Enhancing Weakly-Supervised Histopathology Image Segmentation with Knowledge Distillation on MIL-Based Pseudo-Labels

Segmenting tumors in histological images is vital for cancer diagnosis. While fully supervised models excel with pixel-level annotations, creating such annotations is labor-intensive and costly. Accurate histopathology image segmentation under weakly-supervised conditions with coarse-grained image labels is still a challenging problem. Although multiple instance learning (MIL) has shown promise in segmentation tasks, surprisingly, no previous pseudo-supervision methods have used MIL-based outputs as pseudo-masks for training. We suspect this stems from concerns over noises in MIL results affecting pseudo supervision quality. To explore the potential of leveraging MIL-based segmentation for pseudo supervision, we propose a novel distillation framework for histopathology image segmentation. This framework introduces a iterative fusion-knowledge distillation strategy, enabling the student model to learn directly from the teacher's comprehensive outcomes. Through dynamic role reversal between the fixed teacher and learnable student models and the incorporation of weighted cross-entropy loss for model optimization, our approach prevents performance deterioration and noise amplification during knowledge distillation. Experimental results on public histopathology datasets, Camelyon16 and Digestpath2019, demonstrate that our approach not only complements various MIL-based segmentation methods but also significantly enhances their performance. Additionally, our method achieves new SOTA in the field.

Stability and Generalization for Stochastic Recursive Momentum-based Algorithms for (Strongly-)Convex One to $K$-Level Stochastic Optimizations

STOchastic Recursive Momentum (STORM)-based algorithms have been widely developed to solve one to $K$-level ($K \geq 3$) stochastic optimization problems. Specifically, they use estimators to mitigate the biased gradient issue and achieve near-optimal convergence results. However, there is relatively little work on understanding their generalization performance, particularly evident during the transition from one to $K$-level optimization contexts. This paper provides a comprehensive generalization analysis of three representative STORM-based algorithms: STORM, COVER, and SVMR, for one, two, and $K$-level stochastic optimizations under both convex and strongly convex settings based on algorithmic stability. Firstly, we define stability for $K$-level optimizations and link it to generalization. Then, we detail the stability results for three prominent STORM-based algorithms. Finally, we derive their excess risk bounds by balancing stability results with optimization errors. Our theoretical results provide strong evidence to complete STORM-based algorithms: (1) Each estimator may decrease their stability due to variance with its estimation target. (2) Every additional level might escalate the generalization error, influenced by the stability and the variance between its cumulative stochastic gradient and the true gradient. (3) Increasing the batch size for the initial computation of estimators presents a favorable trade-off, enhancing the generalization performance.

MGSER-SAM: Memory-Guided Soft Experience Replay with Sharpness-Aware Optimization for Enhanced Continual Learning

Deep neural networks suffer from the catastrophic forgetting problem in the field of continual learning (CL). To address this challenge, we propose MGSER-SAM, a novel memory replay-based algorithm specifically engineered to enhance the generalization capabilities of CL models. We first intergrate the SAM optimizer, a component designed for optimizing flatness, which seamlessly fits into well-known Experience Replay frameworks such as ER and DER++. Then, MGSER-SAM distinctively addresses the complex challenge of reconciling conflicts in weight perturbation directions between ongoing tasks and previously stored memories, which is underexplored in the SAM optimizer. This is effectively accomplished by the strategic integration of soft logits and the alignment of memory gradient directions, where the regularization terms facilitate the concurrent minimization of various training loss terms integral to the CL process. Through rigorous experimental analysis conducted across multiple benchmarks, MGSER-SAM has demonstrated a consistent ability to outperform existing baselines in all three CL scenarios. Comparing to the representative memory replay-based baselines ER and DER++, MGSER-SAM not only improves the testing accuracy by $24.4\%$ and $17.6\%$ respectively, but also achieves the lowest forgetting on each benchmark.

Open Challenges and Opportunities in Federated Foundation Models Towards Biomedical Healthcare

This survey explores the transformative impact of foundation models (FMs) in artificial intelligence, focusing on their integration with federated learning (FL) for advancing biomedical research. Foundation models such as ChatGPT, LLaMa, and CLIP, which are trained on vast datasets through methods including unsupervised pretraining, self-supervised learning, instructed fine-tuning, and reinforcement learning from human feedback, represent significant advancements in machine learning. These models, with their ability to generate coherent text and realistic images, are crucial for biomedical applications that require processing diverse data forms such as clinical reports, diagnostic images, and multimodal patient interactions. The incorporation of FL with these sophisticated models presents a promising strategy to harness their analytical power while safeguarding the privacy of sensitive medical data. This approach not only enhances the capabilities of FMs in medical diagnostics and personalized treatment but also addresses critical concerns about data privacy and security in healthcare. This survey reviews the current applications of FMs in federated settings, underscores the challenges, and identifies future research directions including scaling FMs, managing data diversity, and enhancing communication efficiency within FL frameworks. The objective is to encourage further research into the combined potential of FMs and FL, laying the groundwork for groundbreaking healthcare innovations.

Dual-Image Enhanced CLIP for Zero-Shot Anomaly Detection

Image Anomaly Detection has been a challenging task in Computer Vision field. The advent of Vision-Language models, particularly the rise of CLIP-based frameworks, has opened new avenues for zero-shot anomaly detection. Recent studies have explored the use of CLIP by aligning images with normal and prompt descriptions. However, the exclusive dependence on textual guidance often falls short, highlighting the critical importance of additional visual references. In this work, we introduce a Dual-Image Enhanced CLIP approach, leveraging a joint vision-language scoring system. Our methods process pairs of images, utilizing each as a visual reference for the other, thereby enriching the inference process with visual context. This dual-image strategy markedly enhanced both anomaly classification and localization performances. Furthermore, we have strengthened our model with a test-time adaptation module that incorporates synthesized anomalies to refine localization capabilities. Our approach significantly exploits the potential of vision-language joint anomaly detection and demonstrates comparable performance with current SOTA methods across various datasets.

Generative manufacturing systems using diffusion models and ChatGPT

In this study, we introduce Generative Manufacturing Systems (GMS) as a novel approach to effectively manage and coordinate autonomous manufacturing assets, thereby enhancing their responsiveness and flexibility to address a wide array of production objectives and human preferences. Deviating from traditional explicit modeling, GMS employs generative AI, including diffusion models and ChatGPT, for implicit learning from envisioned futures, marking a shift from a model-optimum to a training-sampling decision-making. Through the integration of generative AI, GMS enables complex decision-making through interactive dialogue with humans, allowing manufacturing assets to generate multiple high-quality global decisions that can be iteratively refined based on human feedback. Empirical findings showcase GMS's substantial improvement in system resilience and responsiveness to uncertainties, with decision times reduced from seconds to milliseconds. The study underscores the inherent creativity and diversity in the generated solutions, facilitating human-centric decision-making through seamless and continuous human-machine interactions.

Reinforcement Learning with Generative Models for Compact Support Sets

Foundation models contain a wealth of information from their vast number of training samples. However, most prior arts fail to extract this information in a precise and efficient way for small sample sizes. In this work, we propose a framework utilizing reinforcement learning as a control for foundation models, allowing for the granular generation of small, focused synthetic support sets to augment the performance of neural network models on real data classification tasks. We first allow a reinforcement learning agent access to a novel context based dictionary; the agent then uses this dictionary with a novel prompt structure to form and optimize prompts as inputs to generative models, receiving feedback based on a reward function combining the change in validation accuracy and entropy. A support set is formed this way over several exploration steps. Our framework produced excellent results, increasing classification accuracy by significant margins for no additional labelling or data cost.

FastLogAD: Log Anomaly Detection with Mask-Guided Pseudo Anomaly Generation and Discrimination

Nowadays large computers extensively output logs to record the runtime status and it has become crucial to identify any suspicious or malicious activities from the information provided by the realtime logs. Thus, fast log anomaly detection is a necessary task to be implemented for automating the infeasible manual detection. Most of the existing unsupervised methods are trained only on normal log data, but they usually require either additional abnormal data for hyperparameter selection or auxiliary datasets for discriminative model optimization. In this paper, aiming for a highly effective discriminative model that enables rapid anomaly detection,we propose FastLogAD, a generator-discriminator framework trained to exhibit the capability of generating pseudo-abnormal logs through the Mask-Guided Anomaly Generation (MGAG) model and efficiently identifying the anomalous logs via the Discriminative Abnormality Separation (DAS) model. Particularly, pseudo-abnormal logs are generated by replacing randomly masked tokens in a normal sequence with unlikely candidates. During the discriminative stage, FastLogAD learns a distinct separation between normal and pseudoabnormal samples based on their embedding norms, allowing the selection of a threshold without exposure to any test data and achieving competitive performance. Extensive experiments on several common benchmarks show that our proposed FastLogAD outperforms existing anomaly detection approaches. Furthermore, compared to previous methods, FastLogAD achieves at least x10 speed increase in anomaly detection over prior work. Our implementation is available at https://github.com/YifeiLin0226/FastLogAD.

Structural Teacher-Student Normality Learning for Multi-Class Anomaly Detection and Localization

Visual anomaly detection is a challenging open-set task aimed at identifying unknown anomalous patterns while modeling normal data. The knowledge distillation paradigm has shown remarkable performance in one-class anomaly detection by leveraging teacher-student network feature comparisons. However, extending this paradigm to multi-class anomaly detection introduces novel scalability challenges. In this study, we address the significant performance degradation observed in previous teacher-student models when applied to multi-class anomaly detection, which we identify as resulting from cross-class interference. To tackle this issue, we introduce a novel approach known as Structural Teacher-Student Normality Learning (SNL): (1) We propose spatial-channel distillation and intra-&inter-affinity distillation techniques to measure structural distance between the teacher and student networks. (2) We introduce a central residual aggregation module (CRAM) to encapsulate the normal representation space of the student network. We evaluate our proposed approach on two anomaly detection datasets, MVTecAD and VisA. Our method surpasses the state-of-the-art distillation-based algorithms by a significant margin of 3.9% and 1.5% on MVTecAD and 1.2% and 2.5% on VisA in the multi-class anomaly detection and localization tasks, respectively. Furthermore, our algorithm outperforms the current state-of-the-art unified models on both MVTecAD and VisA.

SISSA: Real-time Monitoring of Hardware Functional Safety and Cybersecurity with In-vehicle SOME/IP Ethernet Traffic

Scalable service-Oriented Middleware over IP (SOME/IP) is an Ethernet communication standard protocol in the Automotive Open System Architecture (AUTOSAR), promoting ECU-to-ECU communication over the IP stack. However, SOME/IP lacks a robust security architecture, making it susceptible to potential attacks. Besides, random hardware failure of ECU will disrupt SOME/IP communication. In this paper, we propose SISSA, a SOME/IP communication traffic-based approach for modeling and analyzing in-vehicle functional safety and cyber security. Specifically, SISSA models hardware failures with the Weibull distribution and addresses five potential attacks on SOME/IP communication, including Distributed Denial-of-Services, Man-in-the-Middle, and abnormal communication processes, assuming a malicious user accesses the in-vehicle network. Subsequently, SISSA designs a series of deep learning models with various backbones to extract features from SOME/IP sessions among ECUs. We adopt residual self-attention to accelerate the model's convergence and enhance detection accuracy, determining whether an ECU is under attack, facing functional failure, or operating normally. Additionally, we have created and annotated a dataset encompassing various classes, including indicators of attack, functionality, and normalcy. This contribution is noteworthy due to the scarcity of publicly accessible datasets with such characteristics.Extensive experimental results show the effectiveness and efficiency of SISSA.