ThermoNeRF: Multimodal Neural Radiance Fields for Thermal Novel View Synthesis

Thermal scene reconstruction exhibit great potential for applications across a broad spectrum of fields, including building energy consumption analysis and non-destructive testing. However, existing methods typically require dense scene measurements and often rely on RGB images for 3D geometry reconstruction, with thermal information being projected post-reconstruction. This two-step strategy, adopted due to the lack of texture in thermal images, can lead to disparities between the geometry and temperatures of the reconstructed objects and those of the actual scene. To address this challenge, we propose ThermoNeRF, a novel multimodal approach based on Neural Radiance Fields, capable of rendering new RGB and thermal views of a scene jointly. To overcome the lack of texture in thermal images, we use paired RGB and thermal images to learn scene density, while distinct networks estimate color and temperature information. Furthermore, we introduce ThermoScenes, a new dataset to palliate the lack of available RGB+thermal datasets for scene reconstruction. Experimental results validate that ThermoNeRF achieves accurate thermal image synthesis, with an average mean absolute error of 1.5$^\circ$C, an improvement of over 50% compared to using concatenated RGB+thermal data with Nerfacto, a state-of-the-art NeRF method.

A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma

The infiltration of T-lymphocytes in the stroma and tumour is an indication of an effective immune response against the tumour, resulting in better survival. In this study, our aim is to explore the prognostic significance of tumour-associated stroma infiltrating lymphocytes (TASILs) in head and neck squamous cell carcinoma (HNSCC) through an AI based automated method. A deep learning based automated method was employed to segment tumour, stroma and lymphocytes in digitally scanned whole slide images of HNSCC tissue slides. The spatial patterns of lymphocytes and tumour-associated stroma were digitally quantified to compute the TASIL-score. Finally, prognostic significance of the TASIL-score for disease-specific and disease-free survival was investigated with the Cox proportional hazard analysis. Three different cohorts of Haematoxylin & Eosin (H&E) stained tissue slides of HNSCC cases (n=537 in total) were studied, including publicly available TCGA head and neck cancer cases. The TASIL-score carries prognostic significance (p=0.002) for disease-specific survival of HNSCC patients. The TASIL-score also shows a better separation between low- and high-risk patients as compared to the manual TIL scoring by pathologists for both disease-specific and disease-free survival. A positive correlation of TASIL-score with molecular estimates of CD8+ T cells was also found, which is in line with existing findings. To the best of our knowledge, this is the first study to automate the quantification of TASIL from routine H&E slides of head and neck cancer. Our TASIL-score based findings are aligned with the clinical knowledge with the added advantages of objectivity, reproducibility and strong prognostic value. A comprehensive evaluation on large multicentric cohorts is required before the proposed digital score can be adopted in clinical practice.