Closing the Domain Gap in Biomedical Imaging by In-Context Control Samples

The central problem in biomedical imaging are batch effects: systematic technical variations unrelated to the biological signal of interest. These batch effects critically undermine experimental reproducibility and are the primary cause of failure of deep learning systems on new experimental batches, preventing their practical use in the real world. Despite years of research, no method has succeeded in closing this performance gap for deep learning models. We propose Control-Stabilized Adaptive Risk Minimization via Batch Normalization (CS-ARM-BN), a meta-learning adaptation method that exploits negative control samples. Such unperturbed reference images are present in every experimental batch by design and serve as stable context for adaptation. We validate our novel method on Mechanism-of-Action (MoA) classification, a crucial task for drug discovery, on the large-scale JUMP-CP dataset. The accuracy of standard ResNets drops from 0.939 $\pm$ 0.005, on the training domain, to 0.862 $\pm$ 0.060 on data from new experimental batches. Foundation models, even after Typical Variation Normalization, fail to close this gap. We are the first to show that meta-learning approaches close the domain gap by achieving 0.935 $\pm$ 0.018. If the new experimental batches exhibit strong domain shifts, such as being generated in a different lab, meta-learning approaches can be stabilized with control samples, which are always available in biomedical experiments. Our work shows that batch effects in bioimaging data can be effectively neutralized through principled in-context adaptation, which also makes them practically usable and efficient.

Evaluating Histogram Matching for Robust Deep learning-Based Grapevine Disease Detection

Variability in illumination is a primary factor limiting deep learning robustness for field-based plant disease detection. This study evaluates Histogram Matching (HM), a technique that transforms the pixel intensity distribution of an image to match a reference profile, to mitigate this in grapevine classification, distinguishing among healthy leaves, downy mildew, and spider mite damage. We propose a dual-stage integration of HM: (i) as a preprocessing step for normalization, and (ii) as a data augmentation technique to introduce controlled training variability. Experiments using 1,469 RGB images (comprising homogeneous leaf-focused and heterogeneous canopy samples) to train ResNet-18 models demonstrate that this combination significantly enhances robustness on real-world canopy images. While leaf-focused samples showed marginal gains, the canopy subset improved markedly, indicating that balancing normalization with histogram-based diversification effectively bridges the domain gap caused by uncontrolled lighting.

Concept Inconsistency in Dermoscopic Concept Bottleneck Models: A Rough-Set Analysis of the Derm7pt Dataset

Concept Bottleneck Models (CBMs) route predictions exclusively through a clinically grounded concept layer, binding interpretability to concept-label consistency. When a dataset contains concept-level inconsistencies, identical concept profiles mapped to conflicting diagnosis labels create an unresolvable bottleneck that imposes a hard ceiling on achievable accuracy. In this paper, we apply rough set theory to the Derm7pt dermoscopy benchmark and characterize the full extent and clinical structure of this inconsistency. Among 305 unique concept profiles formed by the 7 dermoscopic criteria of the 7-point melanoma checklist, 50 (16.4%) are inconsistent, spanning 306 images (30.3% of the dataset). This yields a theoretical accuracy ceiling of 92.1%, independent of backbone architecture or training strategy for CBMs that exclusively operate with hard concepts. In addition, we characterize the conflict-severity distribution, identify the clinical features most responsible for boundary ambiguity, and evaluate two filtering strategies with quantified effects on dataset composition and CBM interpretability. Symmetric removal of all boundary-region images yields Derm7pt+, a fully consistent benchmark subset of 705 images with perfect quality of classification and no hard accuracy ceiling. Building on this filtered dataset, we present a hard CBM evaluated across 19 backbone architectures from the EfficientNet, DenseNet, ResNet, and Wide ResNet families. Under symmetric filtering, explored for completeness, EfficientNet-B5 achieves the best label F1 score (0.85) and label accuracy (0.90) on the held-out test set, with a concept accuracy of 0.70. Under asymmetric filtering, EfficientNet-B7 leads across all four metrics, reaching a label F1 score of 0.82 and concept accuracy of 0.70. These results establish reproducible baselines for concept-consistent CBM evaluation on dermoscopic data.

Cognitive Alignment At No Cost: Inducing Human Attention Biases For Interpretable Vision Transformers

For state-of-the-art image understanding, Vision Transformers (ViTs) have become the standard architecture but their processing diverges substantially from human attentional characteristics. We investigate whether this cognitive gap can be shrunk by fine-tuning the self-attention weights of Google's ViT-B/16 on human saliency fixation maps. To isolate the effects of semantically relevant signals from generic human supervision, the tuned model is compared against a shuffled control. Fine-tuning significantly improved alignment across five saliency metrics and induced three hallmark human-like biases: tuning reversed the baseline's anti-human large-object bias toward small-objects, amplified the animacy preference and diminished extreme attention entropy. Bayesian parity analysis provides decisive to very-strong evidence that this cognitive alignment comes at no cost to the model's original classification performance on in- (ImageNet), corrupted (ImageNet-C) and out-of-distribution (ObjectNet) benchmarks. An equivalent procedure applied to a ResNet-50 Convolutional Neural Network (CNN) instead degraded both alignment and accuracy, suggesting that the ViT's modular self-attention mechanism is uniquely suited for dissociating spatial priority from representational logic. These findings demonstrate that biologically grounded priors can be instilled as a free emergent property of human-aligned attention, to improve transformer interpretability.

EfficientPENet: Real-Time Depth Completion from Sparse LiDAR via Lightweight Multi-Modal Fusion

Depth completion from sparse LiDAR measurements and corresponding RGB images is a prerequisite for accurate 3D perception in robotic systems. Existing methods achieve high accuracy on standard benchmarks but rely on heavy backbone architectures that preclude real-time deployment on embedded hardware. We present EfficientPENet, a two-branch depth completion network that replaces the conventional ResNet encoder with a modernized ConvNeXt backbone, introduces sparsity-invariant convolutions for the depth stream, and refines predictions through a Convolutional Spatial Propagation Network (CSPN). The RGB branch leverages ImageNet-pretrained ConvNeXt blocks with Layer Normalization, 7x7 depthwise convolutions, and stochastic depth regularization. Features from both branches are merged via late fusion and decoded through a multi-scale deep supervision strategy. We further introduce a position-aware test-time augmentation scheme that corrects coordinate tensors during horizontal flipping, yielding consistent error reduction at inference. On the KITTI depth completion benchmark, EfficientPENet achieves an RMSE of 631.94 mm with 36.24M parameters and a latency of 20.51 ms, operating at 48.76 FPS. This represents a 3.7 times reduction in parameters and a 23 times speedup relative to BP-Net, while maintaining competitive accuracy. These results establish EfficientPENet as a practical solution for real-time depth completion on resource-constrained edge platforms such as the NVIDIA Jetson.

VIGILant: an automatic classification pipeline for glitches in the Virgo detector

Glitches frequently contaminate data in gravitational-wave detectors, complicating the observation and analysis of astrophysical signals. This work introduces VIGILant, an automatic pipeline for classification and visualization of glitches in the Virgo detector. Using a curated dataset of Virgo O3b glitches, two machine learning approaches are evaluated: tree-based models (Decision Tree, Random Forest and XGBoost) using structured Omicron parameters, and Convolutional Neural Networks (ResNet) trained on spectrogram images. While tree-based models offer higher interpretability and fast training, the ResNet34 model achieved superior performance, reaching a F1 score of 0.9772 and accuracy of 0.9833 in the testing set, with inference times of tens of milliseconds per glitch. The pipeline has been deployed for daily operation at the Virgo site since observing run O4c, providing the Virgo collaboration with an interactive dashboard to monitor glitch populations and detector behavior. This allows to identify low-confidence predictions, highlighting glitches requiring further attention.

Quantization of Spiking Neural Networks Beyond Accuracy

Quantization is a natural complement to the sparse, event-driven computation of Spiking Neural Networks, reducing memory bandwidth and arithmetic cost for deployment on resource-constrained hardware. However, existing SNN quantization evaluation focuses almost exclusively on accuracy, overlooking whether a quantized network preserves the firing behavior of its full-precision counterpart. We demonstrate that quantization method, clipping range, and bit-width can produce substantially different firing distributions at equivalent accuracy, differences invisible to standard metrics but relevant to deployment, where firing activity governs effective sparsity, state storage, and event-processing load. To capture this gap, we propose Earth Mover's Distance as a diagnostic metric for firing distribution divergence, and apply it systematically across weight and membrane quantization on SEW-ResNet architectures trained on CIFAR-10 and CIFAR-100. We find that uniform quantization induces distributional drift even when accuracy is preserved, while LQ-Net style learned quantization maintains firing behavior close to the full-precision baseline. Our results suggest that behavior preservation should be treated as an evaluation criterion alongside accuracy, and that EMD provides a principled tool for assessing it.

Heuristic Style Transfer for Real-Time, Efficient Weather Attribute Detection

We present lightweight and efficient architectures to detect weather conditions from RGB images, predicting the weather type (sunny, rain, snow, fog) and 11 complementary attributes such as intensity, visibility, and ground condition, for a total of 53 classes across the tasks. This work examines to what extent weather conditions manifest as variations in visual style. We investigate style-inspired techniques, including Gram matrices, a truncated ResNet-50 targeting lower and intermediate layers, and PatchGAN-style architectures, within a multi-task framework with attention mechanisms. Two families are introduced: RTM (ResNet50-Truncated-MultiTasks) and PMG (PatchGAN-MultiTasks-Gram), together with their variants. Our contributions include automation of Gram-matrix computation, integration of PatchGAN into supervised multi-task learning, and local style capture through local Gram for improved spatial coherence. We also release a dataset of 503,875 images annotated with 12 weather attributes under a Creative Commons Attribution (CC-BY) license. The models achieve F1 scores above 96 percent on our internal test set and above 78 percent in zero-shot evaluation on several external datasets, confirming their generalization ability. The PMG architecture, with fewer than 5 million parameters, runs in real time with a small memory footprint, making it suitable for embedded systems. The modular design of the models also allows style-related or weather-related tasks to be added or removed as needed.

SpanKey: Dynamic Key Space Conditioning for Neural Network Access Control

SpanKey is a lightweight way to gate inference without encrypting weights or chasing leaderboard accuracy on gated inference. The idea is to condition activations on secret keys. A basis matrix $B$ defines a low-dimensional key subspace $Span(B)$; during training we sample coefficients $α$ and form keys $k=α^\top B$, then inject them into intermediate activations with additive or multiplicative maps and strength $γ$. Valid keys lie in $Span(B)$; invalid keys are sampled outside that subspace. We make three points. (i) Mechanism: subspace key injection and a multi-layer design space. (ii) Failure mode: key absorption, together with two analytical results (a Beta-energy split and margin-tail diagnostics), explains weak baseline separation in energy and margin terms -- these are not a security theorem. iii) Deny losses and experiments: Modes A--C and extensions, with CIFAR-10 ResNet-18 runs and MNIST ablations for Mode B. We summarize setup and first-order analysis, injectors, absorption, deny losses and ablations, a threat discussion that does not promise cryptography, and closing remarks on scale. Code: \texttt{https://github.com/mindmemory-ai/dksc}

Orthogonal Subspace Projection for Continual Machine Unlearning via SVD-Based LoRA

Continual machine unlearning aims to remove the influence of data that should no longer be retained, while preserving the usefulness of the model on everything else. This setting becomes especially difficult when deletion requests arrive sequentially, because the model must repeatedly adapt without erasing previously retained knowledge. Low-Rank Adaptation (LoRA) offers an efficient way to implement such updates, but naively combining many sequential LoRA modules leads to parameter collision, causing \textit{strong interference} between tasks. We propose a static alternative based on Singular Value Decomposition (SVD)-guided orthogonal subspace projection. Our method constrains each new LoRA update during training so that it lies in the orthogonal complement of the subspaces used by earlier unlearning tasks. This preserves task isolation without requiring dynamic routing at deployment. Experiments on CIFAR-100 with ResNet-20 and on MNIST show stable behavior across long sequences of unlearning tasks. After thirty sequential unlearning tasks, state-of-the-art static fusion reduces retained accuracy from 60.39\% to 12.70\%, whereas the proposed in-training constrained optimization maintains baseline performance ($\sim$58.1\%) while preserving strong unlearning efficacy.