Deep Learning-Based Longitudinal Prediction of Childhood Myopia Progression Using Fundus Image Sequences and Baseline Refraction Data

Childhood myopia constitutes a significant global health concern. It exhibits an escalating prevalence and has the potential to evolve into severe, irreversible conditions that detrimentally impact familial well-being and create substantial economic costs. Contemporary research underscores the importance of precisely predicting myopia progression to enable timely and effective interventions, thereby averting severe visual impairment in children. Such predictions predominantly rely on subjective clinical assessments, which are inherently biased and resource-intensive, thus hindering their widespread application. In this study, we introduce a novel, high-accuracy method for quantitatively predicting the myopic trajectory and myopia risk in children using only fundus images and baseline refraction data. This approach was validated through a six-year longitudinal study of 3,408 children in Henan, utilizing 16,211 fundus images and corresponding refractive data. Our method based on deep learning demonstrated predictive accuracy with an error margin of 0.311D per year and AUC scores of 0.944 and 0.995 for forecasting the risks of developing myopia and high myopia, respectively. These findings confirm the utility of our model in supporting early intervention strategies and in significantly reducing healthcare costs, particularly by obviating the need for additional metadata and repeated consultations. Furthermore, our method was designed to rely only on fundus images and refractive error data, without the need for meta data or multiple inquiries from doctors, strongly reducing the associated medical costs and facilitating large-scale screening. Our model can even provide good predictions based on only a single time measurement. Consequently, the proposed method is an important means to reduce medical inequities caused by economic disparities.

Intelligent machines work in unstructured environments by differential neural computing

Expecting intelligent machines to efficiently work in real world requires a new method to understand unstructured information in unknown environments with good accuracy, scalability and generalization, like human. Here, a memristive neural computing based perceptual signal differential processing and learning method for intelligent machines is presented, via extracting main features of environmental information and applying associated encoded stimuli to memristors, we successfully obtain human-like ability in processing unstructured environmental information, such as amplification (>720%) and adaptation (<50%) of mechanical stimuli. The method also exhibits good scalability and generalization, validated in two typical applications of intelligent machines: object grasping and autonomous driving. In the former, a robot hand experimentally realizes safe and stable grasping, through learning unknown object features (e.g., sharp corner and smooth surface) with a single memristor in 1 ms. In the latter, the decision-making information of 10 unstructured environments in autonomous driving (e.g., overtaking cars, pedestrians) are accurately (94%) extracted with a 40x25 memristor array. By mimicking the intrinsic nature of human low-level perception mechanisms in electronic memristive neural circuits, the proposed method is adaptable to diverse sensing technologies, helping intelligent machines to generate smart high-level decisions in real world.