RadGenome-Chest CT: A Grounded Vision-Language Dataset for Chest CT Analysis

Developing generalist foundation model has recently attracted tremendous attention among researchers in the field of AI for Medicine (AI4Medicine). A pivotal insight in developing these models is their reliance on dataset scaling, which emphasizes the requirements on developing open-source medical image datasets that incorporate diverse supervision signals across various imaging modalities. In this paper, we introduce RadGenome-Chest CT, a comprehensive, large-scale, region-guided 3D chest CT interpretation dataset based on CT-RATE. Specifically, we leverage the latest powerful universal segmentation and large language models, to extend the original datasets (over 25,692 non-contrast 3D chest CT volume and reports from 20,000 patients) from the following aspects: (i) organ-level segmentation masks covering 197 categories, which provide intermediate reasoning visual clues for interpretation; (ii) 665 K multi-granularity grounded reports, where each sentence of the report is linked to the corresponding anatomical region of CT volume in the form of a segmentation mask; (iii) 1.3 M grounded VQA pairs, where questions and answers are all linked with reference segmentation masks, enabling models to associate visual evidence with textual explanations. All grounded reports and VQA pairs in the validation set have gone through manual verification to ensure dataset quality. We believe that RadGenome-Chest CT can significantly advance the development of multimodal medical foundation models, by training to generate texts based on given segmentation regions, which is unattainable with previous relevant datasets. We will release all segmentation masks, grounded reports, and VQA pairs to facilitate further research and development in this field.

One Model to Rule them All: Towards Universal Segmentation for Medical Images with Text Prompts

In this study, we focus on building up a model that can Segment Anything in medical scenarios, driven by Text prompts, termed as SAT. Our main contributions are three folds: (i) on data construction, we combine multiple knowledge sources to construct a multi-modal medical knowledge tree; Then we build up a large-scale segmentation dataset for training, by collecting over 11K 3D medical image scans from 31 segmentation datasets with careful standardization on both visual scans and label space; (ii) on model training, we formulate a universal segmentation model, that can be prompted by inputting medical terminologies in text form. We present a knowledge-enhanced representation learning framework, and a series of strategies for effectively training on the combination of a large number of datasets; (iii) on model evaluation, we train a SAT-Nano with only 107M parameters, to segment 31 different segmentation datasets with text prompt, resulting in 362 categories. We thoroughly evaluate the model from three aspects: averaged by body regions, averaged by classes, and average by datasets, demonstrating comparable performance to 36 specialist nnUNets, i.e., we train nnUNet models on each dataset/subset, resulting in 36 nnUNets with around 1000M parameters for the 31 datasets. We will release all the codes, and models used in this report, i.e., SAT-Nano. Moreover, we will offer SAT-Ultra in the near future, which is trained with model of larger size, on more diverse datasets. Webpage URL: https://zhaoziheng.github.io/MedUniSeg.

Can GPT-4V Serve Medical Applications? Case Studies on GPT-4V for Multimodal Medical Diagnosis

Driven by the large foundation models, the development of artificial intelligence has witnessed tremendous progress lately, leading to a surge of general interest from the public. In this study, we aim to assess the performance of OpenAI's newest model, GPT-4V(ision), specifically in the realm of multimodal medical diagnosis. Our evaluation encompasses 17 human body systems, including Central Nervous System, Head and Neck, Cardiac, Chest, Hematology, Hepatobiliary, Gastrointestinal, Urogenital, Gynecology, Obstetrics, Breast, Musculoskeletal, Spine, Vascular, Oncology, Trauma, Pediatrics, with images taken from 8 modalities used in daily clinic routine, e.g., X-ray, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Digital Subtraction Angiography (DSA), Mammography, Ultrasound, and Pathology. We probe the GPT-4V's ability on multiple clinical tasks with or without patent history provided, including imaging modality and anatomy recognition, disease diagnosis, report generation, disease localisation. Our observation shows that, while GPT-4V demonstrates proficiency in distinguishing between medical image modalities and anatomy, it faces significant challenges in disease diagnosis and generating comprehensive reports. These findings underscore that while large multimodal models have made significant advancements in computer vision and natural language processing, it remains far from being used to effectively support real-world medical applications and clinical decision-making. All images used in this report can be found in https://github.com/chaoyi-wu/GPT-4V_Medical_Evaluation.

PMC-VQA: Visual Instruction Tuning for Medical Visual Question Answering

In this paper, we focus on the problem of Medical Visual Question Answering (MedVQA), which is crucial in efficiently interpreting medical images with vital clinic-relevant information. Firstly, we reframe the problem of MedVQA as a generation task that naturally follows the human-machine interaction, we propose a generative-based model for medical visual understanding by aligning visual information from a pre-trained vision encoder with a large language model. Secondly, we establish a scalable pipeline to construct a large-scale medical visual question-answering dataset, named PMC-VQA, which contains 227k VQA pairs of 149k images that cover various modalities or diseases. Thirdly, we pre-train our proposed model on PMC-VQA and then fine-tune it on multiple public benchmarks, e.g., VQA-RAD and SLAKE, outperforming existing work by a large margin. Additionally, we propose a test set that has undergone manual verification, which is significantly more challenging, even the best models struggle to solve.

PMC-CLIP: Contrastive Language-Image Pre-training using Biomedical Documents

Foundation models trained on large-scale dataset gain a recent surge in CV and NLP. In contrast, development in biomedical domain lags far behind due to data scarcity. To address this issue, we build and release PMC-OA, a biomedical dataset with 1.6M image-caption pairs collected from PubMedCentral's OpenAccess subset, which is 8 times larger than before. PMC-OA covers diverse modalities or diseases, with majority of the image-caption samples aligned at finer-grained level, i.e., subfigure and subcaption. While pretraining a CLIP-style model on PMC-OA, our model named PMC-CLIP achieves state-of-the-art results on various downstream tasks, including image-text retrieval on ROCO, MedMNIST image classification, Medical VQA, i.e. +8.1% R@10 on image-text retrieval, +3.9% accuracy on image classification.

K-Space Transformer for Fast MRI Reconstruction with Implicit Representation

This paper considers the problem of fast MRI reconstruction. We propose a novel Transformer-based framework for directly processing the sparsely sampled signals in k-space, going beyond the limitation of regular grids as ConvNets do. We adopt an implicit representation of spectrogram, treating spatial coordinates as inputs, and dynamically query the partially observed measurements to complete the spectrogram, i.e. learning the inductive bias in k-space. To strive a balance between computational cost and reconstruction quality, we build an hierarchical structure with low-resolution and high-resolution decoders respectively. To validate the necessity of our proposed modules, we have conducted extensive experiments on two public datasets, and demonstrate superior or comparable performance over state-of-the-art approaches.