Multimodal Learning on Low-Quality Data with Conformal Predictive Self-Calibration

Multimodal learning often grapples with the challenge of low-quality data, which predominantly manifests as two facets: modality imbalance and noisy corruption. While these issues are often studied in isolation, we argue that they share a common root in the predictive uncertainty towards the reliability of individual modalities and instances during learning. In this paper, we propose a unified framework, termed Conformal Predictive Self-Calibration (CPSC), which leverages conformal prediction to equip the model with the ability to perform self-guided calibration on-the-fly. The core of our proposed CPSC lies in a novel self-calibrating training loop that seamlessly integrates two key modules: (1) Representation Self-Calibration, which decomposes unimodal features into components, and selectively fuses the most robust ones identified by a conformal predictor to enhance feature resilience. (2) Gradient Self-Calibration, which recalibrates the gradient flow during backpropagation based on instance-wise reliability scores, steering the optimization towards more trustworthy directions. Furthermore, we also devise a self-update strategy for the conformal predictor to ensure the entire system co-evolves consistently throughout the training process. Extensive experiments on six benchmark datasets under both imbalanced and noisy settings demonstrate that our CPSC framework consistently outperforms existing state-of-the-art methods. Our code is available at https://github.com/XunCHN/CPSC.

MedDialBench: Benchmarking LLM Diagnostic Robustness under Parametric Adversarial Patient Behaviors

Interactive medical dialogue benchmarks have shown that LLM diagnostic accuracy degrades significantly when interacting with non-cooperative patients, yet existing approaches either apply adversarial behaviors without graded severity or case-specific grounding, or reduce patient non-cooperation to a single ungraded axis, and none analyze cross-dimension interactions. We introduce MedDialBench, a benchmark enabling controlled, dose-response characterization of how individual patient behavior dimensions affect LLM diagnostic robustness. It decomposes patient behavior into five dimensions -- Logic Consistency, Health Cognition, Expression Style, Disclosure, and Attitude -- each with graded severity levels and case-specific behavioral scripts. This controlled factorial design enables graded sensitivity analysis, dose-response profiling, and cross-dimension interaction detection. Evaluating five frontier LLMs across 7,225 dialogues (85 cases x 17 configurations x 5 models), we find a fundamental asymmetry: information pollution (fabricating symptoms) produces 1.7-3.4x larger accuracy drops than information deficit (withholding information), and fabricating is the only configuration achieving statistical significance across all five models (McNemar p < 0.05). Among six dimension combinations, fabricating is the sole driver of super-additive interaction: all three fabricating-involving pairs produce O/E ratios of 0.70-0.81 (35-44% of eligible cases fail under the combination despite succeeding under each dimension alone), while all non-fabricating pairs show purely additive effects (O/E ~ 1.0). Inquiry strategy moderates deficit but not pollution: exhaustive questioning recovers withheld information, but cannot compensate for fabricated inputs. Models exhibit distinct vulnerability profiles, with worst-case drops ranging from 38.8 to 54.1 percentage points.

ESL-Bench: An Event-Driven Synthetic Longitudinal Benchmark for Health Agents

Longitudinal health agents must reason across multi-source trajectories that combine continuous device streams, sparse clinical exams, and episodic life events - yet evaluating them is hard: real-world data cannot be released at scale, and temporally grounded attribution questions seldom admit definitive answers without structured ground truth. We present ESL-Bench, an event-driven synthesis framework and benchmark providing 100 synthetic users, each with a 1-5 year trajectory comprising a health profile, a multi-phase narrative plan, daily device measurements, periodic exam records, and an event log with explicit per-indicator impact parameters. Each indicator follows a baseline stochastic process driven by discrete events with sigmoid-onset, exponential-decay kernels under saturation and projection constraints; a hybrid pipeline delegates sparse semantic artifacts to LLM-based planning and dense indicator dynamics to algorithmic simulation with hard physiological bounds. Users are each paired with 100 evaluation queries across five dimensions - Lookup, Trend, Comparison, Anomaly, Explanation - stratified into Easy, Medium, and Hard tiers, with all ground-truth answers programmatically computable from the recorded event-indicator relationships. Evaluating 13 methods spanning LLMs with tools, DB-native agents, and memory-augmented RAG, we find that DB agents (48-58%) substantially outperform memory RAG baselines (30-38%), with the gap concentrated on Comparison and Explanation queries where multi-hop reasoning and evidence attribution are required.

A Comparative Study of Traditional Machine Learning, Deep Learning, and Large Language Models for Mental Health Forecasting using Smartphone Sensing Data

Smartphone sensing offers an unobtrusive and scalable way to track daily behaviors linked to mental health, capturing changes in sleep, mobility, and phone use that often precede symptoms of stress, anxiety, or depression. While most prior studies focus on detection that responds to existing conditions, forecasting mental health enables proactive support through Just-in-Time Adaptive Interventions. In this paper, we present the first comprehensive benchmarking study comparing traditional machine learning (ML), deep learning (DL), and large language model (LLM) approaches for mental health forecasting using the College Experience Sensing (CES) dataset, the most extensive longitudinal dataset of college student mental health to date. We systematically evaluate models across temporal windows, feature granularities, personalization strategies, and class imbalance handling. Our results show that DL models, particularly Transformer (Macro-F1 = 0.58), achieve the best overall performance, while LLMs show strength in contextual reasoning but weaker temporal modeling. Personalization substantially improves forecasts of severe mental health states. By revealing how different modeling approaches interpret phone sensing behavioral data over time, this work lays the groundwork for next-generation, adaptive, and human-centered mental health technologies that can advance both research and real-world well-being.

What Makes Reasoning Invalid: Echo Reflection Mitigation for Large Language Models

Large Language Models (LLMs) have demonstrated remarkable performance across a wide range of reasoning tasks. Recent methods have further improved LLM performance in complex mathematical reasoning. However, when extending these methods beyond the domain of mathematical reasoning to tasks involving complex domain-specific knowledge, we observe a consistent failure of LLMs to generate novel insights during the reflection stage. Instead of conducting genuine cognitive refinement, the model tends to mechanically reiterate earlier reasoning steps without introducing new information or perspectives, a phenomenon referred to as "Echo Reflection". We attribute this behavior to two key defects: (1) Uncontrollable information flow during response generation, which allows premature intermediate thoughts to propagate unchecked and distort final decisions; (2) Insufficient exploration of internal knowledge during reflection, leading to repeating earlier findings rather than generating new cognitive insights. Building on these findings, we proposed a novel reinforcement learning method termed Adaptive Entropy Policy Optimization (AEPO). Specifically, the AEPO framework consists of two major components: (1) Reflection-aware Information Filtration, which quantifies the cognitive information flow and prevents the final answer from being affected by earlier bad cognitive information; (2) Adaptive-Entropy Optimization, which dynamically balances exploration and exploitation across different reasoning stages, promoting both reflective diversity and answer correctness. Extensive experiments demonstrate that AEPO consistently achieves state-of-the-art performance over mainstream reinforcement learning baselines across diverse benchmarks.

Investigating Advanced Reasoning of Large Language Models via Black-Box Interaction

Existing tasks fall short in evaluating reasoning ability of Large Language Models (LLMs) in an interactive, unknown environment. This deficiency leads to the isolated assessment of deductive, inductive, and abductive reasoning, neglecting the integrated reasoning process that is indispensable for humans discovery of real world. We introduce a novel evaluation paradigm, \textit{black-box interaction}, to tackle this challenge. A black-box is defined by a hidden function that maps a specific set of inputs to outputs. LLMs are required to unravel the hidden function behind the black-box by interacting with it in given exploration turns, and reasoning over observed input-output pairs. Leveraging this idea, we build the \textsc{Oracle} benchmark which comprises 6 types of black-box task and 96 black-boxes. 19 modern LLMs are benchmarked. o3 ranks first in 5 of the 6 tasks, achieving over 70\% accuracy on most easy black-boxes. But it still struggles with some hard black-box tasks, where its average performance drops below 40\%. Further analysis indicates a universal difficulty among LLMs: They lack the high-level planning capability to develop efficient and adaptive exploration strategies for hypothesis refinement.

AgentDistill: Training-Free Agent Distillation with Generalizable MCP Boxes

While knowledge distillation has become a mature field for compressing large language models (LLMs) into smaller ones by aligning their outputs or internal representations, the distillation of LLM-based agents, which involve planning, memory, and tool use, remains relatively underexplored. Existing agent distillation methods typically replay full teacher trajectories or imitate step-by-step teacher tool usage, but they often struggle to train student agents to dynamically plan and act in novel environments. We propose AgentDistill, a novel, training-free agent distillation framework that enables efficient and scalable knowledge transfer via direct reuse of Model-Context-Protocols (MCPs), which are structured and reusable task-solving modules autonomously generated by teacher agents. The reuse of these distilled MCPs enables student agents to generalize their capabilities across domains and solve new problems with minimal supervision or human intervention. Experiments on biomedical and mathematical benchmarks demonstrate that our distilled student agents, built on small language models, can achieve performance comparable to advanced systems using large LLMs such as OctoTools (GPT-4o), highlighting the effectiveness of our framework in building scalable and cost-efficient intelligent agents.

Alita: Generalist Agent Enabling Scalable Agentic Reasoning with Minimal Predefinition and Maximal Self-Evolution

Recent advances in large language models (LLMs) have enabled agents to autonomously perform complex, open-ended tasks. However, many existing frameworks depend heavily on manually predefined tools and workflows, which hinder their adaptability, scalability, and generalization across domains. In this work, we introduce Alita--a generalist agent designed with the principle of "Simplicity is the ultimate sophistication," enabling scalable agentic reasoning through minimal predefinition and maximal self-evolution. For minimal predefinition, Alita is equipped with only one component for direct problem-solving, making it much simpler and neater than previous approaches that relied heavily on hand-crafted, elaborate tools and workflows. This clean design enhances its potential to generalize to challenging questions, without being limited by tools. For Maximal self-evolution, we enable the creativity of Alita by providing a suite of general-purpose components to autonomously construct, refine, and reuse external capabilities by generating task-related model context protocols (MCPs) from open source, which contributes to scalable agentic reasoning. Notably, Alita achieves 75.15% pass@1 and 87.27% pass@3 accuracy, which is top-ranking among general-purpose agents, on the GAIA benchmark validation dataset, 74.00% and 52.00% pass@1, respectively, on Mathvista and PathVQA, outperforming many agent systems with far greater complexity. More details will be updated at $\href{https://github.com/CharlesQ9/Alita}{https://github.com/CharlesQ9/Alita}$.

On Path to Multimodal Historical Reasoning: HistBench and HistAgent

Recent advances in large language models (LLMs) have led to remarkable progress across domains, yet their capabilities in the humanities, particularly history, remain underexplored. Historical reasoning poses unique challenges for AI, involving multimodal source interpretation, temporal inference, and cross-linguistic analysis. While general-purpose agents perform well on many existing benchmarks, they lack the domain-specific expertise required to engage with historical materials and questions. To address this gap, we introduce HistBench, a new benchmark of 414 high-quality questions designed to evaluate AI's capacity for historical reasoning and authored by more than 40 expert contributors. The tasks span a wide range of historical problems-from factual retrieval based on primary sources to interpretive analysis of manuscripts and images, to interdisciplinary challenges involving archaeology, linguistics, or cultural history. Furthermore, the benchmark dataset spans 29 ancient and modern languages and covers a wide range of historical periods and world regions. Finding the poor performance of LLMs and other agents on HistBench, we further present HistAgent, a history-specific agent equipped with carefully designed tools for OCR, translation, archival search, and image understanding in History. On HistBench, HistAgent based on GPT-4o achieves an accuracy of 27.54% pass@1 and 36.47% pass@2, significantly outperforming LLMs with online search and generalist agents, including GPT-4o (18.60%), DeepSeek-R1(14.49%) and Open Deep Research-smolagents(20.29% pass@1 and 25.12% pass@2). These results highlight the limitations of existing LLMs and generalist agents and demonstrate the advantages of HistAgent for historical reasoning.

EmoAgent: Assessing and Safeguarding Human-AI Interaction for Mental Health Safety

The rise of LLM-driven AI characters raises safety concerns, particularly for vulnerable human users with psychological disorders. To address these risks, we propose EmoAgent, a multi-agent AI framework designed to evaluate and mitigate mental health hazards in human-AI interactions. EmoAgent comprises two components: EmoEval simulates virtual users, including those portraying mentally vulnerable individuals, to assess mental health changes before and after interactions with AI characters. It uses clinically proven psychological and psychiatric assessment tools (PHQ-9, PDI, PANSS) to evaluate mental risks induced by LLM. EmoGuard serves as an intermediary, monitoring users' mental status, predicting potential harm, and providing corrective feedback to mitigate risks. Experiments conducted in popular character-based chatbots show that emotionally engaging dialogues can lead to psychological deterioration in vulnerable users, with mental state deterioration in more than 34.4% of the simulations. EmoGuard significantly reduces these deterioration rates, underscoring its role in ensuring safer AI-human interactions. Our code is available at: https://github.com/1akaman/EmoAgent