Virtual Multiplex Staining for Histological Images using a Marker-wise Conditioned Diffusion Model

Multiplex imaging is revolutionizing pathology by enabling the simultaneous visualization of multiple biomarkers within tissue samples, providing molecular-level insights that traditional hematoxylin and eosin (H&E) staining cannot provide. However, the complexity and cost of multiplex data acquisition have hindered its widespread adoption. Additionally, most existing large repositories of H&E images lack corresponding multiplex images, limiting opportunities for multimodal analysis. To address these challenges, we leverage recent advances in latent diffusion models (LDMs), which excel at modeling complex data distributions utilizing their powerful priors for fine-tuning to a target domain. In this paper, we introduce a novel framework for virtual multiplex staining that utilizes pretrained LDM parameters to generate multiplex images from H&E images using a conditional diffusion model. Our approach enables marker-by-marker generation by conditioning the diffusion model on each marker, while sharing the same architecture across all markers. To tackle the challenge of varying pixel value distributions across different marker stains and to improve inference speed, we fine-tune the model for single-step sampling, enhancing both color contrast fidelity and inference efficiency through pixel-level loss functions. We validate our framework on two publicly available datasets, notably demonstrating its effectiveness in generating up to 18 different marker types with improved accuracy, a substantial increase over the 2-3 marker types achieved in previous approaches. This validation highlights the potential of our framework, pioneering virtual multiplex staining. Finally, this paper bridges the gap between H&E and multiplex imaging, potentially enabling retrospective studies and large-scale analyses of existing H&E image repositories.

State-Inference-Based Prompting for Natural Language Trading with Game NPCs

Large Language Models enable dynamic game interactions but struggle with rule-governed trading systems. Current implementations suffer from rule violations, such as item hallucinations and calculation errors, that erode player trust. Here, State-Inference-Based Prompting (SIBP) enables reliable trading through autonomous dialogue state inference and context-specific rule adherence. The approach decomposes trading into six states within a unified prompt framework, implementing context-aware item referencing and placeholder-based price calculations. Evaluation across 100 trading dialogues demonstrates >97% state compliance, >95% referencing accuracy, and 99.7% calculation precision. SIBP maintains computational efficiency while outperforming baseline approaches, establishing a practical foundation for trustworthy NPC interactions in commercial games.

DualEdit: Dual Editing for Knowledge Updating in Vision-Language Models

Model editing aims to efficiently update a pre-trained model's knowledge without the need for time-consuming full retraining. While existing pioneering editing methods achieve promising results, they primarily focus on editing single-modal language models (LLMs). However, for vision-language models (VLMs), which involve multiple modalities, the role and impact of each modality on editing performance remain largely unexplored. To address this gap, we explore the impact of textual and visual modalities on model editing and find that: (1) textual and visual representations reach peak sensitivity at different layers, reflecting their varying importance; and (2) editing both modalities can efficiently update knowledge, but this comes at the cost of compromising the model's original capabilities. Based on our findings, we propose DualEdit, an editor that modifies both textual and visual modalities at their respective key layers. Additionally, we introduce a gating module within the more sensitive textual modality, allowing DualEdit to efficiently update new knowledge while preserving the model's original information. We evaluate DualEdit across multiple VLM backbones and benchmark datasets, demonstrating its superiority over state-of-the-art VLM editing baselines as well as adapted LLM editing methods on different evaluation metrics.

RSCF: Relation-Semantics Consistent Filter for Entity Embedding of Knowledge Graph

In knowledge graph embedding, leveraging relation specific entity transformation has markedly enhanced performance. However, the consistency of embedding differences before and after transformation remains unaddressed, risking the loss of valuable inductive bias inherent in the embeddings. This inconsistency stems from two problems. First, transformation representations are specified for relations in a disconnected manner, allowing dissimilar transformations and corresponding entity embeddings for similar relations. Second, a generalized plug-in approach as a SFBR (Semantic Filter Based on Relations) disrupts this consistency through excessive concentration of entity embeddings under entity-based regularization, generating indistinguishable score distributions among relations. In this paper, we introduce a plug-in KGE method, Relation-Semantics Consistent Filter (RSCF). Its entity transformation has three features for enhancing semantic consistency: 1) shared affine transformation of relation embeddings across all relations, 2) rooted entity transformation that adds an entity embedding to its change represented by the transformed vector, and 3) normalization of the change to prevent scale reduction. To amplify the advantages of consistency that preserve semantics on embeddings, RSCF adds relation transformation and prediction modules for enhancing the semantics. In knowledge graph completion tasks with distance-based and tensor decomposition models, RSCF significantly outperforms state-of-the-art KGE methods, showing robustness across all relations and their frequencies.

Affordance-Aware Object Insertion via Mask-Aware Dual Diffusion

As a common image editing operation, image composition involves integrating foreground objects into background scenes. In this paper, we expand the application of the concept of Affordance from human-centered image composition tasks to a more general object-scene composition framework, addressing the complex interplay between foreground objects and background scenes. Following the principle of Affordance, we define the affordance-aware object insertion task, which aims to seamlessly insert any object into any scene with various position prompts. To address the limited data issue and incorporate this task, we constructed the SAM-FB dataset, which contains over 3 million examples across more than 3,000 object categories. Furthermore, we propose the Mask-Aware Dual Diffusion (MADD) model, which utilizes a dual-stream architecture to simultaneously denoise the RGB image and the insertion mask. By explicitly modeling the insertion mask in the diffusion process, MADD effectively facilitates the notion of affordance. Extensive experimental results show that our method outperforms the state-of-the-art methods and exhibits strong generalization performance on in-the-wild images. Please refer to our code on https://github.com/KaKituken/affordance-aware-any.

Multimodal Learning for Embryo Viability Prediction in Clinical IVF

In clinical In-Vitro Fertilization (IVF), identifying the most viable embryo for transfer is important to increasing the likelihood of a successful pregnancy. Traditionally, this process involves embryologists manually assessing embryos' static morphological features at specific intervals using light microscopy. This manual evaluation is not only time-intensive and costly, due to the need for expert analysis, but also inherently subjective, leading to variability in the selection process. To address these challenges, we develop a multimodal model that leverages both time-lapse video data and Electronic Health Records (EHRs) to predict embryo viability. One of the primary challenges of our research is to effectively combine time-lapse video and EHR data, owing to their inherent differences in modality. We comprehensively analyze our multimodal model with various modality inputs and integration approaches. Our approach will enable fast and automated embryo viability predictions in scale for clinical IVF.

Is What You Ask For What You Get? Investigating Concept Associations in Text-to-Image Models

Text-to-image (T2I) models are increasingly used in impactful real-life applications. As such, there is a growing need to audit these models to ensure that they generate desirable, task-appropriate images. However, systematically inspecting the associations between prompts and generated content in a human-understandable way remains challenging. To address this, we propose \emph{Concept2Concept}, a framework where we characterize conditional distributions of vision language models using interpretable concepts and metrics that can be defined in terms of these concepts. This characterization allows us to use our framework to audit models and prompt-datasets. To demonstrate, we investigate several case studies of conditional distributions of prompts, such as user defined distributions or empirical, real world distributions. Lastly, we implement Concept2Concept as an open-source interactive visualization tool facilitating use by non-technical end-users. Warning: This paper contains discussions of harmful content, including CSAM and NSFW material, which may be disturbing to some readers.

MoRA: LoRA Guided Multi-Modal Disease Diagnosis with Missing Modality

Multi-modal pre-trained models efficiently extract and fuse features from different modalities with low memory requirements for fine-tuning. Despite this efficiency, their application in disease diagnosis is under-explored. A significant challenge is the frequent occurrence of missing modalities, which impairs performance. Additionally, fine-tuning the entire pre-trained model demands substantial computational resources. To address these issues, we introduce Modality-aware Low-Rank Adaptation (MoRA), a computationally efficient method. MoRA projects each input to a low intrinsic dimension but uses different modality-aware up-projections for modality-specific adaptation in cases of missing modalities. Practically, MoRA integrates into the first block of the model, significantly improving performance when a modality is missing. It requires minimal computational resources, with less than 1.6% of the trainable parameters needed compared to training the entire model. Experimental results show that MoRA outperforms existing techniques in disease diagnosis, demonstrating superior performance, robustness, and training efficiency.

Aligning Sight and Sound: Advanced Sound Source Localization Through Audio-Visual Alignment

Recent studies on learning-based sound source localization have mainly focused on the localization performance perspective. However, prior work and existing benchmarks overlook a crucial aspect: cross-modal interaction, which is essential for interactive sound source localization. Cross-modal interaction is vital for understanding semantically matched or mismatched audio-visual events, such as silent objects or off-screen sounds. In this paper, we first comprehensively examine the cross-modal interaction of existing methods, benchmarks, evaluation metrics, and cross-modal understanding tasks. Then, we identify the limitations of previous studies and make several contributions to overcome the limitations. First, we introduce a new synthetic benchmark for interactive sound source localization. Second, we introduce new evaluation metrics to rigorously assess sound source localization methods, focusing on accurately evaluating both localization performance and cross-modal interaction ability. Third, we propose a learning framework with a cross-modal alignment strategy to enhance cross-modal interaction. Lastly, we evaluate both interactive sound source localization and auxiliary cross-modal retrieval tasks together to thoroughly assess cross-modal interaction capabilities and benchmark competing methods. Our new benchmarks and evaluation metrics reveal previously overlooked issues in sound source localization studies. Our proposed novel method, with enhanced cross-modal alignment, shows superior sound source localization performance. This work provides the most comprehensive analysis of sound source localization to date, with extensive validation of competing methods on both existing and new benchmarks using new and standard evaluation metrics.

Joint-Task Regularization for Partially Labeled Multi-Task Learning

Multi-task learning has become increasingly popular in the machine learning field, but its practicality is hindered by the need for large, labeled datasets. Most multi-task learning methods depend on fully labeled datasets wherein each input example is accompanied by ground-truth labels for all target tasks. Unfortunately, curating such datasets can be prohibitively expensive and impractical, especially for dense prediction tasks which require per-pixel labels for each image. With this in mind, we propose Joint-Task Regularization (JTR), an intuitive technique which leverages cross-task relations to simultaneously regularize all tasks in a single joint-task latent space to improve learning when data is not fully labeled for all tasks. JTR stands out from existing approaches in that it regularizes all tasks jointly rather than separately in pairs -- therefore, it achieves linear complexity relative to the number of tasks while previous methods scale quadratically. To demonstrate the validity of our approach, we extensively benchmark our method across a wide variety of partially labeled scenarios based on NYU-v2, Cityscapes, and Taskonomy.