Supporting Mitosis Detection AI Training with Inter-Observer Eye-Gaze Consistencies

The expansion of artificial intelligence (AI) in pathology tasks has intensified the demand for doctors' annotations in AI development. However, collecting high-quality annotations from doctors is costly and time-consuming, creating a bottleneck in AI progress. This study investigates eye-tracking as a cost-effective technology to collect doctors' behavioral data for AI training with a focus on the pathology task of mitosis detection. One major challenge in using eye-gaze data is the low signal-to-noise ratio, which hinders the extraction of meaningful information. We tackled this by levering the properties of inter-observer eye-gaze consistencies and creating eye-gaze labels from consistent eye-fixations shared by a group of observers. Our study involved 14 non-medical participants, from whom we collected eye-gaze data and generated eye-gaze labels based on varying group sizes. We assessed the efficacy of such eye-gaze labels by training Convolutional Neural Networks (CNNs) and comparing their performance to those trained with ground truth annotations and a heuristic-based baseline. Results indicated that CNNs trained with our eye-gaze labels closely followed the performance of ground-truth-based CNNs, and significantly outperformed the baseline. Although primarily focused on mitosis, we envision that insights from this study can be generalized to other medical imaging tasks.

Domain generalization across tumor types, laboratories, and species -- insights from the 2022 edition of the Mitosis Domain Generalization Challenge

Recognition of mitotic figures in histologic tumor specimens is highly relevant to patient outcome assessment. This task is challenging for algorithms and human experts alike, with deterioration of algorithmic performance under shifts in image representations. Considerable covariate shifts occur when assessment is performed on different tumor types, images are acquired using different digitization devices, or specimens are produced in different laboratories. This observation motivated the inception of the 2022 challenge on MItosis Domain Generalization (MIDOG 2022). The challenge provided annotated histologic tumor images from six different domains and evaluated the algorithmic approaches for mitotic figure detection provided by nine challenge participants on ten independent domains. Ground truth for mitotic figure detection was established in two ways: a three-expert consensus and an independent, immunohistochemistry-assisted set of labels. This work represents an overview of the challenge tasks, the algorithmic strategies employed by the participants, and potential factors contributing to their success. With an $F_1$ score of 0.764 for the top-performing team, we summarize that domain generalization across various tumor domains is possible with today's deep learning-based recognition pipelines. When assessed against the immunohistochemistry-assisted reference standard, all methods resulted in reduced recall scores, but with only minor changes in the order of participants in the ranking.

Next Steps for Human-Centered Generative AI: A Technical Perspective

Through iterative, cross-disciplinary discussions, we define and propose next-steps for Human-centered Generative AI (HGAI) from a technical perspective. We contribute a roadmap that lays out future directions of Generative AI spanning three levels: Aligning with human values; Accommodating humans' expression of intents; and Augmenting humans' abilities in a collaborative workflow. This roadmap intends to draw interdisciplinary research teams to a comprehensive list of emergent ideas in HGAI, identifying their interested topics while maintaining a coherent big picture of the future work landscape.

Designing and Evaluating Interfaces that Highlight News Coverage Diversity Using Discord Questions

Modern news aggregators do the hard work of organizing a large news stream, creating collections for a given news story with tens of source options. This paper shows that navigating large source collections for a news story can be challenging without further guidance. In this work, we design three interfaces -- the Annotated Article, the Recomposed Article, and the Question Grid -- aimed at accompanying news readers in discovering coverage diversity while they read. A first usability study with 10 journalism experts confirms the designed interfaces all reveal coverage diversity and determine each interface's potential use cases and audiences. In a second usability study, we developed and implemented a reading exercise with 95 novice news readers to measure exposure to coverage diversity. Results show that Annotated Article users are able to answer questions 34% more completely than with two existing interfaces while finding the interface equally easy to use.

GANravel: User-Driven Direction Disentanglement in Generative Adversarial Networks

Generative adversarial networks (GANs) have many application areas including image editing, domain translation, missing data imputation, and support for creative work. However, GANs are considered 'black boxes'. Specifically, the end-users have little control over how to improve editing directions through disentanglement. Prior work focused on new GAN architectures to disentangle editing directions. Alternatively, we propose GANravel a user-driven direction disentanglement tool that complements the existing GAN architectures and allows users to improve editing directions iteratively. In two user studies with 16 participants each, GANravel users were able to disentangle directions and outperformed the state-of-the-art direction discovery baselines in disentanglement performance. In the second user study, GANravel was used in a creative task of creating dog memes and was able to create high-quality edited images and GIFs.

Discord Questions: A Computational Approach To Diversity Analysis in News Coverage

There are many potential benefits to news readers accessing diverse sources. Modern news aggregators do the hard work of organizing the news, offering readers a plethora of source options, but choosing which source to read remains challenging. We propose a new framework to assist readers in identifying source differences and gaining an understanding of news coverage diversity. The framework is based on the generation of Discord Questions: questions with a diverse answer pool, explicitly illustrating source differences. To assemble a prototype of the framework, we focus on two components: (1) discord question generation, the task of generating questions answered differently by sources, for which we propose an automatic scoring method, and create a model that improves performance from current question generation (QG) methods by 5%, (2) answer consolidation, the task of grouping answers to a question that are semantically similar, for which we collect data and repurpose a method that achieves 81% balanced accuracy on our realistic test set. We illustrate the framework's feasibility through a prototype interface. Even though model performance at discord QG still lags human performance by more than 15%, generated questions are judged to be more interesting than factoid questions and can reveal differences in the level of detail, sentiment, and reasoning of sources in news coverage.

Detecting Mitoses with a Convolutional Neural Network for MIDOG 2022 Challenge

This work presents a mitosis detection method with only one vanilla Convolutional Neural Network (CNN). Our approach consists of two steps: given an image, we first apply a CNN using a sliding window technique to extract patches that have mitoses; we then calculate each extracted patch's class activation map to obtain the mitosis's precise location. To increase the model generalizability, we train the CNN with a series of data augmentation techniques, a loss that copes with noise-labeled images, and an active learning strategy. Our approach achieved an F1 score of 0.7323 with an EfficientNet-b3 model in the preliminary test phase of the MIDOG 2022 challenge.

GANzilla: User-Driven Direction Discovery in Generative Adversarial Networks

Generative Adversarial Network (GAN) is widely adopted in numerous application areas, such as data preprocessing, image editing, and creativity support. However, GAN's 'black box' nature prevents non-expert users from controlling what data a model generates, spawning a plethora of prior work that focused on algorithm-driven approaches to extract editing directions to control GAN. Complementarily, we propose a GANzilla: a user-driven tool that empowers a user with the classic scatter/gather technique to iteratively discover directions to meet their editing goals. In a study with 12 participants, GANzilla users were able to discover directions that (i) edited images to match provided examples (closed-ended tasks) and that (ii) met a high-level goal, e.g., making the face happier, while showing diversity across individuals (open-ended tasks).

Roman: Making Everyday Objects Robotically Manipulable with 3D-Printable Add-on Mechanisms

One important vision of robotics is to provide physical assistance by manipulating different everyday objects, e.g., hand tools, kitchen utensils. However, many objects designed for dexterous hand-control are not easily manipulable by a single robotic arm with a generic parallel gripper. Complementary to existing research on developing grippers and control algorithms, we present Roman, a suite of hardware design and software tool support for robotic engineers to create 3D printable mechanisms attached to everyday handheld objects, making them easier to be manipulated by conventional robotic arms. The Roman hardware comes with a versatile magnetic gripper that can snap on/off handheld objects and drive add-on mechanisms to perform tasks. Roman also provides software support to register and author control programs. To validate our approach, we designed and fabricated Roman mechanisms for 14 everyday objects/tasks presented within a design space and conducted expert interviews with robotic engineers indicating that Roman serves as a practical alternative for enabling robotic manipulation of everyday objects.