G2DR: A Genotype-First Framework for Genetics-Informed Target Prioritization and Drug Repurposing

Human genetics offers a promising route to therapeutic discovery, yet practical frameworks translating genotype-derived signal into ranked target and drug hypotheses remain limited, particularly when matched disease transcriptomics are unavailable. Here we present G2DR, a genotype-first prioritization framework propagating inherited variation through genetically predicted expression, multi-method gene-level testing, pathway enrichment, network context, druggability, and multi-source drug--target evidence integration. In a migraine case study with 733 UK Biobank participants under stratified five-fold cross-validation, we imputed expression across seven transcriptome-weight resources and ranked genes using a reproducibility-aware discovery score from training and validation data, followed by a balanced integrated score for target selection. Discovery-based prioritization generalized to held-out data, achieving gene-level ROC-AUC of 0.775 and PR-AUC of 0.475, while retaining enrichment for curated migraine biology. Mapping prioritized genes to compounds via Open Targets, DGIdb, and ChEMBL yielded drug sets enriched for migraine-linked compounds relative to a global background, though recovery favoured broader mechanism-linked and off-label space over migraine-specific approved therapies. Directionality filtering separated broadly recovered compounds from mechanistically compatible candidates. G2DR is a modular framework for genetics-informed hypothesis generation, not a clinically actionable recommendation system. All outputs require independent experimental, pharmacological, and clinical validation.

Ontology-Based Knowledge Modeling and Uncertainty-Aware Outdoor Air Quality Assessment Using Weighted Interval Type-2 Fuzzy Logic

Outdoor air pollution is a major concern for the environment and public health, especially in areas where urbanization is taking place rapidly. The Indian Air Quality Index (IND-AQI), developed by the Central Pollution Control Board (CPCB), is a standardized reporting system for air quality based on pollutants such as PM2.5, PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), carbon monoxide (CO), and ammonia (NH3). However, the traditional calculation of the AQI uses crisp thresholds and deterministic aggregation rules, which are not suitable for handling uncertainty and transitions between classes. To address these limitations, this study proposes a hybrid ontology-based uncertainty-aware framework integrating Weighted Interval Type-2 Fuzzy Logic with semantic knowledge modeling. Interval Type-2 fuzzy sets are used to model uncertainty near AQI class boundaries, while pollutant importance weights are determined using Interval Type-2 Fuzzy Analytic Hierarchy Process (IT2-FAHP) to reflect their relative health impacts. In addition, an OWL-based air quality ontology extending the Semantic Sensor Network (SSN) ontology is developed to represent pollutants, monitoring stations, AQI categories, regulatory standards, and environmental governance actions. Semantic reasoning is implemented using SWRL rules and validated through SPARQL queries to infer AQI categories, health risks, and recommended mitigation actions. Experimental evaluation using CPCB air quality datasets demonstrates that the proposed framework improves AQI classification reliability and uncertainty handling compared with traditional crisp and Type-1 fuzzy approaches, while enabling explainable semantic reasoning and intelligent decision support for air quality monitoring systems

Low-pass Personalized Subgraph Federated Recommendation

Federated Recommender Systems (FRS) preserve privacy by training decentralized models on client-specific user-item subgraphs without sharing raw data. However, FRS faces a unique challenge: subgraph structural imbalance, where drastic variations in subgraph scale (user/item counts) and connectivity (item degree) misalign client representations, making it challenging to train a robust model that respects each client's unique structural characteristics. To address this, we propose a Low-pass Personalized Subgraph Federated recommender system (LPSFed). LPSFed leverages graph Fourier transforms and low-pass spectral filtering to extract low-frequency structural signals that remain stable across subgraphs of varying size and degree, allowing robust personalized parameter updates guided by similarity to a neutral structural anchor. Additionally, we leverage a localized popularity bias-aware margin that captures item-degree imbalance within each subgraph and incorporates it into a personalized bias correction term to mitigate recommendation bias. Supported by theoretical analysis and validated on five real-world datasets, LPSFed achieves superior recommendation accuracy and enhances model robustness.

PolicySim: An LLM-Based Agent Social Simulation Sandbox for Proactive Policy Optimization

Social platforms serve as central hubs for information exchange, where user behaviors and platform interventions jointly shape opinions. However, intervention policies like recommendation and content filtering, can unintentionally amplify echo chambers and polarization, posing significant societal risks. Proactively evaluating the impact of such policies is therefore crucial. Existing approaches primarily rely on reactive online A/B testing, where risks are identified only after deployment, making risk identification delayed and costly. LLM-based social simulations offer a promising pre-deployment alternative, but current methods fall short in realistically modeling platform interventions and incorporating feedback from the platform. Bridging these gaps is essential for building actionable frameworks to assess and optimize platform policies. To this end, we propose PolicySim, an LLM-based social simulation sandbox for the proactive assessment and optimization of intervention policies. PolicySim models the bidirectional dynamics between user behavior and platform interventions through two key components: (1) a user agent module refined via supervised fine-tuning (SFT) and direct preference optimization (DPO) to achieve platform-specific behavioral realism; and (2) an adaptive intervention module that employs a contextual bandit with message passing to capture dynamic network structures. Experiments show that PolicySim can accurately simulate platform ecosystems at both micro and macro levels and support effective intervention policy.

How Well Does Generative Recommendation Generalize?

A widely held hypothesis for why generative recommendation (GR) models outperform conventional item ID-based models is that they generalize better. However, there is few systematic way to verify this hypothesis beyond a superficial comparison of overall performance. To address this gap, we categorize each data instance based on the specific capability required for a correct prediction: either memorization (reusing item transition patterns observed during training) or generalization (composing known patterns to predict unseen item transitions). Extensive experiments show that GR models perform better on instances that require generalization, whereas item ID-based models perform better when memorization is more important. To explain this divergence, we shift the analysis from the item level to the token level and show that what appears to be item-level generalization often reduces to token-level memorization for GR models. Finally, we show that the two paradigms are complementary. We propose a simple memorization-aware indicator that adaptively combines them on a per-instance basis, leading to improved overall recommendation performance.

From Token to Item: Enhancing Large Language Models for Recommendation via Item-aware Attention Mechanism

Large Language Models (LLMs) have recently gained increasing attention in the field of recommendation. Existing LLM-based methods typically represent items as token sequences, and apply attention layers on these tokens to generate recommendations. However, by inheriting the standard attention mechanism, these methods focus on modeling token-level relations. This token-centric focus overlooks the item as the fundamental unit of recommendation, preventing existing methods from effectively capturing collaborative relations at the item level. In this work, we revisit the role of tokens in LLM-driven recommendation and categorize their relations into two types: (1) intra-item token relations, which present the content semantics of an item, e.g., name, color, and size; and (2) inter-item token relations, which encode collaborative relations across items. Building on these insights, we propose a novel framework with an item-aware attention mechanism (IAM) to enhance LLMs for recommendation. Specifically, IAM devises two complementary attention layers: (1) an intra-item attention layer, which restricts attention to tokens within the same item, modeling item content semantics; and (2) an inter-item attention layer, which attends exclusively to token relations across items, capturing item collaborative relations. Through this stacked design, IAM explicitly emphasizes items as the fundamental units in recommendation, enabling LLMs to effectively exploit item-level collaborative relations. Extensive experiments on several public datasets demonstrate the effectiveness of IAM in enhancing LLMs for personalized recommendation.

DALI: LLM-Agent Enhanced Dual-Stream Adaptive Leadership Identification for Group Recommendations

Group recommendation systems play a pivotal role in supporting collective decisions across various contexts, from leisure activities to organizational team-building. Existing group recommendation approaches typically use either handcrafted aggregation rules (e.g. mean, least misery, weighted sum) or neural aggregation models (e.g. attention-based deep learning frameworks), yet both fall short in distinguishing leader-dominated from collaborative groups and often misrepresent true group preferences, especially when a single member disproportionately influences group choices. To address these limitations, we propose the Dual-stream Adaptive Leadership Identification (DALI) framework, which uniquely combines the symbolic reasoning capabilities of Large Language Models (LLMs) with neural network-based representation learning. Specifically, DALI introduces two key innovations: a dynamic rule generation module that autonomously formulates and evolves identification rules through iterative performance feedback, and a neuro-symbolic aggregation mechanism that concurrently employs symbolic reasoning to robustly recognize leadership groups and attention-based neural aggregation to accurately model collaborative group dynamics. Experiments conducted on the Mafengwo travel dataset confirm that DALI significantly improves recommendation accuracy compared to existing frameworks, highlighting its capability to dynamically adapt to complex, real-world group decision environments.

The Multiverse of Time Series Machine Learning: an Archive for Multivariate Time Series Classification

Time series machine learning (TSML) is a growing research field that spans a wide range of tasks. The popularity of established tasks such as classification, clustering, and extrinsic regression has, in part, been driven by the availability of benchmark datasets. An archive of 30 multivariate time series classification datasets, introduced in 2018 and commonly known as the UEA archive, has since become an essential resource cited in hundreds of publications. We present a substantial expansion of this archive that more than quadruples its size, from 30 to 133 classification problems. We also release preprocessed versions of datasets containing missing values or unequal length series, bringing the total number of datasets to 147. Reflecting the growth of the archive and the broader community, we rebrand it as the Multiverse archive to capture its diversity of domains. The Multiverse archive includes datasets from multiple sources, consolidating other collections and standalone datasets into a single, unified repository. Recognising that running experiments across the full archive is computationally demanding, we recommend a subset of the full archive called Multiverse-core (MV-core) for initial exploration. To support researchers in using the new archive, we provide detailed guidance and a baseline evaluation of established and recent classification algorithms, establishing performance benchmarks for future research. We have created a dedicated repository for the Multiverse archive that provides a common aeon and scikit-learn compatible framework for reproducibility, an extensive record of published results, and an interactive interface to explore the results.

OCP: Orthogonal Constrained Projection for Sparse Scaling in Industrial Commodity Recommendation

In industrial commodity recommendation systems, the representation quality of Item-Id vocabularies directly impacts the scalability and generalization ability of recommendation models. A key challenge is that traditional Item-Id vocabularies, when subjected to sparse scaling, suffer from low-frequency information interference, which restricts their expressive power for massive item sets and leads to representation collapse. To address this issue, we propose an Orthogonal Constrained Projection method to optimize embedding representation. By enforcing orthogonality, the projection constrains the backpropagation manifold, aligning the singular value spectrum of the learned embeddings with the orthogonal basis. This alignment ensures high singular entropy, thereby preserving isotropic generalized features while suppressing spurious correlations and overfitting to rare items. Empirical results demonstrate that OCP accelerates loss convergence and enhances the model's scalability; notably, it enables consistent performance gains when scaling up dense layers. Large-scale industrial deployment on JD.com further confirms its efficacy, yielding a 12.97% increase in UCXR and an 8.9% uplift in GMV, highlighting its robust utility for scaling up both sparse vocabularies and dense architectures.

Interplay: Training Independent Simulators for Reference-Free Conversational Recommendation

Training conversational recommender systems (CRS) requires extensive dialogue data, which is challenging to collect at scale. To address this, researchers have used simulated user-recommender conversations. Traditional simulation approaches often utilize a single large language model (LLM) that generates entire conversations with prior knowledge of the target items, leading to scripted and artificial dialogues. We propose a reference-free simulation framework that trains two independent LLMs, one as the user and one as the conversational recommender. These models interact in real-time without access to predetermined target items, but preference summaries and target attributes, enabling the recommender to genuinely infer user preferences through dialogue. This approach produces more realistic and diverse conversations that closely mirror authentic human-AI interactions. Our reference-free simulators match or exceed existing methods in quality, while offering a scalable solution for generating high-quality conversational recommendation data without constraining conversations to pre-defined target items. We conduct both quantitative and human evaluations to confirm the effectiveness of our reference-free approach.