Early and Prediagnostic Detection of Pancreatic Cancer from Computed Tomography

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest solid malignancies, is often detected at a late and inoperable stage. Retrospective reviews of prediagnostic CT scans, when conducted by expert radiologists aware that the patient later developed PDAC, frequently reveal lesions that were previously overlooked. To help detecting these lesions earlier, we developed an automated system named ePAI (early Pancreatic cancer detection with Artificial Intelligence). It was trained on data from 1,598 patients from a single medical center. In the internal test involving 1,009 patients, ePAI achieved an area under the receiver operating characteristic curve (AUC) of 0.939-0.999, a sensitivity of 95.3%, and a specificity of 98.7% for detecting small PDAC less than 2 cm in diameter, precisely localizing PDAC as small as 2 mm. In an external test involving 7,158 patients across 6 centers, ePAI achieved an AUC of 0.918-0.945, a sensitivity of 91.5%, and a specificity of 88.0%, precisely localizing PDAC as small as 5 mm. Importantly, ePAI detected PDACs on prediagnostic CT scans obtained 3 to 36 months before clinical diagnosis that had originally been overlooked by radiologists. It successfully detected and localized PDACs in 75 of 159 patients, with a median lead time of 347 days before clinical diagnosis. Our multi-reader study showed that ePAI significantly outperformed 30 board-certified radiologists by 50.3% (P < 0.05) in sensitivity while maintaining a comparable specificity of 95.4% in detecting PDACs early and prediagnostic. These findings suggest its potential of ePAI as an assistive tool to improve early detection of pancreatic cancer.

Context-Aware Dynamic Chunking for Streaming Tibetan Speech Recognition

In this work, we propose a streaming speech recognition framework for Amdo Tibetan, built upon a hybrid CTC/Atten-tion architecture with a context-aware dynamic chunking mechanism. The proposed strategy adaptively adjusts chunk widths based on encoding states, enabling flexible receptive fields, cross-chunk information exchange, and robust adaptation to varying speaking rates, thereby alleviating the context truncation problem of fixed-chunk methods. To further capture the linguistic characteristics of Tibetan, we construct a lexicon grounded in its orthographic principles, providing linguistically motivated modeling units. During decoding, an external language model is integrated to enhance semantic consistency and improve recognition of long sentences. Experimental results show that the proposed framework achieves a word error rate (WER) of 6.23% on the test set, yielding a 48.15% relative improvement over the fixed-chunk baseline, while significantly reducing recognition latency and maintaining performance close to global decoding.

Listening, Imagining \& Refining: A Heuristic Optimized ASR Correction Framework with LLMs

Automatic Speech Recognition (ASR) systems remain prone to errors that affect downstream applications. In this paper, we propose LIR-ASR, a heuristic optimized iterative correction framework using LLMs, inspired by human auditory perception. LIR-ASR applies a "Listening-Imagining-Refining" strategy, generating phonetic variants and refining them in context. A heuristic optimization with finite state machine (FSM) is introduced to prevent the correction process from being trapped in local optima and rule-based constraints help maintain semantic fidelity. Experiments on both English and Chinese ASR outputs show that LIR-ASR achieves average reductions in CER/WER of up to 1.5 percentage points compared to baselines, demonstrating substantial accuracy gains in transcription.

FMSD-TTS: Few-shot Multi-Speaker Multi-Dialect Text-to-Speech Synthesis for Ü-Tsang, Amdo and Kham Speech Dataset Generation

Tibetan is a low-resource language with minimal parallel speech corpora spanning its three major dialects-\"U-Tsang, Amdo, and Kham-limiting progress in speech modeling. To address this issue, we propose FMSD-TTS, a few-shot, multi-speaker, multi-dialect text-to-speech framework that synthesizes parallel dialectal speech from limited reference audio and explicit dialect labels. Our method features a novel speaker-dialect fusion module and a Dialect-Specialized Dynamic Routing Network (DSDR-Net) to capture fine-grained acoustic and linguistic variations across dialects while preserving speaker identity. Extensive objective and subjective evaluations demonstrate that FMSD-TTS significantly outperforms baselines in both dialectal expressiveness and speaker similarity. We further validate the quality and utility of the synthesized speech through a challenging speech-to-speech dialect conversion task. Our contributions include: (1) a novel few-shot TTS system tailored for Tibetan multi-dialect speech synthesis, (2) the public release of a large-scale synthetic Tibetan speech corpus generated by FMSD-TTS, and (3) an open-source evaluation toolkit for standardized assessment of speaker similarity, dialect consistency, and audio quality.