Single-cell RNA sequencing (scRNA-seq) is essential for unraveling cellular heterogeneity and diversity, offering invaluable insights for bioinformatics advancements. Despite its potential, traditional clustering methods in scRNA-seq data analysis often neglect the structural information embedded in gene expression profiles, crucial for understanding cellular correlations and dependencies. Existing strategies, including graph neural networks, face challenges in handling the inefficiency due to scRNA-seq data's intrinsic high-dimension and high-sparsity. Addressing these limitations, we introduce scCDCG (single-cell RNA-seq Clustering via Deep Cut-informed Graph), a novel framework designed for efficient and accurate clustering of scRNA-seq data that simultaneously utilizes intercellular high-order structural information. scCDCG comprises three main components: (i) A graph embedding module utilizing deep cut-informed techniques, which effectively captures intercellular high-order structural information, overcoming the over-smoothing and inefficiency issues prevalent in prior graph neural network methods. (ii) A self-supervised learning module guided by optimal transport, tailored to accommodate the unique complexities of scRNA-seq data, specifically its high-dimension and high-sparsity. (iii) An autoencoder-based feature learning module that simplifies model complexity through effective dimension reduction and feature extraction. Our extensive experiments on 6 datasets demonstrate scCDCG's superior performance and efficiency compared to 7 established models, underscoring scCDCG's potential as a transformative tool in scRNA-seq data analysis. Our code is available at: https://github.com/XPgogogo/scCDCG.
Continuous Relation Extraction (CRE) aims to incrementally learn relation knowledge from a non-stationary stream of data. Since the introduction of new relational tasks can overshadow previously learned information, catastrophic forgetting becomes a significant challenge in this domain. Current replay-based training paradigms prioritize all data uniformly and train memory samples through multiple rounds, which would result in overfitting old tasks and pronounced bias towards new tasks because of the imbalances of the replay set. To handle the problem, we introduce the DecouPled CRE (DP-CRE) framework that decouples the process of prior information preservation and new knowledge acquisition. This framework examines alterations in the embedding space as new relation classes emerge, distinctly managing the preservation and acquisition of knowledge. Extensive experiments show that DP-CRE significantly outperforms other CRE baselines across two datasets.
Despite the inherent limitations of existing Large Language Models in directly reading and interpreting single-cell omics data, they demonstrate significant potential and flexibility as the Foundation Model. This research focuses on how to train and adapt the Large Language Model with the capability to interpret and distinguish cell types in single-cell RNA sequencing data. Our preliminary research results indicate that these foundational models excel in accurately categorizing known cell types, demonstrating the potential of the Large Language Models as effective tools for uncovering new biological insights.
In addressing the imbalanced issue of data within the realm of Natural Language Processing, text data augmentation methods have emerged as pivotal solutions. This data imbalance is prevalent in the research proposals submitted during the funding application process. Such imbalances, resulting from the varying popularity of disciplines or the emergence of interdisciplinary studies, significantly impede the precision of downstream topic models that deduce the affiliated disciplines of these proposals. At the data level, proposals penned by experts and scientists are inherently complex technological texts, replete with intricate terminologies, which augmenting such specialized text data poses unique challenges. At the system level, this, in turn, compromises the fairness of AI-assisted reviewer assignment systems, which raises a spotlight on solving this issue. This study leverages large language models (Llama V1) as data generators to augment research proposals categorized within intricate disciplinary hierarchies, aiming to rectify data imbalances and enhance the equity of expert assignments. We first sample within the hierarchical structure to find the under-represented class. Then we designed a prompt for keyword-based research proposal generation. Our experiments attests to the efficacy of the generated data, demonstrating that research proposals produced using the prompts can effectively address the aforementioned issues and generate high quality scientific text data, thus help the model overcome the imbalanced issue.
Feature transformation aims to generate new pattern-discriminative feature space from original features to improve downstream machine learning (ML) task performances. However, the discrete search space for the optimal feature explosively grows on the basis of combinations of features and operations from low-order forms to high-order forms. Existing methods, such as exhaustive search, expansion reduction, evolutionary algorithms, reinforcement learning, and iterative greedy, suffer from large search space. Overly emphasizing efficiency in algorithm design usually sacrifices stability or robustness. To fundamentally fill this gap, we reformulate discrete feature transformation as a continuous space optimization task and develop an embedding-optimization-reconstruction framework. This framework includes four steps: 1) reinforcement-enhanced data preparation, aiming to prepare high-quality transformation-accuracy training data; 2) feature transformation operation sequence embedding, intending to encapsulate the knowledge of prepared training data within a continuous space; 3) gradient-steered optimal embedding search, dedicating to uncover potentially superior embeddings within the learned space; 4) transformation operation sequence reconstruction, striving to reproduce the feature transformation solution to pinpoint the optimal feature space.
As a specific case of graph transfer learning, unsupervised domain adaptation on graphs aims for knowledge transfer from label-rich source graphs to unlabeled target graphs. However, graphs with topology and attributes usually have considerable cross-domain disparity and there are numerous real-world scenarios where merely a subset of nodes are labeled in the source graph. This imposes critical challenges on graph transfer learning due to serious domain shifts and label scarcity. To address these challenges, we propose a method named Semi-supervised Graph Domain Adaptation (SGDA). To deal with the domain shift, we add adaptive shift parameters to each of the source nodes, which are trained in an adversarial manner to align the cross-domain distributions of node embedding, thus the node classifier trained on labeled source nodes can be transferred to the target nodes. Moreover, to address the label scarcity, we propose pseudo-labeling on unlabeled nodes, which improves classification on the target graph via measuring the posterior influence of nodes based on their relative position to the class centroids. Finally, extensive experiments on a range of publicly accessible datasets validate the effectiveness of our proposed SGDA in different experimental settings.
The objective of topic inference in research proposals aims to obtain the most suitable disciplinary division from the discipline system defined by a funding agency. The agency will subsequently find appropriate peer review experts from their database based on this division. Automated topic inference can reduce human errors caused by manual topic filling, bridge the knowledge gap between funding agencies and project applicants, and improve system efficiency. Existing methods focus on modeling this as a hierarchical multi-label classification problem, using generative models to iteratively infer the most appropriate topic information. However, these methods overlook the gap in scale between interdisciplinary research proposals and non-interdisciplinary ones, leading to an unjust phenomenon where the automated inference system categorizes interdisciplinary proposals as non-interdisciplinary, causing unfairness during the expert assignment. How can we address this data imbalance issue under a complex discipline system and hence resolve this unfairness? In this paper, we implement a topic label inference system based on a Transformer encoder-decoder architecture. Furthermore, we utilize interpolation techniques to create a series of pseudo-interdisciplinary proposals from non-interdisciplinary ones during training based on non-parametric indicators such as cross-topic probabilities and topic occurrence probabilities. This approach aims to reduce the bias of the system during model training. Finally, we conduct extensive experiments on a real-world dataset to verify the effectiveness of the proposed method. The experimental results demonstrate that our training strategy can significantly mitigate the unfairness generated in the topic inference task.
Temporal Knowledge Graph (TKG) is an extension of traditional Knowledge Graph (KG) that incorporates the dimension of time. Reasoning on TKGs is a crucial task that aims to predict future facts based on historical occurrences. The key challenge lies in uncovering structural dependencies within historical subgraphs and temporal patterns. Most existing approaches model TKGs relying on entity modeling, as nodes in the graph play a crucial role in knowledge representation. However, the real-world scenario often involves an extensive number of entities, with new entities emerging over time. This makes it challenging for entity-dependent methods to cope with extensive volumes of entities, and effectively handling newly emerging entities also becomes a significant challenge. Therefore, we propose Temporal Inductive Path Neural Network (TiPNN), which models historical information in an entity-independent perspective. Specifically, TiPNN adopts a unified graph, namely history temporal graph, to comprehensively capture and encapsulate information from history. Subsequently, we utilize the defined query-aware temporal paths to model historical path information related to queries on history temporal graph for the reasoning. Extensive experiments illustrate that the proposed model not only attains significant performance enhancements but also handles inductive settings, while additionally facilitating the provision of reasoning evidence through history temporal graphs.