Just Ask for a Table: A Thirty-Token User Prompt Defeats Sponsored Recommendations in Twelve LLMs

Wu et al. (2026) showed that most frontier large language models (LLMs) recommend a sponsored, roughly twice-as-expensive flight when their system prompt contains a soft sponsorship cue. We reproduce their evaluation on ten open-weight chat models plus the two of their twenty-three models that are still reachable today (gpt-3.5-turbo, gpt-4o). All reported rates in this paper are produced under the same judge the original paper used (gpt-4o); we additionally store every label under an open-weight (gpt-oss-120b) and a smaller proprietary (gpt-4o-mini) judge for an ablation. Three findings emerge. First, a prose description of an LLM evaluation pipeline is not, on its own, sufficient for accurate reproduction: we surfaced three silent implementation failures that each shifted a reported rate by tens of percentage points. Second, the central claims do generalise - the gpt-3.5-turbo logistic-regression intercept of alpha = 0.81 is within four points of the original alpha = 0.86, and 200 of 200 trials on gpt-3.5-turbo and gpt-4o promote a payday lender to a financially distressed user. Third, a thirty-token user prompt that asks the assistant for a neutral comparison table first cuts sponsored recommendation from 46.9% to 1.0% averaged across our ten open-source models, and from 53.0% to 0% averaged across the two OpenAI models. AI literacy and price-comparison portals are likely market-level mitigations; the harmful-product cell is bounded by neither. Raw data, labels and analysis scripts are at https://github.com/akmaier/Paper-LLM-Ads .

Retina-RAG: Retrieval-Augmented Vision-Language Modeling for Joint Retinal Diagnosis and Clinical Report Generation

Diabetic Retinopathy (DR) is a leading cause of preventable blindness among working-age adults worldwide, yet most automated screening systems are limited to image-level classification and lack clinically structured reporting. We propose Retina-RAG, a low-cost modular framework that jointly performs DR severity grading, macular edema (ME) detection, and report generation. The architecture decouples a high-performance retinal classifier and a parameter-efficient vision-language model (Qwen2.5-VL-7B-Instruct) adapted via Low-Rank Adaptation (LoRA), enabling flexible component integration. A retrieval-augmented generation (RAG) module injects curated ophthalmic knowledge together with structured classifier outputs at inference time to improve diagnostic consistency and reduce hallucinations. Retina-RAG achieves an F1-score of 0.731 for DR grading and 0.948 for ME detection, substantially outperforming zero-shot Qwen (0.096, 0.732) and MMed-RAG (0.541, 0.641) on a retinal disease detection dataset with captions. For report generation, Retina-RAG attains ROUGE-L 0.429 and SBERT similarity 0.884, exceeding all baselines. The full framework operates on a single consumer-grade GPU, demonstrating that clinically structured retinal AI can be achieved with modest computational resources.

Safety and accuracy follow different scaling laws in clinical large language models

Clinical LLMs are often scaled by increasing model size, context length, retrieval complexity, or inference-time compute, with the implicit expectation that higher accuracy implies safer behavior. This assumption is incomplete in medicine, where a few confident, high-risk, or evidence-contradicting errors can matter more than average benchmark performance. We introduce SaFE-Scale, a framework for measuring how clinical LLM safety changes across model scale, evidence quality, retrieval strategy, context exposure, and inference-time compute. To instantiate this framework, we introduce RadSaFE-200, a Radiology Safety-Focused Evaluation benchmark of 200 multiple-choice questions with clinician-defined clean evidence, conflict evidence, and option-level labels for high-risk error, unsafe answer, and evidence contradiction. We evaluated 34 locally deployed LLMs across six deployment conditions: closed-book prompting (zero-shot), clean evidence, conflict evidence, standard RAG, agentic RAG, and max-context prompting. Clean evidence produced the strongest improvement, increasing mean accuracy from 73.5% to 94.1%, while reducing high-risk error from 12.0% to 2.6%, contradiction from 12.7% to 2.3%, and dangerous overconfidence from 8.0% to 1.6%. Standard RAG and agentic RAG did not reproduce this safety profile: agentic RAG improved accuracy over standard RAG and reduced contradiction, but high-risk error and dangerous overconfidence remained elevated. Max-context prompting increased latency without closing the safety gap, and additional inference-time compute produced only limited gains. Worst-case analysis showed that clinically consequential errors concentrated in a small subset of questions. Clinical LLM safety is therefore not a passive consequence of scaling, but a deployment property shaped by evidence quality, retrieval design, context construction, and collective failure behavior.

Disentangling Shared and Task-Specific Representations from Multi-Modal Clinical Data

Real-world clinical data is inherently multimodal, providing complementary evidence that mirrors the practical necessity of jointly assessing multiple related outcomes. Although multi-task learning can improve efficiency by sharing information across outcomes, existing approaches often fail to balance shared representation learning with outcome-specific modeling. Hard parameter sharing can trigger negative transfer when task gradients conflict, while flexible sharing may still entangle shared and task-specific signals. To address this, we propose a multi-task framework built on a unified Transformer for multimodal fusion, augmented with Orthogonal Task Decomposition (OrthTD) to split patient representations into shared and task-specific subspaces and impose a geometric orthogonality constraint to reduce redundancy and isolate task-specific signals. We evaluated OrthTD on a real-world cohort of 12,430 surgical patients for predicting four outcomes. OrthTD achieved average AUC (area under the receiver operating characteristic curve) of 87.5% and average AUPRC (area under the precision-recall curve) of 37.2%, consistently outperformed advanced tabular and multi-task methods. Notably, OrthTD achieves substantial gains in AUPRC, indicating superior performance in identifying rare events within imbalanced clinical data. These results suggest that enforcing non-redundant shared and task-specific representations can improve multi-outcome prediction from multimodal clinical data.

Beating the Style Detector: Three Hours of Agentic Research on the AI-Text Arms Race

Reproducing an empirical NLP study used to take weeks. Given the released data and a modern agentic-research harness, we redo every experiment of a recent ACL\,2026 study on personal-style post-editing of LLM drafts -- and add three new ones -- with the human investigator acting only as a reviewer-in-the-loop. We reproduce all seven preregistered hypotheses and recover the paper's headline correlation between perceived self-similarity and embedding-measured self-similarity to three decimal places ($r{=}{+}0.244$, $p{<}10^{-8}$, $n{=}648$). Under a leakage-free held-out protocol, GPT-5.5 and Claude\,Opus\,4.7 close $71$--$75\,\%$ of the style gap to the same-author ceiling on $324$ paired tasks, against $24\,\%$ for the human post-edit, and beat the human post-edit on $\sim$$80\,\%$ of tasks. We then frame the same data as an AI-text detection arms race. A leave-authors-out linear SVM on LUAR-MUD embeddings reaches AUC $0.93$--$1.00$ across approaches; six diagnostics show that GPT-5.5 detection is mostly a length confound while Opus detection is a genuine stylistic signature. Given $T{=}20$ feedback iterations against the frozen detector, an Opus agent flips two of five held-out test mimics to the human half-space and shrinks every margin by an order of magnitude. With moderate effort against a known detector, a frontier LLM can already efficiently lower its own AI-detection probability. All code, $648$ mimic drafts, trained detectors, diagnostics, and adversarial trajectories are released.

Generative Drifting for Conditional Medical Image Generation

Conditional medical image generation plays an important role in many clinically relevant imaging tasks. However, existing methods still face a fundamental challenge in balancing inference efficiency, patient-specific fidelity, and distribution-level plausibility, particularly in high-dimensional 3D medical imaging. In this work, we propose GDM, a generative drifting framework that reformulates deterministic medical image prediction as a multi-objective learning problem to jointly promote distribution-level plausibility and patient-specific fidelity while retaining one-step inference. GDM extends drifting to 3D medical imaging through an attractive-repulsive drift that minimizes the discrepancy between the generator pushforward and the target distribution. To enable stable drifting-based learning in 3D volumetric data, GDM constructs a multi-level feature bank from a medical foundation encoder to support reliable affinity estimation and drifting field computation across complementary global, local, and spatial representations. In addition, a gradient coordination strategy in the shared output space improves optimization balance under competing distribution-level and fidelity-oriented objectives. We evaluate the proposed framework on two representative tasks, MRI-to-CT synthesis and sparse-view CT reconstruction. Experimental results show that GDM consistently outperforms a wide range of baselines, including GAN-based, flow-matching-based, and SDE-based generative models, as well as supervised regression methods, while improving the balance among anatomical fidelity, quantitative reliability, perceptual realism, and inference efficiency. These findings suggest that GDM provides a practical and effective framework for conditional 3D medical image generation.

Biomedical systems biology workflow orchestration and execution with PoSyMed

The rapid growth of scientific software has created practical barriers for bioinformatics research. Although powerful statistical, artificial intelligence (AI)-based methods are now widely available, their effective use is often hindered by fragmented distribution, inconsistent documentation, complex dependencies, and difficult-to-reproduce execution environments. As a result, reusing published tools and workflow adaptation to own date remains technically demanding and time-intensive, even for experienced users. Here, we present PoSyMed, an open and modular platform for the controlled integration, composition, and execution of bioinformatics tools and workflows. PoSyMed combines a backend-centered platform architecture with formal tool descriptions, controlled container-based build and execution processes, persistent workflow state, and a dialogue-based user interface. Large language models (LLM) are integrated not as autonomous decision-makers, but as human-computer interface with bounded semantic assistants that help identify tools, propose workflow steps, and support parameterization within a typed, validated, and human-supervised execution environment. PoSyMed is designed to improve reproducibility, traceability, and transparency in practical biomedical analysis within one platform. We describe the system architecture and evaluate its behavior across representative biological software scenarios with respect to workflow support, interaction design, and platform extensibility. PoSyMed is publicly available at https://apps.cosy.bio/posymed.

ProtoCLIP: Prototype-Aligned Latent Refinement for Robust Zero-Shot Chest X-Ray Classification

Zero-shot vision-language models (VLMs) have shown promise for chest radiograph classification, but their performance is often limited by confounding label co-occurrence, long-tail class imbalance, and transfer instability under domain shift. We propose ProtoCLIP, a refinement strategy for CLIP-style VLMs that improves zero-shot discrimination through targeted data curation and distilled anchor alignment. Specifically, we construct pathology-focused training subsets with curated negative samples to reduce co-occurrence bias. We also introduce a representation-preserving distillation objective to stabilize adaptation while maintaining semantic structure and improving discrimination of clinically relevant co-occurring pathologies. Evaluated on an unseen dataset VinDr-CXR, ProtoCLIP improves AUC by 2-10 percentage points over a strong CLIP-based baseline across multiple findings. For pneumothorax specifically, ProtoCLIP achieves a state-of-the-art AUC of 0.94. These results demonstrate that anchor-guided refinement, coupled with curated supervision and controlled adaptation, can mitigate common zero-shot transfer failures in medical VLMs without requiring large-scale retraining.

Learning to Concatenate Quantum Codes

Concatenating quantum error correction codes scales error correction capability by driving logical error rates down double-exponentially across levels. However, the noise structure shifts under concatenation, making it hard to choose an optimal code sequence. We automate this choice by estimating the effective noise channel after each level and selecting the next code accordingly. In particular, we use learning-based methods to tailor small, non-additive encoders when the noise exhibits sufficient structure, then switch to standard codes once the noise is nearly uniform. In simulations, this level-wise adaptation achieves a target logical error rate with far fewer qubits than concatenating stabilizer codes alone--reducing qubit counts by up to two orders of magnitude for strongly structured noise. Therefore, this hybrid, learning-based strategy offers a promising tool for early fault-tolerant quantum computing.

Convergent Representations of Linguistic Constructions in Human and Artificial Neural Systems

Understanding how the brain processes linguistic constructions is a central challenge in cognitive neuroscience and linguistics. Recent computational studies show that artificial neural language models spontaneously develop differentiated representations of Argument Structure Constructions (ASCs), generating predictions about when and how construction-level information emerges during processing. The present study tests these predictions in human neural activity using electroencephalography (EEG). Ten native English speakers listened to 200 synthetically generated sentences across four construction types (transitive, ditransitive, caused-motion, resultative) while neural responses were recorded. Analyses using time-frequency methods, feature extraction, and machine learning classification revealed construction-specific neural signatures emerging primarily at sentence-final positions, where argument structure becomes fully disambiguated, and most prominently in the alpha band. Pairwise classification showed reliable differentiation, especially between ditransitive and resultative constructions, while other pairs overlapped. Crucially, the temporal emergence and similarity structure of these effects mirror patterns in recurrent and transformer-based language models, where constructional representations arise during integrative processing stages. These findings support the view that linguistic constructions are neurally encoded as distinct form-meaning mappings, in line with Construction Grammar, and suggest convergence between biological and artificial systems on similar representational solutions. More broadly, this convergence is consistent with the idea that learning systems discover stable regions within an underlying representational landscape - recently termed a Platonic representational space - that constrains the emergence of efficient linguistic abstractions.