ScaleFold: Reducing AlphaFold Initial Training Time to 10 Hours

AlphaFold2 has been hailed as a breakthrough in protein folding. It can rapidly predict protein structures with lab-grade accuracy. However, its implementation does not include the necessary training code. OpenFold is the first trainable public reimplementation of AlphaFold. AlphaFold training procedure is prohibitively time-consuming, and gets diminishing benefits from scaling to more compute resources. In this work, we conducted a comprehensive analysis on the AlphaFold training procedure based on Openfold, identified that inefficient communications and overhead-dominated computations were the key factors that prevented the AlphaFold training from effective scaling. We introduced ScaleFold, a systematic training method that incorporated optimizations specifically for these factors. ScaleFold successfully scaled the AlphaFold training to 2080 NVIDIA H100 GPUs with high resource utilization. In the MLPerf HPC v3.0 benchmark, ScaleFold finished the OpenFold benchmark in 7.51 minutes, shown over $6\times$ speedup than the baseline. For training the AlphaFold model from scratch, ScaleFold completed the pretraining in 10 hours, a significant improvement over the seven days required by the original AlphaFold pretraining baseline.

Learning at the Speed of Wireless: Online Real-Time Learning for AI-Enabled MIMO in NextG

Integration of artificial intelligence (AI) and machine learning (ML) into the air interface has been envisioned as a key technology for next-generation (NextG) cellular networks. At the air interface, multiple-input multiple-output (MIMO) and its variants such as multi-user MIMO (MU-MIMO) and massive/full-dimension MIMO have been key enablers across successive generations of cellular networks with evolving complexity and design challenges. Initiating active investigation into leveraging AI/ML tools to address these challenges for MIMO becomes a critical step towards an AI-enabled NextG air interface. At the NextG air interface, the underlying wireless environment will be extremely dynamic with operation adaptations performed on a sub-millisecond basis by MIMO operations such as MU-MIMO scheduling and rank/link adaptation. Given the enormously large number of operation adaptation possibilities, we contend that online real-time AI/ML-based approaches constitute a promising paradigm. To this end, we outline the inherent challenges and offer insights into the design of such online real-time AI/ML-based solutions for MIMO operations. An online real-time AI/ML-based method for MIMO-OFDM channel estimation is then presented, serving as a potential roadmap for developing similar techniques across various MIMO operations in NextG.

Federated Dynamic Spectrum Access

Due to the growing volume of data traffic produced by the surge of Internet of Things (IoT) devices, the demand for radio spectrum resources is approaching their limitation defined by Federal Communications Commission (FCC). To this end, Dynamic Spectrum Access (DSA) is considered as a promising technology to handle this spectrum scarcity. However, standard DSA techniques often rely on analytical modeling wireless networks, making its application intractable in under-measured network environments. Therefore, utilizing neural networks to approximate the network dynamics is an alternative approach. In this article, we introduce a Federated Learning (FL) based framework for the task of DSA, where FL is a distributive machine learning framework that can reserve the privacy of network terminals under heterogeneous data distributions. We discuss the opportunities, challenges, and opening problems of this framework. To evaluate its feasibility, we implement a Multi-Agent Reinforcement Learning (MARL)-based FL as a realization associated with its initial evaluation results.

Differential Privacy Meets Federated Learning under Communication Constraints

The performance of federated learning systems is bottlenecked by communication costs and training variance. The communication overhead problem is usually addressed by three communication-reduction techniques, namely, model compression, partial device participation, and periodic aggregation, at the cost of increased training variance. Different from traditional distributed learning systems, federated learning suffers from data heterogeneity (since the devices sample their data from possibly different distributions), which induces additional variance among devices during training. Various variance-reduced training algorithms have been introduced to combat the effects of data heterogeneity, while they usually cost additional communication resources to deliver necessary control information. Additionally, data privacy remains a critical issue in FL, and thus there have been attempts at bringing Differential Privacy to this framework as a mediator between utility and privacy requirements. This paper investigates the trade-offs between communication costs and training variance under a resource-constrained federated system theoretically and experimentally, and how communication reduction techniques interplay in a differentially private setting. The results provide important insights into designing practical privacy-aware federated learning systems.