CaresAI at CT-DEB26: Detecting Dosing Errors In Clinical Trials Using Domain-Specific Transformer Embeddings and Classification Models

Medication errors, particularly dosing errors in clinical trials (CT), can lead to patient harm, adverse drug events and worse patient outcomes. Dosing errors are preventable, and early identification can improve trial integrity and mitigate subsequent clinical and financial burden. This study aims to detect dosing errors within CT protocols by evaluating text representations of trial information using transformer-based language models trained on biomedical corpora. CT textual data was encoded using several models, including ClinicalBERT, PubMedBERT, BioBERT, and MedCPT, and integrated with categorical features. These text embeddings were used as input to classical machine learning models and neural network architectures within an experimental framework. Performance was primarily assessed using ROC-AUC with respect to predicting dosage error. Under a logistic regression baseline, BioBERT consistently outperformed alternative encoders, achieving an ROC-AUC of 0.794, a 3.95% improvement over the ClinicalBERT baseline. Combining multiple embeddings did not yield improvements, indicating that domain alignment outweighs representational stacking. Gradient boosting models, support vector classifiers, logistic regression, and residual neural networks achieved the strongest performance for predicting dosage error, achieving ROC-AUCs: 0.821 to 0.853. Overall, the integration of domain-specific transformer embeddings with structured metadata enables discrimination of trials meeting a predefined elevated dosing error risk criterion, advancing safety monitoring and supporting informed regulatory decision-making.

Exploring Motivations for Algorithm Mention in the Domain of Natural Language Processing: A Deep Learning Approach

With the rise of data-intensive science, algorithms have become central to scientific research. In academic papers, algorithms are mentioned for different purposes, such as describing, using, comparing, or improving methods for specific research tasks. Identifying these purposes can reveal relationships among algorithms and help assess their roles and value. Taking natural language processing (NLP) as an example, this study proposes a sentence-level framework for identifying, analyzing, and tracing the evolution of motivations for mentioning algorithms. We first identify algorithm entities and algorithm-related sentences from full-text papers through manual annotation and machine learning. We then classify mention motivations using pretrained models and data augmentation, and analyze their distribution and temporal evolution. The results show that deep learning models trained with augmented data outperform traditional machine learning models in motivation classification. In NLP papers, more than half of algorithm-related sentences express direct use, whereas improvement is the least frequent motivation. The diversity of motivations has increased over time. For specific algorithm categories, grammar-based algorithms are more often mentioned for description, while machine learning algorithms are more often mentioned for use. Over time, use motivations have gradually replaced description motivations across different algorithms, and the number of motivation types associated with individual algorithms has declined significantly. This study reveals how authors mention algorithm entities in academic writing and provides a basis for future research on algorithm relationship identification and algorithm impact evaluation.

How much of an LLM-generated clinical corpus is actually new? A production-scale measurement of content redundancy for provenance classification

Clinical machine learning increasingly relies on training corpora generated by large language models (LLMs) rather than annotated by clinicians, and such corpora are described and reused largely on the basis of their reported scale. We test whether volume reflects information content. Analysing the complete output of a multi-agent clinical extraction pipeline applied to 167,034 patient narratives, 2.51 billion generated tokens across the ten text-bearing channels of an eleven-channel pipeline, we introduce Provenance-based Redundancy Decomposition, a token-level classification of the entire output by source. Only 10.9% of the output is trainable-unique content while 79.4% is redundant; raw token count overstates information content by roughly ninefold. The redundancy arises through two distinct mechanisms, verbatim copying of source context into per-item fields, and duplication of generated text across records, of which only the former is losslessly removable. An independent, model-free analysis based on lossless compression confirms the redundancy, recovering the two mechanisms without reference to the provenance labels. One pipeline channel carries almost no redundancy, showing that the level of redundancy depends on how each channel is structured rather than being a fixed property of LLM extraction. Because uncorrected redundancy up-weights the longer, more complex presentations that generate the most items, it skews the token-level training distribution of the corpus, a property we measure directly. In a controlled downstream test, de-duplicating the corpus before adaptation improved a clinical encoder on external disease-recognition benchmarks at equal token budget, robustly across adaptation depths and replicated on a second benchmark, confirming that the redundancy carries a measurable cost beyond storage. The classification tool is released openly.

Class-frequency Guided Noise Schedule for Diffusion Models

In this paper, we are the first to examine the correlations between class frequency and the multi-scale noise schedule within diffusion models. For score-based generative models, low-density regions often lead to inaccurately estimated scores, thereby compromising the generation quality. Although the multi-scale noise schedule can alleviate this issue during the diffusion process, low-frequency classes still face the challenge of large low-density regions, resulting in more inaccurate estimated scores than high-frequency classes. Furthermore, high-frequency classes tend to dominate the score space, causing a convergence of most data points towards generating samples from these classes. Consequently, samples generated within low-frequency classes exhibit suboptimal quality and limited diversity. To address this challenge, we propose the \textit{Class-frequency Guided (CFRG)} noise schedule, leveraging the insight that low-frequency classes should be endowed with larger-scale noises. To illustrate the effectiveness of our method, we conduct experiments on various tasks, including image generation, image classification, and text-to-image generation, using imbalanced datasets, \textit{i.e.}, CIFAR-100-LT, and ImageNet-LT. By employing the CFRG noise schedule, we achieve substantial improvements over baselines, manifesting the crucial role of frequency statistics in noise schedule design.

Comparing BERT Sentence-Pair Classification and Few-Shot LLM Prompting for Detecting Threat and Solution Framing in German Climate News

News media play a central role in shaping public perceptions of climate change, and whether coverage emphasizes threats or solutions has measurable effects on audience engagement and policy support. Automated detection of these framing patterns at the sentence level would allow researchers to analyze large corpora that are infeasible to code manually. We present a systematic comparison of two approaches for classifying sentences from German-language climate news articles as threat-oriented, solution-oriented, both, or neither. The first approach uses few-shot prompting with an open-weights large language model (Llama 4 Maverick), employing chain-of-thought reasoning and structured output with confidence scoring. The second approach fine-tunes a German BERT model (deepset/gbert-large) for sentence-pair classification, where the preceding sentence provides contextual information for the target sentence. Both approaches implement two independent binary classifiers, one for threat framing and one for solution framing. We evaluate both methods on a corpus of 440 Austrian newspaper articles that were manually coded following a detailed coding scheme developed with domain experts. The fine-tuned BERT classifiers achieve an F1 score of 0.83 for both the threat and solution tasks, while the LLM-based classifiers reach an F1 of 0.78. An ablation study confirms that providing the preceding sentence as context improves BERT classification performance substantially compared to single-sentence input. These results contribute to the growing body of work comparing fine-tuned encoder models with prompted generative models for text classification in computational social science.

A Comparative Study on Affective Cues in Text Embeddings Across Psychological Emotion Theories

Text encoders are known for their utility in natural language processing, as they are able to efficiently compress inputs into dense vectors while preserving semantics. These models have been applied to affective computing, in particular to help with solving sentiment analysis and emotion recognition tasks. Nevertheless, it remains unclear to what extent the latent representations produced by modern text encoders capture well-defined psychological theories of affect. In this work, we investigate the affective capabilities of twelve recently released text encoders by probing their generated embeddings as input features for solving regression and classification tasks across three established emotion frameworks, using both word- and sentence-level data. Additionally, we apply a semantic data-leakage prevention technique to improve robustness in word-level evaluations. Our main findings show that the latent manifolds of the latest instruction-aware open-weight encoders enclose an equal or even a larger amount of affective information in comparison with proprietary counterparts when evaluated at word level. In contrast, embeddings of task-tuned and proprietary encoders reach the highest scores on sentence-level affective classification. Furthermore, a qualitative analysis of latent representations and their encoded affective cues is provided.

Estimating Uncertainty in Classifier Performance with Applications to Large Language Models and Nested Data

Researchers increasingly use text classification--supervised models or large language models--to measure constructs from natural language, providing metrics such as recall and precision as evidence of their validity. Yet, though these metrics are point estimates subject to sampling variation, measures of uncertainty are inconsistently reported alongside them. Further, when they are reported, they are often estimated with methods that are not appropriate when relevant labelled datasets are small or performance is high. To increase and improve confidence interval reporting in the field, this paper evaluates confidence interval methods for performance metrics under conditions typical of social science text classification: small to moderate sample sizes, infrequent constructs, and texts nested within individuals. Across simulations, default methods such as the Wald interval and the basic percentile bootstrap are the least accurate, with coverage sometimes far below the nominal 95% level. Accuracy is improved with the use of Agresti-Coull, Wilson, Clopper-Pearson, and a novel pseudo-count regularized bootstrap (which is particularly relevant to the calculation of F1). When texts are nested within individuals, we demonstrate that adjustment for both effective N and the appropriate degrees of freedom is necessary for producing accurate analytic intervals. Among bootstrap intervals, the hierarchical bootstrap is more accurate than the cluster bootstrap when individuals produce a moderate number of texts but overly conservative when individuals produce only a few. By providing guidance to the field on appropriate interval estimation, we aim to improve the transparency of machine learning applications, and to encourage greater attention to the validation sample size at the design stage.

Robust Zero-shot Anomaly Detection under Limited Auxiliary Anomaly Priors

Zero-shot anomaly detection aims to identify defects in arbitrary novel domains; however, existing models assume that the auxiliary data contains a rich diversity of anomalies, neglecting the far more complex and unpredictable variations in real-world target domains. This study introduces DIVE, the first approach to investigate the scenario of limited auxiliary anomaly priors and resolve the resulting substantial performance degradation. Through a shallow-and-deep text embedding injection strategy during visual encoding, DIVE learns to abstract generic anomaly concepts shared across the auxiliary training domain and diverse target domains. Moreover, we propose a disentanglement mechanism to tackle the suboptimal alignment between visual embeddings entangled with object semantics and object-agnostic textual prompts. Experiments demonstrate that, under the setting of limited anomaly patterns in auxiliary data, DIVE outperforms SOTA baselines by up to 16.2% and 28.5% on two classification metrics, and 23.4%, 24.1%, and 47.0% on three segmentation metrics, in terms of average performance across twelve datasets. Furthermore, it maintains highly competitive performance when auxiliary data exhibits sufficient anomaly diversity.

Learning Moral Diversity: Modelling Individual Perspectives in Moral Classification of Texts

Understanding moral values in social media text offers insight into moral judgement formation, and supervised NLP models trained on crowdsourced data have achieved strong classification performance. However, most approaches simplify the problem by aggregating multiple annotators' labels into a single "ground truth", overlooking the inherent subjectivity of the task. In practice, there are disagreements between annotators caused by personal viewpoint or inherent ambiguities, particularly for short tweets. Here, we extend a pretrained language model with a layer that learns annotator-specific features. Our model improves predictions of individual annotations and yields representations that reveal meaningful insights into annotators' moral perspectives. We show that models trained on aggregated labels may hide variation and give a misleading impression of performance. Overall, we demonstrate that disagreement reflects the inherent subjectivity of the task and that modelling individual perspectives creates benefits for moral classification of texts.

AnySimLite: A Lightweight Few-Shot Similarity Encoder for On-Device Speech-Adjacent Classification

To minimize privacy concerns and inference latency on edge devices like smartphones, lightweight on-device models remain important for end-user applications. Many of these applications involve natural language classification, but deploying multiple specialized models creates a memory footprint challenge. We investigate: Can a single lightweight architecture solve multiple Speech-Adjacent (SA) classification tasks through reduction to a nuanced text similarity formulation? We propose AnySimLite, a lightweight similarity encoder that combines word-level and character-level channels. Together with a dataset transformation strategy, we evaluate AnySimLite across multiple SA classification tasks and show that it consistently achieves state-of-the-art (SOTA) or SOTA-competitive performance in few-shot settings while maintaining a low memory footprint. Even in the worst case, the performance drop remains below 7% while using $<\frac{1}{250}^{\mathrm{th}}$ of the model size of the SOTA qLLaMA_LoRA-7B baseline.