Distributional Deep Learning for Super-Resolution of 4D Flow MRI under Domain Shift

Super-resolution is widely used in medical imaging to enhance low-quality data, reducing scan time and improving abnormality detection. Conventional super-resolution approaches typically rely on paired datasets of downsampled and original high resolution images, training models to reconstruct high resolution images from their artificially degraded counterparts. However, in real-world clinical settings, low resolution data often arise from acquisition mechanisms that differ significantly from simple downsampling. As a result, these inputs may lie outside the domain of the training data, leading to poor model generalization due to domain shift. To address this limitation, we propose a distributional deep learning framework that improves model robustness and domain generalization. We develop this approch for enhancing the resolution of 4D Flow MRI (4DF). This is a novel imaging modality that captures hemodynamic flow velocity and clinically relevant metrics such as vessel wall stress. These metrics are critical for assessing aneurysm rupture risk. Our model is initially trained on high resolution computational fluid dynamics (CFD) simulations and their downsampled counterparts. It is then fine-tuned on a small, harmonized dataset of paired 4D Flow MRI and CFD samples. We derive the theoretical properties of our distributional estimators and demonstrate that our framework significantly outperforms traditional deep learning approaches through real data applications. This highlights the effectiveness of distributional learning in addressing domain shift and improving super-resolution performance in clinically realistic scenarios.

MTFM: A Scalable and Alignment-free Foundation Model for Industrial Recommendation in Meituan

Industrial recommendation systems typically involve multiple scenarios, yet existing cross-domain (CDR) and multi-scenario (MSR) methods often require prohibitive resources and strict input alignment, limiting their extensibility. We propose MTFM (Meituan Foundation Model for Recommendation), a transformer-based framework that addresses these challenges. Instead of pre-aligning inputs, MTFM transforms cross-domain data into heterogeneous tokens, capturing multi-scenario knowledge in an alignment-free manner. To enhance efficiency, we first introduce a multi-scenario user-level sample aggregation that significantly enhances training throughput by reducing the total number of instances. We further integrate Grouped-Query Attention and a customized Hybrid Target Attention to minimize memory usage and computational complexity. Furthermore, we implement various system-level optimizations, such as kernel fusion and the elimination of CPU-GPU blocking, to further enhance both training and inference throughput. Offline and online experiments validate the effectiveness of MTFM, demonstrating that significant performance gains are achieved by scaling both model capacity and multi-scenario training data.

CAAL: Confidence-Aware Active Learning for Heteroscedastic Atmospheric Regression

Quantifying the impacts of air pollution on health and climate relies on key atmospheric particle properties such as toxicity and hygroscopicity. However, these properties typically require complex observational techniques or expensive particle-resolved numerical simulations, limiting the availability of labeled data. We therefore estimate these hard-to-measure particle properties from routinely available observations (e.g., air pollutant concentrations and meteorological conditions). Because routine observations only indirectly reflect particle composition and structure, the mapping from routine observations to particle properties is noisy and input-dependent, yielding a heteroscedastic regression setting. With a limited and costly labeling budget, the central challenge is to select which samples to measure or simulate. While active learning is a natural approach, most acquisition strategies rely on predictive uncertainty. Under heteroscedastic noise, this signal conflates reducible epistemic uncertainty with irreducible aleatoric uncertainty, causing limited budgets to be wasted in noise-dominated regions. To address this challenge, we propose a confidence-aware active learning framework (CAAL) for efficient and robust sample selection in heteroscedastic settings. CAAL consists of two components: a decoupled uncertainty-aware training objective that separately optimises the predictive mean and noise level to stabilise uncertainty estimation, and a confidence-aware acquisition function that dynamically weights epistemic uncertainty using predicted aleatoric uncertainty as a reliability signal. Experiments on particle-resolved numerical simulations and real atmospheric observations show that CAAL consistently outperforms standard AL baselines. The proposed framework provides a practical and general solution for the efficient expansion of high-cost atmospheric particle property databases.

DS-HGCN: A Dual-Stream Hypergraph Convolutional Network for Predicting Student Engagement via Social Contagion

Student engagement is a critical factor influencing academic success and learning outcomes. Accurately predicting student engagement is essential for optimizing teaching strategies and providing personalized interventions. However, most approaches focus on single-dimensional feature analysis and assessing engagement based on individual student factors. In this work, we propose a dual-stream multi-feature fusion model based on hypergraph convolutional networks (DS-HGCN), incorporating social contagion of student engagement. DS-HGCN enables accurate prediction of student engagement states by modeling multi-dimensional features and their propagation mechanisms between students. The framework constructs a hypergraph structure to encode engagement contagion among students and captures the emotional and behavioral differences and commonalities by multi-frequency signals. Furthermore, we introduce a hypergraph attention mechanism to dynamically weigh the influence of each student, accounting for individual differences in the propagation process. Extensive experiments on public benchmark datasets demonstrate that our proposed method achieves superior performance and significantly outperforms existing state-of-the-art approaches.

FactorPortrait: Controllable Portrait Animation via Disentangled Expression, Pose, and Viewpoint

We introduce FactorPortrait, a video diffusion method for controllable portrait animation that enables lifelike synthesis from disentangled control signals of facial expressions, head movement, and camera viewpoints. Given a single portrait image, a driving video, and camera trajectories, our method animates the portrait by transferring facial expressions and head movements from the driving video while simultaneously enabling novel view synthesis from arbitrary viewpoints. We utilize a pre-trained image encoder to extract facial expression latents from the driving video as control signals for animation generation. Such latents implicitly capture nuanced facial expression dynamics with identity and pose information disentangled, and they are efficiently injected into the video diffusion transformer through our proposed expression controller. For camera and head pose control, we employ Plücker ray maps and normal maps rendered from 3D body mesh tracking. To train our model, we curate a large-scale synthetic dataset containing diverse combinations of camera viewpoints, head poses, and facial expression dynamics. Extensive experiments demonstrate that our method outperforms existing approaches in realism, expressiveness, control accuracy, and view consistency.

MTGR: Industrial-Scale Generative Recommendation Framework in Meituan

Scaling law has been extensively validated in many domains such as natural language processing and computer vision. In the recommendation system, recent work has adopted generative recommendations to achieve scalability, but their generative approaches require abandoning the carefully constructed cross features of traditional recommendation models. We found that this approach significantly degrades model performance, and scaling up cannot compensate for it at all. In this paper, we propose MTGR (Meituan Generative Recommendation) to address this issue. MTGR is modeling based on the HSTU architecture and can retain the original deep learning recommendation model (DLRM) features, including cross features. Additionally, MTGR achieves training and inference acceleration through user-level compression to ensure efficient scaling. We also propose Group-Layer Normalization (GLN) to enhance the performance of encoding within different semantic spaces and the dynamic masking strategy to avoid information leakage. We further optimize the training frameworks, enabling support for our models with 10 to 100 times computational complexity compared to the DLRM, without significant cost increases. MTGR achieved 65x FLOPs for single-sample forward inference compared to the DLRM model, resulting in the largest gain in nearly two years both offline and online. This breakthrough was successfully deployed on Meituan, the world's largest food delivery platform, where it has been handling the main traffic.

Beyond Static Testbeds: An Interaction-Centric Agent Simulation Platform for Dynamic Recommender Systems

Evaluating and iterating upon recommender systems is crucial, yet traditional A/B testing is resource-intensive, and offline methods struggle with dynamic user-platform interactions. While agent-based simulation is promising, existing platforms often lack a mechanism for user actions to dynamically reshape the environment. To bridge this gap, we introduce RecInter, a novel agent-based simulation platform for recommender systems featuring a robust interaction mechanism. In RecInter platform, simulated user actions (e.g., likes, reviews, purchases) dynamically update item attributes in real-time, and introduced Merchant Agents can reply, fostering a more realistic and evolving ecosystem. High-fidelity simulation is ensured through Multidimensional User Profiling module, Advanced Agent Architecture, and LLM fine-tuned on Chain-of-Thought (CoT) enriched interaction data. Our platform achieves significantly improved simulation credibility and successfully replicates emergent phenomena like Brand Loyalty and the Matthew Effect. Experiments demonstrate that this interaction mechanism is pivotal for simulating realistic system evolution, establishing our platform as a credible testbed for recommender systems research.

Foundations of a Knee Joint Digital Twin from qMRI Biomarkers for Osteoarthritis and Knee Replacement

This study forms the basis of a digital twin system of the knee joint, using advanced quantitative MRI (qMRI) and machine learning to advance precision health in osteoarthritis (OA) management and knee replacement (KR) prediction. We combined deep learning-based segmentation of knee joint structures with dimensionality reduction to create an embedded feature space of imaging biomarkers. Through cross-sectional cohort analysis and statistical modeling, we identified specific biomarkers, including variations in cartilage thickness and medial meniscus shape, that are significantly associated with OA incidence and KR outcomes. Integrating these findings into a comprehensive framework represents a considerable step toward personalized knee-joint digital twins, which could enhance therapeutic strategies and inform clinical decision-making in rheumatological care. This versatile and reliable infrastructure has the potential to be extended to broader clinical applications in precision health.

Nested Deep Learning Model Towards A Foundation Model for Brain Signal Data

Epilepsy affects over 50 million people globally, with EEG/MEG-based spike detection playing a crucial role in diagnosis and treatment. Manual spike identification is time-consuming and requires specialized training, limiting the number of professionals available to analyze EEG/MEG data. To address this, various algorithmic approaches have been developed. However, current methods face challenges in handling varying channel configurations and in identifying the specific channels where spikes originate. This paper introduces a novel Nested Deep Learning (NDL) framework designed to overcome these limitations. NDL applies a weighted combination of signals across all channels, ensuring adaptability to different channel setups, and allows clinicians to identify key channels more accurately. Through theoretical analysis and empirical validation on real EEG/MEG datasets, NDL demonstrates superior accuracy in spike detection and channel localization compared to traditional methods. The results show that NDL improves prediction accuracy, supports cross-modality data integration, and can be fine-tuned for various neurophysiological applications.

Nested Deep Learning Model: A Foundation Model for Brain Signal Data

Epilepsy affects over 50 million people globally, with EEG/MEG-based spike detection playing a crucial role in diagnosis and treatment. Manual spike identification is time-consuming and requires specialized training, limiting the number of professionals available to analyze EEG/MEG data. To address this, various algorithmic approaches have been developed. However, current methods face challenges in handling varying channel configurations and in identifying the specific channels where spikes originate. This paper introduces a novel Nested Deep Learning (NDL) framework designed to overcome these limitations. NDL applies a weighted combination of signals across all channels, ensuring adaptability to different channel setups, and allows clinicians to identify key channels more accurately. Through theoretical analysis and empirical validation on real EEG/MEG datasets, NDL demonstrates superior accuracy in spike detection and channel localization compared to traditional methods. The results show that NDL improves prediction accuracy, supports cross-modality data integration, and can be fine-tuned for various neurophysiological applications.