Path and Bone-Contour Regularized Unpaired MRI-to-CT Translation

Accurate MRI-to-CT translation promises the integration of complementary imaging information without the need for additional imaging sessions. Given the practical challenges associated with acquiring paired MRI and CT scans, the development of robust methods capable of leveraging unpaired datasets is essential for advancing the MRI-to-CT translation. Current unpaired MRI-to-CT translation methods, which predominantly rely on cycle consistency and contrastive learning frameworks, frequently encounter challenges in accurately translating anatomical features that are highly discernible on CT but less distinguishable on MRI, such as bone structures. This limitation renders these approaches less suitable for applications in radiation therapy, where precise bone representation is essential for accurate treatment planning. To address this challenge, we propose a path- and bone-contour regularized approach for unpaired MRI-to-CT translation. In our method, MRI and CT images are projected to a shared latent space, where the MRI-to-CT mapping is modeled as a continuous flow governed by neural ordinary differential equations. The optimal mapping is obtained by minimizing the transition path length of the flow. To enhance the accuracy of translated bone structures, we introduce a trainable neural network to generate bone contours from MRI and implement mechanisms to directly and indirectly encourage the model to focus on bone contours and their adjacent regions. Evaluations conducted on three datasets demonstrate that our method outperforms existing unpaired MRI-to-CT translation approaches, achieving lower overall error rates. Moreover, in a downstream bone segmentation task, our approach exhibits superior performance in preserving the fidelity of bone structures. Our code is available at: https://github.com/kennysyp/PaBoT.

A Deep Learning-Driven Inhalation Injury Grading Assistant Using Bronchoscopy Images

Inhalation injuries present a challenge in clinical diagnosis and grading due to Conventional grading methods such as the Abbreviated Injury Score (AIS) being subjective and lacking robust correlation with clinical parameters like mechanical ventilation duration and patient mortality. This study introduces a novel deep learning-based diagnosis assistant tool for grading inhalation injuries using bronchoscopy images to overcome subjective variability and enhance consistency in severity assessment. Our approach leverages data augmentation techniques, including graphic transformations, Contrastive Unpaired Translation (CUT), and CycleGAN, to address the scarcity of medical imaging data. We evaluate the classification performance of two deep learning models, GoogLeNet and Vision Transformer (ViT), across a dataset significantly expanded through these augmentation methods. The results demonstrate GoogLeNet combined with CUT as the most effective configuration for grading inhalation injuries through bronchoscopy images and achieves a classification accuracy of 97.8%. The histograms and frequency analysis evaluations reveal variations caused by the augmentation CUT with distribution changes in the histogram and texture details of the frequency spectrum. PCA visualizations underscore the CUT substantially enhances class separability in the feature space. Moreover, Grad-CAM analyses provide insight into the decision-making process; mean intensity for CUT heatmaps is 119.6, which significantly exceeds 98.8 of the original datasets. Our proposed tool leverages mechanical ventilation periods as a novel grading standard, providing comprehensive diagnostic support.

Visual Perturbation and Adaptive Hard Negative Contrastive Learning for Compositional Reasoning in Vision-Language Models

Vision-Language Models (VLMs) are essential for multimodal tasks, especially compositional reasoning (CR) tasks, which require distinguishing fine-grained semantic differences between visual and textual embeddings. However, existing methods primarily fine-tune the model by generating text-based hard negative samples, neglecting the importance of image-based negative samples, which results in insufficient training of the visual encoder and ultimately impacts the overall performance of the model. Moreover, negative samples are typically treated uniformly, without considering their difficulty levels, and the alignment of positive samples is insufficient, which leads to challenges in aligning difficult sample pairs. To address these issues, we propose Adaptive Hard Negative Perturbation Learning (AHNPL). AHNPL translates text-based hard negatives into the visual domain to generate semantically disturbed image-based negatives for training the model, thereby enhancing its overall performance. AHNPL also introduces a contrastive learning approach using a multimodal hard negative loss to improve the model's discrimination of hard negatives within each modality and a dynamic margin loss that adjusts the contrastive margin according to sample difficulty to enhance the distinction of challenging sample pairs. Experiments on three public datasets demonstrate that our method effectively boosts VLMs' performance on complex CR tasks. The source code is available at https://github.com/nynu-BDAI/AHNPL.

MAGIC: Motion-Aware Generative Inference via Confidence-Guided LLM

Recent advances in static 3D generation have intensified the demand for physically consistent dynamic 3D content. However, existing video generation models, including diffusion-based methods, often prioritize visual realism while neglecting physical plausibility, resulting in implausible object dynamics. Prior approaches for physics-aware dynamic generation typically rely on large-scale annotated datasets or extensive model fine-tuning, which imposes significant computational and data collection burdens and limits scalability across scenarios. To address these challenges, we present MAGIC, a training-free framework for single-image physical property inference and dynamic generation, integrating pretrained image-to-video diffusion models with iterative LLM-based reasoning. Our framework generates motion-rich videos from a static image and closes the visual-to-physical gap through a confidence-driven LLM feedback loop that adaptively steers the diffusion model toward physics-relevant motion. To translate visual dynamics into controllable physical behavior, we further introduce a differentiable MPM simulator operating directly on 3D Gaussians reconstructed from the single image, enabling physically grounded, simulation-ready outputs without any supervision or model tuning. Experiments show that MAGIC outperforms existing physics-aware generative methods in inference accuracy and achieves greater temporal coherence than state-of-the-art video diffusion models.

DragNeXt: Rethinking Drag-Based Image Editing

Drag-Based Image Editing (DBIE), which allows users to manipulate images by directly dragging objects within them, has recently attracted much attention from the community. However, it faces two key challenges: (\emph{\textcolor{magenta}{i}}) point-based drag is often highly ambiguous and difficult to align with users' intentions; (\emph{\textcolor{magenta}{ii}}) current DBIE methods primarily rely on alternating between motion supervision and point tracking, which is not only cumbersome but also fails to produce high-quality results. These limitations motivate us to explore DBIE from a new perspective -- redefining it as deformation, rotation, and translation of user-specified handle regions. Thereby, by requiring users to explicitly specify both drag areas and types, we can effectively address the ambiguity issue. Furthermore, we propose a simple-yet-effective editing framework, dubbed \textcolor{SkyBlue}{\textbf{DragNeXt}}. It unifies DBIE as a Latent Region Optimization (LRO) problem and solves it through Progressive Backward Self-Intervention (PBSI), simplifying the overall procedure of DBIE while further enhancing quality by fully leveraging region-level structure information and progressive guidance from intermediate drag states. We validate \textcolor{SkyBlue}{\textbf{DragNeXt}} on our NextBench, and extensive experiments demonstrate that our proposed method can significantly outperform existing approaches. Code will be released on github.

The Moon's Many Faces: A Single Unified Transformer for Multimodal Lunar Reconstruction

Multimodal learning is an emerging research topic across multiple disciplines but has rarely been applied to planetary science. In this contribution, we identify that reflectance parameter estimation and image-based 3D reconstruction of lunar images can be formulated as a multimodal learning problem. We propose a single, unified transformer architecture trained to learn shared representations between multiple sources like grayscale images, digital elevation models, surface normals, and albedo maps. The architecture supports flexible translation from any input modality to any target modality. Predicting DEMs and albedo maps from grayscale images simultaneously solves the task of 3D reconstruction of planetary surfaces and disentangles photometric parameters and height information. Our results demonstrate that our foundation model learns physically plausible relations across these four modalities. Adding more input modalities in the future will enable tasks such as photometric normalization and co-registration.

PathBench: A comprehensive comparison benchmark for pathology foundation models towards precision oncology

The emergence of pathology foundation models has revolutionized computational histopathology, enabling highly accurate, generalized whole-slide image analysis for improved cancer diagnosis, and prognosis assessment. While these models show remarkable potential across cancer diagnostics and prognostics, their clinical translation faces critical challenges including variability in optimal model across cancer types, potential data leakage in evaluation, and lack of standardized benchmarks. Without rigorous, unbiased evaluation, even the most advanced PFMs risk remaining confined to research settings, delaying their life-saving applications. Existing benchmarking efforts remain limited by narrow cancer-type focus, potential pretraining data overlaps, or incomplete task coverage. We present PathBench, the first comprehensive benchmark addressing these gaps through: multi-center in-hourse datasets spanning common cancers with rigorous leakage prevention, evaluation across the full clinical spectrum from diagnosis to prognosis, and an automated leaderboard system for continuous model assessment. Our framework incorporates large-scale data, enabling objective comparison of PFMs while reflecting real-world clinical complexity. All evaluation data comes from private medical providers, with strict exclusion of any pretraining usage to avoid data leakage risks. We have collected 15,888 WSIs from 8,549 patients across 10 hospitals, encompassing over 64 diagnosis and prognosis tasks. Currently, our evaluation of 19 PFMs shows that Virchow2 and H-Optimus-1 are the most effective models overall. This work provides researchers with a robust platform for model development and offers clinicians actionable insights into PFM performance across diverse clinical scenarios, ultimately accelerating the translation of these transformative technologies into routine pathology practice.

TopicVD: A Topic-Based Dataset of Video-Guided Multimodal Machine Translation for Documentaries

Most existing multimodal machine translation (MMT) datasets are predominantly composed of static images or short video clips, lacking extensive video data across diverse domains and topics. As a result, they fail to meet the demands of real-world MMT tasks, such as documentary translation. In this study, we developed TopicVD, a topic-based dataset for video-supported multimodal machine translation of documentaries, aiming to advance research in this field. We collected video-subtitle pairs from documentaries and categorized them into eight topics, such as economy and nature, to facilitate research on domain adaptation in video-guided MMT. Additionally, we preserved their contextual information to support research on leveraging the global context of documentaries in video-guided MMT. To better capture the shared semantics between text and video, we propose an MMT model based on a cross-modal bidirectional attention module. Extensive experiments on the TopicVD dataset demonstrate that visual information consistently improves the performance of the NMT model in documentary translation. However, the MMT model's performance significantly declines in out-of-domain scenarios, highlighting the need for effective domain adaptation methods. Additionally, experiments demonstrate that global context can effectively improve translation performance. % Dataset and our implementations are available at https://github.com/JinzeLv/TopicVD

Multimodal Spatial Language Maps for Robot Navigation and Manipulation

Grounding language to a navigating agent's observations can leverage pretrained multimodal foundation models to match perceptions to object or event descriptions. However, previous approaches remain disconnected from environment mapping, lack the spatial precision of geometric maps, or neglect additional modality information beyond vision. To address this, we propose multimodal spatial language maps as a spatial map representation that fuses pretrained multimodal features with a 3D reconstruction of the environment. We build these maps autonomously using standard exploration. We present two instances of our maps, which are visual-language maps (VLMaps) and their extension to audio-visual-language maps (AVLMaps) obtained by adding audio information. When combined with large language models (LLMs), VLMaps can (i) translate natural language commands into open-vocabulary spatial goals (e.g., "in between the sofa and TV") directly localized in the map, and (ii) be shared across different robot embodiments to generate tailored obstacle maps on demand. Building upon the capabilities above, AVLMaps extend VLMaps by introducing a unified 3D spatial representation integrating audio, visual, and language cues through the fusion of features from pretrained multimodal foundation models. This enables robots to ground multimodal goal queries (e.g., text, images, or audio snippets) to spatial locations for navigation. Additionally, the incorporation of diverse sensory inputs significantly enhances goal disambiguation in ambiguous environments. Experiments in simulation and real-world settings demonstrate that our multimodal spatial language maps enable zero-shot spatial and multimodal goal navigation and improve recall by 50% in ambiguous scenarios. These capabilities extend to mobile robots and tabletop manipulators, supporting navigation and interaction guided by visual, audio, and spatial cues.

Adaptive Spatial Augmentation for Semi-supervised Semantic Segmentation

In semi-supervised semantic segmentation (SSSS), data augmentation plays a crucial role in the weak-to-strong consistency regularization framework, as it enhances diversity and improves model generalization. Recent strong augmentation methods have primarily focused on intensity-based perturbations, which have minimal impact on the semantic masks. In contrast, spatial augmentations like translation and rotation have long been acknowledged for their effectiveness in supervised semantic segmentation tasks, but they are often ignored in SSSS. In this work, we demonstrate that spatial augmentation can also contribute to model training in SSSS, despite generating inconsistent masks between the weak and strong augmentations. Furthermore, recognizing the variability among images, we propose an adaptive augmentation strategy that dynamically adjusts the augmentation for each instance based on entropy. Extensive experiments show that our proposed Adaptive Spatial Augmentation (\textbf{ASAug}) can be integrated as a pluggable module, consistently improving the performance of existing methods and achieving state-of-the-art results on benchmark datasets such as PASCAL VOC 2012, Cityscapes, and COCO.