Predict and Interpret Health Risk using EHR through Typical Patients

Predicting health risks from electronic health records (EHR) is a topic of recent interest. Deep learning models have achieved success by modeling temporal and feature interaction. However, these methods learn insufficient representations and lead to poor performance when it comes to patients with few visits or sparse records. Inspired by the fact that doctors may compare the patient with typical patients and make decisions from similar cases, we propose a Progressive Prototypical Network (PPN) to select typical patients as prototypes and utilize their information to enhance the representation of the given patient. In particular, a progressive prototype memory and two prototype separation losses are proposed to update prototypes. Besides, a novel integration is introduced for better fusing information from patients and prototypes. Experiments on three real-world datasets demonstrate that our model brings improvement on all metrics. To make our results better understood by physicians, we developed an application at http://ppn.ai-care.top. Our code is released at https://github.com/yzhHoward/PPN.

OpenNet: Incremental Learning for Autonomous Driving Object Detection with Balanced Loss

Automated driving object detection has always been a challenging task in computer vision due to environmental uncertainties. These uncertainties include significant differences in object sizes and encountering the class unseen. It may result in poor performance when traditional object detection models are directly applied to automated driving detection. Because they usually presume fixed categories of common traffic participants, such as pedestrians and cars. Worsely, the huge class imbalance between common and novel classes further exacerbates performance degradation. To address the issues stated, we propose OpenNet to moderate the class imbalance with the Balanced Loss, which is based on Cross Entropy Loss. Besides, we adopt an inductive layer based on gradient reshaping to fast learn new classes with limited samples during incremental learning. To against catastrophic forgetting, we employ normalized feature distillation. By the way, we improve multi-scale detection robustness and unknown class recognition through FPN and energy-based detection, respectively. The Experimental results upon the CODA dataset show that the proposed method can obtain better performance than that of the existing methods.

Exploit the antenna response consistency to define the alignment criteria for CSI data

Self-supervised learning (SSL) for WiFi-based human activity recognition (HAR) holds great promise due to its ability to address the challenge of insufficient labeled data. However, directly transplanting SSL algorithms, especially contrastive learning, originally designed for other domains to CSI data, often fails to achieve the expected performance. We attribute this issue to the inappropriate alignment criteria, which disrupt the semantic distance consistency between the feature space and the input space. To address this challenge, we introduce \textbf{A}netenna \textbf{R}esponse \textbf{C}onsistency (ARC) as a solution to define proper alignment criteria. ARC is designed to retain semantic information from the input space while introducing robustness to real-world noise. We analyze ARC from the perspective of CSI data structure, demonstrating that its optimal solution leads to a direct mapping from input CSI data to action vectors in the feature map. Furthermore, we provide extensive experimental evidence to validate the effectiveness of ARC in improving the performance of self-supervised learning for WiFi-based HAR.

Self-Supervised Learning for WiFi CSI-Based Human Activity Recognition: A Systematic Study

Recently, with the advancement of the Internet of Things (IoT), WiFi CSI-based HAR has gained increasing attention from academic and industry communities. By integrating the deep learning technology with CSI-based HAR, researchers achieve state-of-the-art performance without the need of expert knowledge. However, the scarcity of labeled CSI data remains the most prominent challenge when applying deep learning models in the context of CSI-based HAR due to the privacy and incomprehensibility of CSI-based HAR data. On the other hand, SSL has emerged as a promising approach for learning meaningful representations from data without heavy reliance on labeled examples. Therefore, considerable efforts have been made to address the challenge of insufficient data in deep learning by leveraging SSL algorithms. In this paper, we undertake a comprehensive inventory and analysis of the potential held by different categories of SSL algorithms, including those that have been previously studied and those that have not yet been explored, within the field. We provide an in-depth investigation of SSL algorithms in the context of WiFi CSI-based HAR. We evaluate four categories of SSL algorithms using three publicly available CSI HAR datasets, each encompassing different tasks and environmental settings. To ensure relevance to real-world applications, we design performance metrics that align with specific requirements. Furthermore, our experimental findings uncover several limitations and blind spots in existing work, highlighting the barriers that need to be addressed before SSL can be effectively deployed in real-world WiFi-based HAR applications. Our results also serve as a practical guideline for industry practitioners and provide valuable insights for future research endeavors in this field.

M$^3$Care: Learning with Missing Modalities in Multimodal Healthcare Data

Multimodal electronic health record (EHR) data are widely used in clinical applications. Conventional methods usually assume that each sample (patient) is associated with the unified observed modalities, and all modalities are available for each sample. However, missing modality caused by various clinical and social reasons is a common issue in real-world clinical scenarios. Existing methods mostly rely on solving a generative model that learns a mapping from the latent space to the original input space, which is an unstable ill-posed inverse problem. To relieve the underdetermined system, we propose a model solving a direct problem, dubbed learning with Missing Modalities in Multimodal healthcare data (M3Care). M3Care is an end-to-end model compensating the missing information of the patients with missing modalities to perform clinical analysis. Instead of generating raw missing data, M3Care imputes the task-related information of the missing modalities in the latent space by the auxiliary information from each patient's similar neighbors, measured by a task-guided modality-adaptive similarity metric, and thence conducts the clinical tasks. The task-guided modality-adaptive similarity metric utilizes the uncensored modalities of the patient and the other patients who also have the same uncensored modalities to find similar patients. Experiments on real-world datasets show that M3Care outperforms the state-of-the-art baselines. Moreover, the findings discovered by M3Care are consistent with experts and medical knowledge, demonstrating the capability and the potential of providing useful insights and explanations.

On the design of Massive MIMO-QAM detector via $\ell_2$-Box ADMM approach

In this letter, we develop an $\ell_2$-box maximum likelihood (ML) formulation for massive multiple-input multiple-output (MIMO) quadrature amplitude modulation (QAM) signal detection and customize an alternating direction method of multipliers (ADMM) algorithm to solve the nonconvex optimization model. In the $\ell_2$-box ADMM implementation, all variables are solved analytically. Moreover, several theoretical results related to convergence, iteration complexity, and computational complexity are presented. Simulation results demonstrate the effectiveness of the proposed $\ell_2$-box ADMM detector in comparison with state-of-the-arts approaches.

Designing Binary Sequence Set with Optimized Correlation Properties via ADMM Approach

In this paper, we design low correlation binary sequences favorable in wireless communication and radar applications. First, we formulate the designing problem as a nonconvex combination optimization problem with flexible correlation interval; second, by relaxing constraints and introducing auxiliary variables, the original minimization problem is equivalent to a consensus continuous optimization problem; third, to achieve its good approximate solution efficiently, we propose the distributed executable algorithms based on alternating direction method of multipliers (ADMM); fourth, we prove that the proposed ADMM algorithms can converge to some stationary point of the approximate problem. Moreover, the computational complexity analysis is considered. Simulation results demonstrate that the proposed ADMM approaches outperform state-of-the-art ones in either computational cost or selection of correlation interval of the designed binary sequences.

Efficient QAM Signal Detector for Massive MIMO Systems via PS-ADMM Approach

In this paper, we design an efficient quadrature amplitude modulation (QAM) signal detector for massive multiple-input multiple-output (MIMO) communication systems via the penalty-sharing alternating direction method of multipliers (PS-ADMM). Its main content is as follows: first, we formulate QAM-MIMO detection as a maximum-likelihood optimization problem with bound relaxation constraints. Decomposing QAM signals into a sum of multiple binary variables and exploiting introduced binary variables as penalty functions, we transform the detection optimization model to a non-convex sharing problem; second, a customized ADMM algorithm is presented to solve the formulated non-convex optimization problem. In the implementation, all variables can be solved analytically and in parallel; third, it is proved that the proposed PS-ADMM algorithm converges under mild conditions. Simulation results demonstrate the effectiveness of the proposed approach.

Interpretable Machine Learning for COVID-19: An Empirical Study on Severity Prediction Task

Black-box nature hinders the deployment of many high-accuracy models in medical diagnosis. It is risky to put one's life in the hands of models that medical researchers do not trust. However, to understand the mechanism of a new virus, such as COVID-19, machine learning models may catch important symptoms that medical practitioners do not notice due to the surge of infected patients during a pandemic. In this work, the interpretation of machine learning models reveals that a high C-reactive protein (CRP) corresponds to severe infection, and severe patients usually go through a cardiac injury, which is consistent with well-established medical knowledge. Additionally, through the interpretation of machine learning models, we find phlegm and diarrhea are two important symptoms, without which indicate a high risk of turning severe. These two symptoms are not recognized at the early stage of the outbreak, whereas our findings are corroborated by later autopsies of COVID-19 patients. We find patients with a high N-terminal pro B-type natriuretic peptide (NTproBNP) have a significantly increased risk of death which does not receive much attention initially but proves true by the following-up study. Thus, we suggest interpreting machine learning models can offer help to diagnosis at the early stage of an outbreak.

Is AI Model Interpretable to Combat with COVID? An Empirical Study on Severity Prediction Task

Black-box nature hinders the deployment of many high-accuracy models in medical diagnosis. Putting one's life in the hands of models that medical researchers do not trust it's irresponsible. However, to understand the mechanism of a new virus, such as COVID-19, machine learning models may catch important symptoms that medical practitioners do not notice due to the surge of infected patients caused by a pandemic. In this work, the interpretation of machine learning models reveals a high CRP corresponds to severe infection, and severe patients usually go through a cardiac injury, which is consistent with medical knowledge. Additionally, through the interpretation of machine learning models, we find phlegm and diarrhea are two important symptoms, without which indicate a high risk of turning severe. These two symptoms are not recognized at the early stage of the outbreak, but later our findings are corroborated by autopsies of COVID-19 patients. And we find patients with a high NTproBNP have a significantly increased risk of death which does not receive much attention initially but proves true by the following-up study. Thus, we suggest interpreting machine learning models can offer help to understanding a new virus at the early stage of an outbreak.