Abstract:Natural language user preferences provide an interpretable interface for LLM personalization. However, universal preference summaries often contain information irrelevant to a particular downstream task. Directly supplying the full preference summary therefore wastes context capacity and introduces cross-task distraction, while manually designing task-specific preference views is difficult to scale. In this work, we study \emph{task-specific preference adaptation}: given a universal user preference summary and a downstream task, derive a task-conditioned representation that preserves sufficient decision-relevant evidence while removing redundant context. To this end, we propose \textsc{AlignXada}, a training-free meta-learning framework that induces reusable textual refinement policies for adapting universal preference summaries to task-specific ones. The refinement policy is iteratively optimized by a meta learner through verbal reinforcement learning. Across 13 tasks and three downstream models (39 task--model cells), \textsc{AlignXada} achieves an average gain of 3.82 points, improving 33 cells while retaining only 22.8\% of the original profile tokens and outperforming RAG in 36 cells. An extended faithfulness analysis further shows that the refined profiles remain largely grounded in the source preferences while preserving task-relevant personalization signals, suggesting that profile-side adaptation serves as a practical complement to universal memory construction for lifelong personalized agents.
Abstract:Task decomposition aims to transform ambiguous instructions into executable atomic subtasks, thereby guiding high-precision tool retrieval. However, our analysis reveals that directly adopting tool retrieval metrics, i.e., Recall or NDCG, as rewards for task decomposition can easily induce reward hacking in reinforcement learning-based methods. Specifically, models tend to maximize retrieval matching through strategies such as repetitive decomposition. This spurious correlation between the shallow features of decomposition results and retrieval metric impairs generalization in Out-of-Domain (OOD) scenarios involving unseen tools. To address this issue, we propose PCTD, a Preference-guided Counterfactual Task Decomposition framework. PCTD quantifies the marginal causal gain of decomposition on retrieval ranking through a counterfactual reward, thereby cutting off spurious correlations at their source. Meanwhile, it introduces a preference reward to impose fine-grained structural supervision on logical coherence and atomicity, encouraging the model to generate high-quality decompositions. In addition, we construct MTDTool, the task decomposition benchmark specifically designed for mobile multi-turn interactions. Extensive experiments demonstrate that PCTD alleviates repetitive decomposition and surpasses SOTA methods in retrieval, decomposition quality, and OOD generalization.
Abstract:Data augmentation (DA) has been proven to be an effective means for improving protein representation learning (PRL) by generating additional training samples. Although mainstream perturbation- and sampling-based augmentation methods can produce data containing sufficient variations, they carry the risk of disrupting the protein structure and function. Some crafted protein homology modeling tools can generate conformations, but reduce structural diversity. The above dilemmas lead us to a question: Can we restore the disrupted structure caused by DA operations, providing data with both the original structure and diverse variations? In this work, we first analyze and empirically reveal the structure defect and performance degradation issues of existing DA methods. Based on the findings, we propose a simple yet effective DA method, Manifold Restore Mixing (MRM), for protein representation learning. Specifically, inspired by manifold mixup, we mix the hidden representations of original and augmented protein data to generate new samples that restore structural information lost in DA while introducing diverse variations. Furthermore, we develop a sample difficulty scheduler that adjusts the beta distribution in mixup to provide models with progressively challenging mixed samples during training, which improves the final performance. Comprehensive experiments on various PRL backbones and downstream tasks demonstrate the effectiveness and generalization of our method. The complete code and weights will be released upon acceptance. We provide a implementation at https://github.com/KingGugu/MRM.
Abstract:Sub-sequence splitting (SSS) has been demonstrated as an effective approach to mitigate data sparsity in sequential recommendation (SR) by splitting a raw user interaction sequence into multiple sub-sequences. Previous studies have demonstrated its ability to enhance the performance of SR models significantly. However, in this work, we discover that \textbf{(i). SSS may interfere with the evaluation of the model's actual performance.} We observed that many recent state-of-the-art SR models employ SSS during the data reading stage (not mentioned in the papers). When we removed this operation, performance significantly declined, even falling below that of earlier classical SR models. The varying improvements achieved by SSS and different splitting methods across different models prompt us to analyze further when SSS proves effective. We find that \textbf{(ii). SSS demonstrates strong capabilities only when specific splitting methods, target strategies, and loss functions are used together.} Inappropriate combinations may even harm performance. Furthermore, we analyze why sub-sequence splitting yields such remarkable performance gains and find that \textbf{(iii). it evens out the distribution of training data while increasing the likelihood that different items are targeted.} Finally, we provide suggestions for overcoming SSS interference, along with a discussion on data augmentation methods and future directions. We hope this work will prompt the broader community to re-examine the impact of data splitting on SR and promote fairer, more rigorous model evaluation. All analysis code and data will be made available upon acceptance. We provide a simple, anonymous implementation at https://github.com/KingGugu/SSS4SR.
Abstract:Sequential Recommendation (SR) learns user preferences from their historical interaction sequences and provides personalized suggestions. In real-world scenarios, most items exhibit sparse interactions, known as the tail-item problem. This issue limits the model's ability to accurately capture item transition patterns. To tackle this, large language models (LLMs) offer a promising solution by capturing semantic relationships between items. Despite previous efforts to leverage LLM-derived embeddings for enriching tail items, they still face the following limitations: 1) They struggle to effectively fuse collaborative signals with semantic knowledge, leading to suboptimal item embedding quality. 2) Existing methods overlook the structural inconsistency between the ID and LLM embedding spaces, causing conflicting signals that degrade recommendation accuracy. In this work, we propose a Fusion and Alignment Enhancement framework with LLMs for Tail-item Sequential Recommendation (FAERec), which improves item representations by generating coherently-fused and structurally consistent embeddings. For the information fusion challenge, we design an adaptive gating mechanism that dynamically fuses ID and LLM embeddings. Then, we propose a dual-level alignment approach to mitigate structural inconsistency. The item-level alignment establishes correspondences between ID and LLM embeddings of the same item through contrastive learning, while the feature-level alignment constrains the correlation patterns between corresponding dimensions across the two embedding spaces. Furthermore, the weights of the two alignments are adjusted by a curriculum learning scheduler to avoid premature optimization of the complex feature-level objective. Extensive experiments across three widely used datasets with multiple representative SR backbones demonstrate the effectiveness and generalizability of our framework.
Abstract:Direct Preference Optimization (DPO) guides large language models (LLMs) to generate recommendations aligned with user historical behavior distributions by minimizing preference alignment loss. However, our systematic empirical research and theoretical analysis reveal that DPO tends to amplify spurious correlations caused by environmental confounders during the alignment process, significantly undermining the generalization capability of LLM-based generative recommendation methods in out of distribution (OOD) scenarios. To mitigate this issue, we propose CausalDPO, an extension of DPO that incorporates a causal invariance learning mechanism. This method introduces a backdoor adjustment strategy during the preference alignment phase to eliminate interference from environmental confounders, explicitly models the latent environmental distribution using a soft clustering approach, and enhances robust consistency across diverse environments through invariance constraints. Theoretical analysis demonstrates that CausalDPO can effectively capture users stable preference structures across multiple environments, thereby improving the OOD generalization performance of LLM-based recommendation models. We conduct extensive experiments under four representative distribution shift settings to validate the effectiveness of CausalDPO, achieving an average performance improvement of 17.17% across four evaluation metrics.
Abstract:Large language models (LLMs) are increasingly applied in scientific research, offering new capabilities for knowledge discovery and reasoning. In single-cell biology, however, evaluation practices for both general and specialized LLMs remain inadequate: existing benchmarks are fragmented across tasks, adopt formats such as multiple-choice classification that diverge from real-world usage, and rely on metrics lacking interpretability and biological grounding. We present SC-ARENA, a natural language evaluation framework tailored to single-cell foundation models. SC-ARENA formalizes a virtual cell abstraction that unifies evaluation targets by representing both intrinsic attributes and gene-level interactions. Within this paradigm, we define five natural language tasks (cell type annotation, captioning, generation, perturbation prediction, and scientific QA) that probe core reasoning capabilities in cellular biology. To overcome the limitations of brittle string-matching metrics, we introduce knowledge-augmented evaluation, which incorporates external ontologies, marker databases, and scientific literature to support biologically faithful and interpretable judgments. Experiments and analysis across both general-purpose and domain-specialized LLMs demonstrate that (i) under the Virtual Cell unified evaluation paradigm, current models achieve uneven performance on biologically complex tasks, particularly those demanding mechanistic or causal understanding; and (ii) our knowledge-augmented evaluation framework ensures biological correctness, provides interpretable, evidence-grounded rationales, and achieves high discriminative capacity, overcoming the brittleness and opacity of conventional metrics. SC-Arena thus provides a unified and interpretable framework for assessing LLMs in single-cell biology, pointing toward the development of biology-aligned, generalizable foundation models.
Abstract:Test-time reinforcement learning generates multiple candidate answers via repeated rollouts and performs online updates using pseudo-labels constructed by majority voting. To reduce overhead and improve exploration, prior work introduces tree structured rollouts, which share reasoning prefixes and branch at key nodes to improve sampling efficiency. However, this paradigm still faces two challenges: (1) high entropy branching can trigger rollout collapse, where the branching budget concentrates on a few trajectories with consecutive high-entropy segments, rapidly reducing the number of effective branches; (2) early pseudo-labels are noisy and biased, which can induce self-reinforcing overfitting, causing the policy to sharpen prematurely and suppress exploration. To address these issues, we propose Entropy Confidence Hybrid Group Relative Policy Optimization (ECHO). During rollout, ECHO jointly leverages local entropy and group level confidence to adaptively control branch width, and further introduces online confidence-based pruning to terminate persistently low confidence branches, avoiding high entropy traps and mitigating collapse. During policy updates, ECHO employs confidence adaptive clipping and an entropy confidence hybrid advantage shaping approach to enhance training robustness and mitigate early stage bias. Experiments demonstrate that ECHO achieves consistent gains on multiple mathematical and visual reasoning benchmarks, and generalizes more effectively under a limited rollout budget.
Abstract:Sequential recommendation (SR) learns user preferences based on their historical interaction sequences and provides personalized suggestions. In real-world scenarios, most users can only interact with a handful of items, while the majority of items are seldom consumed. This pervasive long-tail challenge limits the model's ability to learn user preferences. Despite previous efforts to enrich tail items/users with knowledge from head parts or improve tail learning through additional contextual information, they still face the following issues: 1) They struggle to improve the situation where interactions of tail users/items are scarce, leading to incomplete preferences learning for the tail parts. 2) Existing methods often degrade overall or head parts performance when improving accuracy for tail users/items, thereby harming the user experience. We propose Tail-Aware Data Augmentation (TADA) for long-tail sequential recommendation, which enhances the interaction frequency for tail items/users while maintaining head performance, thereby promoting the model's learning capabilities for the tail. Specifically, we first capture the co-occurrence and correlation among low-popularity items by a linear model. Building upon this, we design two tail-aware augmentation operators, T-Substitute and T-Insert. The former replaces the head item with a relevant item, while the latter utilizes co-occurrence relationships to extend the original sequence by incorporating both head and tail items. The augmented and original sequences are mixed at the representation level to preserve preference knowledge. We further extend the mix operation across different tail-user sequences and augmented sequences to generate richer augmented samples, thereby improving tail performance. Comprehensive experiments demonstrate the superiority of our method. The codes are provided at https://github.com/KingGugu/TADA.
Abstract:We study the problem of personalization in large language models (LLMs). Prior work predominantly represents user preferences as implicit, model-specific vectors or parameters, yielding opaque ``black-box'' profiles that are difficult to interpret and transfer across models and tasks. In contrast, we advocate natural language as a universal, model- and task-agnostic interface for preference representation. The formulation leads to interpretable and reusable preference descriptions, while naturally supporting continual evolution as new interactions are observed. To learn such representations, we introduce a two-stage training framework that combines supervised fine-tuning on high-quality synthesized data with reinforcement learning to optimize long-term utility and cross-task transferability. Based on this framework, we develop AlignXplore+, a universal preference reasoning model that generates textual preference summaries. Experiments on nine benchmarks show that our 8B model achieves state-of-the-art performanc -- outperforming substantially larger open-source models -- while exhibiting strong transferability across tasks, model families, and interaction formats.