Quantum-Inspired Geometric Classification with Correlation Group Structures and VQC Decision Modeling

We propose a geometry-driven quantum-inspired classification framework that integrates Correlation Group Structures (CGR), compact SWAP-test-based overlap estimation, and selective variational quantum decision modelling. Rather than directly approximating class posteriors, the method adopts a geometry-first paradigm in which samples are evaluated relative to class medoids using overlap-derived Euclidean-like and angular similarity channels. CGR organizes features into anchor-centered correlation neighbourhoods, generating nonlinear, correlation-weighted representations that enhance robustness in heterogeneous tabular spaces. These geometric signals are fused through a non-probabilistic margin-based fusion score, serving as a lightweight and data-efficient primary classifier for small-to-moderate datasets. On Heart Disease, Breast Cancer, and Wine Quality datasets, the fusion-score classifier achieves 0.8478, 0.8881, and 0.9556 test accuracy respectively, with macro-F1 scores of 0.8463, 0.8703, and 0.9522, demonstrating competitive and stable performance relative to classical baselines. For large-scale and highly imbalanced regimes, we construct compact Delta-distance contrastive features and train a variational quantum classifier (VQC) as a nonlinear refinement layer. On the Credit Card Fraud dataset (0.17% prevalence), the Delta + VQC pipeline achieves approximately 0.85 minority recall at an alert rate of approximately 1.31%, with ROC-AUC 0.9249 and PR-AUC 0.3251 under full-dataset evaluation. These results highlight the importance of operating-point-aware assessment in rare-event detection and demonstrate that the proposed hybrid geometric-variational framework provides interpretable, scalable, and regime-adaptive classification across heterogeneous data settings.

Detection and Classification of (Pre)Cancerous Cells in Pap Smears: An Ensemble Strategy for the RIVA Cervical Cytology Challenge

Automated detection and classification of cervical cells in conventional Pap smear images can strengthen cervical cancer screening at scale by reducing manual workload, improving triage, and increasing consistency across readers. However, it is challenged by severe class imbalance and frequent nuclear overlap. We present our approach to the RIVA Cervical Cytology Challenge (ISBI 2026), which requires multi-class detection of eight Bethesda cell categories under these conditions. Using YOLOv11m as the base architecture, we systematically evaluate three strategies to improve detection performance: loss reweighting, data resampling and transfer learning. We build an ensemble by combining models trained under each strategy, promoting complementary detection behavior and combining them through Weighted Boxes Fusion (WBF). The ensemble achieves a mAP50-95 of 0.201 on the preliminary test set and 0.147 on the final test set, representing a 29% improvement over the best individual model on the final test set and demonstrating the effectiveness of combining complementary imbalance mitigation strategies.

Interpretable Prostate Cancer Detection using a Small Cohort of MRI Images

Prostate cancer is a leading cause of mortality in men, yet interpretation of T2-weighted prostate MRI remains challenging due to subtle and heterogeneous lesions. We developed an interpretable framework for automatic cancer detection using a small dataset of 162 T2-weighted images (102 cancer, 60 normal), addressing data scarcity through transfer learning and augmentation. We performed a comprehensive comparison of Vision Transformers (ViT, Swin), CNNs (ResNet18), and classical methods (Logistic Regression, SVM, HOG+SVM). Transfer-learned ResNet18 achieved the best performance (90.9% accuracy, 95.2% sensitivity, AUC 0.905) with only 11M parameters, while Vision Transformers showed lower performance despite substantially higher complexity. Notably, HOG+SVM achieved comparable accuracy (AUC 0.917), highlighting the effectiveness of handcrafted features in small datasets. Unlike state-of-the-art approaches relying on biparametric MRI (T2+DWI) and large cohorts, our method achieves competitive performance using only T2-weighted images, reducing acquisition complexity and computational cost. In a reader study of 22 cases, five radiologists achieved a mean sensitivity of 67.5% (Fleiss Kappa = 0.524), compared to 95.2% for the AI model, suggesting potential for AI-assisted screening to reduce missed cancers and improve consistency. Code and data are publicly available.

Colon-Bench: An Agentic Workflow for Scalable Dense Lesion Annotation in Full-Procedure Colonoscopy Videos

Early screening via colonoscopy is critical for colon cancer prevention, yet developing robust AI systems for this domain is hindered by the lack of densely annotated, long-sequence video datasets. Existing datasets predominantly focus on single-class polyp detection and lack the rich spatial, temporal, and linguistic annotations required to evaluate modern Multimodal Large Language Models (MLLMs). To address this critical gap, we introduce Colon-Bench, generated via a novel multi-stage agentic workflow. Our pipeline seamlessly integrates temporal proposals, bounding-box tracking, AI-driven visual confirmation, and human-in-the-loop review to scalably annotate full-procedure videos. The resulting verified benchmark is unprecedented in scope, encompassing 528 videos, 14 distinct lesion categories (including polyps, ulcers, and bleeding), over 300,000 bounding boxes, 213,000 segmentation masks, and 133,000 words of clinical descriptions. We utilize Colon-Bench to rigorously evaluate state-of-the-art MLLMs across lesion classification, Open-Vocabulary Video Object Segmentation (OV-VOS), and video Visual Question Answering (VQA). The MLLM results demonstrate surprisingly high localization performance in medical domains compared to SAM-3. Finally, we analyze common VQA errors from MLLMs to introduce a novel "colon-skill" prompting strategy, improving zero-shot MLLM performance by up to 9.7% across most MLLMs. The dataset and the code are available at https://abdullahamdi.com/colon-bench .

Novel Architecture of RPA In Oral Cancer Lesion Detection

Accurate and early detection of oral cancer lesions is crucial for effective diagnosis and treatment. This study evaluates two RPA implementations, OC-RPAv1 and OC-RPAv2, using a test set of 31 images. OC-RPAv1 processes one image per prediction in an average of 0.29 seconds, while OCRPAv2 employs a Singleton design pattern and batch processing, reducing prediction time to just 0.06 seconds per image. This represents a 60-100x efficiency improvement over standard RPA methods, showcasing that design patterns and batch processing can enhance scalability and reduce costs in oral cancer detection

First-Mover Bias in Gradient Boosting Explanations: Mechanism, Detection, and Resolution

We isolate and empirically characterize first-mover bias -- a path-dependent concentration of feature importance caused by sequential residual fitting in gradient boosting -- as a specific mechanistic cause of the well-known instability of SHAP-based feature rankings under multicollinearity. When correlated features compete for early splits, gradient boosting creates a self-reinforcing advantage for whichever feature is selected first: subsequent trees inherit modified residuals that favor the incumbent, concentrating SHAP importance on an arbitrary feature rather than distributing it across the correlated group. Scaling up a single model amplifies this effect -- a Large Single Model with the same total tree count as our method produces the worst explanations of any approach tested. We demonstrate that model independence is sufficient to resolve first-mover bias in the linear regime, and remains the most effective mitigation under nonlinear data-generating processes. Both our proposed method, DASH (Diversified Aggregation of SHAP), and simple seed-averaging (Stochastic Retrain) restore stability by breaking the sequential dependency chain, confirming that the operative mechanism is independence between explained models. At rho=0.9, both achieve stability=0.977, while the single-best workflow degrades to 0.958 and the Large Single Model to 0.938. On the Breast Cancer dataset, DASH improves stability from 0.32 to 0.93 (+0.61) against a tree-count-matched baseline. DASH additionally provides two diagnostic tools -- the Feature Stability Index (FSI) and Importance-Stability (IS) Plot -- that detect first-mover bias without ground truth, enabling practitioners to audit explanation reliability before acting on feature rankings. Software and reproducible benchmarks are available at https://github.com/DrakeCaraker/dash-shap.

Automated Detection of Malignant Lesions in the Ovary Using Deep Learning Models and XAI

The unrestrained proliferation of cells that are malignant in nature is cancer. In recent times, medical professionals are constantly acquiring enhanced diagnostic and treatment abilities by implementing deep learning models to analyze medical data for better clinical decision, disease diagnosis and drug discovery. A majority of cancers are studied and treated by incorporating these technologies. However, ovarian cancer remains a dilemma as it has inaccurate non-invasive detection procedures and a time consuming, invasive procedure for accurate detection. Thus, in this research, several Convolutional Neural Networks such as LeNet-5, ResNet, VGGNet and GoogLeNet/Inception have been utilized to develop 15 variants and choose a model that accurately detects and identifies ovarian cancer. For effective model training, the dataset OvarianCancer&SubtypesDatasetHistopathology from Mendeley has been used. After constructing a model, we utilized Explainable Artificial Intelligence (XAI) models such as LIME, Integrated Gradients and SHAP to explain the black box outcome of the selected model. For evaluating the performance of the model, Accuracy, Precision, Recall, F1-Score, ROC Curve and AUC have been used. From the evaluation, it was seen that the slightly compact InceptionV3 model with ReLu had the overall best result achieving an average score of 94% across all the performance metrics in the augmented dataset. Lastly for XAI, the three aforementioned XAI have been used for an overall comparative analysis. It is the aim of this research that the contributions of the study will help in achieving a better detection method for ovarian cancer.

Synthetic Melanoma Image Generation and Evaluation Using Generative Adversarial Networks

Melanoma is the most lethal form of skin cancer, and early detection is critical for improving patient outcomes. Although dermoscopy combined with deep learning has advanced automated skin-lesion analysis, progress is hindered by limited access to large, well-annotated datasets and by severe class imbalance, where melanoma images are substantially underrepresented. To address these challenges, we present the first systematic benchmarking study comparing four GAN architectures-DCGAN, StyleGAN2, and two StyleGAN3 variants (T/R)-for high-resolution melanoma-specific synthesis. We train and optimize all models on two expert-annotated benchmarks (ISIC 2018 and ISIC 2020) under unified preprocessing and hyperparameter exploration, with particular attention to R1 regularization tuning. Image quality is assessed through a multi-faceted protocol combining distribution-level metrics (FID), sample-level representativeness (FMD), qualitative dermoscopic inspection, downstream classification with a frozen EfficientNet-based melanoma detector, and independent evaluation by two board-certified dermatologists. StyleGAN2 achieves the best balance of quantitative performance and perceptual quality, attaining FID scores of 24.8 (ISIC 2018) and 7.96 (ISIC 2020) at gamma=0.8. The frozen classifier recognizes 83% of StyleGAN2-generated images as melanoma, while dermatologists distinguish synthetic from real images at only 66.5% accuracy (chance = 50%), with low inter-rater agreement (kappa = 0.17). In a controlled augmentation experiment, adding synthetic melanoma images to address class imbalance improved melanoma detection AUC from 0.925 to 0.945 on a held-out real-image test set. These findings demonstrate that StyleGAN2-generated melanoma images preserve diagnostically relevant features and can provide a measurable benefit for mitigating class imbalance in melanoma-focused machine learning pipelines.

A Computer-aided Framework for Detecting Osteosarcoma in Computed Tomography Scans

Osteosarcoma is the most common primary bone cancer, mainly affecting the youngest and oldest populations. Its detection at early stages is crucial to reduce the probability of developing bone metastasis. In this context, accurate and fast diagnosis is essential to help physicians during the prognosis process. The research goal is to automate the diagnosis of osteosarcoma through a pipeline that includes the preprocessing, detection, postprocessing, and visualization of computed tomography (CT) scans. Thus, this paper presents a machine learning and visualization framework for classifying CT scans using different convolutional neural network (CNN) models. Preprocessing includes data augmentation and identification of the region of interest in scans. Post-processing includes data visualization to render a 3D bone model that highlights the affected area. An evaluation on 12 patients revealed the effectiveness of our framework, obtaining an area under the curve (AUC) of 94.8\% and a specificity of 94.6\%.

A Lightweight Multi-Cancer Tumor Localization Framework for Deployable Digital Pathology

Accurate localization of tumor regions from hematoxylin and eosin-stained whole-slide images is fundamental for translational research including spatial analysis, molecular profiling, and tissue architecture investigation. However, deep learning-based tumor detection trained within specific cancers may exhibit reduced robustness when applied across different tumor types. We investigated whether balanced training across cancers at modest scale can achieve high performance and generalize to unseen tumor types. A multi-cancer tumor localization model (MuCTaL) was trained on 79,984 non-overlapping tiles from four cancers (melanoma, hepatocellular carcinoma, colorectal cancer, and non-small cell lung cancer) using transfer learning with DenseNet169. The model achieved a tile-level ROC-AUC of 0.97 in validation data from the four training cancers, and 0.71 on an independent pancreatic ductal adenocarcinoma cohort. A scalable inference workflow was built to generate spatial tumor probability heatmaps compatible with existing digital pathology tools. Code and models are publicly available at https://github.com/AivaraX-AI/MuCTaL.