ESN-DAGMM: A Lightweight Framework for Unsupervised Time-Series Data Monitoring in 5G O-RAN Networks

Open Radio Access Network (O-RAN) is an important 5G network architecture enabling flexible communication with adaptive strategies for different verticals. However, testing for O-RAN deployments involve massive volumes of time-series data (e.g., key performance indicators), creating critical challenges for scalable, unsupervised monitoring without labels or high computational overhead. To address this, we present ESN-DAGMM, a lightweight adaptation of the Deep Autoencoding Gaussian Mixture Model (DAGMM) framework for time series analysis. Our model utilizes an Echo State Network (ESN) to efficiently model temporal dependencies, proving effective in O-RAN networks where training samples are highly limited. Combined with DAGMM's integratation of dimensionality reduction and density estimation, we present a scalable framework for unsupervised monitoring of high volume network telemetry. When trained on only 10% of an O-RAN video-streaming dataset, ESN-DAGMM achieved on average 269.59% higher quality clustering than baselines under identical conditions, all while maintaining competitive reconstruction error. By extending DAGMM to capture temporal dynamics, ESN-DAGMM offers a practical solution for time-series analysis using very limited training samples, outperforming baselines and enabling operator's control over the clustering-reconstruction trade-off.

Dynamic Heartbeat Modeling with Recurrent Neural Networks and Inverse Gaussian Point Process Modeling

Heart rate variability (HRV) analysis is important for the assessment of autonomic cardiovascular regulation. The inverse Gaussian process (IGP) has been widely used for beat-to-beat HRV modeling, as it gives a physiological relevant interpretation of heart depolarization process. A key challenge in IGP-based heartbeat modeling is the accurate estimation of time-varying parameters. In this study, we investigated whether recurrent neural networks (RNNs) can be used for IGP parameter identification and thereby enhance probabilistic modeling of R-R dynamics. Specifically, four representative RNN architectures, namely, GRU, LSTM, Structured State Space sequence model (S4), and Mamba, were evaluated using the Kolmogorov-Smirnov statistics. The results demonstrate the possibility of combining neural sequence models with the IGP framework for beat-wise R-R series modeling. This approach provides a flexible basis for probabilistic HRV modeling and for future incorporation of more complex physiological mechanisms and dynamic conditions.

A unified data format for managing diabetes time-series data: DIAbetes eXchange (DIAX)

Diabetes devices, including Continuous Glucose Monitoring (CGM), Smart Insulin Pens, and Automated Insulin Delivery systems, generate rich time-series data widely used in research and machine learning. However, inconsistent data formats across sources hinder sharing, integration, and analysis. We present DIAX (DIAbetes eXchange), a standardized JSON-based format for unifying diabetes time-series data, including CGM, insulin, and meal signals. DIAX promotes interoperability, reproducibility, and extensibility, particularly for machine learning applications. An open-source repository provides tools for dataset conversion, cross-format compatibility, visualization, and community contributions. DIAX is a translational resource, not a data host, ensuring flexibility without imposing data-sharing constraints. Currently, DIAX is compatible with other standardization efforts and supports major datasets (DCLP3, DCLP5, IOBP2, PEDAP, T1Dexi, Loop), totaling over 10 million patient-hours of data. https://github.com/Center-for-Diabetes-Technology/DIAX

Fun-TSG: A Function-Driven Multivariate Time Series Generator with Variable-Level Anomaly Labeling

Reliable evaluation of anomaly detection methods in multivariate time series remains an open challenge, largely due to the limitations of existing benchmark datasets. Current resources often lack fine-grained anomaly annotations, do not provide explicit intervariable and temporal dependencies, and offer little insight into the underlying generative mechanisms. These shortcomings hinder the development and rigorous comparison of detection models, especially those targeting interpretable and variable-specific outputs. To address this gap, we introduce Fun-TSG, a fully customizable time series generator designed to support high-quality evaluation of anomaly detection systems. Our tool enables both fully automated generation, based on randomly sampled dependency structures and anomaly types, and manual generation through user-defined equations and anomaly configurations. In both cases, it provides full transparency over the data generation process, including access to ground-truth anomaly labels at the variable and timestamp levels. Fun-TSG supports the creation of diverse, interpretable, and reproducible benchmarking scenarios, enabling fine-grained performance analysis for both classical and modern anomaly detection models.

SLALOM: Simulation Lifecycle Analysis via Longitudinal Observation Metrics for Social Simulation

Large Language Model (LLM) agents offer a potentially-transformative path forward for generative social science but face a critical crisis of validity. Current simulation evaluation methodologies suffer from the "stopped clock" problem: they confirm that a simulation reached the correct final outcome while ignoring whether the trajectory leading to it was sociologically plausible. Because the internal reasoning of LLMs is opaque, verifying the "black box" of social mechanisms remains a persistent challenge. In this paper, we introduce SLALOM (Simulation Lifecycle Analysis via Longitudinal Observation Metrics), a framework that shifts validation from outcome verification to process fidelity. Drawing on Pattern-Oriented Modeling (POM), SLALOM treats social phenomena as multivariate time series that must traverse specific SLALOM gates, or intermediate waypoint constraints representing distinct phases. By utilizing Dynamic Time Warping (DTW) to align simulated trajectories with empirical ground truth, SLALOM offers a quantitative metric to assess structural realism, helping to differentiate plausible social dynamics from stochastic noise and contributing to more robust policy simulation standards.

Bias-Corrected Adaptive Conformal Inference for Multi-Horizon Time Series Forecasting

Adaptive Conformal Inference (ACI) provides distribution-free prediction intervals with asymptotic coverage guarantees for time series under distribution shift. However, ACI only adapts the quantile threshold -- it cannot shift the interval center. When a base forecaster develops persistent bias after a regime change, ACI compensates by widening intervals symmetrically, producing unnecessarily conservative bands. We propose Bias-Corrected ACI (BC-ACI), which augments standard ACI with an online exponentially weighted moving average (EWM) estimate of forecast bias. BC-ACI corrects nonconformity scores before quantile computation and re-centers prediction intervals, addressing the root cause of miscalibration rather than its symptom. An adaptive dead-zone threshold suppresses corrections when estimated bias is indistinguishable from noise, ensuring no degradation on well-calibrated data. In controlled experiments across 688 runs spanning two base models, four synthetic regimes, and three real datasets, BC-ACI reduces Winkler interval scores by 13--17% under mean and compound distribution shifts (Wilcoxon p < 0.001) while maintaining equivalent performance on stationary data (ratio 1.002x). We provide finite-sample analysis showing that coverage guarantees degrade gracefully with bias estimation error.

Constant-Factor Approximation for the Uniform Decision Tree

We resolve a long-standing open question, about the existence of a constant-factor approximation algorithm for the average-case \textsc{Decision Tree} problem with uniform probability distribution over the hypotheses. We answer the question in the affirmative by providing a simple polynomial-time algorithm with approximation ratio of $\frac{2}{1-\sqrt{(e+1)/(2e)}}+ε<11.57$. This improves upon the currently best-known, greedy algorithm which achieves $O(\log n/{\log\log n})$-approximation. The first key ingredient in our analysis is the usage of a decomposition technique known from problems related to \textsc{Hierarchical Clustering} [SODA '17, WALCOM '26], which allows us to decompose the optimal decision tree into a series of objects called separating subfamilies. The second crucial idea is to reduce the subproblem of finding a \textsc{Separating Subfamily} to an instance of the \textsc{Maximum Coverage} problem. To do so, we analyze the properties of cutting cliques into small pieces, which represent pairs of hypotheses to be separated. This allows us to obtain a good approximation for the \textsc{Separating Subfamily} problem, which then enables the design of the approximation algorithm for the original problem.

QARIMA: A Quantum Approach To Classical Time Series Analysis

We present a quantum-inspired ARIMA methodology that integrates quantum-assisted lag discovery with \emph{fixed-configuration} variational quantum circuits (VQCs) for parameter estimation and weak-lag refinement. Differencing and candidate lags are identified via swap-test-driven quantum autocorrelation (QACF) and quantum partial autocorrelation (QPACF), with a delayed-matrix construction that aligns quantum projections to time-domain regressors, followed by standard information-criterion parsimony. Given the screened orders $(p,d,q)$, we retain a fixed VQC ansatz, optimizer, and training budget, preventing hyperparameter leakage, and deploy the circuit in two estimation roles: VQC-AR for autoregressive coefficients and VQC-MA for moving-average coefficients. Between screening and estimation, a lightweight VQC weak-lag refinement re-weights or prunes screened AR lags without altering $(p,d,q)$. Across environmental and industrial datasets, we perform rolling-origin evaluations against automated classical ARIMA, reporting out-of-sample mean squared error (MSE), mean absolute percentage error (MAPE), and Diebold--Mariano tests on MSE and MAE. Empirically, the seven quantum contributions -- (1) differencing selection, (2) QACF, (3) QPACF, (4) swap-test primitives with delayed-matrix construction, (5) VQC-AR, (6) VQC weak-lag refinement, and (7) VQC-MA -- collectively reduce meta-optimization overhead and make explicit where quantum effects enter order discovery, lag refinement, and AR/MA parameter estimation.

Time-Series Classification with Multivariate Statistical Dependence Features

In this paper, we propose a novel framework for non-stationary time-series analysis that replaces conventional correlation-based statistics with direct estimation of statistical dependence in the normalized joint density of input and target signals, the cross density ratio (CDR). Unlike windowed correlation estimates, this measure is independent of sample order and robust to regime changes. The method builds on the functional maximal correlation algorithm (FMCA), which constructs a projection space by decomposing the eigenspectrum of the CDR. Multiscale features from this eigenspace are classified using a lightweight single-hidden-layer perceptron. On the TI-46 digit speech corpus, our approach outperforms hidden Markov models (HMMs) and state-of-the-art spiking neural networks, achieving higher accuracy with fewer than 10 layers and a storage footprint under 5 MB.

At FullTilt: Real-Time Open-Set 3D Macromolecule Detection Directly from Tilted 2D Projections

Open-set 3D macromolecule detection in cryogenic electron tomography eliminates the need for target-specific model retraining. However, strict VRAM constraints prohibit processing an entire 3D tomogram, forcing current methods to rely on slow sliding-window inference over extracted subvolumes. To overcome this, we propose FullTilt, an end-to-end framework that redefines 3D detection by operating directly on aligned 2D tilt-series. Because a tilt-series contains significantly fewer images than slices in a reconstructed tomogram, FullTilt eliminates redundant volumetric computation, accelerating inference by orders of magnitude. To process the entire tilt-series simultaneously, we introduce a tilt-series encoder to efficiently fuse cross-view information. We further propose a multiclass visual prompt encoder for flexible prompting, a tilt-aware query initializer to effectively anchor 3D queries, and an auxiliary geometric primitives module to enhance the model's understanding of multi-view geometry while improving robustness to adverse imaging artifacts. Extensive evaluations on three real-world datasets demonstrate that FullTilt achieves state-of-the-art zero-shot performance while drastically reducing runtime and VRAM requirements, paving the way for rapid, large-scale visual proteomics analysis. All code and data will be publicly available upon publication.