Fundus-R1: Training a Fundus-Reading MLLM with Knowledge-Aware Reasoning on Public Data

Fundus imaging such as CFP, OCT and UWF is crucial for the early detection of retinal anomalies and diseases. Fundus image understanding, due to its knowledge-intensive nature, poses a challenging vision-language task. An emerging approach to addressing the task is to post-train a generic multimodal large language model (MLLM), either by supervised finetuning (SFT) or by reinforcement learning with verifiable rewards (RLVR), on a considerable amount of in-house samples paired with high-quality clinical reports. However, these valuable samples are not publicly accessible, which not only hinders reproducibility but also practically limits research to few players. To overcome the barrier, we make a novel attempt to train a reasoning-enhanced fundus-reading MLLM, which we term Fundus-R1, using exclusively public datasets, wherein over 94\% of the data are annotated with only image-level labels. Our technical contributions are two-fold. First, we propose a RAG-based method for composing image-specific, knowledge-aware reasoning traces. Such auto-generated traces link visual findings identified by a generic MLLM to the image labels in terms of ophthalmic knowledge. Second, we enhance RLVR with a process reward that encourages self-consistency of the generated reasoning trace in each rollout. Extensive experiments on three fundus-reading benchmarks, i.e., FunBench, Omni-Fundus and GMAI-Fundus, show that Fundus-R1 clearly outperforms multiple baselines, including its generic counterpart (Qwen2.5-VL) and a stronger edition post-trained without using the generated traces. This work paves the way for training powerful fundus-reading MLLMs with publicly available data.

EI: Early Intervention for Multimodal Imaging based Disease Recognition

Current methods for multimodal medical imaging based disease recognition face two major challenges. First, the prevailing "fusion after unimodal image embedding" paradigm cannot fully leverage the complementary and correlated information in the multimodal data. Second, the scarcity of labeled multimodal medical images, coupled with their significant domain shift from natural images, hinders the use of cutting-edge Vision Foundation Models (VFMs) for medical image embedding. To jointly address the challenges, we propose a novel Early Intervention (EI) framework. Treating one modality as target and the rest as reference, EI harnesses high-level semantic tokens from the reference as intervention tokens to steer the target modality's embedding process at an early stage. Furthermore, we introduce Mixture of Low-varied-Ranks Adaptation (MoR), a parameter-efficient fine-tuning method that employs a set of low-rank adapters with varied ranks and a weight-relaxed router for VFM adaptation. Extensive experiments on three public datasets for retinal disease, skin lesion, and keen anomaly classification verify the effectiveness of the proposed method against a number of competitive baselines.

SAVE: Speech-Aware Video Representation Learning for Video-Text Retrieval

For video-text retrieval, the use of CLIP has been a de facto choice. Since CLIP provides only image and text encoders, this consensus has led to a biased paradigm that entirely ignores the sound track of videos. While several attempts have been made to reintroduce audio -- typically by incorporating an audio encoder and fusing its output with visual features -- these methods face two challenges: ineffective representation of speech content and suboptimal vision-audio fusion. To address these issues jointly, we propose SAVE, a Speech Aware Video rEpresentation learning method. SAVE improves upon AVIGATE, a SOTA audiovisual method, with a dedicated speech branch for more effective speech embedding. Furthermore, we introduce soft-ALBEF for early vision-audio alignment that facilitates fusion. Extensive experiments on five benchmarks show that SAVE compares favorably against the SOTA, outperforming AVIGATE by +4.1% on MSRVTT-9k, +1.9% on MSRVTT-7k, +2.5% on VATEX, +9.8% on Charades, and +2.1% on LSMDC, in light of the SumR metric.

Cross-modal Fundus Image Registration under Large FoV Disparity

Previous work on cross-modal fundus image registration (CMFIR) assumes small cross-modal Field-of-View (FoV) disparity. By contrast, this paper is targeted at a more challenging scenario with large FoV disparity, to which directly applying current methods fails. We propose Crop and Alignment for cross-modal fundus image Registration(CARe), a very simple yet effective method. Specifically, given an OCTA with smaller FoV as a source image and a wide-field color fundus photograph (wfCFP) as a target image, our Crop operation exploits the physiological structure of the retina to crop from the target image a sub-image with its FoV roughly aligned with that of the source. This operation allows us to re-purpose the previous small-FoV-disparity oriented methods for subsequent image registration. Moreover, we improve spatial transformation by a double-fitting based Alignment module that utilizes the classical RANSAC algorithm and polynomial-based coordinate fitting in a sequential manner. Extensive experiments on a newly developed test set of 60 OCTA-wfCFP pairs verify the viability of CARe for CMFIR.

Hybrid-Tower: Fine-grained Pseudo-query Interaction and Generation for Text-to-Video Retrieval

The Text-to-Video Retrieval (T2VR) task aims to retrieve unlabeled videos by textual queries with the same semantic meanings. Recent CLIP-based approaches have explored two frameworks: Two-Tower versus Single-Tower framework, yet the former suffers from low effectiveness, while the latter suffers from low efficiency. In this study, we explore a new Hybrid-Tower framework that can hybridize the advantages of the Two-Tower and Single-Tower framework, achieving high effectiveness and efficiency simultaneously. We propose a novel hybrid method, Fine-grained Pseudo-query Interaction and Generation for T2VR, ie, PIG, which includes a new pseudo-query generator designed to generate a pseudo-query for each video. This enables the video feature and the textual features of pseudo-query to interact in a fine-grained manner, similar to the Single-Tower approaches to hold high effectiveness, even before the real textual query is received. Simultaneously, our method introduces no additional storage or computational overhead compared to the Two-Tower framework during the inference stage, thus maintaining high efficiency. Extensive experiments on five commonly used text-video retrieval benchmarks demonstrate that our method achieves a significant improvement over the baseline, with an increase of $1.6\% \sim 3.9\%$ in R@1. Furthermore, our method matches the efficiency of Two-Tower models while achieving near state-of-the-art performance, highlighting the advantages of the Hybrid-Tower framework.

Multi-Object Sketch Animation by Scene Decomposition and Motion Planning

Sketch animation, which brings static sketches to life by generating dynamic video sequences, has found widespread applications in GIF design, cartoon production, and daily entertainment. While current sketch animation methods perform well in single-object sketch animation, they struggle in multi-object scenarios. By analyzing their failures, we summarize two challenges of transitioning from single-object to multi-object sketch animation: object-aware motion modeling and complex motion optimization. For multi-object sketch animation, we propose MoSketch based on iterative optimization through Score Distillation Sampling (SDS), without any other data for training. We propose four modules: LLM-based scene decomposition, LLM-based motion planning, motion refinement network and compositional SDS, to tackle the two challenges in a divide-and-conquer strategy. Extensive qualitative and quantitative experiments demonstrate the superiority of our method over existing sketch animation approaches. MoSketch takes a pioneering step towards multi-object sketch animation, opening new avenues for future research and applications. The code will be released.

FunBench: Benchmarking Fundus Reading Skills of MLLMs

Multimodal Large Language Models (MLLMs) have shown significant potential in medical image analysis. However, their capabilities in interpreting fundus images, a critical skill for ophthalmology, remain under-evaluated. Existing benchmarks lack fine-grained task divisions and fail to provide modular analysis of its two key modules, i.e., large language model (LLM) and vision encoder (VE). This paper introduces FunBench, a novel visual question answering (VQA) benchmark designed to comprehensively evaluate MLLMs' fundus reading skills. FunBench features a hierarchical task organization across four levels (modality perception, anatomy perception, lesion analysis, and disease diagnosis). It also offers three targeted evaluation modes: linear-probe based VE evaluation, knowledge-prompted LLM evaluation, and holistic evaluation. Experiments on nine open-source MLLMs plus GPT-4o reveal significant deficiencies in fundus reading skills, particularly in basic tasks such as laterality recognition. The results highlight the limitations of current MLLMs and emphasize the need for domain-specific training and improved LLMs and VEs.

Convolutional Prompting for Broad-Domain Retinal Vessel Segmentation

Previous research on retinal vessel segmentation is targeted at a specific image domain, mostly color fundus photography (CFP). In this paper we make a brave attempt to attack a more challenging task of broad-domain retinal vessel segmentation (BD-RVS), which is to develop a unified model applicable to varied domains including CFP, SLO, UWF, OCTA and FFA. To that end, we propose Dual Convoltuional Prompting (DCP) that learns to extract domain-specific features by localized prompting along both position and channel dimensions. DCP is designed as a plug-in module that can effectively turn a R2AU-Net based vessel segmentation network to a unified model, yet without the need of modifying its network structure. For evaluation we build a broad-domain set using five public domain-specific datasets including ROSSA, FIVES, IOSTAR, PRIME-FP20 and VAMPIRE. In order to benchmark BD-RVS on the broad-domain dataset, we re-purpose a number of existing methods originally developed in other contexts, producing eight baseline methods in total. Extensive experiments show the the proposed method compares favorably against the baselines for BD-RVS.

Mitigating Hallucination in Multimodal Large Language Model via Hallucination-targeted Direct Preference Optimization

Multimodal Large Language Models (MLLMs) are known to hallucinate, which limits their practical applications. Recent works have attempted to apply Direct Preference Optimization (DPO) to enhance the performance of MLLMs, but have shown inconsistent improvements in mitigating hallucinations. To address this issue more effectively, we introduce Hallucination-targeted Direct Preference Optimization (HDPO) to reduce hallucinations in MLLMs. Unlike previous approaches, our method tackles hallucinations from their diverse forms and causes. Specifically, we develop three types of preference pair data targeting the following causes of MLLM hallucinations: (1) insufficient visual capabilities, (2) long context generation, and (3) multimodal conflicts. Experimental results demonstrate that our method achieves superior performance across multiple hallucination evaluation datasets, surpassing most state-of-the-art (SOTA) methods and highlighting the potential of our approach. Ablation studies and in-depth analyses further confirm the effectiveness of our method and suggest the potential for further improvements through scaling up.

Beyond Coarse-Grained Matching in Video-Text Retrieval

Video-text retrieval has seen significant advancements, yet the ability of models to discern subtle differences in captions still requires verification. In this paper, we introduce a new approach for fine-grained evaluation. Our approach can be applied to existing datasets by automatically generating hard negative test captions with subtle single-word variations across nouns, verbs, adjectives, adverbs, and prepositions. We perform comprehensive experiments using four state-of-the-art models across two standard benchmarks (MSR-VTT and VATEX) and two specially curated datasets enriched with detailed descriptions (VLN-UVO and VLN-OOPS), resulting in a number of novel insights: 1) our analyses show that the current evaluation benchmarks fall short in detecting a model's ability to perceive subtle single-word differences, 2) our fine-grained evaluation highlights the difficulty models face in distinguishing such subtle variations. To enhance fine-grained understanding, we propose a new baseline that can be easily combined with current methods. Experiments on our fine-grained evaluations demonstrate that this approach enhances a model's ability to understand fine-grained differences.