ARANet: Attention-based Residual Adversarial Network with Deep Supervision for Radiotherapy Dose Prediction of Cervical Cancer

Radiation therapy is the mainstay treatment for cervical cancer, and its ultimate goal is to ensure the planning target volume (PTV) reaches the prescribed dose while reducing dose deposition of organs-at-risk (OARs) as much as possible. To achieve these clinical requirements, the medical physicist needs to manually tweak the radiotherapy plan repeatedly in a trial-anderror manner until finding the optimal one in the clinic. However, such trial-and-error processes are quite time-consuming, and the quality of plans highly depends on the experience of the medical physicist. In this paper, we propose an end-to-end Attentionbased Residual Adversarial Network with deep supervision, namely ARANet, to automatically predict the 3D dose distribution of cervical cancer. Specifically, given the computer tomography (CT) images and their corresponding segmentation masks of PTV and OARs, ARANet employs a prediction network to generate the dose maps. We also utilize a multi-scale residual attention module and deep supervision mechanism to enforce the prediction network to extract more valuable dose features while suppressing irrelevant information. Our proposed method is validated on an in-house dataset including 54 cervical cancer patients, and experimental results have demonstrated its obvious superiority compared to other state-of-the-art methods.

Seismic Data Interpolation based on Denoising Diffusion Implicit Models with Resampling

The incompleteness of the seismic data caused by missing traces along the spatial extension is a common issue in seismic acquisition due to the existence of obstacles and economic constraints, which severely impairs the imaging quality of subsurface geological structures. Recently, deep learningbased seismic interpolation methods have attained promising progress, while achieving stable training of generative adversarial networks is not easy, and performance degradation is usually notable if the missing patterns in the testing and training do not match. In this paper, we propose a novel seismic denoising diffusion implicit model with resampling. The model training is established on the denoising diffusion probabilistic model, where U-Net is equipped with the multi-head self-attention to match the noise in each step. The cosine noise schedule, serving as the global noise configuration, promotes the high utilization of known trace information by accelerating the passage of the excessive noise stages. The model inference utilizes the denoising diffusion implicit model, conditioning on the known traces, to enable high-quality interpolation with fewer diffusion steps. To enhance the coherency between the known traces and the missing traces within each reverse step, the inference process integrates a resampling strategy to achieve an information recap on the former interpolated traces. Extensive experiments conducted on synthetic and field seismic data validate the superiority of our model and its robustness to various missing patterns. In addition, uncertainty quantification and ablation studies are also investigated.