VAMOS-OCTA: Vessel-Aware Multi-Axis Orthogonal Supervision for Inpainting Motion-Corrupted OCT Angiography Volumes

Handheld Optical Coherence Tomography Angiography (OCTA) enables noninvasive retinal imaging in uncooperative or pediatric subjects, but is highly susceptible to motion artifacts that severely degrade volumetric image quality. Sudden motion during 3D acquisition can lead to unsampled retinal regions across entire B-scans (cross-sectional slices), resulting in blank bands in en face projections. We propose VAMOS-OCTA, a deep learning framework for inpainting motion-corrupted B-scans using vessel-aware multi-axis supervision. We employ a 2.5D U-Net architecture that takes a stack of neighboring B-scans as input to reconstruct a corrupted center B-scan, guided by a novel Vessel-Aware Multi-Axis Orthogonal Supervision (VAMOS) loss. This loss combines vessel-weighted intensity reconstruction with axial and lateral projection consistency, encouraging vascular continuity in native B-scans and across orthogonal planes. Unlike prior work that focuses primarily on restoring the en face MIP, VAMOS-OCTA jointly enhances both cross-sectional B-scan sharpness and volumetric projection accuracy, even under severe motion corruptions. We trained our model on both synthetic and real-world corrupted volumes and evaluated its performance using both perceptual quality and pixel-wise accuracy metrics. VAMOS-OCTA consistently outperforms prior methods, producing reconstructions with sharp capillaries, restored vessel continuity, and clean en face projections. These results demonstrate that multi-axis supervision offers a powerful constraint for restoring motion-degraded 3D OCTA data. Our source code is available at https://github.com/MedICL-VU/VAMOS-OCTA.

Advanced Geometric Correction Algorithms for 3D Medical Reconstruction: Comparison of Computed Tomography and Macroscopic Imaging

This paper introduces a hybrid two-stage registration framework for reconstructing three-dimensional (3D) kidney anatomy from macroscopic slices, using CT-derived models as the geometric reference standard. The approach addresses the data-scarcity and high-distortion challenges typical of macroscopic imaging, where fully learning-based registration (e.g., VoxelMorph) often fails to generalize due to limited training diversity and large nonrigid deformations that exceed the capture range of unconstrained convolutional filters. In the proposed pipeline, the Optimal Cross-section Matching (OCM) algorithm first performs constrained global alignment: translation, rotation, and uniform scaling to establish anatomically consistent slice initialization. Next, a lightweight deep-learning refinement network, inspired by VoxelMorph, predicts residual local deformations between consecutive slices. The core novelty of this architecture lies in its hierarchical decomposition of the registration manifold. This hybrid OCM+DL design integrates explicit geometric priors with the flexible learning capacity of neural networks, ensuring stable optimization and plausible deformation fields even with few training examples. Experiments on an original dataset of 40 kidneys demonstrated better results compared to single-stage baselines. The pipeline maintains physical calibration via Hough-based grid detection and employs Bezier-based contour smoothing for robust meshing and volume estimation. Although validated on kidney data, the proposed framework generalizes to other soft-tissue organs reconstructed from optical or photographic cross-sections. By decoupling interpretable global optimization from data-efficient deep refinement, the method advances the precision, reproducibility, and anatomical realism of multimodal 3D reconstructions for surgical planning, morphological assessment, and medical education.

AI-Driven Three-Dimensional Reconstruction and Quantitative Analysis for Burn Injury Assessment

Accurate, reproducible burn assessment is critical for treatment planning, healing monitoring, and medico-legal documentation, yet conventional visual inspection and 2D photography are subjective and limited for longitudinal comparison. This paper presents an AI-enabled burn assessment and management platform that integrates multi-view photogrammetry, 3D surface reconstruction, and deep learning-based segmentation within a structured clinical workflow. Using standard multi-angle images from consumer-grade cameras, the system reconstructs patient-specific 3D burn surfaces and maps burn regions onto anatomy to compute objective metrics in real-world units, including surface area, TBSA, depth-related geometric proxies, and volumetric change. Successive reconstructions are spatially aligned to quantify healing progression over time, enabling objective tracking of wound contraction and depth reduction. The platform also supports structured patient intake, guided image capture, 3D analysis and visualization, treatment recommendations, and automated report generation. Simulation-based evaluation demonstrates stable reconstructions, consistent metric computation, and clinically plausible longitudinal trends, supporting a scalable, non-invasive approach to objective, geometry-aware burn assessment and decision support in acute and outpatient care.

Agreement-Driven Multi-View 3D Reconstruction for Live Cattle Weight Estimation

Accurate cattle live weight estimation is vital for livestock management, welfare, and productivity. Traditional methods, such as manual weighing using a walk-over weighing system or proximate measurements using body condition scoring, involve manual handling of stock and can impact productivity from both a stock and economic perspective. To address these issues, this study investigated a cost-effective, non-contact method for live weight calculation in cattle using 3D reconstruction. The proposed pipeline utilized multi-view RGB images with SAM 3D-based agreement-guided fusion, followed by ensemble regression. Our approach generates a single 3D point cloud per animal and compares classical ensemble models with deep learning models under low-data conditions. Results show that SAM 3D with multi-view agreement fusion outperforms other 3D generation methods, while classical ensemble models provide the most consistent performance for practical farm scenarios (R$^2$ = 0.69 $\pm$ 0.10, MAPE = 2.22 $\pm$ 0.56 \%), making this practical for on-farm implementation. These findings demonstrate that improving reconstruction quality is more critical than increasing model complexity for scalable deployment on farms where producing a large volume of 3D data is challenging.

Fully 3D Unrolled Magnetic Resonance Fingerprinting Reconstruction via Staged Pretraining and Implicit Gridding

Magnetic Resonance Fingerprinting (MRF) enables fast quantitative imaging, yet reconstructing high-resolution 3D data remains computationally demanding. Non-Cartesian reconstructions require repeated non-uniform FFTs, and the commonly used Locally Low Rank (LLR) prior adds computational overhead and becomes insufficient at high accelerations. Learned 3D priors could address these limitations, but training them at scale is challenging due to memory and runtime demands. We propose SPUR-iG, a fully 3D deep unrolled subspace reconstruction framework that integrates efficient data consistency with a progressive training strategy. Data consistency leverages implicit GROG, which grids non-Cartesian data onto a Cartesian grid with an implicitly learned kernel, enabling FFT-based updates with minimal artifacts. Training proceeds in three stages: (1) pretraining a denoiser with extensive data augmentation, (2) greedy per-iteration unrolled training, and (3) final fine-tuning with gradient checkpointing. Together, these stages make large-scale 3D unrolled learning feasible within a reasonable compute budget. On a large in vivo dataset with retrospective undersampling, SPUR-iG improves subspace coefficient maps quality and quantitative accuracy at 1-mm isotropic resolution compared with LLR and a hybrid 2D/3D unrolled baseline. Whole-brain reconstructions complete in under 15-seconds, with up to $\times$111 speedup for 2-minute acquisitions. Notably, $T_1$ maps with our method from 30-second scans achieve accuracy on par with or exceeding LLR reconstructions from 2-minute scans. Overall, the framework improves both accuracy and speed in large-scale 3D MRF reconstruction, enabling efficient and reliable accelerated quantitative imaging.

Three-dimensional visualization of X-ray micro-CT with large-scale datasets: Efficiency and accuracy for real-time interaction

As Micro-CT technology continues to refine its characterization of material microstructures, industrial CT ultra-precision inspection is generating increasingly large datasets, necessitating solutions to the trade-off between accuracy and efficiency in the 3D characterization of defects during ultra-precise detection. This article provides a unique perspective on recent advances in accurate and efficient 3D visualization using Micro-CT, tracing its evolution from medical imaging to industrial non-destructive testing (NDT). Among the numerous CT reconstruction and volume rendering methods, this article selectively reviews and analyzes approaches that balance accuracy and efficiency, offering a comprehensive analysis to help researchers quickly grasp highly efficient and accurate 3D reconstruction methods for microscopic features. By comparing the principles of computed tomography with advancements in microstructural technology, this article examines the evolution of CT reconstruction algorithms from analytical methods to deep learning techniques, as well as improvements in volume rendering algorithms, acceleration, and data reduction. Additionally, it explores advanced lighting models for high-accuracy, photorealistic, and efficient volume rendering. Furthermore, this article envisions potential directions in CT reconstruction and volume rendering. It aims to guide future research in quickly selecting efficient and precise methods and developing new ideas and approaches for real-time online monitoring of internal material defects through virtual-physical interaction, for applying digital twin model to structural health monitoring (SHM).

Diffusion Model-Based Data Augmentation for Enhanced Neuron Segmentation

Neuron segmentation in electron microscopy (EM) aims to reconstruct the complete neuronal connectome; however, current deep learning-based methods are limited by their reliance on large-scale training data and extensive, time-consuming manual annotations. Traditional methods augment the training set through geometric and photometric transformations; however, the generated samples remain highly correlated with the original images and lack structural diversity. To address this limitation, we propose a diffusion-based data augmentation framework capable of generating diverse and structurally plausible image-label pairs for neuron segmentation. Specifically, the framework employs a resolution-aware conditional diffusion model with multi-scale conditioning and EM resolution priors to enable voxel-level image synthesis from 3D masks. It further incorporates a biology-guided mask remodeling module that produces augmented masks with enhanced structural realism. Together, these components effectively enrich the training set and improve segmentation performance. On the AC3 and AC4 datasets under low-annotation regimes, our method improves the ARAND metric by 32.1% and 30.7%, respectively, when combined with two different post-processing methods. Our code is available at https://github.com/HeadLiuYun/NeuroDiff.

ThermoSplat: Cross-Modal 3D Gaussian Splatting with Feature Modulation and Geometry Decoupling

Multi-modal scene reconstruction integrating RGB and thermal infrared data is essential for robust environmental perception across diverse lighting and weather conditions. However, extending 3D Gaussian Splatting (3DGS) to multi-spectral scenarios remains challenging. Current approaches often struggle to fully leverage the complementary information of multi-modal data, typically relying on mechanisms that either tend to neglect cross-modal correlations or leverage shared representations that fail to adaptively handle the complex structural correlations and physical discrepancies between spectrums. To address these limitations, we propose ThermoSplat, a novel framework that enables deep spectral-aware reconstruction through active feature modulation and adaptive geometry decoupling. First, we introduce a Cross-Modal FiLM Modulation mechanism that dynamically conditions shared latent features on thermal structural priors, effectively guiding visible texture synthesis with reliable cross-modal geometric cues. Second, to accommodate modality-specific geometric inconsistencies, we propose a Modality-Adaptive Geometric Decoupling scheme that learns independent opacity offsets and executes an independent rasterization pass for the thermal branch. Additionally, a hybrid rendering pipeline is employed to integrate explicit Spherical Harmonics with implicit neural decoding, ensuring both semantic consistency and high-frequency detail preservation. Extensive experiments on the RGBT-Scenes dataset demonstrate that ThermoSplat achieves state-of-the-art rendering quality across both visible and thermal spectrums.

Atlas-Assisted Segment Anything Model for Fetal Brain MRI (FeTal-SAM)

This paper presents FeTal-SAM, a novel adaptation of the Segment Anything Model (SAM) tailored for fetal brain MRI segmentation. Traditional deep learning methods often require large annotated datasets for a fixed set of labels, making them inflexible when clinical or research needs change. By integrating atlas-based prompts and foundation-model principles, FeTal-SAM addresses two key limitations in fetal brain MRI segmentation: (1) the need to retrain models for varying label definitions, and (2) the lack of insight into whether segmentations are driven by genuine image contrast or by learned spatial priors. We leverage multi-atlas registration to generate spatially aligned label templates that serve as dense prompts, alongside a bounding-box prompt, for SAM's segmentation decoder. This strategy enables binary segmentation on a per-structure basis, which is subsequently fused to reconstruct the full 3D segmentation volumes. Evaluations on two datasets, the dHCP dataset and an in-house dataset demonstrate FeTal-SAM's robust performance across gestational ages. Notably, it achieves Dice scores comparable to state-of-the-art baselines which were trained for each dataset and label definition for well-contrasted structures like cortical plate and cerebellum, while maintaining the flexibility to segment any user-specified anatomy. Although slightly lower accuracy is observed for subtle, low-contrast structures (e.g., hippocampus, amygdala), our results highlight FeTal-SAM's potential to serve as a general-purpose segmentation model without exhaustive retraining. This method thus constitutes a promising step toward clinically adaptable fetal brain MRI analysis tools.

High-Fidelity 3D Tooth Reconstruction by Fusing Intraoral Scans and CBCT Data via a Deep Implicit Representation

High-fidelity 3D tooth models are essential for digital dentistry, but must capture both the detailed crown and the complete root. Clinical imaging modalities are limited: Cone-Beam Computed Tomography (CBCT) captures the root but has a noisy, low-resolution crown, while Intraoral Scanners (IOS) provide a high-fidelity crown but no root information. A naive fusion of these sources results in unnatural seams and artifacts. We propose a novel, fully-automated pipeline that fuses CBCT and IOS data using a deep implicit representation. Our method first segments and robustly registers the tooth instances, then creates a hybrid proxy mesh combining the IOS crown and the CBCT root. The core of our approach is to use this noisy proxy to guide a class-specific DeepSDF network. This optimization process projects the input onto a learned manifold of ideal tooth shapes, generating a seamless, watertight, and anatomically coherent model. Qualitative and quantitative evaluations show our method uniquely preserves both the high-fidelity crown from IOS and the patient-specific root morphology from CBCT, overcoming the limitations of each modality and naive stitching.