Reducing Positional Variance in Cross-sectional Abdominal CT Slices with Deep Conditional Generative Models

2D low-dose single-slice abdominal computed tomography (CT) slice enables direct measurements of body composition, which are critical to quantitatively characterizing health relationships on aging. However, longitudinal analysis of body composition changes using 2D abdominal slices is challenging due to positional variance between longitudinal slices acquired in different years. To reduce the positional variance, we extend the conditional generative models to our C-SliceGen that takes an arbitrary axial slice in the abdominal region as the condition and generates a defined vertebral level slice by estimating the structural changes in the latent space. Experiments on 1170 subjects from an in-house dataset and 50 subjects from BTCV MICCAI Challenge 2015 show that our model can generate high quality images in terms of realism and similarity. External experiments on 20 subjects from the Baltimore Longitudinal Study of Aging (BLSA) dataset that contains longitudinal single abdominal slices validate that our method can harmonize the slice positional variance in terms of muscle and visceral fat area. Our approach provides a promising direction of mapping slices from different vertebral levels to a target slice to reduce positional variance for single slice longitudinal analysis. The source code is available at: https://github.com/MASILab/C-SliceGen.

UNesT: Local Spatial Representation Learning with Hierarchical Transformer for Efficient Medical Segmentation

Transformer-based models, capable of learning better global dependencies, have recently demonstrated exceptional representation learning capabilities in computer vision and medical image analysis. Transformer reformats the image into separate patches and realize global communication via the self-attention mechanism. However, positional information between patches is hard to preserve in such 1D sequences, and loss of it can lead to sub-optimal performance when dealing with large amounts of heterogeneous tissues of various sizes in 3D medical image segmentation. Additionally, current methods are not robust and efficient for heavy-duty medical segmentation tasks such as predicting a large number of tissue classes or modeling globally inter-connected tissues structures. Inspired by the nested hierarchical structures in vision transformer, we proposed a novel 3D medical image segmentation method (UNesT), employing a simplified and faster-converging transformer encoder design that achieves local communication among spatially adjacent patch sequences by aggregating them hierarchically. We extensively validate our method on multiple challenging datasets, consisting anatomies of 133 structures in brain, 14 organs in abdomen, 4 hierarchical components in kidney, and inter-connected kidney tumors). We show that UNesT consistently achieves state-of-the-art performance and evaluate its generalizability and data efficiency. Particularly, the model achieves whole brain segmentation task complete ROI with 133 tissue classes in single network, outperforms prior state-of-the-art method SLANT27 ensembled with 27 network tiles, our model performance increases the mean DSC score of the publicly available Colin and CANDI dataset from 0.7264 to 0.7444 and from 0.6968 to 0.7025, respectively.

Longitudinal Variability Analysis on Low-dose Abdominal CT with Deep Learning-based Segmentation

Metabolic health is increasingly implicated as a risk factor across conditions from cardiology to neurology, and efficiency assessment of body composition is critical to quantitatively characterizing these relationships. 2D low dose single slice computed tomography (CT) provides a high resolution, quantitative tissue map, albeit with a limited field of view. Although numerous potential analyses have been proposed in quantifying image context, there has been no comprehensive study for low-dose single slice CT longitudinal variability with automated segmentation. We studied a total of 1816 slices from 1469 subjects of Baltimore Longitudinal Study on Aging (BLSA) abdominal dataset using supervised deep learning-based segmentation and unsupervised clustering method. 300 out of 1469 subjects that have two year gap in their first two scans were pick out to evaluate longitudinal variability with measurements including intraclass correlation coefficient (ICC) and coefficient of variation (CV) in terms of tissues/organs size and mean intensity. We showed that our segmentation methods are stable in longitudinal settings with Dice ranged from 0.821 to 0.962 for thirteen target abdominal tissues structures. We observed high variability in most organ with ICC<0.5, low variability in the area of muscle, abdominal wall, fat and body mask with average ICC>0.8. We found that the variability in organ is highly related to the cross-sectional position of the 2D slice. Our efforts pave quantitative exploration and quality control to reduce uncertainties in longitudinal analysis.

Fengshenbang 1.0: Being the Foundation of Chinese Cognitive Intelligence

Nowadays, foundation models become one of fundamental infrastructures in artificial intelligence, paving ways to the general intelligence. However, the reality presents two urgent challenges: existing foundation models are dominated by the English-language community; users are often given limited resources and thus cannot always use foundation models. To support the development of the Chinese-language community, we introduce an open-source project, called Fengshenbang, which leads by the research center for Cognitive Computing and Natural Language (CCNL). Our project has comprehensive capabilities, including large pre-trained models, user-friendly APIs, benchmarks, datasets, and others. We wrap all these in three sub-projects: the Fengshenbang Model, the Fengshen Framework, and the Fengshen Benchmark. An open-source roadmap, Fengshenbang, aims to re-evaluate the open-source community of Chinese pre-trained large-scale models, prompting the development of the entire Chinese large-scale model community. We also want to build a user-centered open-source ecosystem to allow individuals to access the desired models to match their computing resources. Furthermore, we invite companies, colleges, and research institutions to collaborate with us to build the large-scale open-source model-based ecosystem. We hope that this project will be the foundation of Chinese cognitive intelligence.

Blind Quality Assessment of 3D Dense Point Clouds with Structure Guided Resampling

Objective quality assessment of 3D point clouds is essential for the development of immersive multimedia systems in real-world applications. Despite the success of perceptual quality evaluation for 2D images and videos, blind/no-reference metrics are still scarce for 3D point clouds with large-scale irregularly distributed 3D points. Therefore, in this paper, we propose an objective point cloud quality index with Structure Guided Resampling (SGR) to automatically evaluate the perceptually visual quality of 3D dense point clouds. The proposed SGR is a general-purpose blind quality assessment method without the assistance of any reference information. Specifically, considering that the human visual system (HVS) is highly sensitive to structure information, we first exploit the unique normal vectors of point clouds to execute regional pre-processing which consists of keypoint resampling and local region construction. Then, we extract three groups of quality-related features, including: 1) geometry density features; 2) color naturalness features; 3) angular consistency features. Both the cognitive peculiarities of the human brain and naturalness regularity are involved in the designed quality-aware features that can capture the most vital aspects of distorted 3D point clouds. Extensive experiments on several publicly available subjective point cloud quality databases validate that our proposed SGR can compete with state-of-the-art full-reference, reduced-reference, and no-reference quality assessment algorithms.

Personality-Driven Social Multimedia Content Recommendation

Social media marketing plays a vital role in promoting brand and product values to wide audiences. In order to boost their advertising revenues, global media buying platforms such as Facebook Ads constantly reduce the reach of branded organic posts, pushing brands to spend more on paid media ads. In order to run organic and paid social media marketing efficiently, it is necessary to understand the audience, tailoring the content to fit their interests and online behaviours, which is impossible to do manually at a large scale. At the same time, various personality type categorization schemes such as the Myers-Briggs Personality Type indicator make it possible to reveal the dependencies between personality traits and user content preferences on a wider scale by categorizing audience behaviours in a unified and structured manner. This problem is yet to be studied in depth by the research community, while the level of impact of different personality traits on content recommendation accuracy has not been widely utilised and comprehensively evaluated so far. Specifically, in this work we investigate the impact of human personality traits on the content recommendation model by applying a novel personality-driven multi-view content recommender system called Personality Content Marketing Recommender Engine, or PersiC. Our experimental results and real-world case study demonstrate not just PersiC's ability to perform efficient human personality-driven multi-view content recommendation, but also allow for actionable digital ad strategy recommendations, which when deployed are able to improve digital advertising efficiency by over 420% as compared to the original human-guided approach.

Pseudo-Label Guided Multi-Contrast Generalization for Non-Contrast Organ-Aware Segmentation

Non-contrast computed tomography (NCCT) is commonly acquired for lung cancer screening, assessment of general abdominal pain or suspected renal stones, trauma evaluation, and many other indications. However, the absence of contrast limits distinguishing organ in-between boundaries. In this paper, we propose a novel unsupervised approach that leverages pairwise contrast-enhanced CT (CECT) context to compute non-contrast segmentation without ground-truth label. Unlike generative adversarial approaches, we compute the pairwise morphological context with CECT to provide teacher guidance instead of generating fake anatomical context. Additionally, we further augment the intensity correlations in 'organ-specific' settings and increase the sensitivity to organ-aware boundary. We validate our approach on multi-organ segmentation with paired non-contrast & contrast-enhanced CT scans using five-fold cross-validation. Full external validations are performed on an independent non-contrast cohort for aorta segmentation. Compared with current abdominal organs segmentation state-of-the-art in fully supervised setting, our proposed pipeline achieves a significantly higher Dice by 3.98% (internal multi-organ annotated), and 8.00% (external aorta annotated) for abdominal organs segmentation. The code and pretrained models are publicly available at https://github.com/MASILab/ContrastMix.

Characterizing Renal Structures with 3D Block Aggregate Transformers

Efficiently quantifying renal structures can provide distinct spatial context and facilitate biomarker discovery for kidney morphology. However, the development and evaluation of the transformer model to segment the renal cortex, medulla, and collecting system remains challenging due to data inefficiency. Inspired by the hierarchical structures in vision transformer, we propose a novel method using a 3D block aggregation transformer for segmenting kidney components on contrast-enhanced CT scans. We construct the first cohort of renal substructures segmentation dataset with 116 subjects under institutional review board (IRB) approval. Our method yields the state-of-the-art performance (Dice of 0.8467) against the baseline approach of 0.8308 with the data-efficient design. The Pearson R achieves 0.9891 between the proposed method and manual standards and indicates the strong correlation and reproducibility for volumetric analysis. We extend the proposed method to the public KiTS dataset, the method leads to improved accuracy compared to transformer-based approaches. We show that the 3D block aggregation transformer can achieve local communication between sequence representations without modifying self-attention, and it can serve as an accurate and efficient quantification tool for characterizing renal structures.

No-Reference Point Cloud Quality Assessment via Domain Adaptation

We present a novel no-reference quality assessment metric, the image transferred point cloud quality assessment (IT-PCQA), for 3D point clouds. For quality assessment, deep neural network (DNN) has shown compelling performance on no-reference metric design. However, the most challenging issue for no-reference PCQA is that we lack large-scale subjective databases to drive robust networks. Our motivation is that the human visual system (HVS) is the decision-maker regardless of the type of media for quality assessment. Leveraging the rich subjective scores of the natural images, we can quest the evaluation criteria of human perception via DNN and transfer the capability of prediction to 3D point clouds. In particular, we treat natural images as the source domain and point clouds as the target domain, and infer point cloud quality via unsupervised adversarial domain adaptation. To extract effective latent features and minimize the domain discrepancy, we propose a hierarchical feature encoder and a conditional-discriminative network. Considering that the ultimate purpose is regressing objective score, we introduce a novel conditional cross entropy loss in the conditional-discriminative network to penalize the negative samples which hinder the convergence of the quality regression network. Experimental results show that the proposed method can achieve higher performance than traditional no-reference metrics, even comparable results with full-reference metrics. The proposed method also suggests the feasibility of assessing the quality of specific media content without the expensive and cumbersome subjective evaluations.

Which One is Better: Assessing Objective Metrics for Point Cloud Compression

Point cloud compression (PCC) has made remarkable achievement in recent years. In the mean time, point cloud quality assessment (PCQA) also realize gratifying development. Some recently emerged metrics present robust performance on public point cloud assessment databases. However, these metrics have not been evaluated specifically for PCC to verify whether they exhibit consistent performance with the subjective perception. In this paper, we establish a new dataset for compression evaluation first, which contains 175 compressed point clouds in total, deriving from 7 compression algorithms with 5 compression levels. Then leveraging the proposed dataset, we evaluate the performance of the existing PCQA metrics in terms of different compression types. The results demonstrate some deficiencies of existing metrics in compression evaluation.