Towards NeuroAI: Introducing Neuronal Diversity into Artificial Neural Networks

Throughout history, the development of artificial intelligence, particularly artificial neural networks, has been open to and constantly inspired by the increasingly deepened understanding of the brain, such as the inspiration of neocognitron, which is the pioneering work of convolutional neural networks. Per the motives of the emerging field: NeuroAI, a great amount of neuroscience knowledge can help catalyze the next generation of AI by endowing a network with more powerful capabilities. As we know, the human brain has numerous morphologically and functionally different neurons, while artificial neural networks are almost exclusively built on a single neuron type. In the human brain, neuronal diversity is an enabling factor for all kinds of biological intelligent behaviors. Since an artificial network is a miniature of the human brain, introducing neuronal diversity should be valuable in terms of addressing those essential problems of artificial networks such as efficiency, interpretability, and memory. In this Primer, we first discuss the preliminaries of biological neuronal diversity and the characteristics of information transmission and processing in a biological neuron. Then, we review studies of designing new neurons for artificial networks. Next, we discuss what gains can neuronal diversity bring into artificial networks and exemplary applications in several important fields. Lastly, we discuss the challenges and future directions of neuronal diversity to explore the potential of NeuroAI.

Single Neuron Segmentation using Graph-based Global Reasoning with Auxiliary Skeleton Loss from 3D Optical Microscope Images

One of the critical steps in improving accurate single neuron reconstruction from three-dimensional (3D) optical microscope images is the neuronal structure segmentation. However, they are always hard to segment due to the lack in quality. Despite a series of attempts to apply convolutional neural networks (CNNs) on this task, noise and disconnected gaps are still challenging to alleviate with the neglect of the non-local features of graph-like tubular neural structures. Hence, we present an end-to-end segmentation network by jointly considering the local appearance and the global geometry traits through graph reasoning and a skeleton-based auxiliary loss. The evaluation results on the Janelia dataset from the BigNeuron project demonstrate that our proposed method exceeds the counterpart algorithms in performance.

AIDE: Annotation-efficient deep learning for automatic medical image segmentation

Accurate image segmentation is crucial for medical imaging applications. The prevailing deep learning approaches typically rely on very large training datasets with high-quality manual annotations, which are often not available in medical imaging. We introduce Annotation-effIcient Deep lEarning (AIDE) to handle imperfect datasets with an elaborately designed cross-model self-correcting mechanism. AIDE improves the segmentation Dice scores of conventional deep learning models on open datasets possessing scarce or noisy annotations by up to 30%. For three clinical datasets containing 11,852 breast images of 872 patients from three medical centers, AIDE consistently produces segmentation maps comparable to those generated by the fully supervised counterparts as well as the manual annotations of independent radiologists by utilizing only 10% training annotations. Such a 10-fold improvement of efficiency in utilizing experts' labels has the potential to promote a wide range of biomedical applications.