GuideSkill: Evolving Executable LLM Agent Skills for Guideline-Grounded Clinical Reasoning

Clinical practice guidelines (CPGs) encode diagnostic criteria, but LLM systems typically retrieve guideline text or absorb it through training rather than execute its rules. We introduce GuideSkill, an external reasoning layer that compiles disease-specific criteria into executable functions returning ordinal diagnostic-support scores. GuideSkill-Zero is initialized from guidelines, while GuideSkill-Evo uses case--diagnosis pairs to refine covered skills and add missing diagnoses. At inference, an LLM proposes a differential diagnosis, grounds the features required by each matched skill, and fuses its ranking with the executed skill scores. Across four benchmarks and four backbones, GuideSkill-Zero improves macro-average accuracy over guideline RAG by 13.45% on average. GuideSkill-Evo achieves the highest macro-average for every backbone, improves over direct inference by 18.49% relatively, and increases gold-label skill coverage from 56.5% to 99.5%. On Qwen3.5-9B, it also exceeds the strongest parameter-update baseline by 11.16% without updating the backbone. Expert evaluation further indicates that GuideSkill produces clinically sound and broadly acceptable skills, suggesting that its initialized and evolved rules are reliable and practically meaningful. These results support executable skills as a model-agnostic mechanism for combining guideline-derived procedures with case-derived diagnostic patterns.

OmniDelta: Skill-Driven Budget Allocation for Token Compression in OmniLLMs

Emerging Omni-modal Large Language Models (OmniLLMs) enable unified understanding of text, audio, and video, but their long audio-video token sequences introduce substantial memory and inference costs. Existing compression methods mainly focus on selecting important tokens under fixed budgets, leaving the preceding budget-allocation problem underexplored. We show that direct query-to-audio/video similarity is unreliable for inter-modal budget allocation, and that uniform intra-modal budgets can miss key evidence while retaining redundant content. To address these limitations, we propose OmniDelta, a training-free, skill-driven framework that couples intent-aware inter-modal allocation with content-aware intra-modal allocation. OmniDelta first constructs audio and video skill pools to shift the fixed retained-token budget according to query demand, then reallocates modality budgets over audio segments and video frames using local complexity and temporal redundancy. The resulting local budgets can be combined with existing pruning strategies, preserving the total retained-token ratio while changing where the budget is spent. Experiments on four audio-video benchmarks with two Qwen2.5-Omni models show that OmniDelta establishes a new accuracy-efficiency Pareto frontier across pruning ratios. At 25% token retention on Qwen2.5-Omni-7B, OmniDelta reduces GPU memory by 22.0% and achieves a 1.64x end-to-end speedup over full-token inference.

SEED: Self-Evolving On-Policy Distillation for Agentic Reinforcement Learning

Large language models are increasingly trained as interactive agents for long-horizon tasks involving multi-turn interaction, tool use, and environment feedback. Outcome-based reinforcement learning (RL) provides a practical optimization paradigm, but its sparse trajectory-level rewards offer limited guidance on intermediate decisions, leaving a supervision gap between episode-level outcomes and token-level policy learning. We propose SEED (SElf-Evolving On-Policy Distillation), a self-evolving framework that converts completed on-policy trajectories into training-time hindsight skills and distills their behavioral effect back into the policy model. SEED first fine-tunes the policy to analyze completed trajectories and generate natural-language skills that capture reusable workflows, decisive observations, or failure-avoidance rules. During RL, the current policy both collects trajectories and serves as the analyzer that extracts hindsight skills from them. Policy updates therefore improve subsequent decision making and skill analysis together, allowing hindsight supervision to evolve with the policy. SEED then re-scores the sampled actions under ordinary and skill-augmented contexts, converting the skill-induced probability shift into a dense token-level on-policy distillation signal. This signal is jointly optimized with outcome-based RL, keeping the auxiliary supervision aligned with the current trajectory distribution. Extensive experiments on text-based and vision-based agentic tasks show that SEED consistently improves performance and sample efficiency, exhibiting robust generalization to unseen scenarios. Our code is available at https://github.com/jinyangwu/SEED.

D-cut: Adaptive Verification Depth Pruning for Batched Speculative Decoding

Speculative decoding accelerates large language model (LLM) inference without compromising output quality. Recent parallel drafting methods further improve single-request performance by decoupling draft length from drafting latency, enabling longer drafts and higher mean accepted tokens (MAT). However, under high request concurrency, long drafts waste substantial computation on rejected tokens, increasing verification cost and potentially making speculative decoding slower than autoregressive decoding. We present D-Cut, an adaptive pruning method that selects draft tokens jointly across the batch and concentrates the verification budget on tokens most likely to be accepted. D-Cut is motivated by two observations. First, acceptance lengths vary considerably across concurrent requests; D-Cut therefore performs cross-request pruning, allocating the verification budget adaptively according to draft confidence. Second, verification cost depends strongly on the deployment environment, including GPU architecture and parallelism strategy; D-Cut incorporates a runtime cost model to adapt its pruning depth to the target environment. Experiments on dense and mixture-of-experts (MoE) models show that, under high concurrency, D-Cut improves the average speedup from \(1.26\times\) to \(1.65\times\), restores acceleration in dense-model configurations where long-draft baselines are slower than autoregressive decoding, and achieves up to \(3.0\times\) speedup over autoregressive decoding on MoE models.

OPID: On-Policy Skill Distillation for Agentic Reinforcement Learning

Outcome-based reinforcement learning provides a stable optimization backbone for language agents, but its sparse trajectory-level rewards provide little guidance on which intermediate decisions should be reinforced or suppressed. On-policy self-distillation offers dense token-level supervision, yet existing skill-conditioned variants often rely on external skill memories or retrieved privileged context, which are costly to maintain and can be mismatched with the state distribution induced by the current policy in multi-turn interaction. We propose \textbf{OPID} (\textbf{O}n-\textbf{P}olicy Sk\textbf{i}ll \textbf{D}istillation), a framework that extracts skill supervision directly from completed on-policy trajectories. OPID represents trajectory hindsight as hierarchical skills: episode-level skills capture global workflows or failure-avoidance rules, while step-level skills capture local decision knowledge at critical timesteps. A critical-first routing mechanism uses step-level skills when critical decisions are identified and falls back to episode-level skills as default guidance otherwise. The selected skill is injected into the interaction history, allowing the old policy to re-score the same sampled response under both original and skill-augmented contexts. The resulting log-probability shift yields a token-level self-distillation advantage, which is combined with the outcome advantage for policy optimization. OPID thus preserves RL as the primary training objective while introducing dense, distribution-matched hindsight supervision. Experiments on ALFWorld, WebShop and Search-based QA demonstrate that OPID generally improves agent performance, sample efficiency, and robustness over outcome-only RL and existing skill-distillation baselines. Our code is available at https://github.com/jinyangwu/OPID/tree/main.

Breaking Entropy Bounds: Accelerating RL Training via MTP with Rejection Sampling

Reinforcement learning (RL) has become a key component in modern large language models, yet the rollout stage remains the key bottleneck in RL training pipelines. Although Multi-Token Prediction (MTP) offers a natural solution to accelerate rollouts through speculative decoding, many studies have observed that MTP acceptance rates degrade significantly during RL training, leading to limited speedup performance. To address this bottleneck, we present Bebop, a systematic study of MTP in LLM post-training, and offer practical recipes to integrate MTP into large-scale RL pipelines. First, we reveal that the MTP acceptance rate is fundamentally bounded by the fluctuation of model entropy, which demonstrates a clear negative linear relationship with the rise of entropy in the RL stage. Second, we show that probabilistic rejection sampling largely alleviates the disturbance introduced by entropy in RL compared to greedy draft sampling. We further identify that the conventional MTP training objectives (cross-entropy or KL) are suboptimal in such settings, and therefore we propose a novel end-to-end TV loss that directly optimizes multi-step rejection sampling acceptance rate, yielding ~10% acceptance rate improvements, achieving up to 95% acceptance rates and up to 25% extra inference throughput gains across mathematical reasoning, code generation, and agentic tasks. Third, we test various online MTP training strategies during RL and show that pre-RL MTP training with e2e TV loss and rejection sampling achieves a consistent acceptance rate and speedup throughout the entire RL, eliminating the need for costly online MTP updating. We provide extensive experiments and analysis that validate our findings. Experimental results show our method achieves up to 1.8x end-to-end acceleration in async RL training of Qwen3.5, Qwen3.6, and Qwen3.7 models.

Beyond Prompt-Based Planning: MCP-Native Graph Planning-based Biomedical Agent System

Biomedical agents promise to automate complex biological workflows, yet current systems face two fundamental bottlenecks: bioinformatics tools are highly heterogeneous in interfaces and execution environments, while agent planning still relies on flat prompt-retrieved tool descriptions. As biomedical software ecosystems grow, this coupling between tool coverage and context size leads to tool confusion, unstable planning, and inefficient execution. We introduce BioManus, an MCP-native biomedical agent built on graph-scaffolded planning over structured biological capabilities. BioManus first introduces the BioinfoMCP Compiler, which converts heterogeneous bioinformatics software into standardized MCP servers, yielding a large executable MCP ecosystem. It then organizes this ecosystem as a typed heterogeneous MCP graph over tools, operations, datatypes, and workflow stages. At inference time, BioManus retrieves compact task-specific subgraphs, synthesizes operation-level workflow scaffolds. This design decouples planning complexity from raw tool inventory size, achieving a context compression ratio of Theta(N / (h * m_bar)) under high-recall retrieval, where N is the total tool count, h is the workflow horizon, and m_bar (much smaller than N) is the average number of candidate tools per operation. Experiments on BioAgentBench and LAB-Bench show that BioManus improves execution accuracy, workflow validity, and context efficiency over advanced biomedical agent baselines. This work suggests a paradigm shift: scalable biomedical reasoning requires structured executable capability graphs rather than increasingly larger prompt-level tool retrieval.

MedGuideX: Internalizing Decision Logic from Executable Guidelines into Large Language Models for Clinical Reasoning

Clinical practice guidelines (CPGs) encode evidence-based decision logic that clinicians apply by evaluating patient variables, conditional criteria, and recommendation rules. However, existing methods often use CPGs as free-text training data or retrieval sources, underutilizing their procedural decision structure. To better exploit this structure, we introduce a guideline-derived training pipeline that transforms CPG recommendations into executable clinical decision logic and uses it to generate factual and counterfactual question-answering data. Theses data teach models both guideline-supported decisions and how decisions change under different patient conditions. Post-training a medical LLM on the generated data yields MedGuideX. Across four clinical reasoning benchmarks, MedGuideX achieves a 10.28% relative improvement in average accuracy. Physician evaluation further shows that MedGuideX better recovers clinician authored reasoning steps and produces physician-preferred rationales in faithfulness, validity, completeness, and clarity. Overall, our results show that executable decision logic from CPGs can be transformed into scalable supervision for building reliable medical LLMs.

Maestro: Reinforcement Learning to Orchestrate Hierarchical Model-Skill Ensembles

The proliferation of large language models (LLMs) and modular skills has endowed autonomous agents with increasingly powerful capabilities. Existing frameworks typically rely on monolithic LLMs and fixed logic to interface with these skills. This gives rise to a critical bottleneck: different LLMs offer distinct advantages across diverse domains, yet current frameworks fail to exploit the complementary strengths of models and skills, thereby limiting their performance on downstream tasks. In this paper, we present Maestro (Multimodal Agent for Expert-Skill Targeted Reinforced Orchestration), a Reinforcement Learning (RL)-driven orchestration framework that reframes heterogeneous multimodal tasks as a sequential decision-making process over a hierarchical model-skill registry. Rather than consolidating all knowledge into a single model, Maestro trains a lightweight policy to dynamically compose ensembles of frozen expert models and a two-tier skill library, deciding at each step whether to invoke an external expert, which model-skill pair to select, and when to terminate. The policy is optimized via outcome-based RL, requiring no step-level supervision. We evaluate Maestro across ten representative multimodal benchmarks spanning mathematical reasoning, chart understanding, high-resolution perception, and domain-specific analysis. With only a 4B orchestrator, Maestro achieves an average accuracy of 70.1%, surpassing both GPT-5 (69.3%) and Gemini-2.5-Pro (68.7%). Crucially, the learned coordination policy generalizes to unseen models and skills without retraining: augmenting the registry with out-of-domain experts yields a 59.5% average on four challenging benchmarks, outperforming all closed-source baselines. Maestro further maintains high computational efficiency with low latency. The source code is available at https://github.com/jinyangwu/Maestro.

Draft Less, Retrieve More: Hybrid Tree Construction for Speculative Decoding

Speculative decoding (SD) accelerates large language model inference by leveraging a draft-then-verify paradigm. To maximize the acceptance rate, recent methods construct expansive draft trees, which unfortunately incur severe VRAM bandwidth and computational overheads that bottleneck end-to-end speedups. While dynamic-depth pruning can reduce this latency by removing marginal branches, it also discards potentially valid candidates, preventing the acceptance rate from reaching the upper bound of dense trees. In this paper, we identify a critical opportunity in resource allocation: the transition from dense to pruned drafting frees up significant computational budget. To break this Pareto tradeoff, we introduce Graft, a compensation framework that couples pruning and retrieval as mutually reinforcing operations. Pruning supplies sufficient budget for retrieval, while retrieval compensates for pruning-induced coverage loss and recovers accepted length. By employing a sequential `prune-then-graft' mechanism, Graft attaches highly predictive retrieved tokens into positions opened by pruning, filling the topological gaps with near-zero overhead. Graft is entirely training-free and lossless. Comprehensive evaluations show that Graft establishes a new Pareto frontier across practical deployment settings, including short-context generation, long-context generation, and large-scale models. On short-context benchmarks, it achieves up to 5.41$\times$ speedup and improves average speedup over EAGLE-3 by up to 21.8% on the large-scale Qwen3-235B. We also provide a preliminary exploration of applying Graft to the DFlash-style block drafting paradigm, offering initial evidence and insights for extending grafting beyond autoregressive draft trees.