Comparative Evaluation of Deep Learning-Based and WHO-Informed Approaches for Sperm Morphology Assessment

Assessment of sperm morphological quality remains a critical yet subjective component of male fertility evaluation, often limited by inter-observer variability and resource constraints. This study presents a comparative biomedical artificial intelligence framework evaluating an image-based deep learning model (HuSHeM) alongside a clinically grounded baseline derived from World Health Organization criteria augmented with the Systemic Inflammation Response Index (WHO(+SIRI)). The HuSHeM model was trained on high-resolution sperm morphology images and evaluated using an independent clinical cohort. Model performance was assessed using discrimination, calibration, and clinical utility analyses. The HuSHeM model demonstrated higher discriminative performance, as reflected by an increased area under the receiver operating characteristic curve with relatively narrow confidence intervals compared to WHO(+SIRI). Precision-recall analysis further indicated improved performance under class imbalance, with higher precision-recall area values across evaluated thresholds. Calibration analysis indicated closer agreement between predicted probabilities and observed outcomes for HuSHeM, while decision curve analysis suggested greater net clinical benefit across clinically relevant threshold probabilities. These findings suggest that image-based deep learning may offer improved predictive reliability and clinical utility compared with traditional rule-based and inflammation-augmented criteria. The proposed framework supports objective and reproducible assessment of sperm morphology and may serve as a decision-support tool within fertility screening and referral workflows. The proposed models are intended as decision-support or referral tools and are not designed to replace clinical judgment or laboratory assessment.

Interpretable Deep Transfer Learning for Breast Ultrasound Cancer Detection: A Multi-Dataset Study

Breast cancer remains a leading cause of cancer-related mortality among women worldwide. Ultrasound imaging, widely used due to its safety and cost-effectiveness, plays a key role in early detection, especially in patients with dense breast tissue. This paper presents a comprehensive study on the application of machine learning and deep learning techniques for breast cancer classification using ultrasound images. Using datasets such as BUSI, BUS-BRA, and BrEaST-Lesions USG, we evaluate classical machine learning models (SVM, KNN) and deep convolutional neural networks (ResNet-18, EfficientNet-B0, GoogLeNet). Experimental results show that ResNet-18 achieves the highest accuracy (99.7%) and perfect sensitivity for malignant lesions. Classical ML models, though outperformed by CNNs, achieve competitive performance when enhanced with deep feature extraction. Grad-CAM visualizations further improve model transparency by highlighting diagnostically relevant image regions. These findings support the integration of AI-based diagnostic tools into clinical workflows and demonstrate the feasibility of deploying high-performing, interpretable systems for ultrasound-based breast cancer detection.