GuidedMorph: Two-Stage Deformable Registration for Breast MRI

Accurately registering breast MR images from different time points enables the alignment of anatomical structures and tracking of tumor progression, supporting more effective breast cancer detection, diagnosis, and treatment planning. However, the complexity of dense tissue and its highly non-rigid nature pose challenges for conventional registration methods, which primarily focus on aligning general structures while overlooking intricate internal details. To address this, we propose \textbf{GuidedMorph}, a novel two-stage registration framework designed to better align dense tissue. In addition to a single-scale network for global structure alignment, we introduce a framework that utilizes dense tissue information to track breast movement. The learned transformation fields are fused by introducing the Dual Spatial Transformer Network (DSTN), improving overall alignment accuracy. A novel warping method based on the Euclidean distance transform (EDT) is also proposed to accurately warp the registered dense tissue and breast masks, preserving fine structural details during deformation. The framework supports paradigms that require external segmentation models and with image data only. It also operates effectively with the VoxelMorph and TransMorph backbones, offering a versatile solution for breast registration. We validate our method on ISPY2 and internal dataset, demonstrating superior performance in dense tissue, overall breast alignment, and breast structural similarity index measure (SSIM), with notable improvements by over 13.01% in dense tissue Dice, 3.13% in breast Dice, and 1.21% in breast SSIM compared to the best learning-based baseline.

BreastDCEDL: Curating a Comprehensive DCE-MRI Dataset and developing a Transformer Implementation for Breast Cancer Treatment Response Prediction

Breast cancer remains a leading cause of cancer-related mortality worldwide, making early detection and accurate treatment response monitoring critical priorities. We present BreastDCEDL, a curated, deep learning-ready dataset comprising pre-treatment 3D Dynamic Contrast-Enhanced MRI (DCE-MRI) scans from 2,070 breast cancer patients drawn from the I-SPY1, I-SPY2, and Duke cohorts, all sourced from The Cancer Imaging Archive. The raw DICOM imaging data were rigorously converted into standardized 3D NIfTI volumes with preserved signal integrity, accompanied by unified tumor annotations and harmonized clinical metadata including pathologic complete response (pCR), hormone receptor (HR), and HER2 status. Although DCE-MRI provides essential diagnostic information and deep learning offers tremendous potential for analyzing such complex data, progress has been limited by lack of accessible, public, multicenter datasets. BreastDCEDL addresses this gap by enabling development of advanced models, including state-of-the-art transformer architectures that require substantial training data. To demonstrate its capacity for robust modeling, we developed the first transformer-based model for breast DCE-MRI, leveraging Vision Transformer (ViT) architecture trained on RGB-fused images from three contrast phases (pre-contrast, early post-contrast, and late post-contrast). Our ViT model achieved state-of-the-art pCR prediction performance in HR+/HER2- patients (AUC 0.94, accuracy 0.93). BreastDCEDL includes predefined benchmark splits, offering a framework for reproducible research and enabling clinically meaningful modeling in breast cancer imaging.

Lightweight Relational Embedding in Task-Interpolated Few-Shot Networks for Enhanced Gastrointestinal Disease Classification

Traditional diagnostic methods like colonoscopy are invasive yet critical tools necessary for accurately diagnosing colorectal cancer (CRC). Detection of CRC at early stages is crucial for increasing patient survival rates. However, colonoscopy is dependent on obtaining adequate and high-quality endoscopic images. Prolonged invasive procedures are inherently risky for patients, while suboptimal or insufficient images hamper diagnostic accuracy. These images, typically derived from video frames, often exhibit similar patterns, posing challenges in discrimination. To overcome these challenges, we propose a novel Deep Learning network built on a Few-Shot Learning architecture, which includes a tailored feature extractor, task interpolation, relational embedding, and a bi-level routing attention mechanism. The Few-Shot Learning paradigm enables our model to rapidly adapt to unseen fine-grained endoscopic image patterns, and the task interpolation augments the insufficient images artificially from varied instrument viewpoints. Our relational embedding approach discerns critical intra-image features and captures inter-image transitions between consecutive endoscopic frames, overcoming the limitations of Convolutional Neural Networks (CNNs). The integration of a light-weight attention mechanism ensures a concentrated analysis of pertinent image regions. By training on diverse datasets, the model's generalizability and robustness are notably improved for handling endoscopic images. Evaluated on Kvasir dataset, our model demonstrated superior performance, achieving an accuracy of 90.1\%, precision of 0.845, recall of 0.942, and an F1 score of 0.891. This surpasses current state-of-the-art methods, presenting a promising solution to the challenges of invasive colonoscopy by optimizing CRC detection through advanced image analysis.

Enhancing breast cancer detection on screening mammogram using self-supervised learning and a hybrid deep model of Swin Transformer and Convolutional Neural Network

Purpose: The scarcity of high-quality curated labeled medical training data remains one of the major limitations in applying artificial intelligence (AI) systems to breast cancer diagnosis. Deep models for mammogram analysis and mass (or micro-calcification) detection require training with a large volume of labeled images, which are often expensive and time-consuming to collect. To reduce this challenge, we proposed a novel method that leverages self-supervised learning (SSL) and a deep hybrid model, named \textbf{HybMNet}, which combines local self-attention and fine-grained feature extraction to enhance breast cancer detection on screening mammograms. Approach: Our method employs a two-stage learning process: (1) SSL Pretraining: We utilize EsViT, a SSL technique, to pretrain a Swin Transformer (Swin-T) using a limited set of mammograms. The pretrained Swin-T then serves as the backbone for the downstream task. (2) Downstream Training: The proposed HybMNet combines the Swin-T backbone with a CNN-based network and a novel fusion strategy. The Swin-T employs local self-attention to identify informative patch regions from the high-resolution mammogram, while the CNN-based network extracts fine-grained local features from the selected patches. A fusion module then integrates global and local information from both networks to generate robust predictions. The HybMNet is trained end-to-end, with the loss function combining the outputs of the Swin-T and CNN modules to optimize feature extraction and classification performance. Results: The proposed method was evaluated for its ability to detect breast cancer by distinguishing between benign (normal) and malignant mammograms. Leveraging SSL pretraining and the HybMNet model, it achieved AUC of 0.864 (95% CI: 0.852, 0.875) on the CMMD dataset and 0.889 (95% CI: 0.875, 0.903) on the INbreast dataset, highlighting its effectiveness.

Dynamic Contextual Attention Network: Transforming Spatial Representations into Adaptive Insights for Endoscopic Polyp Diagnosis

Colorectal polyps are key indicators for early detection of colorectal cancer. However, traditional endoscopic imaging often struggles with accurate polyp localization and lacks comprehensive contextual awareness, which can limit the explainability of diagnoses. To address these issues, we propose the Dynamic Contextual Attention Network (DCAN). This novel approach transforms spatial representations into adaptive contextual insights, using an attention mechanism that enhances focus on critical polyp regions without explicit localization modules. By integrating contextual awareness into the classification process, DCAN improves decision interpretability and overall diagnostic performance. This advancement in imaging could lead to more reliable colorectal cancer detection, enabling better patient outcomes.

Mitigating Catastrophic Forgetting in the Incremental Learning of Medical Images

This paper proposes an Incremental Learning (IL) approach to enhance the accuracy and efficiency of deep learning models in analyzing T2-weighted (T2w) MRI medical images prostate cancer detection using the PI-CAI dataset. We used multiple health centers' artificial intelligence and radiology data, focused on different tasks that looked at prostate cancer detection using MRI (PI-CAI). We utilized Knowledge Distillation (KD), as it employs generated images from past tasks to guide the training of models for subsequent tasks. The approach yielded improved performance and faster convergence of the models. To demonstrate the versatility and robustness of our approach, we evaluated it on the PI-CAI dataset, a diverse set of medical imaging modalities including OCT and PathMNIST, and the benchmark continual learning dataset CIFAR-10. Our results indicate that KD can be a promising technique for IL in medical image analysis in which data is sourced from individual health centers and the storage of large datasets is not feasible. By using generated images from prior tasks, our method enables the model to retain and apply previously acquired knowledge without direct access to the original data.

Robustness and sex differences in skin cancer detection: logistic regression vs CNNs

Deep learning has been reported to achieve high performances in the detection of skin cancer, yet many challenges regarding the reproducibility of results and biases remain. This study is a replication (different data, same analysis) of a study on Alzheimer's disease [28] which studied robustness of logistic regression (LR) and convolutional neural networks (CNN) across patient sexes. We explore sex bias in skin cancer detection, using the PAD-UFES-20 dataset with LR trained on handcrafted features reflecting dermatological guidelines (ABCDE and the 7-point checklist), and a pre-trained ResNet-50 model. We evaluate these models in alignment with [28]: across multiple training datasets with varied sex composition to determine their robustness. Our results show that both the LR and the CNN were robust to the sex distributions, but the results also revealed that the CNN had a significantly higher accuracy (ACC) and area under the receiver operating characteristics (AUROC) for male patients than for female patients. We hope these findings to contribute to the growing field of investigating potential bias in popular medical machine learning methods. The data and relevant scripts to reproduce our results can be found in our Github.

Vision-Language Model-Based Semantic-Guided Imaging Biomarker for Early Lung Cancer Detection

Objective: A number of machine learning models have utilized semantic features, deep features, or both to assess lung nodule malignancy. However, their reliance on manual annotation during inference, limited interpretability, and sensitivity to imaging variations hinder their application in real-world clinical settings. Thus, this research aims to integrate semantic features derived from radiologists' assessments of nodules, allowing the model to learn clinically relevant, robust, and explainable features for predicting lung cancer. Methods: We obtained 938 low-dose CT scans from the National Lung Screening Trial with 1,246 nodules and semantic features. The Lung Image Database Consortium dataset contains 1,018 CT scans, with 2,625 lesions annotated for nodule characteristics. Three external datasets were obtained from UCLA Health, the LUNGx Challenge, and the Duke Lung Cancer Screening. We finetuned a pretrained Contrastive Language-Image Pretraining model with a parameter-efficient fine-tuning approach to align imaging and semantic features and predict the one-year lung cancer diagnosis. Results: We evaluated the performance of the one-year diagnosis of lung cancer with AUROC and AUPRC and compared it to three state-of-the-art models. Our model demonstrated an AUROC of 0.90 and AUPRC of 0.78, outperforming baseline state-of-the-art models on external datasets. Using CLIP, we also obtained predictions on semantic features, such as nodule margin (AUROC: 0.81), nodule consistency (0.81), and pleural attachment (0.84), that can be used to explain model predictions. Conclusion: Our approach accurately classifies lung nodules as benign or malignant, providing explainable outputs, aiding clinicians in comprehending the underlying meaning of model predictions. This approach also prevents the model from learning shortcuts and generalizes across clinical settings.

A Comprehensive Study on Medical Image Segmentation using Deep Neural Networks

Over the past decade, Medical Image Segmentation (MIS) using Deep Neural Networks (DNNs) has achieved significant performance improvements and holds great promise for future developments. This paper presents a comprehensive study on MIS based on DNNs. Intelligent Vision Systems are often evaluated based on their output levels, such as Data, Information, Knowledge, Intelligence, and Wisdom (DIKIW),and the state-of-the-art solutions in MIS at these levels are the focus of research. Additionally, Explainable Artificial Intelligence (XAI) has become an important research direction, as it aims to uncover the "black box" nature of previous DNN architectures to meet the requirements of transparency and ethics. The study emphasizes the importance of MIS in disease diagnosis and early detection, particularly for increasing the survival rate of cancer patients through timely diagnosis. XAI and early prediction are considered two important steps in the journey from "intelligence" to "wisdom." Additionally, the paper addresses existing challenges and proposes potential solutions to enhance the efficiency of implementing DNN-based MIS.

White Light Specular Reflection Data Augmentation for Deep Learning Polyp Detection

Colorectal cancer is one of the deadliest cancers today, but it can be prevented through early detection of malignant polyps in the colon, primarily via colonoscopies. While this method has saved many lives, human error remains a significant challenge, as missing a polyp could have fatal consequences for the patient. Deep learning (DL) polyp detectors offer a promising solution. However, existing DL polyp detectors often mistake white light reflections from the endoscope for polyps, which can lead to false positives.To address this challenge, in this paper, we propose a novel data augmentation approach that artificially adds more white light reflections to create harder training scenarios. Specifically, we first generate a bank of artificial lights using the training dataset. Then we find the regions of the training images that we should not add these artificial lights on. Finally, we propose a sliding window method to add the artificial light to the areas that fit of the training images, resulting in augmented images. By providing the model with more opportunities to make mistakes, we hypothesize that it will also have more chances to learn from those mistakes, ultimately improving its performance in polyp detection. Experimental results demonstrate the effectiveness of our new data augmentation method.