directly on the leaves of a union PlenOctree structure of the dynamic sequence. We show that the resulting FPO enables compact memory overload to handle dynamic objects and supports efficient fine-tuning. Extensive experiments show that the proposed method is 3000 times faster than the original NeRF and achieves over an order of magnitude acceleration over SOTA while preserving high visual quality for the free-viewpoint rendering of unseen dynamic scenes.