BDEC:Brain Deep Embedded Clustering model

An essential premise for neuroscience brain network analysis is the successful segmentation of the cerebral cortex into functionally homogeneous regions. Resting-state functional magnetic resonance imaging (rs-fMRI), capturing the spontaneous activities of the brain, provides the potential for cortical parcellation. Previous parcellation methods can be roughly categorized into three groups, mainly employing either local gradient, global similarity, or a combination of both. The traditional clustering algorithms, such as "K-means" and "Spectral clustering" may affect the reproducibility or the biological interpretation of parcellations; The region growing-based methods influence the expression of functional homogeneity in the brain at a large scale; The parcellation method based on probabilistic graph models inevitably introduce model assumption biases. In this work, we develop an assumption-free model called as BDEC, which leverages the robust data fitting capability of deep learning. To the best of our knowledge, this is the first study that uses deep learning algorithm for rs-fMRI-based parcellation. By comparing with nine commonly used brain parcellation methods, the BDEC model demonstrates significantly superior performance in various functional homogeneity indicators. Furthermore, it exhibits favorable results in terms of validity, network analysis, task homogeneity, and generalization capability. These results suggest that the BDEC parcellation captures the functional characteristics of the brain and holds promise for future voxel-wise brain network analysis in the dimensionality reduction of fMRI data.

Estimating Continuous Muscle Fatigue For Multi-Muscle Coordinated Exercise: A Pilot Study

Assessing the progression of muscle fatigue for daily exercises provides vital indicators for precise rehabilitation, personalized training dose, especially under the context of Metaverse. Assessing fatigue of multi-muscle coordination-involved daily exercises requires the neuromuscular features that represent the fatigue-induced characteristics of spatiotemporal adaptions of multiple muscles and the estimator that captures the time-evolving progression of fatigue. In this paper, we propose to depict fatigue by the features of muscle compensation and spinal module activation changes and estimate continuous fatigue by a physiological rationale model. First, we extract muscle synergy fractionation and the variance of spinal module spikings as features inspired by the prior of fatigue-induced neuromuscular adaptations. Second, we treat the features as observations and develop a Bayesian Gaussian process to capture the time-evolving progression. Third, we solve the issue of lacking supervision information by mathematically formulating the time-evolving characteristics of fatigue as the loss function. Finally, we adapt the metrics that follow the physiological principles of fatigue to quantitatively evaluate the performance. Our extensive experiments present a 0.99 similarity between days, a over 0.7 similarity with other views of fatigue and a nearly 1 weak monotonicity, which outperform other methods. This study would aim the objective assessment of muscle fatigue.

Detecting and Correcting IMU Movements During Joint Angle Estimation

Inertial measurement units (IMUs) increasingly function as a basic component of wearable sensor network (WSN)systems. IMU-based joint angle estimation (JAE) is a relatively typical usage of IMUs, with extensive applications. However, the issue that IMUs move with respect to their original placement during JAE is still a research gap, and limits the robustness of deploying the technique in real-world application scenarios. In this study, we propose to detect and correct the IMU movement online in a relatively computationally lightweight manner. Particularly, we first experimentally investigate the influence of IMU movements. Second, we design the metrics for detecting IMU movements by mathematically formulating how the IMU movement affects the IMU measurements. Third, we determine the optimal thresholds of metrics by synthetic IMU data from a significantly amended simulation model. Finally, a correction method is proposed to correct the effects of IMU movements. We demonstrate our method on both synthetic data and real-user data. The results demonstrate our method is a promising solution to detecting and correcting IMU movements during JAE.

Continuous Prediction of Lower-Limb Kinematics From Multi-Modal Biomedical Signals

The fast-growing techniques of measuring and fusing multi-modal biomedical signals enable advanced motor intent decoding schemes of lowerlimb exoskeletons, meeting the increasing demand for rehabilitative or assistive applications of take-home healthcare. Challenges of exoskeletons motor intent decoding schemes remain in making a continuous prediction to compensate for the hysteretic response caused by mechanical transmission. In this paper, we solve this problem by proposing an ahead of time continuous prediction of lower limb kinematics, with the prediction of knee angles during level walking as a case study. Firstly, an end-to-end kinematics prediction network(KinPreNet), consisting of a feature extractor and an angle predictor, is proposed and experimentally compared with features and methods traditionally used in ahead-of-time prediction of gait phases. Secondly, inspired by the electromechanical delay(EMD), we further explore our algorithm's capability of compensating response delay of mechanical transmission by validating the performance of the different sections of prediction time. And we experimentally reveal the time boundary of compensating the hysteretic response. Thirdly, a comparison of employing EMG signals or not is performed to reveal the EMG and kinematic signals collaborated contributions to the continuous prediction. During the experiments, EMG signals of nine muscles and knee angles calculated from inertial measurement unit (IMU) signals are recorded from ten healthy subjects. To the best of our knowledge, this is the first study of continuously predicting lower-limb kinematics in an ahead-of-time manner based on the electromechanical delay (EMD).