Improving Channel Estimation via Multimodal Diffusion Models with Flow Matching

Deep generative models offer a powerful alternative to conventional channel estimation by learning complex channel distributions. By integrating the rich environmental information available in modern sensing-aided networks, this paper proposes MultiCE-Flow, a multimodal channel estimation framework based on flow matching and diffusion transformer (DiT). We design a specialized multimodal perception module that fuses LiDAR, camera, and location data into a semantic condition, while treating sparse pilots as a structural condition. These conditions guide a DiT backbone to reconstruct high-fidelity channels. Unlike standard diffusion models, we employ flow matching to learn a linear trajectory from noise to data, enabling efficient one-step sampling. By leveraging environmental semantics, our method mitigates the ill-posed nature of estimation with sparse pilots. Extensive experiments demonstrate that MultiCE-Flow consistently outperforms traditional baselines and existing generative models. Notably, it exhibits superior robustness to out-of-distribution scenarios and varying pilot densities, making it suitable for environment-aware communication systems.

CELLS: Cost-Effective Evolution in Latent Space for Goal-Directed Molecular Generation

Efficiently discovering molecules that meet various property requirements can significantly benefit the drug discovery industry. Since it is infeasible to search over the entire chemical space, recent works adopt generative models for goal-directed molecular generation. They tend to utilize the iterative processes, optimizing the parameters of the molecular generative models at each iteration to produce promising molecules for further validation. Assessments are exploited to evaluate the generated molecules at each iteration, providing direction for model optimization. However, most previous works require a massive number of expensive and time-consuming assessments, e.g., wet experiments and molecular dynamic simulations, leading to the lack of practicability. To reduce the assessments in the iterative process, we propose a cost-effective evolution strategy in latent space, which optimizes the molecular latent representation vectors instead. We adopt a pre-trained molecular generative model to map the latent and observation spaces, taking advantage of the large-scale unlabeled molecules to learn chemical knowledge. To further reduce the number of expensive assessments, we introduce a pre-screener as the proxy to the assessments. We conduct extensive experiments on multiple optimization tasks comparing the proposed framework to several advanced techniques, showing that the proposed framework achieves better performance with fewer assessments.