VS-DDPM: Efficient Low-Cost Diffusion Model for Medical Modality Translation

Diffusion models produce high-quality synthetic data but suffer from slow inference. We propose 3D Variable-Step Denoising Diffusion Probabilistic Model (VS-DDPM) a framework engineered to maintain generative quality while accelerating inference by several factors. We tested our approach on four tasks (missing MRI, tumor removal, MRI-to-sCT, and CBCT-to-sCT) within the BraTS2025 and SynthRAD2025 challenges. Designed for high efficiency under hardware and time constrains imposed by both challenges. VS-DDPM achieved state-of-the-art (SOTA) performance in missing MRI synthesis, yielding Dice scores of 0.80, 0.83, and 0.88 for the enhancing tumor, tumor core, and whole tumor regions, respectively, alongside a structural similarity index (SSIM) of 0.95. For MRI tumor removal, the model attained a root mean squared error (RMSE) of 0.053, a peak signal-to-noise ratio (PSNR) of 26.77, and an SSIM of 0.918. While the framework demonstrated competitive performance in MRI-to-sCT and CBCT-to-sCT tasks, it did not reach SOTA benchmarks, potentially due to sensitivities in data pre and post-processing pipelines or specific loss function configurations. These results demonstrate that VS-DDPM provides a robust and tunable solution for high-fidelity 3D medical image synthesis. The code is available in https://github.com/andre-fs-ferreira/SynthRAD_by_Faking_it.

Wan-Image: Pushing the Boundaries of Generative Visual Intelligence

We present Wan-Image, a unified visual generation system explicitly engineered to paradigm-shift image generation models from casual synthesizers into professional-grade productivity tools. While contemporary diffusion models excel at aesthetic generation, they frequently encounter critical bottlenecks in rigorous design workflows that demand absolute controllability, complex typography rendering, and strict identity preservation. To address these challenges, Wan-Image features a natively unified multi-modal architecture by synergizing the cognitive capabilities of large language models with the high-fidelity pixel synthesis of diffusion transformers, which seamlessly translates highly nuanced user intents into precise visual outputs. It is fundamentally powered by large-scale multi-modal data scaling, a systematic fine-grained annotation engine, and curated reinforcement learning data to surpass basic instruction following and unlock expert-level professional capabilities. These include ultra-long complex text rendering, hyper-diverse portrait generation, palette-guided generation, multi-subject identity preservation, coherent sequential visual generation, precise multi-modal interactive editing, native alpha-channel generation, and high-efficiency 4K synthesis. Across diverse human evaluations, Wan-Image exceeds Seedream 5.0 Lite and GPT Image 1.5 in overall performance, reaching parity with Nano Banana Pro in challenging tasks. Ultimately, Wan-Image revolutionizes visual content creation across e-commerce, entertainment, education, and personal productivity, redefining the boundaries of professional visual synthesis.

Cycle-Consistent Search: Question Reconstructability as a Proxy Reward for Search Agent Training

Reinforcement Learning (RL) has shown strong potential for optimizing search agents in complex information retrieval tasks. However, existing approaches predominantly rely on gold supervision, such as ground-truth answers, which is difficult to scale. To address this limitation, we propose Cycle-Consistent Search (CCS), a gold-supervision-free framework for training search agents, inspired by cycle-consistency techniques from unsupervised machine translation and image-to-image translation. Our key hypothesis is that an optimal search trajectory, unlike insufficient or irrelevant ones, serves as a lossless encoding of the question's intent. Consequently, a high-quality trajectory should preserve the information required to accurately reconstruct the original question, thereby inducing a reward signal for policy optimization. However, naive cycle-consistency objectives are vulnerable to information leakage, as reconstruction may rely on superficial lexical cues rather than the underlying search process. To reduce this effect, we apply information bottlenecks, including exclusion of the final response and named entity recognition (NER) masking of search queries. These constraints force reconstruction to rely on retrieved observations together with the structural scaffold, ensuring that the resulting reward signal reflects informational adequacy rather than linguistic redundancy. Experiments on question-answering benchmarks show that CCS achieves performance comparable to supervised baselines while outperforming prior methods that do not rely on gold supervision. These results suggest that CCS provides a scalable training paradigm for training search agents in settings where gold supervision is unavailable.

REVEAL: Multimodal Vision-Language Alignment of Retinal Morphometry and Clinical Risks for Incident AD and Dementia Prediction

The retina provides a unique, noninvasive window into Alzheimer's disease (AD) and dementia, capturing early structural changes through morphometric features, while systemic and lifestyle risk factors reflect well-established contributors to disease susceptibility long before clinical symptom onset. However, current retinal analysis frameworks typically model imaging and risk factors separately, limiting their ability to capture joint multimodal patterns critical for early risk prediction. Moreover, existing methods rarely incorporate mechanisms to organize or align patients with similar retinal and clinical characteristics, constraining the learning of coherent cross-modal associations. To address these limitations, we introduce REVEAL (REtinal-risk Vision-Language Early Alzheimer's Learning), a framework that aligns color fundus photographs with individualized disease-specific risk profiles for predicting incident AD and dementia, on average 8 years before diagnosis (range: 1-11 years). Because real-world risk factors are structured questionnaire data, we translate them into clinically interpretable narratives compatible with pretrained vision-language models (VLMs). We further propose a group-aware contrastive learning (GACL) strategy that clusters patients with similar retinal morphometry and risk factors as positive pairs, strengthening multimodal alignment. This unified representation learning framework substantially outperforms state-of-the-art retinal imaging models paired with clinical text encoders, as well as general-purpose VLMs, demonstrating the value of jointly modeling retinal biomarkers and clinical risk factors. By providing a generalizable and noninvasive approach for early AD and dementia risk stratification, REVEAL has the potential to enable earlier intervention and improve preventive care at the population level.

VGGT-Segmentor: Geometry-Enhanced Cross-View Segmentation

Instance-level object segmentation across disparate egocentric and exocentric views is a fundamental challenge in visual understanding, critical for applications in embodied AI and remote collaboration. This task is exceptionally difficult due to severe changes in scale, perspective, and occlusion, which destabilize direct pixel-level matching. While recent geometry-aware models like VGGT provide a strong foundation for feature alignment, we find they often fail at dense prediction tasks due to significant pixel-level projection drift, even when their internal object-level attention remains consistent. To bridge this gap, we introduce VGGT-Segmentor (VGGT-S), a framework that unifies robust geometric modeling with pixel-accurate semantic segmentation. VGGT-S leverages VGGT's powerful cross-view feature representation and introduces a novel Union Segmentation Head. This head operates in three stages: mask prompt fusion, point-guided prediction, and iterative mask refinement, effectively translating high-level feature alignment into a precise segmentation mask. Furthermore, we propose a single-image self-supervised training strategy that eliminates the need for paired annotations and enables strong generalization. On the Ego-Exo4D benchmark, VGGT-S sets a new state-of-the-art, achieving 67.7% and 68.0% average IoU for Ego to Exo and Exo to Ego tasks, respectively, significantly outperforming prior methods. Notably, our correspondence-free pretrained model surpasses most fully-supervised baselines, demonstrating the effectiveness and scalability of our approach.

When Meaning Isn't Literal: Exploring Idiomatic Meaning Across Languages and Modalities

Idiomatic reasoning, deeply intertwined with metaphor and culture, remains a blind spot for contemporary language models, whose progress skews toward surface-level lexical and semantic cues. For instance, the Bengali idiom \textit{\foreignlanguage{bengali}{\char"0986\char"0999\char"09CD\char"0997\char"09C1 \char"09B0 \char"09AB\char"09B2 \char"099F\char"0995}} (angur fol tok, ``grapes are sour''): it encodes denial-driven rationalization, yet naive models latch onto the literal fox-and-grape imagery. Addressing this oversight, we present ``Mediom,'' a multilingual, multimodal idiom corpus of 3,533 Hindi, Bengali, and Thai idioms, each paired with gold-standard explanations, cross-lingual translations, and carefully aligned text--image representations. We benchmark both large language models (textual reasoning) and vision-language models (figurative disambiguation) on Mediom, exposing systematic failures in metaphor comprehension. To mitigate these gaps, we propose ``HIDE,'' a Hinting-based Idiom Explanation framework that leverages error-feedback retrieval and targeted diagnostic cues for iterative reasoning refinement. Collectively, Mediom and HIDE establish a rigorous test bed and methodology for culturally grounded, multimodal idiom understanding embedded with reasoning hints in next-generation AI systems.

Bridging MRI and PET physiology: Untangling complementarity through orthogonal representations

Multimodal imaging analysis often relies on joint latent representations, yet these approaches rarely define what information is shared versus modality-specific. Clarifying this distinction is clinically relevant, as it delineates the irreducible contribution of each modality and informs rational acquisition strategies. We propose a subspace decomposition framework that reframes multimodal fusion as a problem of orthogonal subspace separation rather than translation. We decompose Prostate-Specific Membrane Antigen (PSMA) PET uptake into an MRI-explainable physiological envelope and an orthogonal residual reflecting signal components not expressible within the MRI feature manifold. Using multiparametric MRI, we train an intensity-based, non-spatial implicit neural representation (INR) to map MRI feature vectors to PET uptake. We introduce a projection-based regularization using singular value decomposition to penalize residual components lying within the span of the MRI feature manifold. This enforces mathematical orthogonality between tissue-level physiological properties (structure, diffusion, perfusion) and intracellular PSMA expression. Tested on 13 prostate cancer patients, the model demonstrates that residual components spanned by MRI features are absorbed into the learned envelope, while the orthogonal residual is largest in tumour regions. This indicates that PSMA PET contains signal components not recoverable from MRI-derived physiological descriptors. The resulting decomposition provides a structured characterization of modality complementarity grounded in representation geometry rather than image translation.

Distilling Photon-Counting CT into Routine Chest CT through Clinically Validated Degradation Modeling

Photon-counting CT (PCCT) provides superior image quality with higher spatial resolution and lower noise compared to conventional energy-integrating CT (EICT), but its limited clinical availability restricts large-scale research and clinical deployment. To bridge this gap, we propose SUMI, a simulated degradation-to-enhancement method that learns to reverse realistic acquisition artifacts in low-quality EICT by leveraging high-quality PCCT as reference. Our central insight is to explicitly model realistic acquisition degradations, transforming PCCT into clinically plausible lower-quality counterparts and learning to invert this process. The simulated degradations were validated for clinical realism by board-certified radiologists, enabling faithful supervision without requiring paired acquisitions at scale. As outcomes of this technical contribution, we: (1) train a latent diffusion model on 1,046 PCCTs, using an autoencoder first pre-trained on both these PCCTs and 405,379 EICTs from 145 hospitals to extract general CT latent features that we release for reuse in other generative medical imaging tasks; (2) construct a large-scale dataset of over 17,316 publicly available EICTs enhanced to PCCT-like quality, with radiologist-validated voxel-wise annotations of airway trees, arteries, veins, lungs, and lobes; and (3) demonstrate substantial improvements: across external data, SUMI outperforms state-of-the-art image translation methods by 15% in SSIM and 20% in PSNR, improves radiologist-rated clinical utility in reader studies, and enhances downstream top-ranking lesion detection performance, increasing sensitivity by up to 15% and F1 score by up to 10%. Our results suggest that emerging imaging advances can be systematically distilled into routine EICT using limited high-quality scans as reference.

Visual Instruction-Finetuned Language Model for Versatile Brain MR Image Tasks

LLMs have demonstrated remarkable capabilities in linguistic reasoning and are increasingly adept at vision-language tasks. The integration of image tokens into transformers has enabled direct visual input and output, advancing research from image-to-text descriptions to text-to-image generation. However, simple text-to-image generation holds limited clinical utility. In medical imaging, tasks such as image segmentation for localizing pathologies or image translation for reconstructing missing sequences have much greater clinical importance. Despite this, integrating these diverse, clinically relevant tasks within a single, versatile language model remains unexplored. Our method, LLaBIT (Large Language Model for Brain Image Translation), extends the visual reasoning of LLMs to these clinically meaningful tasks in the brain MRI domain. To mitigate the spatial information loss inherent in image tokenization, we incorporate a mechanism to reuse feature maps from the image encoder, minimizing data degradation. We also generate text data using LLMs with strict predefined instructions to augment limited image-text paired data in brain MRI. We comprehensively evaluated our method on five brain MRI datasets across four distinct tasks: report generation, visual question answering, image segmentation, and image translation. Our model not only demonstrated superior performance across all tasks but also outperformed specialized, task-specific models in direct comparisons, highlighting its efficacy and versatility

Brain-Grasp: Graph-based Saliency Priors for Improved fMRI-based Visual Brain Decoding

Recent progress in brain-guided image generation has improved the quality of fMRI-based reconstructions; however, fundamental challenges remain in preserving object-level structure and semantic fidelity. Many existing approaches overlook the spatial arrangement of salient objects, leading to conceptually inconsistent outputs. We propose a saliency-driven decoding framework that employs graph-informed saliency priors to translate structural cues from brain signals into spatial masks. These masks, together with semantic information extracted from embeddings, condition a diffusion model to guide image regeneration, helping preserve object conformity while maintaining natural scene composition. In contrast to pipelines that invoke multiple diffusion stages, our approach relies on a single frozen model, offering a more lightweight yet effective design. Experiments show that this strategy improves both conceptual alignment and structural similarity to the original stimuli, while also introducing a new direction for efficient, interpretable, and structurally grounded brain decoding.