When Age-Invariant Face Recognition Meets Face Age Synthesis: A Multi-Task Learning Framework

To minimize the effects of age variation in face recognition, previous work either extracts identity-related discriminative features by minimizing the correlation between identity- and age-related features, called age-invariant face recognition (AIFR), or removes age variation by transforming the faces of different age groups into the same age group, called face age synthesis (FAS); however, the former lacks visual results for model interpretation while the latter suffers from artifacts compromising downstream recognition. Therefore, this paper proposes a unified, multi-task framework to jointly handle these two tasks, termed MTLFace, which can learn age-invariant identity-related representation while achieving pleasing face synthesis. Specifically, we first decompose the mixed face feature into two uncorrelated components -- identity- and age-related feature -- through an attention mechanism, and then decorrelate these two components using multi-task training and continuous domain adaption. In contrast to the conventional one-hot encoding that achieves group-level FAS, we propose a novel identity conditional module to achieve identity-level FAS, with a weight-sharing strategy to improve the age smoothness of synthesized faces. In addition, we collect and release a large cross-age face dataset with age and gender annotations to advance the development of the AIFR and FAS. Extensive experiments on five benchmark cross-age datasets demonstrate the superior performance of our proposed MTLFace over existing state-of-the-art methods for AIFR and FAS. We further validate MTLFace on two popular general face recognition datasets, showing competitive performance for face recognition in the wild. The source code and dataset are available at~\url{https://github.com/Hzzone/MTLFace}.

RoutingGAN: Routing Age Progression and Regression with Disentangled Learning

Although impressive results have been achieved for age progression and regression, there remain two major issues in generative adversarial networks (GANs)-based methods: 1) conditional GANs (cGANs)-based methods can learn various effects between any two age groups in a single model, but are insufficient to characterize some specific patterns due to completely shared convolutions filters; and 2) GANs-based methods can, by utilizing several models to learn effects independently, learn some specific patterns, however, they are cumbersome and require age label in advance. To address these deficiencies and have the best of both worlds, this paper introduces a dropout-like method based on GAN~(RoutingGAN) to route different effects in a high-level semantic feature space. Specifically, we first disentangle the age-invariant features from the input face, and then gradually add the effects to the features by residual routers that assign the convolution filters to different age groups by dropping out the outputs of others. As a result, the proposed RoutingGAN can simultaneously learn various effects in a single model, with convolution filters being shared in part to learn some specific effects. Experimental results on two benchmarked datasets demonstrate superior performance over existing methods both qualitatively and quantitatively.

Meta ordinal weighting net for improving lung nodule classification

The progression of lung cancer implies the intrinsic ordinal relationship of lung nodules at different stages-from benign to unsure then to malignant. This problem can be solved by ordinal regression methods, which is between classification and regression due to its ordinal label. However, existing convolutional neural network (CNN)-based ordinal regression methods only focus on modifying classification head based on a randomly sampled mini-batch of data, ignoring the ordinal relationship resided in the data itself. In this paper, we propose a Meta Ordinal Weighting Network (MOW-Net) to explicitly align each training sample with a meta ordinal set (MOS) containing a few samples from all classes. During the training process, the MOW-Net learns a mapping from samples in MOS to the corresponding class-specific weight. In addition, we further propose a meta cross-entropy (MCE) loss to optimize the network in a meta-learning scheme. The experimental results demonstrate that the MOW-Net achieves better accuracy than the state-of-the-art ordinal regression methods, especially for the unsure class.

Meta Ordinal Regression Forest For Learning with Unsure Lung Nodules

Deep learning-based methods have achieved promising performance in early detection and classification of lung nodules, most of which discard unsure nodules and simply deal with a binary classification -- malignant vs benign. Recently, an unsure data model (UDM) was proposed to incorporate those unsure nodules by formulating this problem as an ordinal regression, showing better performance over traditional binary classification. To further explore the ordinal relationship for lung nodule classification, this paper proposes a meta ordinal regression forest (MORF), which improves upon the state-of-the-art ordinal regression method, deep ordinal regression forest (DORF), in three major ways. First, MORF can alleviate the biases of the predictions by making full use of deep features while DORF needs to fix the composition of decision trees before training. Second, MORF has a novel grouped feature selection (GFS) module to re-sample the split nodes of decision trees. Last, combined with GFS, MORF is equipped with a meta learning-based weighting scheme to map the features selected by GFS to tree-wise weights while DORF assigns equal weights for all trees. Experimental results on the LIDC-IDRI dataset demonstrate superior performance over existing methods, including the state-of-the-art DORF.

PFA-GAN: Progressive Face Aging with Generative Adversarial Network

Face aging is to render a given face to predict its future appearance, which plays an important role in the information forensics and security field as the appearance of the face typically varies with age. Although impressive results have been achieved with conditional generative adversarial networks (cGANs), the existing cGANs-based methods typically use a single network to learn various aging effects between any two different age groups. However, they cannot simultaneously meet three essential requirements of face aging -- including image quality, aging accuracy, and identity preservation -- and usually generate aged faces with strong ghost artifacts when the age gap becomes large. Inspired by the fact that faces gradually age over time, this paper proposes a novel progressive face aging framework based on generative adversarial network (PFA-GAN) to mitigate these issues. Unlike the existing cGANs-based methods, the proposed framework contains several sub-networks to mimic the face aging process from young to old, each of which only learns some specific aging effects between two adjacent age groups. The proposed framework can be trained in an end-to-end manner to eliminate accumulative artifacts and blurriness. Moreover, this paper introduces an age estimation loss to take into account the age distribution for an improved aging accuracy, and proposes to use the Pearson correlation coefficient as an evaluation metric measuring the aging smoothness for face aging methods. Extensively experimental results demonstrate superior performance over existing (c)GANs-based methods, including the state-of-the-art one, on two benchmarked datasets. The source code is available at~\url{https://github.com/Hzzone/PFA-GAN}.

Stabilizing Deep Tomographic Reconstruction Networks

Tomographic image reconstruction with deep learning is an emerging field of applied artificial intelligence but a recent study reveals that deep reconstruction networks, such as well-known AUTOMAP, are unstable for computed tomography (CT) and magnetic resonance imaging (MRI). Specifically, three kinds of instabilities were identified: (1) strong output artefacts from tiny perturbation, (2) poor detection of small features, and (3) decreased performance with increased input data. These instabilities are believed to be from lacking kernel awareness and nontrivial to overcome, but compressed sensing (CS) reconstruction was reported to be stable due to its kernel awareness. Since deep reconstruction may potentially become the main driving force to achieve better image quality, stabilizing deep reconstruction networks is an urgent challenge. Here we propose an Analytic, Compressive, Iterative Deep (ACID) network to fundamentally address this challenge. Instead of only using deep learning or compressed sensing, ACID consists of four modules including deep reconstruction, CS, analytic mapping, and iterative refinement. In our experiments, ACID eliminated all three kinds of instabilities and significantly improved image quality relative to the methods in the aforementioned PNAS study. ACID is only an example of integrating diverse algorithmic ingredients but it has clearly demonstrated that data-driven reconstruction can be stabilized to outperform reconstruction using CS alone. The power of ACID comes from a unique combination of a deep reconstruction network trained on big data, CS via advanced optimization, and iterative refinement that stabilizes the whole workflow. We anticipate that this integrative closed-loop data driven approach will add great value to clinical and other applications.

Deep Learning Predicts Cardiovascular Disease Risks from Lung Cancer Screening Low Dose Computed Tomography

The high risk population of cardiovascular disease (CVD) is simultaneously at high risk of lung cancer. Given the dominance of low dose computed tomography (LDCT) for lung cancer screening, the feasibility of extracting information on CVD from the same LDCT scan would add major value to patients at no additional radiation dose. However, with strong noise in LDCT images and without electrocardiogram (ECG) gating, CVD risk analysis from LDCT is highly challenging. Here we present an innovative deep learning model to address this challenge. Our deep model was trained with 30,286 LDCT volumes and achieved the state-of-the-art performance (area under the curve (AUC) of 0.869) on 2,085 National Lung Cancer Screening Trial (NLST) subjects, and effectively identified patients with high CVD mortality risks (AUC of 0.768). Our deep model was further calibrated against the clinical gold standard CVD risk scores from ECG-gated dedicated cardiac CT, including coronary artery calcification (CAC) score, CAD-RADS score and MESA 10-year CHD risk score from an independent dataset of 106 subjects. In this validation study, our model achieved AUC of 0.942, 0.809 and 0.817 for CAC, CAD-RADS and MESA scores, respectively. Our deep learning model has the potential to convert LDCT for lung cancer screening into dual-screening quantitative tool for CVD risk estimation.

Deep Ordinal Regression Forests

Ordinal regression is a type of regression techniques used for predicting an ordinal variable. Recent methods formulate an ordinal regression problem as a series of binary classification problems. Such methods cannot ensure the global ordinal relationship is preserved since the relationships among different binary classifiers are neglected. We propose a novel ordinal regression approach called Deep Ordinal Regression Forests (DORFs), which is constructed with the differentiable decision trees for obtaining precise and stable global ordinal relationships. The advantages of the proposed DORFs are twofold. First, instead of learning a series of binary classifiers independently, the proposed method learns an ordinal distribution for ordinal regression. Second, the differentiable decision trees can be trained together with the ordinal distribution in an end-to-end manner. The effectiveness of the proposed DORFs is verified on two ordinal regression tasks, i.e., facial age estimation and image aesthetic assessment, showing significant improvements and better stability over the state-of-the-art ordinal regression methods.

Low-dimensional Manifold Constrained Disentanglement Network for Metal Artifact Reduction

Deep neural network based methods have achieved promising results for CT metal artifact reduction (MAR), most of which use many synthesized paired images for training. As synthesized metal artifacts in CT images may not accurately reflect the clinical counterparts, an artifact disentanglement network (ADN) was proposed with unpaired clinical images directly, producing promising results on clinical datasets. However, without sufficient supervision, it is difficult for ADN to recover structural details of artifact-affected CT images based on adversarial losses only. To overcome these problems, here we propose a low-dimensional manifold (LDM) constrained disentanglement network (DN), leveraging the image characteristics that the patch manifold is generally low-dimensional. Specifically, we design an LDM-DN learning algorithm to empower the disentanglement network through optimizing the synergistic network loss functions while constraining the recovered images to be on a low-dimensional patch manifold. Moreover, learning from both paired and unpaired data, an efficient hybrid optimization scheme is proposed to further improve the MAR performance on clinical datasets. Extensive experiments demonstrate that the proposed LDM-DN approach can consistently improve the MAR performance in paired and/or unpaired learning settings, outperforming competing methods on synthesized and clinical datasets.

Cine Cardiac MRI Motion Artifact Reduction Using a Recurrent Neural Network

Cine cardiac magnetic resonance imaging (MRI) is widely used for diagnosis of cardiac diseases thanks to its ability to present cardiovascular features in excellent contrast. As compared to computed tomography (CT), MRI, however, requires a long scan time, which inevitably induces motion artifacts and causes patients' discomfort. Thus, there has been a strong clinical motivation to develop techniques to reduce both the scan time and motion artifacts. Given its successful applications in other medical imaging tasks such as MRI super-resolution and CT metal artifact reduction, deep learning is a promising approach for cardiac MRI motion artifact reduction. In this paper, we propose a recurrent neural network to simultaneously extract both spatial and temporal features from under-sampled, motion-blurred cine cardiac images for improved image quality. The experimental results demonstrate substantially improved image quality on two clinical test datasets. Also, our method enables data-driven frame interpolation at an enhanced temporal resolution. Compared with existing methods, our deep learning approach gives a superior performance in terms of structural similarity (SSIM) and peak signal-to-noise ratio (PSNR).