XMorpher: Full Transformer for Deformable Medical Image Registration via Cross Attention

An effective backbone network is important to deep learning-based Deformable Medical Image Registration (DMIR), because it extracts and matches the features between two images to discover the mutual correspondence for fine registration. However, the existing deep networks focus on single image situation and are limited in registration task which is performed on paired images. Therefore, we advance a novel backbone network, XMorpher, for the effective corresponding feature representation in DMIR. 1) It proposes a novel full transformer architecture including dual parallel feature extraction networks which exchange information through cross attention, thus discovering multi-level semantic correspondence while extracting respective features gradually for final effective registration. 2) It advances the Cross Attention Transformer (CAT) blocks to establish the attention mechanism between images which is able to find the correspondence automatically and prompts the features to fuse efficiently in the network. 3) It constrains the attention computation between base windows and searching windows with different sizes, and thus focuses on the local transformation of deformable registration and enhances the computing efficiency at the same time. Without any bells and whistles, our XMorpher gives Voxelmorph 2.8% improvement on DSC , demonstrating its effective representation of the features from the paired images in DMIR. We believe that our XMorpher has great application potential in more paired medical images. Our XMorpher is open on https://github.com/Solemoon/XMorpher

MNet: Rethinking 2D/3D Networks for Anisotropic Medical Image Segmentation

The nature of thick-slice scanning causes severe inter-slice discontinuities of 3D medical images, and the vanilla 2D/3D convolutional neural networks (CNNs) fail to represent sparse inter-slice information and dense intra-slice information in a balanced way, leading to severe underfitting to inter-slice features (for vanilla 2D CNNs) and overfitting to noise from long-range slices (for vanilla 3D CNNs). In this work, a novel mesh network (MNet) is proposed to balance the spatial representation inter axes via learning. 1) Our MNet latently fuses plenty of representation processes by embedding multi-dimensional convolutions deeply into basic modules, making the selections of representation processes flexible, thus balancing representation for sparse inter-slice information and dense intra-slice information adaptively. 2) Our MNet latently fuses multi-dimensional features inside each basic module, simultaneously taking the advantages of 2D (high segmentation accuracy of the easily recognized regions in 2D view) and 3D (high smoothness of 3D organ contour) representations, thus obtaining more accurate modeling for target regions. Comprehensive experiments are performed on four public datasets (CT\&MR), the results consistently demonstrate the proposed MNet outperforms the other methods. The code and datasets are available at: https://github.com/zfdong-code/MNet

Speech Denoising Using Only Single Noisy Audio Samples

In this paper, we propose a novel Single Noisy Audio De-noising Framework (SNA-DF) for speech denoising using only single noisy audio samples, which overcomes the limi-tation of constructing either noisy-clean training pairs or multiple independent noisy audio samples. The proposed SNA-DF contains two modules: training audio pairs gener-ated module and audio denoising module. The first module adopts a random audio sub-sampler on single noisy audio samples for the generation of training audio pairs. The sub-sampled training audio pairs are then fed into the audio denoising module, which employs a deep complex U-Net incorporating a complex two-stage transformer (cTSTM) to extract both magnitude and phase information for taking full advantage of the complex features of single noisy au-dios. Experimental results show that the proposed SNA-DF not only eliminates the high dependence on clean targets of traditional audio denoising methods, but also outperforms the methods using multiple noisy audio samples.

CPNet: Cycle Prototype Network for Weakly-supervised 3D Renal Compartments Segmentation on CT Images

Renal compartment segmentation on CT images targets on extracting the 3D structure of renal compartments from abdominal CTA images and is of great significance to the diagnosis and treatment for kidney diseases. However, due to the unclear compartment boundary, thin compartment structure and large anatomy variation of 3D kidney CT images, deep-learning based renal compartment segmentation is a challenging task. We propose a novel weakly supervised learning framework, Cycle Prototype Network, for 3D renal compartment segmentation. It has three innovations: 1) A Cycle Prototype Learning (CPL) is proposed to learn consistency for generalization. It learns from pseudo labels through the forward process and learns consistency regularization through the reverse process. The two processes make the model robust to noise and label-efficient. 2) We propose a Bayes Weakly Supervised Module (BWSM) based on cross-period prior knowledge. It learns prior knowledge from cross-period unlabeled data and perform error correction automatically, thus generates accurate pseudo labels. 3) We present a Fine Decoding Feature Extractor (FDFE) for fine-grained feature extraction. It combines global morphology information and local detail information to obtain feature maps with sharp detail, so the model will achieve fine segmentation on thin structures. Our model achieves Dice of 79.1% and 78.7% with only four labeled images, achieving a significant improvement by about 20% than typical prototype model PANet.

EnMcGAN: Adversarial Ensemble Learning for 3D Complete Renal Structures Segmentation

3D complete renal structures(CRS) segmentation targets on segmenting the kidneys, tumors, renal arteries and veins in one inference. Once successful, it will provide preoperative plans and intraoperative guidance for laparoscopic partial nephrectomy(LPN), playing a key role in the renal cancer treatment. However, no success has been reported in 3D CRS segmentation due to the complex shapes of renal structures, low contrast and large anatomical variation. In this study, we utilize the adversarial ensemble learning and propose Ensemble Multi-condition GAN(EnMcGAN) for 3D CRS segmentation for the first time. Its contribution is three-fold. 1)Inspired by windowing, we propose the multi-windowing committee which divides CTA image into multiple narrow windows with different window centers and widths enhancing the contrast for salient boundaries and soft tissues. And then, it builds an ensemble segmentation model on these narrow windows to fuse the segmentation superiorities and improve whole segmentation quality. 2)We propose the multi-condition GAN which equips the segmentation model with multiple discriminators to encourage the segmented structures meeting their real shape conditions, thus improving the shape feature extraction ability. 3)We propose the adversarial weighted ensemble module which uses the trained discriminators to evaluate the quality of segmented structures, and normalizes these evaluation scores for the ensemble weights directed at the input image, thus enhancing the ensemble results. 122 patients are enrolled in this study and the mean Dice coefficient of the renal structures achieves 84.6%. Extensive experiments with promising results on renal structures reveal powerful segmentation accuracy and great clinical significance in renal cancer treatment.

Deep Complementary Joint Model for Complex Scene Registration and Few-shot Segmentation on Medical Images

Deep learning-based medical image registration and segmentation joint models utilize the complementarity (augmentation data or weakly supervised data from registration, region constraints from segmentation) to bring mutual improvement in complex scene and few-shot situation. However, further adoption of the joint models are hindered: 1) the diversity of augmentation data is reduced limiting the further enhancement of segmentation, 2) misaligned regions in weakly supervised data disturb the training process, 3) lack of label-based region constraints in few-shot situation limits the registration performance. We propose a novel Deep Complementary Joint Model (DeepRS) for complex scene registration and few-shot segmentation. We embed a perturbation factor in the registration to increase the activity of deformation thus maintaining the augmentation data diversity. We take a pixel-wise discriminator to extract alignment confidence maps which highlight aligned regions in weakly supervised data so the misaligned regions' disturbance will be suppressed via weighting. The outputs from segmentation model are utilized to implement deep-based region constraints thus relieving the label requirements and bringing fine registration. Extensive experiments on the CT dataset of MM-WHS 2017 Challenge show great advantages of our DeepRS that outperforms the existing state-of-the-art models.

Generative networks as inverse problems with fractional wavelet scattering networks

Deep learning is a hot research topic in the field of machine learning methods and applications. Generative Adversarial Networks (GANs) and Variational Auto-Encoders (VAEs) provide impressive image generations from Gaussian white noise, but both of them are difficult to train since they need to train the generator (or encoder) and the discriminator (or decoder) simultaneously, which is easy to cause unstable training. In order to solve or alleviate the synchronous training difficult problems of GANs and VAEs, recently, researchers propose Generative Scattering Networks (GSNs), which use wavelet scattering networks (ScatNets) as the encoder to obtain the features (or ScatNet embeddings) and convolutional neural networks (CNNs) as the decoder to generate the image. The advantage of GSNs is the parameters of ScatNets are not needed to learn, and the disadvantage of GSNs is that the expression ability of ScatNets is slightly weaker than CNNs and the dimensional reduction method of Principal Component Analysis (PCA) is easy to lead overfitting in the training of GSNs, and therefore affect the generated quality in the testing process. In order to further improve the quality of generated images while keep the advantages of GSNs, this paper proposes Generative Fractional Scattering Networks (GFRSNs), which use more expressive fractional wavelet scattering networks (FrScatNets) instead of ScatNets as the encoder to obtain the features (or FrScatNet embeddings) and use the similar CNNs of GSNs as the decoder to generate the image. Additionally, this paper develops a new dimensional reduction method named Feature-Map Fusion (FMF) instead of PCA for better keeping the information of FrScatNets and the effect of image fusion on the quality of image generation is also discussed.

SLNSpeech: solving extended speech separation problem by the help of sign language

A speech separation task can be roughly divided into audio-only separation and audio-visual separation. In order to make speech separation technology applied in the real scenario of the disabled, this paper presents an extended speech separation problem which refers in particular to sign language assisted speech separation. However, most existing datasets for speech separation are audios and videos which contain audio and/or visual modalities. To address the extended speech separation problem, we introduce a large-scale dataset named Sign Language News Speech (SLNSpeech) dataset in which three modalities of audio, visual, and sign language are coexisted. Then, we design a general deep learning network for the self-supervised learning of three modalities, particularly, using sign language embeddings together with audio or audio-visual information for better solving the speech separation task. Specifically, we use 3D residual convolutional network to extract sign language features and use pretrained VGGNet model to exact visual features. After that, an improved U-Net with skip connections in feature extraction stage is applied for learning the embeddings among the mixed spectrogram transformed from source audios, the sign language features and visual features. Experiments results show that, besides visual modality, sign language modality can also be used alone to supervise speech separation task. Moreover, we also show the effectiveness of sign language assisted speech separation when the visual modality is disturbed. Source code will be released in http://cheertt.top/homepage/

Evaluation of Algorithms for Multi-Modality Whole Heart Segmentation: An Open-Access Grand Challenge

Knowledge of whole heart anatomy is a prerequisite for many clinical applications. Whole heart segmentation (WHS), which delineates substructures of the heart, can be very valuable for modeling and analysis of the anatomy and functions of the heart. However, automating this segmentation can be arduous due to the large variation of the heart shape, and different image qualities of the clinical data. To achieve this goal, a set of training data is generally needed for constructing priors or for training. In addition, it is difficult to perform comparisons between different methods, largely due to differences in the datasets and evaluation metrics used. This manuscript presents the methodologies and evaluation results for the WHS algorithms selected from the submissions to the Multi-Modality Whole Heart Segmentation (MM-WHS) challenge, in conjunction with MICCAI 2017. The challenge provides 120 three-dimensional cardiac images covering the whole heart, including 60 CT and 60 MRI volumes, all acquired in clinical environments with manual delineation. Ten algorithms for CT data and eleven algorithms for MRI data, submitted from twelve groups, have been evaluated. The results show that many of the deep learning (DL) based methods achieved high accuracy, even though the number of training datasets was limited. A number of them also reported poor results in the blinded evaluation, probably due to overfitting in their training. The conventional algorithms, mainly based on multi-atlas segmentation, demonstrated robust and stable performance, even though the accuracy is not as good as the best DL method in CT segmentation. The challenge, including the provision of the annotated training data and the blinded evaluation for submitted algorithms on the test data, continues as an ongoing benchmarking resource via its homepage (\url{www.sdspeople.fudan.edu.cn/zhuangxiahai/0/mmwhs/}).

Efficient Legendre moment computation for grey level images

Legendre orthogonal moments have been widely used in the field of image analysis. Because their computation by a direct method is very time expensive, recent efforts have been devoted to the reduction of computational complexity. Nevertheless, the existing algorithms are mainly focused on binary images. We propose here a new fast method for computing the Legendre moments, which is not only suitable for binary images but also for grey levels. We first set up the recurrence formula of one-dimensional (1D) Legendre moments by using the recursive property of Legendre polynomials. As a result, the 1D Legendre moments of order p, Lp = Lp(0), can be expressed as a linear combination of Lp-1(1) and Lp-2(0). Based on this relationship, the 1D Legendre moments Lp(0) is thus obtained from the array of L1(a) and L0(a) where a is an integer number less than p. To further decrease the computation complexity, an algorithm, in which no multiplication is required, is used to compute these quantities. The method is then extended to the calculation of the two-dimensional Legendre moments Lpq. We show that the proposed method is more efficient than the direct method.