Semi-Supervised Domain Adaptation with Latent Diffusion for Pathology Image Classification

Deep learning models in computational pathology often fail to generalize across cohorts and institutions due to domain shift. Existing approaches either fail to leverage unlabeled data from the target domain or rely on image-to-image translation, which can distort tissue structures and compromise model accuracy. In this work, we propose a semi-supervised domain adaptation (SSDA) framework that utilizes a latent diffusion model trained on unlabeled data from both the source and target domains to generate morphology-preserving and target-aware synthetic images. By conditioning the diffusion model on foundation model features, cohort identity, and tissue preparation method, we preserve tissue structure in the source domain while introducing target-domain appearance characteristics. The target-aware synthetic images, combined with real, labeled images from the source cohort, are subsequently used to train a downstream classifier, which is then tested on the target cohort. The effectiveness of the proposed SSDA framework is demonstrated on the task of lung adenocarcinoma prognostication. The proposed augmentation yielded substantially better performance on the held-out test set from the target cohort, without degrading source-cohort performance. The approach improved the weighted F1 score on the target-cohort held-out test set from 0.611 to 0.706 and the macro F1 score from 0.641 to 0.716. Our results demonstrate that target-aware diffusion-based synthetic data augmentation provides a promising and effective approach for improving domain generalization in computational pathology.

PMPBench: A Paired Multi-Modal Pan-Cancer Benchmark for Medical Image Synthesis

Contrast medium plays a pivotal role in radiological imaging, as it amplifies lesion conspicuity and improves detection for the diagnosis of tumor-related diseases. However, depending on the patient's health condition or the medical resources available, the use of contrast medium is not always feasible. Recent work has explored AI-based image translation to synthesize contrast-enhanced images directly from non-contrast scans, aims to reduce side effects and streamlines clinical workflows. Progress in this direction has been constrained by data limitations: (1) existing public datasets focus almost exclusively on brain-related paired MR modalities; (2) other collections include partially paired data but suffer from missing modalities/timestamps and imperfect spatial alignment; (3) explicit labeling of CT vs. CTC or DCE phases is often absent; (4) substantial resources remain private. To bridge this gap, we introduce the first public, fully paired, pan-cancer medical imaging dataset spanning 11 human organs. The MR data include complete dynamic contrast-enhanced (DCE) sequences covering all three phases (DCE1-DCE3), while the CT data provide paired non-contrast and contrast-enhanced acquisitions (CTC). The dataset is curated for anatomical correspondence, enabling rigorous evaluation of 1-to-1, N-to-1, and N-to-N translation settings (e.g., predicting DCE phases from non-contrast inputs). Built upon this resource, we establish a comprehensive benchmark. We report results from representative baselines of contemporary image-to-image translation. We release the dataset and benchmark to catalyze research on safe, effective contrast synthesis, with direct relevance to multi-organ oncology imaging workflows. Our code and dataset are publicly available at https://github.com/YifanChen02/PMPBench.

PAINT: Pathology-Aware Integrated Next-Scale Transformation for Virtual Immunohistochemistry

Virtual immunohistochemistry (IHC) aims to computationally synthesize molecular staining patterns from routine Hematoxylin and Eosin (H\&E) images, offering a cost-effective and tissue-efficient alternative to traditional physical staining. However, this task is particularly challenging: H\&E morphology provides ambiguous cues about protein expression, and similar tissue structures may correspond to distinct molecular states. Most existing methods focus on direct appearance synthesis to implicitly achieve cross-modal generation, often resulting in semantic inconsistencies due to insufficient structural priors. In this paper, we propose Pathology-Aware Integrated Next-Scale Transformation (PAINT), a visual autoregressive framework that reformulates the synthesis process as a structure-first conditional generation task. Unlike direct image translation, PAINT enforces a causal order by resolving molecular details conditioned on a global structural layout. Central to this approach is the introduction of a Spatial Structural Start Map (3S-Map), which grounds the autoregressive initialization in observed morphology, ensuring deterministic, spatially aligned synthesis. Experiments on the IHC4BC and MIST datasets demonstrate that PAINT outperforms state-of-the-art methods in structural fidelity and clinical downstream tasks, validating the potential of structure-guided autoregressive modeling.

Investigating Associational Biases in Inter-Model Communication of Large Generative Models

Social bias in generative AI can manifest not only as performance disparities but also as associational bias, whereby models learn and reproduce stereotypical associations between concepts and demographic groups, even in the absence of explicit demographic information (e.g., associating doctors with men). These associations can persist, propagate, and potentially amplify across repeated exchanges in inter-model communication pipelines, where one generative model's output becomes another's input. This is especially salient for human-centred perception tasks, such as human activity recognition and affect prediction, where inferences about behaviour and internal states can lead to errors or stereotypical associations that propagate into unequal treatment. In this work, focusing on human activity and affective expression, we study how such associations evolve within an inter-model communication pipeline that alternates between image generation and image description. Using the RAF-DB and PHASE datasets, we quantify demographic distribution drift induced by model-to-model information exchange and assess whether these drifts are systematic using an explainability pipeline. Our results reveal demographic drifts toward younger representations for both actions and emotions, as well as toward more female-presenting representations, primarily for emotions. We further find evidence that some predictions are supported by spurious visual regions (e.g., background or hair) rather than concept-relevant cues (e.g., body or face). We also examine whether these demographic drifts translate into measurable differences in downstream behaviour, i.e., while predicting activity and emotion labels. Finally, we outline mitigation strategies spanning data-centric, training and deployment interventions, and emphasise the need for careful safeguards when deploying interconnected models in human-centred AI systems.

Optimization and Mobile Deployment for Anthropocene Neural Style Transfer

This paper presents AnthropoCam, a mobile-based neural style transfer (NST) system optimized for the visual synthesis of Anthropocene environments. Unlike conventional artistic NST, which prioritizes painterly abstraction, stylizing human-altered landscapes demands a careful balance between amplifying material textures and preserving semantic legibility. Industrial infrastructures, waste accumulations, and modified ecosystems contain dense, repetitive patterns that are visually expressive yet highly susceptible to semantic erosion under aggressive style transfer. To address this challenge, we systematically investigate the impact of NST parameter configurations on the visual translation of Anthropocene textures, including feature layer selection, style and content loss weighting, training stability, and output resolution. Through controlled experiments, we identify an optimal parameter manifold that maximizes stylistic expression while preventing semantic erasure. Our results demonstrate that appropriate combinations of convolutional depth, loss ratios, and resolution scaling enable the faithful transformation of anthropogenic material properties into a coherent visual language. Building on these findings, we implement a low-latency, feed-forward NST pipeline deployed on mobile devices. The system integrates a React Native frontend with a Flask-based GPU backend, achieving high-resolution inference within 3-5 seconds on general mobile hardware. This enables real-time, in-situ visual intervention at the site of image capture, supporting participatory engagement with Anthropocene landscapes. By coupling domain-specific NST optimization with mobile deployment, AnthropoCam reframes neural style transfer as a practical and expressive tool for real-time environmental visualization in the Anthropocene.

End-to-end example-based sim-to-real RL policy transfer based on neural stylisation with application to robotic cutting

Whereas reinforcement learning has been applied with success to a range of robotic control problems in complex, uncertain environments, reliance on extensive data - typically sourced from simulation environments - limits real-world deployment due to the domain gap between simulated and physical systems, coupled with limited real-world sample availability. We propose a novel method for sim-to-real transfer of reinforcement learning policies, based on a reinterpretation of neural style transfer from image processing to synthesise novel training data from unpaired unlabelled real world datasets. We employ a variational autoencoder to jointly learn self-supervised feature representations for style transfer and generate weakly paired source-target trajectories to improve physical realism of synthesised trajectories. We demonstrate the application of our approach based on the case study of robot cutting of unknown materials. Compared to baseline methods, including our previous work, CycleGAN, and conditional variational autoencoder-based time series translation, our approach achieves improved task completion time and behavioural stability with minimal real-world data. Our framework demonstrates robustness to geometric and material variation, and highlights the feasibility of policy adaptation in challenging contact-rich tasks where real-world reward information is unavailable.

Performance uncertainty in medical image analysis: a large-scale investigation of confidence intervals

Performance uncertainty quantification is essential for reliable validation and eventual clinical translation of medical imaging artificial intelligence (AI). Confidence intervals (CIs) play a central role in this process by indicating how precise a reported performance estimate is. Yet, due to the limited amount of work examining CI behavior in medical imaging, the community remains largely unaware of how many diverse CI methods exist and how they behave in specific settings. The purpose of this study is to close this gap. To this end, we conducted a large-scale empirical analysis across a total of 24 segmentation and classification tasks, using 19 trained models per task group, a broad spectrum of commonly used performance metrics, multiple aggregation strategies, and several widely adopted CI methods. Reliability (coverage) and precision (width) of each CI method were estimated across all settings to characterize their dependence on study characteristics. Our analysis revealed five principal findings: 1) the sample size required for reliable CIs varies from a few dozens to several thousands of cases depending on study parameters; 2) CI behavior is strongly affected by the choice of performance metric; 3) aggregation strategy substantially influences the reliability of CIs, e.g. they require more observations for macro than for micro; 4) the machine learning problem (segmentation versus classification) modulates these effects; 5) different CI methods are not equally reliable and precise depending on the use case. These results form key components for the development of future guidelines on reporting performance uncertainty in medical imaging AI.

PyHealth 2.0: A Comprehensive Open-Source Toolkit for Accessible and Reproducible Clinical Deep Learning

Difficulty replicating baselines, high computational costs, and required domain expertise create persistent barriers to clinical AI research. To address these challenges, we introduce PyHealth 2.0, an enhanced clinical deep learning toolkit that enables predictive modeling in as few as 7 lines of code. PyHealth 2.0 offers three key contributions: (1) a comprehensive toolkit addressing reproducibility and compatibility challenges by unifying 15+ datasets, 20+ clinical tasks, 25+ models, 5+ interpretability methods, and uncertainty quantification including conformal prediction within a single framework that supports diverse clinical data modalities - signals, imaging, and electronic health records - with translation of 5+ medical coding standards; (2) accessibility-focused design accommodating multimodal data and diverse computational resources with up to 39x faster processing and 20x lower memory usage, enabling work from 16GB laptops to production systems; and (3) an active open-source community of 400+ members lowering domain expertise barriers through extensive documentation, reproducible research contributions, and collaborations with academic health systems and industry partners, including multi-language support via RHealth. PyHealth 2.0 establishes an open-source foundation and community advancing accessible, reproducible healthcare AI. Available at pip install pyhealth.

STARS: Shared-specific Translation and Alignment for missing-modality Remote Sensing Semantic Segmentation

Multimodal remote sensing technology significantly enhances the understanding of surface semantics by integrating heterogeneous data such as optical images, Synthetic Aperture Radar (SAR), and Digital Surface Models (DSM). However, in practical applications, the missing of modality data (e.g., optical or DSM) is a common and severe challenge, which leads to performance decline in traditional multimodal fusion models. Existing methods for addressing missing modalities still face limitations, including feature collapse and overly generalized recovered features. To address these issues, we propose \textbf{STARS} (\textbf{S}hared-specific \textbf{T}ranslation and \textbf{A}lignment for missing-modality \textbf{R}emote \textbf{S}ensing), a robust semantic segmentation framework for incomplete multimodal inputs. STARS is built on two key designs. First, we introduce an asymmetric alignment mechanism with bidirectional translation and stop-gradient, which effectively prevents feature collapse and reduces sensitivity to hyperparameters. Second, we propose a Pixel-level Semantic sampling Alignment (PSA) strategy that combines class-balanced pixel sampling with cross-modality semantic alignment loss, to mitigate alignment failures caused by severe class imbalance and improve minority-class recognition.

Cross-Domain Object Detection Using Unsupervised Image Translation

Unsupervised domain adaptation for object detection addresses the adaption of detectors trained in a source domain to work accurately in an unseen target domain. Recently, methods approaching the alignment of the intermediate features proven to be promising, achieving state-of-the-art results. However, these methods are laborious to implement and hard to interpret. Although promising, there is still room for improvements to close the performance gap toward the upper-bound (when training with the target data). In this work, we propose a method to generate an artificial dataset in the target domain to train an object detector. We employed two unsupervised image translators (CycleGAN and an AdaIN-based model) using only annotated data from the source domain and non-annotated data from the target domain. Our key contributions are the proposal of a less complex yet more effective method that also has an improved interpretability. Results on real-world scenarios for autonomous driving show significant improvements, outperforming state-of-the-art methods in most cases, further closing the gap toward the upper-bound.