Agentic large language models improve retrieval-based radiology question answering

Clinical decision-making in radiology increasingly benefits from artificial intelligence (AI), particularly through large language models (LLMs). However, traditional retrieval-augmented generation (RAG) systems for radiology question answering (QA) typically rely on single-step retrieval, limiting their ability to handle complex clinical reasoning tasks. Here we propose an agentic RAG framework enabling LLMs to autonomously decompose radiology questions, iteratively retrieve targeted clinical evidence from Radiopaedia, and dynamically synthesize evidence-based responses. We evaluated 24 LLMs spanning diverse architectures, parameter scales (0.5B to >670B), and training paradigms (general-purpose, reasoning-optimized, clinically fine-tuned), using 104 expert-curated radiology questions from previously established RSNA-RadioQA and ExtendedQA datasets. Agentic retrieval significantly improved mean diagnostic accuracy over zero-shot prompting (73% vs. 64%; P<0.001) and conventional online RAG (73% vs. 68%; P<0.001). The greatest gains occurred in mid-sized models (e.g., Mistral Large improved from 72% to 81%) and small-scale models (e.g., Qwen 2.5-7B improved from 55% to 71%), while very large models (>200B parameters) demonstrated minimal changes (<2% improvement). Additionally, agentic retrieval reduced hallucinations (mean 9.4%) and retrieved clinically relevant context in 46% of cases, substantially aiding factual grounding. Even clinically fine-tuned models exhibited meaningful improvements (e.g., MedGemma-27B improved from 71% to 81%), indicating complementary roles of retrieval and fine-tuning. These results highlight the potential of agentic frameworks to enhance factuality and diagnostic accuracy in radiology QA, particularly among mid-sized LLMs, warranting future studies to validate their clinical utility.

Audio-Vision Contrastive Learning for Phonological Class Recognition

Accurate classification of articulatory-phonological features plays a vital role in understanding human speech production and developing robust speech technologies, particularly in clinical contexts where targeted phonemic analysis and therapy can improve disease diagnosis accuracy and personalized rehabilitation. In this work, we propose a multimodal deep learning framework that combines real-time magnetic resonance imaging (rtMRI) and speech signals to classify three key articulatory dimensions: manner of articulation, place of articulation, and voicing. We perform classification on 15 phonological classes derived from the aforementioned articulatory dimensions and evaluate the system with four audio/vision configurations: unimodal rtMRI, unimodal audio signals, multimodal middle fusion, and contrastive learning-based audio-vision fusion. Experimental results on the USC-TIMIT dataset show that our contrastive learning-based approach achieves state-of-the-art performance, with an average F1-score of 0.81, representing an absolute increase of 0.23 over the unimodal baseline. The results confirm the effectiveness of contrastive representation learning for multimodal articulatory analysis. Our code and processed dataset will be made publicly available at https://github.com/DaE-plz/AC_Contrastive_Phonology to support future research.

SSL4SAR: Self-Supervised Learning for Glacier Calving Front Extraction from SAR Imagery

Glaciers are losing ice mass at unprecedented rates, increasing the need for accurate, year-round monitoring to understand frontal ablation, particularly the factors driving the calving process. Deep learning models can extract calving front positions from Synthetic Aperture Radar imagery to track seasonal ice losses at the calving fronts of marine- and lake-terminating glaciers. The current state-of-the-art model relies on ImageNet-pretrained weights. However, they are suboptimal due to the domain shift between the natural images in ImageNet and the specialized characteristics of remote sensing imagery, in particular for Synthetic Aperture Radar imagery. To address this challenge, we propose two novel self-supervised multimodal pretraining techniques that leverage SSL4SAR, a new unlabeled dataset comprising 9,563 Sentinel-1 and 14 Sentinel-2 images of Arctic glaciers, with one optical image per glacier in the dataset. Additionally, we introduce a novel hybrid model architecture that combines a Swin Transformer encoder with a residual Convolutional Neural Network (CNN) decoder. When pretrained on SSL4SAR, this model achieves a mean distance error of 293 m on the "CAlving Fronts and where to Find thEm" (CaFFe) benchmark dataset, outperforming the prior best model by 67 m. Evaluating an ensemble of the proposed model on a multi-annotator study of the benchmark dataset reveals a mean distance error of 75 m, approaching the human performance of 38 m. This advancement enables precise monitoring of seasonal changes in glacier calving fronts.

Learning Encodings by Maximizing State Distinguishability: Variational Quantum Error Correction

Quantum error correction is crucial for protecting quantum information against decoherence. Traditional codes like the surface code require substantial overhead, making them impractical for near-term, early fault-tolerant devices. We propose a novel objective function for tailoring error correction codes to specific noise structures by maximizing the distinguishability between quantum states after a noise channel, ensuring efficient recovery operations. We formalize this concept with the distinguishability loss function, serving as a machine learning objective to discover resource-efficient encoding circuits optimized for given noise characteristics. We implement this methodology using variational techniques, termed variational quantum error correction (VarQEC). Our approach yields codes with desirable theoretical and practical properties and outperforms standard codes in various scenarios. We also provide proof-of-concept demonstrations on IBM and IQM hardware devices, highlighting the practical relevance of our procedure.

Unsupervised Clustering for Fault Analysis in High-Voltage Power Systems Using Voltage and Current Signals

The widespread use of sensors in modern power grids has led to the accumulation of large amounts of voltage and current waveform data, especially during fault events. However, the lack of labeled datasets poses a significant challenge for fault classification and analysis. This paper explores the application of unsupervised clustering techniques for fault diagnosis in high-voltage power systems. A dataset provided by the Reseau de Transport d'Electricite (RTE) is analyzed, with frequency domain features extracted using the Fast Fourier Transform (FFT). The K-Means algorithm is then applied to identify underlying patterns in the data, enabling automated fault categorization without the need for labeled training samples. The resulting clusters are evaluated in collaboration with power system experts to assess their alignment with real-world fault characteristics. The results demonstrate the potential of unsupervised learning for scalable and data-driven fault analysis, providing a robust approach to detecting and classifying power system faults with minimal prior assumptions.

Impact of Data Sparsity on Machine Learning for Fault Detection in Power System Protection

Germany's transition to a renewable energy-based power system is reshaping grid operations, requiring advanced monitoring and control to manage decentralized generation. Machine learning (ML) has emerged as a powerful tool for power system protection, particularly for fault detection (FD) and fault line identification (FLI) in transmission grids. However, ML model reliability depends on data quality and availability. Data sparsity resulting from sensor failures, communication disruptions, or reduced sampling rates poses a challenge to ML-based FD and FLI. Yet, its impact has not been systematically validated prior to this work. In response, we propose a framework to assess the impact of data sparsity on ML-based FD and FLI performance. We simulate realistic data sparsity scenarios, evaluate their impact, derive quantitative insights, and demonstrate the effectiveness of this evaluation strategy by applying it to an existing ML-based framework. Results show the ML model remains robust for FD, maintaining an F1-score of 0.999 $\pm$ 0.000 even after a 50x data reduction. In contrast, FLI is more sensitive, with performance decreasing by 55.61% for missing voltage measurements and 9.73% due to communication failures at critical network points. These findings offer actionable insights for optimizing ML models for real-world grid protection. This enables more efficient FD and supports targeted improvements in FLI.

Learning Wavelet-Sparse FDK for 3D Cone-Beam CT Reconstruction

Cone-Beam Computed Tomography (CBCT) is essential in medical imaging, and the Feldkamp-Davis-Kress (FDK) algorithm is a popular choice for reconstruction due to its efficiency. However, FDK is susceptible to noise and artifacts. While recent deep learning methods offer improved image quality, they often increase computational complexity and lack the interpretability of traditional methods. In this paper, we introduce an enhanced FDK-based neural network that maintains the classical algorithm's interpretability by selectively integrating trainable elements into the cosine weighting and filtering stages. Recognizing the challenge of a large parameter space inherent in 3D CBCT data, we leverage wavelet transformations to create sparse representations of the cosine weights and filters. This strategic sparsification reduces the parameter count by $93.75\%$ without compromising performance, accelerates convergence, and importantly, maintains the inference computational cost equivalent to the classical FDK algorithm. Our method not only ensures volumetric consistency and boosts robustness to noise, but is also designed for straightforward integration into existing CT reconstruction pipelines. This presents a pragmatic enhancement that can benefit clinical applications, particularly in environments with computational limitations.

VIViT: Variable-Input Vision Transformer Framework for 3D MR Image Segmentation

Self-supervised pretrain techniques have been widely used to improve the downstream tasks' performance. However, real-world magnetic resonance (MR) studies usually consist of different sets of contrasts due to different acquisition protocols, which poses challenges for the current deep learning methods on large-scale pretrain and different downstream tasks with different input requirements, since these methods typically require a fixed set of input modalities or, contrasts. To address this challenge, we propose variable-input ViT (VIViT), a transformer-based framework designed for self-supervised pretraining and segmentation finetuning for variable contrasts in each study. With this ability, our approach can maximize the data availability in pretrain, and can transfer the learned knowledge from pretrain to downstream tasks despite variations in input requirements. We validate our method on brain infarct and brain tumor segmentation, where our method outperforms current CNN and ViT-based models with a mean Dice score of 0.624 and 0.883 respectively. These results highlight the efficacy of our design for better adaptability and performance on tasks with real-world heterogeneous MR data.

Multi-Plane Vision Transformer for Hemorrhage Classification Using Axial and Sagittal MRI Data

Identifying brain hemorrhages from magnetic resonance imaging (MRI) is a critical task for healthcare professionals. The diverse nature of MRI acquisitions with varying contrasts and orientation introduce complexity in identifying hemorrhage using neural networks. For acquisitions with varying orientations, traditional methods often involve resampling images to a fixed plane, which can lead to information loss. To address this, we propose a 3D multi-plane vision transformer (MP-ViT) for hemorrhage classification with varying orientation data. It employs two separate transformer encoders for axial and sagittal contrasts, using cross-attention to integrate information across orientations. MP-ViT also includes a modality indication vector to provide missing contrast information to the model. The effectiveness of the proposed model is demonstrated with extensive experiments on real world clinical dataset consists of 10,084 training, 1,289 validation and 1,496 test subjects. MP-ViT achieved substantial improvement in area under the curve (AUC), outperforming the vision transformer (ViT) by 5.5% and CNN-based architectures by 1.8%. These results highlight the potential of MP-ViT in improving performance for hemorrhage detection when different orientation contrasts are needed.

Perceptual Implications of Automatic Anonymization in Pathological Speech

Automatic anonymization techniques are essential for ethical sharing of pathological speech data, yet their perceptual consequences remain understudied. This study presents the first comprehensive human-centered analysis of anonymized pathological speech, using a structured perceptual protocol involving ten native and non-native German listeners with diverse linguistic, clinical, and technical backgrounds. Listeners evaluated anonymized-original utterance pairs from 180 speakers spanning Cleft Lip and Palate, Dysarthria, Dysglossia, Dysphonia, and age-matched healthy controls. Speech was anonymized using state-of-the-art automatic methods (equal error rates in the range of 30-40%). Listeners completed Turing-style discrimination and quality rating tasks under zero-shot (single-exposure) and few-shot (repeated-exposure) conditions. Discrimination accuracy was high overall (91% zero-shot; 93% few-shot), but varied by disorder (repeated-measures ANOVA: p=0.007), ranging from 96% (Dysarthria) to 86% (Dysphonia). Anonymization consistently reduced perceived quality (from 83% to 59%, p<0.001), with pathology-specific degradation patterns (one-way ANOVA: p=0.005). Native listeners rated original speech slightly higher than non-native listeners (Delta=4%, p=0.199), but this difference nearly disappeared after anonymization (Delta=1%, p=0.724). No significant gender-based bias was observed. Critically, human perceptual outcomes did not correlate with automatic privacy or clinical utility metrics. These results underscore the need for listener-informed, disorder- and context-specific anonymization strategies that preserve privacy while maintaining interpretability, communicative functions, and diagnostic utility, especially for vulnerable populations such as children.